ISRN dentistry最新文献

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Comparative evaluation of two types of immediately loaded implants using biomechanical and histomorphometric tests: an animal case study. 使用生物力学和组织形态计量学测试对两种类型即刻加载植入物的比较评估:动物案例研究。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-07-18 DOI: 10.5402/2012/328945
Mansour Rismanchian, Bijan Movahedian, Navid Khalighinejad, Hamid Badrian, Sayed Mohammad Razavi, Afsaneh Nekouie
{"title":"Comparative evaluation of two types of immediately loaded implants using biomechanical and histomorphometric tests: an animal case study.","authors":"Mansour Rismanchian,&nbsp;Bijan Movahedian,&nbsp;Navid Khalighinejad,&nbsp;Hamid Badrian,&nbsp;Sayed Mohammad Razavi,&nbsp;Afsaneh Nekouie","doi":"10.5402/2012/328945","DOIUrl":"https://doi.org/10.5402/2012/328945","url":null,"abstract":"<p><p>Introduction. In order to minimize the required time to regain esthetic and function, immediately loaded implants were suggested. The aim of this study was to comparatively evaluate the Nisastan and XIve implants using biomechanical and histomorphometric tests. Materials and Methods. In this experimental study, 6 Nisastan one-piece immediately loaded screw type implant (OPILS) and 6 Xive implants with 3.4 mm diameter and 11 mm long were used. The implants were immediately loaded with temporary coating. After three months, the torque required to break bone-implant contact was measured and was recorded. All implants were extracted with surrounding bone and histologically were evaluated. The data were inputted into the SPSS 11.5 to run student T-test statistical analyses (α = 0.05). Results. The success rates of both types of implants was 100%, and none of them failed due to mobility or bone loss. The mean removal torque value (RTV) was 142.08 and 40 N/Cm for Xive and Nisastan implants, respectively, and their RTVs showed a significant difference between two mentioned implants (P = 0.004). None of the histomorphometric values showed significant differences between the two implants (P > 0.05). Discussion. both systems have the capability to induce osseointegration under immediate loads but that Xive implants showed higher capability for bone contact.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"328945"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30804736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Comprehensive Analysis of Bacterial Flora in Postoperative Maxillary Cyst Fluid by 16S rRNA Gene and Culture Methods. 应用16S rRNA基因及培养法综合分析术后上颌囊肿液细菌菌群。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-05-22 DOI: 10.5402/2012/840483
Naoto Sano, Yoshio Yamashita, Kazumasa Fukuda, Hatsumi Taniguchi, Masaaki Goto, Hiroshi Miyamoto
{"title":"Comprehensive Analysis of Bacterial Flora in Postoperative Maxillary Cyst Fluid by 16S rRNA Gene and Culture Methods.","authors":"Naoto Sano,&nbsp;Yoshio Yamashita,&nbsp;Kazumasa Fukuda,&nbsp;Hatsumi Taniguchi,&nbsp;Masaaki Goto,&nbsp;Hiroshi Miyamoto","doi":"10.5402/2012/840483","DOIUrl":"https://doi.org/10.5402/2012/840483","url":null,"abstract":"<p><p>Intracystic fluid was aseptically collected from 11 patients with postoperative maxillary cyst (POMC), and DNA was extracted from the POMC fluid. Bacterial species were identified by sequencing after cloning of approximately 580 bp of the 16S rRNA gene. Identification of pathogenic bacteria was also performed by culture methods. The phylogenetic identity was determined by sequencing 517-596 bp in each of the 1139 16S rRNA gene clones. A total of 1114 clones were classified while the remaining 25 clones were unclassified. A total of 103 bacterial species belonging to 42 genera were identified in POMC fluid samples by 16S rRNA gene analysis. Species of Prevotella (91%), Neisseria (73%), Fusobacterium (73%), Porphyromonas (73%), and Propionibacterium (73%) were found to be highly prevalent in all patients. Streptococcus mitis (64%), Fusobacterium nucleatum (55%), Propionibacterium acnes (55%), Staphylococcus capitis (55%), and Streptococcus salivarius (55%) were detected in more than 6 of the 11 patients. The results obtained by the culture method were different from those obtained by 16S rRNA gene analysis, but both approaches may be necessary for the identification of pathogens, especially of bacteria that are difficult to detect by culture methods, and the development of rational treatments for patients with POMC.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"840483"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30680629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Evaluation of manual and two-rotary niti retreatment systems in removing gutta-percha obturated with two root canal sealers. 手动和双旋转niti再处理系统去除双根管密封剂封闭的杜仲胶的评价。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-09-10 DOI: 10.5402/2012/208241
Athikesavan Jayasenthil, Emmanuel Solomon Sathish, Prashanth Prakash
{"title":"Evaluation of manual and two-rotary niti retreatment systems in removing gutta-percha obturated with two root canal sealers.","authors":"Athikesavan Jayasenthil,&nbsp;Emmanuel Solomon Sathish,&nbsp;Prashanth Prakash","doi":"10.5402/2012/208241","DOIUrl":"https://doi.org/10.5402/2012/208241","url":null,"abstract":"<p><p>Objective. The objective of this study was to evaluate the efficacy of two retreatment NiTi systems (protaper universal retreatment files, R-Endo), when compared to manual technique in removing Gutta-percha obturated with two sealers. Study Design. Sixty extracted single-rooted premolars were instrumented with Protaper rotary files till F3. The specimens were divided into six groups. Groups 1, 2, 3 were obturated with Gutta-percha and zinc oxide eugenol and Groups 4, 5, 6 were obturated with Gutta-percha and AH-plus. The retreatment was carried out in groups 1 and 4 with H-files and GGdrills, groups 2 and 5 with R-endo retreatment files and groups 3 and 6 with Protaper retreatment files. The roots were sectioned and evaluated under optical stereomicroscope. Statistical analysis was performed with one-way ANOVA and Newman-Keul's test at P < 0.05. Results. The manual technique resulted in cleaner canal walls when compared with both rotary retreatment systems. Conclusion. NiTi rotary retreatment files can be used to remove the filling material quickly, but it should be followed by hand instruments to obtain better canal wall cleanliness.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"208241"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/208241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30922390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
A comparison of two pain scales in the assessment of dental pain in East delhi children. 东德里儿童牙痛评估中两种疼痛量表的比较。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-02-14 DOI: 10.5402/2012/247351
Amit Khatri, Namita Kalra
{"title":"A comparison of two pain scales in the assessment of dental pain in East delhi children.","authors":"Amit Khatri, Namita Kalra","doi":"10.5402/2012/247351","DOIUrl":"10.5402/2012/247351","url":null,"abstract":"<p><p>Pain is the most common symptom of oral diseases. Pain perception in children is highly variable and unreliable due to poor communication. Therefore we designed a study to compare pain measurement techniques, that is, visual analogue scale (VAS) and Wong-Baker faces pain rating scale (WBFPS) among Delhi children aged 3 to 14 years undergoing dental extraction. Method. A cross-sectional study was conducted on 180 patients aged 3 to 14 years who had undergone dental extraction. Children were assessed for their pain sensitivity using visual analogue scale (VAS) and Wong-Baker faces pain rating scale (WBFPS ). Result and Conclusion. Pain threshold tends to decline, and the self-management of pain becomes more effective with increasing age. Genderwise result shows that communication ability of boys and girls is similar in all age groups.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"247351"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30539477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of the Removal of Smear Layer by Two Endodontic Irrigants and Nd:YAG Laser: A Scanning Electron Microscopic Study. 两种牙根管冲洗剂和Nd:YAG激光去除牙根管涂片层的比较研究。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-07-16 DOI: 10.5402/2012/620951
Seyed Mohsen Hasheminia, Reza Birang, Mahboobe Feizianfard, Mina Nasouri
{"title":"A Comparative Study of the Removal of Smear Layer by Two Endodontic Irrigants and Nd:YAG Laser: A Scanning Electron Microscopic Study.","authors":"Seyed Mohsen Hasheminia,&nbsp;Reza Birang,&nbsp;Mahboobe Feizianfard,&nbsp;Mina Nasouri","doi":"10.5402/2012/620951","DOIUrl":"https://doi.org/10.5402/2012/620951","url":null,"abstract":"<p><p>The aim of this study was to compare the effect of 17% EDTA, 5% maleic acid, and Nd:YAG laser on smear layer removal by SEM. Eighty single-rooted teeth were divided into three groups of 25 according to the final procedure for smear layer removal: irrigation by 17% EDTA or 5% maleic acid or Nd:YAG laser irradiation. The other five teeth was used as control. Roots were sectioned into buccal and lingual parts, and smear layer presence was recorded in the coronal, middle, and apical thirds under SEM. Data were analyzed by Kruskal-Wallis, Mann-Whitney, Friedman, and Wilcoxon tests. There was no significant difference between smear layer removal of 17% EDTA and 5% maleic acid. Nd:YAG laser showed the least effect significantly. The coronal part of samples was significantly cleaner than the middle, and the middle was cleaner than the apical section. 17% EDTA and 5% maleic acid were more effective in smear layer removal compared to Nd:YAG laser.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"620951"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/620951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30798956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals. 评估牙周病患者和健康人的 PECAM-1 基因多态性。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-03-05 DOI: 10.5402/2012/751920
Mahdi Kdkhodazadeh, Mehrdad Hajilooi, Behzad Houshmand, Sara Khazaei, Leila Gholami, Sara Alijani
{"title":"Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals.","authors":"Mahdi Kdkhodazadeh, Mehrdad Hajilooi, Behzad Houshmand, Sara Khazaei, Leila Gholami, Sara Alijani","doi":"10.5402/2012/751920","DOIUrl":"10.5402/2012/751920","url":null,"abstract":"<p><p>Objective. Our aim in this paper was to investigate the possible genetic association between three Ser563Asn, Leu125Val and Arg670Gly polymorphisms of the PECAM-1 gene and periodontitis. Methods. Genomic DNA was isolated from whole blood of 105 periodontal patient (52 with chronic periodontitis and 53 with aggressive periodontitis) and 101 healthy individuals. Samples were genotyped and analyzed for the three single-nucleotide polymorphisms (SNPs) of PECAM-1 using polymerase chain reaction with sequence-specific primers (PCR-SSPs). Results. A statistically significant difference was found between the genotypic distribution of the Ser563Asn polymorphism in patients with periodontitis compared to controls (P = 0.02). But there were no statistically significant difference between the allele frequencies in the different groups (P = 0.05). The other two polymorphisms did not show a statistically significant difference in their allele and genotype frequencies between the groups. There was no statistically significant difference found for any of the polymorphisms allele and genotype distribution in aggressive and chronic periodontitis either. Conclusions. No significant association was found between the polymorphism tested and the subgroups of periodontitis, further research is still necessary to determine whether this polymorphism can be used as a genetic marker of periodontitis.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"751920"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30540588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro Antimicrobial Effect of a Cold Plasma Jet against Enterococcus faecalis Biofilms. 低温等离子体射流对粪肠球菌生物膜的体外抗菌作用。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-01-24 DOI: 10.5402/2012/295736
Chunqi Jiang, Christoph Schaudinn, David E Jaramillo, Paul Webster, J William Costerton
{"title":"In Vitro Antimicrobial Effect of a Cold Plasma Jet against Enterococcus faecalis Biofilms.","authors":"Chunqi Jiang,&nbsp;Christoph Schaudinn,&nbsp;David E Jaramillo,&nbsp;Paul Webster,&nbsp;J William Costerton","doi":"10.5402/2012/295736","DOIUrl":"https://doi.org/10.5402/2012/295736","url":null,"abstract":"<p><p>The hypothesis that a cold plasma jet has the antimicrobial effect against Enterococcus faecalis biofilms was tested in vitro. 27 hydroxyapatite discs were incubated with E. faecalis for six days to form a monoculture biofilm on the disc surface. The prepared substrata were divided into three groups: the negative control, the positive control (5.25% NaOCl solution), and the plasma treatment group. Resultant colony-forming unit counts were associated with observations of bacterial cell morphology changes using scanning electron microscopy (SEM). Treatment of E. faecalis biofilm with the plasma and 5.25% NaOCl for 5 min resulted in 93.1% and 90.0% kill (P < 0.0001), respectively. SEM detected that nearly no intact bacteria were discernible for the plasma-exposed HA disc surfaces. The demonstrated bactericidal effect of the plasma with direct surface contact may be due to the enhanced oxidation by the locally produced reactive plasma species.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"295736"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30540583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Evaluation of Micromovements and Stresses around Single Wide-Diameter and Double Implants for Replacing Mandibular Molar: A Three-Dimensional FEA. 单颗大直径种植体和双颗种植体置换下颌磨牙的微运动和应力评价:三维有限元分析。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-03-07 DOI: 10.5402/2012/680587
Shrikar R Desai, I Karthikeyan, Rika Singh
{"title":"Evaluation of Micromovements and Stresses around Single Wide-Diameter and Double Implants for Replacing Mandibular Molar: A Three-Dimensional FEA.","authors":"Shrikar R Desai,&nbsp;I Karthikeyan,&nbsp;Rika Singh","doi":"10.5402/2012/680587","DOIUrl":"https://doi.org/10.5402/2012/680587","url":null,"abstract":"<p><p>Purpose. The purpose of this finite element study was to compare stresses, strains, and displacements of double versus single implant, in immediate loading for replacing mandibular molar. Materials and Methods. Two 3D FEM models were made to simulate implant designs. The first model used 6 mm wide-diameter implant to support a single molar crown. The second model used 3.75-3.75 double implant design. Each model was analyzed with a single force magnitude of 70 N in oblique axis in three locations. Results. This FEM study suggested that micromotion can be well controlled by both double implants and 6 mm single wide-diameter implant. The Von Mises stress for double implant had 31%-43% stress reduction compared to the 6 mm implant. Conclusion. Within the limitations of the paper, when the mesiodistal space for artificial tooth is more than 12.5 mm, under immediate loading, the double implant support should be considered.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"680587"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30540587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Comparison of endodontic biomaterials as apical barriers in simulated open apices. 根管生物材料在模拟开放根尖中作为根尖屏障的比较。
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-06-27 DOI: 10.5402/2012/359873
Mamak Adel, Moradi Majd Nima, Shiva Shivaie Kojoori, Hooryeh Norooz Oliaie, Neda Naghavi, Saeed Asgary
{"title":"Comparison of endodontic biomaterials as apical barriers in simulated open apices.","authors":"Mamak Adel,&nbsp;Moradi Majd Nima,&nbsp;Shiva Shivaie Kojoori,&nbsp;Hooryeh Norooz Oliaie,&nbsp;Neda Naghavi,&nbsp;Saeed Asgary","doi":"10.5402/2012/359873","DOIUrl":"https://doi.org/10.5402/2012/359873","url":null,"abstract":"<p><p>Objectives. To evaluate the effect of apical foramen diameter and apical barrier thickness on the sealing ability of mineral trioxide aggregate (MTA) and calcium enriched mixture (CEM) plugs in open apices. Materials and Methods. The fluid filtration method was conducted on a total of 136 roots. Samples were randomly divided into two control (n = 8) and four experimental groups (n = 30). Apical foramen diameters measuring 1.1 and 1.7 mm were shaped for groups \"1 and 3\" and \"2 and 4\", respectively. In groups 1 and 2 MTA plug and in groups 3 and 4 CEM plug was inserted. The groups were further divided into subgroups according to the thickness of the apical plugs (3- or 5-mm). Microleakage was measured at 1, 7, and 30 days. Results. Mixed ANOVA test showed that the microleakage in groups 1 and 3 as well as all 5-mm plug subgroups were significantly less than groups 2 and 4 (P < 0.05) and 3-mm subgroups (P < 0.05), respectively. Microleakage was significantly lower at 30th day (P < 0.05). Conclusions. Reducing canal diameter or increasing apical plug thickness and the time interval increases the sealing ability of apical barriers. Furthermore, in comparison to MTA, CEM plugs demonstrated superior sealing ability.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2012 ","pages":"359873"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/359873","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30760162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin. 牙龈卟啉单胞菌菌膜诱导小鼠巨噬细胞炎症因子和环氧合酶-2的表达及纤维连接蛋白和褪黑素的抑制作用
ISRN dentistry Pub Date : 2012-01-01 Epub Date: 2012-04-01 DOI: 10.5402/2012/350859
Yukio Murakami, Mamoru Machino, Seiichiro Fujisawa
{"title":"Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin.","authors":"Yukio Murakami,&nbsp;Mamoru Machino,&nbsp;Seiichiro Fujisawa","doi":"10.5402/2012/350859","DOIUrl":"https://doi.org/10.5402/2012/350859","url":null,"abstract":"<p><p>Porphyromonas gingivalis (Pg) fimbriae, in addition to lipopolysaccharide, are involved in the pathogenesis of periodontal disease. At the same time, bioactive compounds such as fibronectin (FN) and melatonin in saliva and gingival crevicular fluid have been reported to exert a preventive effect against periodontitis. Here, we review current knowledge regarding the potent inhibitory effects of FN and melatonin against Pg fimbria-induced induction of proinflammatory cytokines, cyclooxygenase-2 (COX-2) expression, and NF-kappa B activation in mouse macrophages and discuss their possible clinical application for prevention of periodontal diseases induced by oral bacteria.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":" ","pages":"350859"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40191936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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