Biomedical Journal最新文献_第3页

Effect of SARS-CoV2 S protein on red blood cells parameters. Some comments SARS-CoV2 S蛋白对红细胞参数的影响一些评论。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100857

Geir Bjørklund , Umberto Tirelli , Salvatore Chirumbolo , Luigi Valdenassi

引用次数: 0

Rhythms under tension: Circadian clocks in an Unsynced Society 紧张下的节奏：不同步社会中的生物钟。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100873

Aila Akosua Kattner

{"title":"Rhythms under tension: Circadian clocks in an Unsynced Society","authors":"Aila Akosua Kattner","doi":"10.1016/j.bj.2025.100873","DOIUrl":"10.1016/j.bj.2025.100873","url":null,"abstract":"<div><div>This special issue of the <em>Biomedical Journal</em> centers on circadian rhythms, examining the molecular mechanisms of the circadian clock, the consequences of circadian disruption, and their implications for health and disease. Featured topics include blue light therapy for sleep disorders in myocardial infarction patients; sex-specific links between clock genes and colorectal cancer; the impact of social jetlag on blood pressure; and how irregular light-dark cycles and misaligned eating patterns affect circadian stability. A study on Stenabolic (SR9009) in mice investigates its potential to mitigate weight gain, insulin resistance, and white fat accumulation under constant light exposure. Additional reviews address the role of purinoreceptors in extracellular vesicle-mediated communication, the evolving understanding of pseudogenes and their functional derivatives, and future prospects for hyperpolarized magnetic resonance imaging. Original research highlights the influence of corticosterone on white adipose tissue expansion in mice and challenges the assumed protective role of pentoxifylline against diabetic retinopathy in patients with chronic kidney disease and diabetes. A novel application of peripheral magnetic stimulation as a treatment for overactive bladder is also explored. Two studies on hidradenitis suppurativa are included: one linking the condition to an increased risk of migraine in women, and another examining its association with alopecia areata. The issue concludes with two letters to the editor on the effects of the SARS-CoV-2 spike protein on erythrocyte biology, along with a request for further clarification, which is addressed in detail.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100873"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice 高脂饮食引起的糖皮质激素增加有助于肥胖小鼠的脂肪生成。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100772

Sheng-Feng Tsai , Pei-Ling Hsu , Mei-Chen Yeh , Hao-Chang Hung , Monica Meng-Chun Shih , Bon-chu Chung , Chia-Yih Wang , Chih-Jen Chang , Yu-Min Kuo

{"title":"High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice","authors":"Sheng-Feng Tsai , Pei-Ling Hsu , Mei-Chen Yeh , Hao-Chang Hung , Monica Meng-Chun Shih , Bon-chu Chung , Chia-Yih Wang , Chih-Jen Chang , Yu-Min Kuo","doi":"10.1016/j.bj.2024.100772","DOIUrl":"10.1016/j.bj.2024.100772","url":null,"abstract":"<div><h3>Background</h3><div>This study was designed to examine how glucocorticoids (GCs) induced by a long-term ingestion of high-fat diet (HFD) mediate the HFD-induced adipose expansion and obesity.</div></div><div><h3>Material and methods</h3><div>To address this goal, we used a unique L/L mouse model that fails to induce its corticosterone (CORT) level, a major type of GCs in rodents, after prolonged exposure to an HFD.</div></div><div><h3>Results</h3><div>We found that, after receiving a 12-week HFD feeding, the L/L mice show less weight gain, milder adipose expansion, and higher plasma levels of triglycerides than the wild-type mice. These changes were reversed by replenishing CORT to L/L mice. When examining the expression levels of various molecules linked to lipid uptake and <em>de novo</em> lipogenesis in CORT-induced adipose expansion, we observed a reduction in the expression of adipose preadipocyte factor 1 (Pref-1), a key regulator in adipogenesis. In 3T3-L1 preadipocyte-like cells, dexamethasone, an agonist of the glucocorticoid receptor, also reduced expressions of Pref-1 and facilitated intracellular accumulation of lipids.</div></div><div><h3>Conclusions</h3><div>Our results suggest that fat ingestion-induced release of CORT contributes to adipose expansion and development of obesity and highlight the pathogenic role of CORT-mediated downregulation of adipose Pref-1 in diet-induced obesity.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100772"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of purinoreceptors in the release of extracellular vesicles and consequences on immune response and cancer progression 嘌呤受体在细胞外囊泡释放中的作用及其对免疫反应和癌症进展的影响。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100805

Thomas Duret , Mohammed Elmallah , Jérôme Rollin , Philippe Gatault , Lin-Hua Jiang , Sébastien Roger

引用次数: 0

Circadian rhythmicity and human health 昼夜节律与人类健康。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100855

Jan Martel , David M. Ojcius , John D. Young

引用次数: 0

Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review 临床超极化磁共振成像的进展、挑战和未来前景：全面回顾。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100802

Ching-Yi Hsieh , Ying-Chieh Lai , Kuan-Ying Lu , Gigin Lin

{"title":"Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review","authors":"Ching-Yi Hsieh , Ying-Chieh Lai , Kuan-Ying Lu , Gigin Lin","doi":"10.1016/j.bj.2024.100802","DOIUrl":"10.1016/j.bj.2024.100802","url":null,"abstract":"<div><div>Hyperpolarized (HP) magnetic resonance imaging (MRI) is a groundbreaking imaging platform advancing from research to clinical practice, offering new possibilities for real-time, non-invasive metabolic imaging. This review explores the latest advancements, challenges, and future directions of HP MRI, emphasizing its transformative impact on both translational research and clinical applications. By employing techniques such as dissolution Dynamic Nuclear Polarization (dDNP), Parahydrogen-Induced Polarization (PHIP), Signal Amplification by Reversible Exchange (SABRE), and Spin-Exchange Optical Pumping (SEOP), HP MRI achieves enhanced nuclear spin polarization, enabling in vivo visualization of metabolic pathways with exceptional sensitivity. Current challenges, such as limited imaging windows, complex pre-scan protocols, and data processing difficulties, are addressed through innovative solutions like advanced pulse sequences, bolus tracking, and kinetic modeling. We highlight the evolution of HP MRI technology, focusing on its potential to revolutionize disease diagnosis and monitoring by revealing metabolic processes beyond the reach of conventional MRI and positron emission tomography (PET). Key advancements include the development of novel tracers like [2–<sup>13</sup>C]pyruvate and [1–<sup>13</sup>C]-alpha-ketoglutarate and improved data analysis techniques, broadening the scope of clinical metabolic imaging. Future prospects emphasize integrating artificial intelligence, standardizing imaging protocols, and developing new hyperpolarized agents to enhance reproducibility and expand clinical capabilities particularly in oncology, cardiology, and neurology. Ultimately, we envisioned HP MRI as a standardized modality for dynamic metabolic imaging in clinical practice.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100802"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The clockwork macrophage: timing in innate immunity. 生物钟巨噬细胞：先天免疫中的定时。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-05-21 DOI: 10.1016/j.bj.2025.100872

Siyu Chen, Nick Ciccone, David Ray

{"title":"The clockwork macrophage: timing in innate immunity.","authors":"Siyu Chen, Nick Ciccone, David Ray","doi":"10.1016/j.bj.2025.100872","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100872","url":null,"abstract":"<p><p>The circadian clock enables organisms to predict daily environmental changes and synchronize their physiology and behaviour accordingly. Macrophages, key sensor cells in the innate immune system, exhibit cell-autonomous circadian rhythmicity. This circadian rhythmic behaviour is synchronised to the central clock in the hypothalamus as a result of neural, and hormonal signals. Macrophage rhythms and responses involve sensing temporal cues, integrating information from tissue-specific environments, and initiating context-appropriate, time-gated responses. On a broader scale, monocytes and macrophages communicate and synchronize with other immune cells, migrate throughout the body, and infiltrate tissues, collectively contributing to circadian regulation in both health and disease. While the field of macrophage circadian biology is rapidly advancing, it is equally important to reflect on its historical development, which has been shaped by over two centuries of accumulating knowledge and technological progress. This review traces key milestones in macrophage and circadian research, examining how recent discoveries have refined our understanding of early foundational questions and setting the stage for future inquiries. Notably, many intriguing questions remain unresolved, including the circadian regulation of macrophage function under steady-state conditions, the tissue-specific heterogeneity of macrophage circadian rhythms, and the role of macrophage circadian clocks in disease pathogenesis and their potential clinical implications.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100872"},"PeriodicalIF":4.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BrainView: A Cloud-based Deep Learning System for Brain Image Segmentation, Tumor Detection and Visualization. BrainView：一个基于云的深度学习系统，用于脑图像分割、肿瘤检测和可视化。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-05-21 DOI: 10.1016/j.bj.2025.100871

Partho Ghose, Hasan M Jamil

{"title":"BrainView: A Cloud-based Deep Learning System for Brain Image Segmentation, Tumor Detection and Visualization.","authors":"Partho Ghose, Hasan M Jamil","doi":"10.1016/j.bj.2025.100871","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100871","url":null,"abstract":"<p><p>A brain tumor is an abnormal growth in the brain that disrupts its functionality and poses a significant threat to human life by damaging neurons. Early detection and classification of brain tumors are crucial to prevent complications and maintain good health. Recent advancements in deep learning techniques have shown immense potential in image classification and segmentation for tumor identification and classification. In this study, we present a platform, BrainView, for detection, and segmentation of brain tumors from Magnetic Resonance Images (MRI) using deep learning. We utilized EfficientNetB7 pre-trained model to design our proposed DeepBrainNet classification model for analyzing brain MRI images to classify its type. We also proposed a EfficinetNetB7 based image segmentation model, called the EffB7-UNet, for tumor localization. Experimental results show significantly high classification (99.96%) and segmentation (92.734%) accuracies for our proposed models. Finally, we discuss the contours of a cloud application for BrainView using Flask and Flutter to help researchers and clinicians use our machine learning models online for research purposes.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100871"},"PeriodicalIF":4.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview: PAI-1 inhibitors and clinical applications. 综述：PAI-1抑制剂及其临床应用。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-05-20 DOI: 10.1016/j.bj.2025.100874

Toshio Miyata

引用次数: 0

Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism. 自噬诱导的成骨细胞来源的外泌体通过重塑肠道微生物代谢来维持骨形成和预防骨质疏松症。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-05-06 DOI: 10.1016/j.bj.2025.100870

Lin Chen, Liesheng Lu, Chunyi Fan, Xiaonan Zhu, Ling Pan, Shanshan Tang, Yufan Wang, Yongde Peng, Li You

{"title":"Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism.","authors":"Lin Chen, Liesheng Lu, Chunyi Fan, Xiaonan Zhu, Ling Pan, Shanshan Tang, Yufan Wang, Yongde Peng, Li You","doi":"10.1016/j.bj.2025.100870","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100870","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis is a chronic disease of bone metabolism with high incidence rates. Recently, exosome therapy has emerged as a promising avenue for the treatment of osteoporosis. However, the role of autophagy-induced osteoblast-derived exosomes (Auto-exo) in osteoporosis has yet to be elucidated.</p><p><strong>Methods: </strong>The effect of Auto-exo in bone formation was assessed in vivo. The composition of gut microbiota was determined through 16S rDNA sequencing, and metabolite profiles were analyzed using liquid chromatography-mass spectrometry (LC-MS). Cell experiments were conducted to explore the role of bilirubin in bone formation.</p><p><strong>Results: </strong>Auto-exo were successfully isolated and identified. Auto-exo promoted bone formation and alleviated osteoporosis progression in a mouse model of osteoporosis. 16S rDNA sequencing revealed that Auto-exo changed diversity and composition of gut microbiota in osteoporotic mice, with a notable increase in Lactobacillus and a decrease in Dubosiella and Faecalibaculum. LC-MS analysis indicated that Auto-exo treatment reduced the elevated levels of bilirubin in osteoporotic mice. Cell experiments uncovered that bilirubin remarkably inhibited osteoblast differentiation. Furthermore, Auto-exo promoted osteoblast differentiation via inhibiting bilirubin production.</p><p><strong>Conclusions: </strong>Our findings demonstrated that Auto-exo promoted bone formation by modulating the gut microbiota-metabolites bilirubin axis, thereby alleviating osteoporosis progression. This discovery provides a novel perspective on the mechanisms underlying the therapeutic effects of Auto-exo in osteoporosis.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100870"},"PeriodicalIF":4.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0