Biomedical Journal最新文献_第7页

Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes 获得性免疫缺陷综合症与 SARS-CoV-2 N 基因型的相关性。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2023.100650

{"title":"Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes","authors":"","doi":"10.1016/j.bj.2023.100650","DOIUrl":"10.1016/j.bj.2023.100650","url":null,"abstract":"<div><h3>Background</h3><p>Epigenetics and clinical observations referring to Betacoronavirus lead to the conjecture that Sarbecovirus may have the ability to infect lymphocytes using a different way than the spike protein. In addition to inducing the death of lymphocytes, thus drastically reducing their population and causing a serious immune deficiency, allows it to remain hidden for long periods of latency using them as a viral reservoir in what is named Long-Covid Disease. Exploring possibilities, the hypothesis is focused on that N protein may be the key of infecting lymphocytes.</p></div><div><h3>Method</h3><p>The present article exhibits a computational assay for the latest complete sequences reported to GISAID, correlating N genotypes with an enhancement in the affinity of the complex that causes immune deficiency in order to determine a good docking with the N protein and some receptors in lymphocytes.</p></div><div><h3>Results</h3><p>A novel high-interaction coupling of N-RBD and CD147 is presented as the main way of infecting lymphocytes, allowing to define those genotypes involved in their affinity enhancement.</p></div><div><h3>Conclusion</h3><p>The hypothesis is consistent with the mutagenic deriving observed on the in-silico assay, which reveals that genotypes N/120 and N/152 are determinant to reduce the Immune Response of the host infecting lymphocytes, allowing the virus persists indefinitely and causing an Acquire Immune Deficiency Syndrome.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 3","pages":"Article 100650"},"PeriodicalIF":4.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417023000872/pdfft?md5=1edaaac170d38d8c21d14f03478af8b3&pid=1-s2.0-S2319417023000872-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10030002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut mycobiome in metabolic diseases: Mechanisms and clinical implication 代谢性疾病中的肠道霉菌生物群：机制和临床意义。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2023.100625

引用次数: 0

Using time-course as an essential factor to accurately predict sepsis-associated mortality among patients with suspected sepsis 将时间进程作为准确预测疑似败血症患者败血症相关死亡率的重要因素。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2023.100632

{"title":"Using time-course as an essential factor to accurately predict sepsis-associated mortality among patients with suspected sepsis","authors":"","doi":"10.1016/j.bj.2023.100632","DOIUrl":"10.1016/j.bj.2023.100632","url":null,"abstract":"<div><h3>Background</h3><p>Biomarker dynamics in different time-courses might be the primary reason why a static measurement of a single biomarker cannot accurately predict sepsis outcomes. Therefore, we conducted this prospective hospital-based cohort study to simultaneously evaluate the performance of several conventional and novel biomarkers of sepsis in predicting sepsis-associated mortality on different days of illness among patients with suspected sepsis.</p></div><div><h3>Methods</h3><p>We evaluated the performance of 15 novel biomarkers including angiopoietin-2, pentraxin 3, sTREM-1, ICAM-1, VCAM-1, sCD14 and 163, E-selectin, P-selectin, TNF-alpha, interferon-gamma, CD64, IL-6, 8, and 10, along with few conventional markers for predicting sepsis-associated mortality. Patients were grouped into quartiles according to the number of days since symptom onset. Receiver operating characteristic curve (ROC) analysis was used to evaluate the biomarker performance.</p></div><div><h3>Results</h3><p>From 2014 to 2017, 1483 patients were enrolled, of which 78% fulfilled the systemic inflammatory response syndrome criteria, 62% fulfilled the sepsis-3 criteria, 32% had septic shock, and 3.3% developed sepsis-associated mortality. IL-6, pentraxin 3, sCD163, and the blood gas profile demonstrated better performance in the early days of illness, both before and after adjusting for potential confounders (adjusted area under ROC curve [AUROC]:0.81–0.88). Notably, the Sequential Organ Failure Assessment (SOFA) score was relatively consistent throughout the course of illness (adjusted AUROC:0.70–0.91).</p></div><div><h3>Conclusion</h3><p>IL-6, pentraxin 3, sCD163, and the blood gas profile showed excellent predictive accuracy in the early days of illness. The SOFA score was consistently predictive of sepsis-associated mortality throughout the course of illness, with an acceptable performance.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 3","pages":"Article 100632"},"PeriodicalIF":4.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417023000690/pdfft?md5=8c7ed27e8824475c4fc37be363f94c91&pid=1-s2.0-S2319417023000690-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10214096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The synergy of 177Lu-FAPI-46 with tyrosine kinase inhibitor in a sarcoma patient-derived xenograft mouse model 肉瘤患者异种移植小鼠模型中 177Lu-FAPI-046 与酪氨酸激酶抑制剂的协同作用

IF 4.1 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2024.100744

Jing-Ren Tseng , Cheng-Lung Hsu , Hsin-Hua Hsieh , Kung-Chu Ho , Yi-Hsiu Chung , Chun-Yi Wu

{"title":"The synergy of 177Lu-FAPI-46 with tyrosine kinase inhibitor in a sarcoma patient-derived xenograft mouse model","authors":"Jing-Ren Tseng , Cheng-Lung Hsu , Hsin-Hua Hsieh , Kung-Chu Ho , Yi-Hsiu Chung , Chun-Yi Wu","doi":"10.1016/j.bj.2024.100744","DOIUrl":"10.1016/j.bj.2024.100744","url":null,"abstract":"<div><h3>Background</h3><p>Given the heterogeneity and high mortality associated with metastatic soft tissue sarcoma, this study aims to evaluate the therapeutic efficacy of combining <sup>177</sup>Lu-FAPI-46 with Pazopanib against this malignancy.</p></div><div><h3>Methods</h3><p>Patient-derived xenograft (PDX)-bearing mice were randomly divided into three groups: the control group, the <sup>177</sup>Lu-FAPI-46 monotherapy group, and the <sup>177</sup>Lu-FAPI-46 combined with Pazopanib therapy group. Therapeutic efficacy was regularly monitored.</p></div><div><h3>Results</h3><p>The microPET imaging showed a 0.84-fold decrease in the T/M ratio of 68Ga-FAPI-46 on day 7/8 post combination therapy, while the control group exhibited a 1.23-fold increase. Combination therapy significantly inhibited tumor proliferation, as evidenced by reduced Ki-67 and increased caspase 3 expressions. Notably, there was no significant body weight loss observed in any group.</p></div><div><h3>Conclusion</h3><p>This study successfully demonstrated the reduction in FAP expression and suppression of tumor volume in sarcoma PDX following the combination therapy of <sup>177</sup>Lu-FAPI-46 with Pazopanib.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 3","pages":"Article 100744"},"PeriodicalIF":4.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417024000477/pdfft?md5=d699bc1c7097a9fd7425c027312f9a35&pid=1-s2.0-S2319417024000477-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The next generation of healthcare ecosystem in the metaverse 元宇宙中的下一代医疗保健生态系统。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2023.100679

Yong Li , Dinesh Visva Gunasekeran , Narrendar RaviChandran , Ting Fang Tan , Jasmine Chiat Ling Ong , Arun James Thirunavukarasu , Bryce W. Polascik , Ranya Habash , Khizer Khaderi , Daniel S.W. Ting

{"title":"The next generation of healthcare ecosystem in the metaverse","authors":"Yong Li , Dinesh Visva Gunasekeran , Narrendar RaviChandran , Ting Fang Tan , Jasmine Chiat Ling Ong , Arun James Thirunavukarasu , Bryce W. Polascik , Ranya Habash , Khizer Khaderi , Daniel S.W. Ting","doi":"10.1016/j.bj.2023.100679","DOIUrl":"10.1016/j.bj.2023.100679","url":null,"abstract":"<div><p>The Metaverse has gained wide attention for being the application interface for the next generation of Internet. The potential of the Metaverse is growing, as Web 3·0 development and adoption continues to advance medicine and healthcare. We define the next generation of interoperable healthcare ecosystem in the Metaverse. We examine the existing literature regarding the Metaverse, explain the technology framework to deliver an immersive experience, along with a technical comparison of legacy and novel Metaverse platforms that are publicly released and in active use. The potential applications of different features of the Metaverse, including avatar-based meetings, immersive simulations, and social interactions are examined with different roles from patients to healthcare providers and healthcare organizations. Present challenges in the development of the Metaverse healthcare ecosystem are discussed, along with potential solutions including capabilities requiring technological innovation, use cases requiring regulatory supervision, and sound governance. This proposed concept and framework of the Metaverse could potentially redefine the traditional healthcare system and enhance digital transformation in healthcare. Similar to AI technology at the beginning of this decade, real-world development and implementation of these capabilities are relatively nascent. Further pragmatic research is needed for the development of an interoperable healthcare ecosystem in the Metaverse.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 3","pages":"Article 100679"},"PeriodicalIF":4.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417023001166/pdfft?md5=63258882a2d39f807c8d3144e43e3bf2&pid=1-s2.0-S2319417023001166-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138481833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The epidemiology of invasive fungal infections in transplant recipients 移植患者真菌感染的流行病学。

IF 5.5 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2024.100719

Dorra Elhaj Mahmoud , Anaïs Hérivaux , Florent Morio , Benoit Briard , Cécile Vigneau , Guillaume Desoubeaux , Jean-Philippe Bouchara , Jean-Pierre Gangneux , Gilles Nevez , Solène Le Gal , Nicolas Papon

{"title":"The epidemiology of invasive fungal infections in transplant recipients","authors":"Dorra Elhaj Mahmoud , Anaïs Hérivaux , Florent Morio , Benoit Briard , Cécile Vigneau , Guillaume Desoubeaux , Jean-Philippe Bouchara , Jean-Pierre Gangneux , Gilles Nevez , Solène Le Gal , Nicolas Papon","doi":"10.1016/j.bj.2024.100719","DOIUrl":"10.1016/j.bj.2024.100719","url":null,"abstract":"<div><p>Transplant patients, including solid-organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients, are exposed to various types of complications, particularly rejection. To prevent these outcomes, transplant recipients commonly receive long-term immunosuppressive regimens that in turn make them more susceptible to a wide array of infectious diseases, notably those caused by opportunistic pathogens. Among these, invasive fungal infections (IFIs) remain a major cause of mortality and morbidity in both SOT and HSCT recipients. Despite the continuing improvement in early diagnostics and treatments of IFIs, the management of these infections in transplant patients is still complicated. Here, we provide an overview concerning the most recent trends in the epidemiology of IFIs in SOT and HSCT recipients by describing the prominent yeast and mold species involved, the timing of post-transplant IFIs and the risk factors associated with their occurrence in these particularly weak populations. We also give special emphasis into basic research advances in the field that recently suggested a role of the global and long-term prophylactic regimen in orchestrating various biological disturbances in the organism and conditioning the emergence of the most adapted fungal strains to the particular physiological profiles of transplant patients.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 3","pages":"Article 100719"},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417024000222/pdfft?md5=c62b435bdbb421652262813ad375b8f3&pid=1-s2.0-S2319417024000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140777555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of gut fungi in Clostridioides difficile infection 肠道真菌在艰难梭菌感染中的作用

IF 5.5 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2023.100686

Lamei Wang , Yangchun Cao , Eddie Lou , Xuanyin Zhao , Xinhua Chen

{"title":"The role of gut fungi in Clostridioides difficile infection","authors":"Lamei Wang , Yangchun Cao , Eddie Lou , Xuanyin Zhao , Xinhua Chen","doi":"10.1016/j.bj.2023.100686","DOIUrl":"10.1016/j.bj.2023.100686","url":null,"abstract":"<div><p><em>Clostridioides difficile,</em> the etiological agent of <em>C. difficile</em> infection (CDI), elicits a spectrum of diarrheal symptoms with varying severity and the potential to result in severe complications such as colonic perforation, pseudomembranous colitis, and toxic megacolon. The perturbation of gut microbiome, often triggered by antibiotic usage, represents the primary factor augmenting the risk of CDI. This underscores the significance of interactions between <em>C. difficile</em> and the microbiome in determining pathogen adaptability. In recent years, researchers have increasingly recognized the pivotal role played by intestinal microbiota in host health and its therapeutic potential as a target for medical interventions. While extensive evidence has been established regarding the involvement of gut bacteria in CDI, our understanding of symbiotic interactions between hosts and fungi within intestinal microbiota remains limited. Herein, we aim to comprehensively elucidate both composition and key characteristics of gut fungal communities that significantly contribute to CDI, thereby enhancing our comprehension from pharmacological and biomarker perspectives while exploring their prospective therapeutic applications for CDI.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 3","pages":"Article 100686"},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417023001233/pdfft?md5=ab1964fe39db322a5608165ba1e185d8&pid=1-s2.0-S2319417023001233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138573591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the mycobiota: The fungal frontier of human health 揭开真菌生物群的神秘面纱：人类健康的真菌前沿。

IF 5.5 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2024.100751

Parvati Iyer , David M. Ojcius

引用次数: 0

Systemic treatments in pancreatic cancer: Taiwan pancreas society recommendation 胰腺癌的全身治疗：台湾胰脏学会建议

IF 4.1 3区医学

Biomedical Journal Pub Date : 2024-06-01 DOI: 10.1016/j.bj.2023.100696

{"title":"Systemic treatments in pancreatic cancer: Taiwan pancreas society recommendation","authors":"","doi":"10.1016/j.bj.2023.100696","DOIUrl":"10.1016/j.bj.2023.100696","url":null,"abstract":"<div><p>Pancreatic cancer is a highly aggressive malignancy with a poor prognosis. Over the past decade, significant therapeutic advancements have improved the survival rates of patients with pancreatic cancer. One of the primary factors contributing to these positive outcomes is the evolution of chemotherapy, from monotherapy to doublet or triplet regimens, and the integration of multimodal approaches. Additionally, targeted agents tailored to patients with specific genetic alterations and the development of cell therapies show promise in benefiting certain subpopulations. This article focuses on examining pivotal studies that explore the role of chemotherapy in neoadjuvant, adjuvant, maintenance, and salvage settings; highlights interesting findings related to cell therapy; and provides an overview of ongoing trials concerning metastatic settings. This review primarily aimed to offer recommendations based on therapeutic evidence, recent advancements in new treatment combinations, and the most innovative approaches. A unique aspect of this review is the inclusion of published papers on clinical trials and real-world data in Taiwan, thus adding a valuable perspective to the overall analysis.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 3","pages":"Article 100696"},"PeriodicalIF":4.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417023001336/pdfft?md5=98f0e24d127c5118a2db9f2e906ba557&pid=1-s2.0-S2319417023001336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139062201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intercellular transfer of MHC molecules in T cell alloimmunity and allotransplantation T 细胞异体免疫和同种异体移植中的 MHC 分子细胞间转移。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2024-05-25 DOI: 10.1016/j.bj.2024.100749

{"title":"Intercellular transfer of MHC molecules in T cell alloimmunity and allotransplantation","authors":"","doi":"10.1016/j.bj.2024.100749","DOIUrl":"10.1016/j.bj.2024.100749","url":null,"abstract":"<div><p>After transplantation of allogeneic tissues and organs, recognition by recipient T cells of donor MHC molecules initiates the pro-inflammatory adaptive immune response leading to allograft rejection. T cell allorecognition has long been known to be mediated via two distinct pathways: the <em>direct pathway</em> in which T cells recognize intact allogeneic MHC molecules displayed on donor cells and the <em>indirect pathway</em> whereby T cells recognize donor MHC peptides processed and presented by recipient antigen-presenting cells (APCs). It is believed that direct allorecognition is the driving force behind early acute allograft rejection while indirect allorecognition is involved in chronic allograft rejection, a progressive condition characterized by graft vasculopathy and tissue fibrosis. Recently, we and others have reported that after transplantation of allogeneic skin and organs, donor MHC molecules are transferred from donor cells to the host's APCs via trogocytosis or extracellular vesicles. Recipient APCs having captured donor MHC molecules can either present them to T cells in their intact form on their surface (<em>semi-direct pathway</em>) or the form of peptides bound to self-MHC molecules (indirect pathway). The present article provides an overview of recent studies evaluating the role of intercellular exchange of MHC molecules in T cell alloimmunity and its contribution to allograft rejection and tolerance.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 5","pages":"Article 100749"},"PeriodicalIF":4.1,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417024000520/pdfft?md5=5e97b85c45ffc848a6e45cd3bc7c9074&pid=1-s2.0-S2319417024000520-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0