Biomedical Journal最新文献

{"title":"Clinical and genomic insights into persistent carbapenem-resistant Klebsiella pneumoniae bacteremia: risk factors, resistance mechanisms, and treatment challenges.","authors":"Shian-Sen Shie, Ya-Han Yang, Yin-Hsiang Kung, Chih-Jung Chen","doi":"10.1016/j.bj.2025.100905","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100905","url":null,"abstract":"<p><strong>Introduction: </strong>Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major cause of nosocomial infections with high mortality rates. Persistent bacteremia, indicative of treatment failure, poses significant clinical challenges. This study aimed to identify clinical parameters for persistent CRKP bacteremia while exploring microbial and genetic characteristics.</p><p><strong>Materials and methods: </strong>A case-control study was conducted on patients with CRKP bacteremia from January 2016 to July 2019 at a tertiary hospital in Taiwan. Clinical, demographic, and microbiological data were collected for 61 cases of persistent bacteremia and 122 matched controls without persistent infections. Conditional logistic regression was used to evaluate risk factors for persistent bacteremia. Whole-genome sequencing (WGS) was used to identify genotypes and factors mediating resistance and virulence in the strains.</p><p><strong>Results: </strong>Persistent CRKP bacteremia was independently associated with mechanical ventilation (adjusted odds ratio [aOR] 11.007, 95% confidence interval [CI] 2.137-56.693), a lower Pitt bacteremia score (aOR 0.642, 95% CI 0.494-0.835), and the use of colistin (aOR 11.18, 95% CI 2.988-41.787) and tigecycline (aOR 16.42, 95% 4.495-60.0) in definitive therapy. Strains from either group shared similar capsular types. WGS identified three dominant multidrug-resistant clones, ST11, ST307, and ST15, harboring carbapenemase and virulence factors encoding yersiniabactin. A strain of hypervirulent clone ST23 exhibited high virulence but lacked carbapenemase genes, suggesting alternative resistance mechanisms of CR phenotype.</p><p><strong>Conclusions: </strong>Antimicrobial regimens with tigecycline and colistin were insufficient for effectively managing CRKP bacteremia. The convergence of resistance and virulence in prevalent clones demands the urgent introduction of novel therapeutics. Aggressive and tailored strategies are critical for improving outcomes in high-risk patients.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100905"},"PeriodicalIF":4.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasminogen Activator Inhibitor-1 in Systemic Sclerosis: A Nexus of Fibrosis, Vasculopathy, and Senescence.","authors":"Takuya Takahashi, Takehiro Takahashi, Yoshihide Asano","doi":"10.1016/j.bj.2025.100906","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100906","url":null,"abstract":"<p><p>Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, has emerged as a multifaceted contributor to the pathogenesis of systemic sclerosis (SSc). Beyond its classical role in inhibiting plasminogen activation, PAI-1 is implicated in the dysregulation of vascular remodeling, promotion of fibrosis, modulation of immune responses, and the maintenance of cellular senescence-all of which are hallmarks of SSc. Notably, elevated PAI-1 expression has been observed in both patient-derived tissues and experimental models of the disease. Mice deficient in the urokinase-type plasminogen activator receptor (uPAR), which functions with its ligand urokinase-type plasminogen activator (uPA) in the plasminogen activation system, exhibit impaired fibrinolysis and spontaneously develop vasculopathy and fibrosis, closely mirroring human SSc. These findings underscore the pathogenic relevance of the uPA-uPAR-PAI-1 axis in disease progression. Moreover, recent studies suggest that pharmacological inhibition of PAI-1 may not only ameliorate fibrosis and vascular abnormalities but also promote the clearance of senescent cells, thereby interrupting the vicious cycle of chronic inflammation and maladaptive tissue remodeling in SSc. This review highlights the emerging roles of PAI-1 in SSc pathophysiology and explores its potential as a novel therapeutic target for disease modification.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100906"},"PeriodicalIF":4.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila.","authors":"Peng-Shiuan Lee, Meng-Hsuan Chiang, Tony Wu, Chia-Lin Wu","doi":"10.1016/j.bj.2025.100907","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100907","url":null,"abstract":"<p><strong>Background: </strong>Thirst and hunger are fundamental survival drives that modulate various aspects of animal behavior through specific neural circuits. Previous studies have demonstrated that dopaminergic neurons (DANs) innervating the mushroom body (MB) in the Drosophila brain play essential roles in innate and learned thirst- and hunger-dependent behaviors, with most experiments focusing on acute water or food deprivation. However, it is unclear whether acute water or food deprivation alters dopamine production and neural activity in MB-innervating DANs.</p><p><strong>Material and methods: </strong>We genetically expressed green fluorescent protein (GFP) in MB-innervating DANs using broadly and specifically labeled GAL4 lines under satiety, thirst, and hunger states. The brains were immunostained with anti-tyrosine hydroxylase (TH) to assess dopamine biosynthesis. Additionally, the transcriptional reporter of intracellular Ca²⁺ (TRIC) was expressed in these DANs using the same GAL4 lines to monitor neural activity under different internal states. Normalized anti-TH and TRIC signals in specific MB compartments were compared between the satiety and thirst groups and between the satiety and hunger groups using unpaired two-tailed t-tests.</p><p><strong>Results: </strong>Neither TH levels nor neural activity in the 13 subtypes of MB-innervating DANs exhibited significant differences during the satiety, thirst, and hunger conditions.</p><p><strong>Conclusion: </strong>This study suggests that 16-hour water deprivation or 24-hour food deprivation does not significantly alter dopamine production and neural activity in MB-innervating DANs. These findings offer insights into the independence of baseline dopaminergic activity from internal states in thirst- or hunger-related behaviors.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100907"},"PeriodicalIF":4.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Radiotherapy with Tyrosine Kinase Inhibitors Might Benefit Survival in Hepatoma Patients with Portal Vein Tumor Thrombosis.","authors":"Hui-Ling Huang, Wei-Ming Lin, Chia-Hsuan Lai, Te-Sheng Chang, Sheng-Nan Lu","doi":"10.1016/j.bj.2025.100904","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100904","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is associated with a poor prognosis, and current treatment options yield suboptimal results. This article aims to share our treatment outcomes for PVTT using tyrosine kinase inhibitors (TKIs), radiation therapy (RT), and their combination.</p><p><strong>Methods: </strong>From 2010 to 2021, a total of 160 Child-Pugh class A HCC patients with PVTT, but without extrahepatic spread, were enrolled. Among them, 26, 10, 81, and 43 patients underwent no treatment, RT, TKIs, and combination therapy, respectively.</p><p><strong>Results: </strong>Compared to the no treatment group (median survival: 2 months), the RT group (4.5 months, p=0.034), TKIs group (5.0 months, p=0.0017), and combination group (15.0 months, p<0.001) all demonstrated a survival benefit. The multivariate Cox model showed adjusted hazard ratios and 95% confidence intervals of 0.35 (0.16-0.78), 0.40 (0.25-0.63) and 0.26 (0.15-0.44) for RT, TKIs, combination groups, respectively. From clinical observation of patients who survived for two years, we found that 20% of RT patients achieved good local control, and the RT group had longer durations of TKI use.</p><p><strong>Conclusions: </strong>In this series, 26.9% (43/160) of HCC patients with PVTT underwent combination treatment with TKIs and RT, achieving a median survival of 15.0 months. The contributions of RT were 20% disease control rate and may extend the duration of TKIs use. Therefore, all candidates without contraindications should be considered for combination treatment.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100904"},"PeriodicalIF":4.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma systemic treatment update: From early to advanced stage","authors":"Wei Teng ,&nbsp;Tai-Chi Wu ,&nbsp;Shi-Ming Lin","doi":"10.1016/j.bj.2024.100815","DOIUrl":"10.1016/j.bj.2024.100815","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) ranks the sixth most common malignancy but the third leading cause of cancer-related mortality in the world. Significant breakthroughs have been made in systemic treatment for HCC over the past two decades, which have improved treatment outcomes. In addition to multiple tyrosine kinase inhibitors (mTKIs), immune checkpoint inhibitors (ICIs) and antiangiogenic drugs are increasingly being applied. The combination of ICI and antiangiogenic or dual ICIs has become the new standard of care due to remarkable response rates. However, currently available systemic regimens are primarily reserved for certain patients in the intermediate and advanced stages who will not benefit from locoregional treatments. Evidence supporting the use of systemic treatment as neoadjuvant or adjuvant therapies in patients with early-stage HCC, especially the high risk of recurrence after curative treatments, remains limited. This review identified recent developments in systemic therapy, including mTKIs and ICIs, considering results on first- and second-line treatment, role of neoadjuvant and adjuvant settings, and combination with loco-regional therapy. Various ongoing clinical trials regarding the role of systemic therapies and potential novel targets in patients with early-, intermediate-, and advanced-stage HCC were also summarized and revealed that systemic therapy is no longer limited to advanced-stage HCC. Moreover, the introduction of T-cell redirecting strategies, including bispecific antibodies and chimeric antigen receptor T cells, has revolutionized the treatment landscape for HCC. Future research should focus on an in-depth exploration of the mechanisms governing the establishment of tumor barriers.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100815"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geography, genes, and germs: An evolutionary entanglement","authors":"Aila Akosua Kattner","doi":"10.1016/j.bj.2025.100888","DOIUrl":"10.1016/j.bj.2025.100888","url":null,"abstract":"<div><div>This journal issue presents an article on genomic surveillance and phylogenetic analysis for monitoring SARS-CoV-2, alongside reviews of recent advances in the treatment of hepatocellular carcinoma and gastric cancer, and current insights into mpox. It includes a perspective on the role of extended reality techniques in pediatric neurosurgery, as well as updates on cleft care and the relationship between mitochondrial bioenergetics and iron. Further contributions explore the link between metastatic potential and cytidine deaminase, miRNA targets involved in hypertrophy and fibrosis during cardiac remodeling, and new deep-learning models for predicting response to cardiac resynchronization therapy. The expression of connexin gap junction proteins in atrial fibrillation is examined in detail, along with a retrospective study on enteral autonomy in pediatric short bowel syndrome. The issue concludes with novel insights into the rare genetic disorder Bietti crystalline dystrophy.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100888"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vertical Facial Patterns on Three-Dimensional Surgical Outcomes and Stability in Skeletal Class II Malocclusion.","authors":"Wasuthorn Poolsin, Ellen Wen-Ching Ko, Carol Yi-Hsuan Chen, Cheng-Hui Lin","doi":"10.1016/j.bj.2025.100894","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100894","url":null,"abstract":"<p><strong>Background: </strong>The surgical outcomes and stability of patients with skeletal Class II malocclusion determine the success of treatment. Variations in surgical interventions, patient responsiveness, and growth patterns across vertical facial morphologies result in varying treatment outcomes and postoperative stability.</p><p><strong>Methods: </strong>This retrospective study recruited 52 adults diagnosed with skeletal Class II malocclusion treated with bimaxillary surgery; these adults were divided into two groups according to their vertical facial patterns. Cone-beam computed tomography images were collected before surgery (T0), after surgery (T1), and after orthodontic treatment (T2). Reconstructed three-dimensional images were used for cephalometric measurements and analysis.</p><p><strong>Results: </strong>From T0 to T1, the Frankfort-mandibular plane angle decreased in the high-angle group but increased in the low-medium-angle group. The mandible advanced 9.02 and 6.21 mm in the high-angle and low-medium-angle groups, respectively. From T1 to T2, significant changes were observed in the anterior mandible horizontal movement of the high-angle group (-1.91 ± 3.63 mm) compared with the low-medium-angle group (-0.57 ± 1.04 mm). There were more patients exhibit clinically significant relapse (> 2 mm) in the high-angle group (44%) than in the low-medium-angle group (20%).</p><p><strong>Conclusion: </strong>The relapse patterns in the two groups were similarly upward and backward. However, the high angle group exhibited greater average postoperative changes. The proportion of patients who exhibited a clinically significant relapse was higher in the high angle group.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100894"},"PeriodicalIF":4.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anisomeles indica enriched with ovatodiolide protects against aspirin-induced gastric ulcers through gut microbiota modulation.","authors":"Hsiu-Man Lien, Yu-Yen Wang, Shiao-Wen Li, Hwai-Jeng Lin, Hui-Yu Wu, Yu-Tsen Huang, Chun-Ya Chen, Chia-Chang Chen, Cheng-Hsun Chiu, Chih-Ho Lai","doi":"10.1016/j.bj.2025.100893","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100893","url":null,"abstract":"<p><strong>Background: </strong>Gastric ulcers are commonly caused by improper use of aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), or Helicobacter pylori infection. Anisomeles indica (L.) Kuntze, a traditional herbal medicine enriched with ovatodiolide, possesses potent anti-bacterial and anti-inflammatory properties and has demonstrated efficacy in improving gastric ulcers in animal models. However, its impact on the gut microbial ecosystem remains unclear. This study aimed to evaluate the therapeutic effects of A. indica fractions enriched with ovatodiolide on aspirin-induced gastric ulcers and to investigate their influence on gut microbiota composition.</p><p><strong>Materials and methods: </strong>Aspirin-induced gastric ulcers were established in mice, followed by treatment with various A. indica fractions. The severity of gastric ulceration was assessed using histopathological analysis. Additionally, 16S rRNA V3-V4 sequencing and 16S amplicon library construction were performed to characterize gut microbiota composition.</p><p><strong>Results: </strong>Our results showed that mice treated with ovatodiolide-enriched A. indica fractions exhibited significant amelioration of gastric ulcers compared to untreated controls. The treatment also enhanced the relative abundance of beneficial gut microbiota, including Lactobacillus and Adlercreutzia. Furthermore, histopathological examination revealed that A. indica treatment significantly upregulated mucin expression in ulcerated gastric tissues, suggesting a protective role in gastric mucosal integrity.</p><p><strong>Conclusions: </strong>This study provides insights into the mechanisms by which A. indica alleviates gastric ulcers, highlighting its ability to modulate gut microbiota and enhance mucosal protection.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100893"},"PeriodicalIF":4.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepant Treponemal Test Results: Identification of Associated Risk Factors Through Machine Learning Technology in 18-Year Electronic Medical Records and National Claims Data.","authors":"Hsin-Yao Wang, Ru-Fang Hu, Ting-Wei Lin, Wan-Ying Lin, Yu-Chiang Wang, Jang-Jih Lu, Yi-Ju Tseng","doi":"10.1016/j.bj.2025.100890","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100890","url":null,"abstract":"<p><strong>Background: </strong>Syphilis is a prevalent disease diagnosed primarily through serological tests. Although one confirmatory treponemal tests (TT), including Treponema pallidum particle agglutination (TPPA) or fluorescent treponema antibody absorption (FTA-Abs), is required for syphilis diagnosis, multiple TTs are commonly administered throughout the disease course. Discrepant TT results can cause confusion and delay treatment. In this study, we identified the clinical characteristics of patients with discrepant TT results and developed a machine learning tool to evaluate the risk of TT discrepancies.</p><p><strong>Materials and methods: </strong>In this retrospective cohort study, electronic health records were linked to national claims records collected from 2001 to 2018. Variables of interest in risk factor identification and machine learning model development included medical histories and demographic characteristics. The association between syphilis treatment and discrepant TT results was assessed.</p><p><strong>Results: </strong>Among 5,780 eligible patients tested for syphilis, 133 (2.30%) had discrepant TT results. HIV and AIDS were identified as prominent risk factors associated with discrepant TT results (adjusted odds ratio = 2.6, 95% confidence interval = 1.4-4.7). Patients with a top 5% risk probability in the LightGBM model were 10 times more likely than others to have discrepant TT results. TPPA was more likely than FTA-Abs to become negative after treatment among patients with discrepant TT results (odds ratio = 9.18, 95% confidence interval = 2.05-41.07).</p><p><strong>Conclusions: </strong>Risk factor identification and machine learning model development can support the interpretation of serological tests for syphilis, enabling accurate diagnosis and clinical decision-making.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100890"},"PeriodicalIF":4.1,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PAI-1 is a common driver of aging and diverse diseases.","authors":"Alireza Khoddam, Toshio Miyata, Douglas Vaughan","doi":"10.1016/j.bj.2025.100892","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100892","url":null,"abstract":"<p><p>Plasminogen activator inhibitor-1 (PAI-1) is a key driver of aging and contributes to diverse pathologies. This review examines PAI-1's multifaceted contributions to aging. At the cellular level, PAI-1 amplifies senescence, exhausts stem cell niches, and disrupts metabolism. These cellular alterations translate into physiological decline: PAI-1 drives cardiovascular aging by promoting vascular senescence and arterial stiffening, contributes to cognitive decline by impairing amyloid-beta clearance, fuels cancer progression through angiogenesis and immune suppression, and exacerbates muscle atrophy by hindering regeneration. A rare loss-of-function SERPINE1 mutation extends lifespan, illustrating how lifelong PAI-1 reduction can positively impact the human healthspan. Looking forward, targeting PAI-1 with inhibitors could mitigate senescence, restore stem cell function, improve metabolic profile, enhance physiological health, and promise a longer healthspan.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100892"},"PeriodicalIF":4.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}