Self/nonself最新文献_第5页

Comparative analysis of NK-cell receptor expression and function across primate species: Perspective on antiviral defenses. 灵长类动物nk细胞受体表达和功能的比较分析:抗病毒防御的观点。

Self/nonself Pub Date : 2010-04-01 Epub Date: 2010-03-06 DOI: 10.4161/self.1.2.11717

Roberto Biassoni, Elisabetta Ugolotti, Andrea De Maria

{"title":"Comparative analysis of NK-cell receptor expression and function across primate species: Perspective on antiviral defenses.","authors":"Roberto Biassoni, Elisabetta Ugolotti, Andrea De Maria","doi":"10.4161/self.1.2.11717","DOIUrl":"https://doi.org/10.4161/self.1.2.11717","url":null,"abstract":"Natural killer (NK) cells are lymphoid effectors that are involved in the innate immune surveillance against infected and/or tumor cells. Their function is under the fine-tuning control of cell surface receptors that display either inhibitory or activating function and in healthy condition, mediate self-tolerance. It is known that inhibitory receptors are characterized by clonal and stochastic distribution and are extremely sensible to any modification, downregulation or loss of MHC class I surface expression that are induced in autologous cells upon viral infection or cancer transformation. This alteration of the MHC class I expression weakens the strength of the inhibitory receptor-induced interaction, thus resulting in a prompt triggering of NK cell function, which ends up in the inhibition of tumor progression and proliferation of pathogen-infected cells. Thus, the inhibitory function of NK cells is only one face of the coin, since NK-cell activation is controlled by different arrays of activating receptors that finally are involved in the induction of cytolysis and/or cytokine release. Interestingly, the inhibitory NK-cell receptors that are involved in dampening NK cell-mediated responses evolved during speciation in different, often structurally unrelated surface-expressed molecules, all using a conserved signaling pathway. In detail, during evolution, the inhibitory receptors that assure the recognition of MHC class I molecules, originate in, at least, three different ways. This ended up in multigene families showing marked structural divergences that coevolved in a convergent way with the availability of appropriate MHC ligand molecules.","PeriodicalId":89270,"journal":{"name":"Self/nonself","volume":"1 2","pages":"103-113"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/self.1.2.11717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29698790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Autoimmunity and asthma: The dirt on the hygiene hypothesis. 自身免疫与哮喘:卫生假说的污点。

Self/nonself Pub Date : 2010-04-01 Epub Date: 2010-02-15 DOI: 10.4161/self.1.2.11550

Mark D Mannie

{"title":"Autoimmunity and asthma: The dirt on the hygiene hypothesis.","authors":"Mark D Mannie","doi":"10.4161/self.1.2.11550","DOIUrl":"https://doi.org/10.4161/self.1.2.11550","url":null,"abstract":"Self peptides shape T-cell development through selectional processes in the thymus and secondary lymphoid organs to promote a diverse and balanced repertoire of conventional and regulatory T cells. Foreign proteins and their derivative peptides permeate our mucosal tissues to constitute another diverse array of peptides that may specify and diversify the mucosal T-cell repertoire. Indeed, the distinction between self peptides and environmental foreign peptides may be academic if both are present constantly within the body. The premise here is that the plethora of foreign peptides, present ubiquitously in our environment and body, form homeostatic niches to foster highly diversified repertoires of conventional and regulatory T cells that recognize persistent environmental peptides as self. Highly diversified repertoires that recognize myriads of self and environmental foreign peptides as homeostatic ligands may be critical for adaptive distinctions of friend or foe in mucosal tissues. The change from our agrarian past to the highly sterile environments of today may adversely impact the diversity and concentrations of foreign peptides that shape the mucosal T-cell repertoire. Various hygiene hypotheses postulate that the lack of factors such as infectious pathogens, innate receptor engagement or Th1 bias is key to the marked increase in immunological disease in modern society. In this version of the hygiene hypothesis, highly diverse constellations of innocuous environmental peptides are postulated to be the critical factor for immune balance and homeostasis.","PeriodicalId":89270,"journal":{"name":"Self/nonself","volume":"1 2","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/self.1.2.11550","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29749426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Membrane binding of intrinsically disordered proteins: Critical importance of an appropriate membrane model. 内在无序蛋白的膜结合:一个合适的膜模型的关键重要性。

Self/nonself Pub Date : 2010-04-01 Epub Date: 2010-02-17 DOI: 10.4161/self.1.2.11547

Alexander B Sigalov

引用次数: 13

Bacterial peptides are intensively present throughout the human proteome. 细菌肽在人类蛋白质组中广泛存在。

Self/nonself Pub Date : 2010-01-01 DOI: 10.4161/self.1.1.9588

Brett Trost, Anthony Kusalik, Guglielmo Lucchese, Darja Kanduc

引用次数: 31

Adaptive immunity: Based on the dual recognition responses of αβT cells. 适应性免疫:基于αβT细胞的双重识别反应。

Self/nonself Pub Date : 2010-01-01 DOI: 10.4161/self.1.1.10441

Yan-Ming Liu, Jing Luo, Clive Bennett

引用次数: 3

The SCHOOL of nature: I. Transmembrane signaling. 大自然的 SCHOOL：I. 跨膜信号传递

Self/nonself Pub Date : 2010-01-01 DOI: 10.4161/self.1.1.10832

Alexander B Sigalov

{"title":"The SCHOOL of nature: I. Transmembrane signaling.","authors":"Alexander B Sigalov","doi":"10.4161/self.1.1.10832","DOIUrl":"10.4161/self.1.1.10832","url":null,"abstract":"Receptor-mediated transmembrane signaling plays an important role in health and disease. Recent significant advances in our understanding of the molecular mechanisms linking ligand binding to receptor activation revealed previously unrecognized striking similarities in the basic structural principles of function of numerous cell surface receptors. In this work, I demonstrate that the Signaling Chain Homooligomerization (SCHOOL)-based mechanism represents a general biological mechanism of transmembrane signal transduction mediated by a variety of functionally unrelated single- and multichain activating receptors. within the SCHOOL platform, ligand binding-induced receptor clustering is translated across the membrane into protein oligomerization in cytoplasmic milieu. This platform resolves a long-standing puzzle in transmembrane signal transduction and reveals the major driving forces coupling recognition and activation functions at the level of protein-protein interactions-biochemical processes that can be influenced and controlled. The basic principles of transmembrane signaling learned from the SCHOOL model can be used in different fields of immunology, virology, molecular and cell biology and others to describe, explain and predict various phenomena and processes mediated by a variety of functionally diverse and unrelated receptors. Beyond providing novel perspectives for fundamental research, the platform opens new avenues for drug discovery and development.","PeriodicalId":89270,"journal":{"name":"Self/nonself","volume":"1 1","pages":"4-39"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091606/pdf/self0101_0004.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30174719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self/Nonself-Immune Recognition and Signaling: A new journal tackles a problem at the center of immunological science. 自身/非自身免疫识别和信号传导：一份新期刊解决了免疫学科学的核心问题。

Self/nonself Pub Date : 2010-01-01 DOI: 10.4161/self.1.1.10682

William E Paul

引用次数: 0

Changing separating distances between immune receptors as a sensitive mechanism regulating T-cell activation. 改变免疫受体之间的分离距离是调节 T 细胞活化的敏感机制。

Self/nonself Pub Date : 2010-01-01 DOI: 10.4161/self.1.1.10380

Yuri Sykulev

引用次数: 0

Self/nonself perception in plants in innate immunity and defense. 植物在先天免疫和防御中的自我/非自我感知。

Self/nonself Pub Date : 2010-01-01 DOI: 10.4161/self.1.1.10442

Natasha M Sanabria, Ju-Chi Huang, Ian A Dubery

{"title":"Self/nonself perception in plants in innate immunity and defense.","authors":"Natasha M Sanabria, Ju-Chi Huang, Ian A Dubery","doi":"10.4161/self.1.1.10442","DOIUrl":"https://doi.org/10.4161/self.1.1.10442","url":null,"abstract":"The ability to distinguish 'self' from 'nonself' is the most fundamental aspect of any immune system. The evolutionary solution in plants to the problems of perceiving and responding to pathogens involves surveillance of nonself, damaged-self and altered-self as danger signals. This is reflected in basal resistance or non-host resistance, which is the innate immune response that protects plants against the majority of pathogens. In the case of surveillance of nonself, plants utilize receptor-like proteins or -kinases (RLP/Ks) as pattern recognition receptors (PRRs), which can detect conserved pathogen/microbe-associated molecular pattern (P/MAMP) molecules. P/MAMP detection serves as an early warning system for the presence of a wide range of potential pathogens and the timely activation of plant defense mechanisms. However, adapted microbes express a suite of effector proteins that often interfere or act as suppressors of these defenses. In response, plants have evolved a second line of defense that includes intracellular nucleotide binding leucine-rich repeat (NB-LRR)-containing resistance proteins, which recognize isolate-specific pathogen effectors once the cell wall has been compromised. This host-immunity acts within the species level and is controlled by polymorphic host genes, where resistance protein-mediated activation of defense is based on an 'altered-self' recognition mechanism.","PeriodicalId":89270,"journal":{"name":"Self/nonself","volume":"1 1","pages":"40-54"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/self.1.1.10442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29872367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 83

Hiways and byways to the secretory synapse. 一直到分泌突触。

Self/nonself Pub Date : 2010-01-01 DOI: 10.4161/self.1.1.10663

Martin Poenie

引用次数: 1