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Retraction: Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of nucleus pulposus cells under high-magnitude compression though inhibiting the p38 MAPK pathway. 撤回：通过抑制 p38 MAPK 通路，成骨蛋白-1 可减轻高强度挤压下髓核细胞的凋亡并增强基质合成。
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-0018_RET
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引用次数: 0
Retraction: Resveratrol enhances matrix biosynthesis of nucleus pulposus cells through activating autophagy via the PI3K/Akt pathway under oxidative damage. 撤回：在氧化损伤条件下，白藜芦醇通过PI3K/Akt途径激活自噬，从而增强髓核细胞的基质生物合成。
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-0544_RET
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引用次数: 0
Retraction: Targeting a LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma. 撤回：靶向 LncRNA P5848-ENO1 轴抑制肝细胞癌的肿瘤生长
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-0896_RET
{"title":"Retraction: Targeting a LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma.","authors":"","doi":"10.1042/BSR-2018-0896_RET","DOIUrl":"10.1042/BSR-2018-0896_RET","url":null,"abstract":"","PeriodicalId":8926,"journal":{"name":"Bioscience Reports","volume":"44 8","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Note: Bioactive lipids in intervertebral disc (IVD) degeneration and its therapeutic implications. 编者按：椎间盘 (IVD) 退化中的生物活性脂质及其治疗意义。
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2019-2117_EDN
{"title":"Editorial Note: Bioactive lipids in intervertebral disc (IVD) degeneration and its therapeutic implications.","authors":"","doi":"10.1042/BSR-2019-2117_EDN","DOIUrl":"10.1042/BSR-2019-2117_EDN","url":null,"abstract":"","PeriodicalId":8926,"journal":{"name":"Bioscience Reports","volume":"44 8","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro. 撤回：高渗环境诱导的氧化应激损伤促进体外髓核细胞衰老
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2019-1711_RET
{"title":"Retraction: Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro.","authors":"","doi":"10.1042/BSR-2019-1711_RET","DOIUrl":"10.1042/BSR-2019-1711_RET","url":null,"abstract":"","PeriodicalId":8926,"journal":{"name":"Bioscience Reports","volume":"44 8","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Responses of apoptosis and matrix metabolism of annulus fibrosus cells to different magnitudes of mechanical tension in vitro. 撤回：环状纤维肌细胞凋亡和基质代谢对体外不同程度机械拉力的反应
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-2375_RET
{"title":"Retraction: Responses of apoptosis and matrix metabolism of annulus fibrosus cells to different magnitudes of mechanical tension in vitro.","authors":"","doi":"10.1042/BSR-2018-2375_RET","DOIUrl":"10.1042/BSR-2018-2375_RET","url":null,"abstract":"","PeriodicalId":8926,"journal":{"name":"Bioscience Reports","volume":"44 8","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells. 撤回：成骨蛋白-1能缓解高糖微环境导致的髓核细胞退行性变化
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2019-0170_RET
{"title":"Retraction: Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells.","authors":"","doi":"10.1042/BSR-2019-0170_RET","DOIUrl":"10.1042/BSR-2019-0170_RET","url":null,"abstract":"","PeriodicalId":8926,"journal":{"name":"Bioscience Reports","volume":"44 8","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway. 撤回：白藜芦醇通过调节 PI3K/Akt 通路抑制 IL-1β 介导的髓核细胞凋亡
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2019-0043_RET
{"title":"Retraction: Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway.","authors":"","doi":"10.1042/BSR-2019-0043_RET","DOIUrl":"10.1042/BSR-2019-0043_RET","url":null,"abstract":"","PeriodicalId":8926,"journal":{"name":"Bioscience Reports","volume":"44 8","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment. 撤回：转化生长因子-β1调节的Fas/FasL通路激活可抑制炎症环境中髓核细胞的凋亡。
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR-2019-1726_RET
{"title":"Retraction: Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment.","authors":"","doi":"10.1042/BSR-2019-1726_RET","DOIUrl":"10.1042/BSR-2019-1726_RET","url":null,"abstract":"","PeriodicalId":8926,"journal":{"name":"Bioscience Reports","volume":"44 8","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3-chymotrypsin-like protease in SARS-CoV-2. SARS-CoV-2 中的 3C 类蛋白酶。
IF 3.8 3区 生物学
Bioscience Reports Pub Date : 2024-08-28 DOI: 10.1042/BSR20231395
Kenana Al Adem, Juliana C Ferreira, Adrian J Villanueva, Samar Fadl, Farah El-Sadaany, Imen Masmoudi, Yugmee Gidiya, Tariro Gurudza, Thyago H S Cardoso, Nitin K Saksena, Wael M Rabeh
{"title":"3-chymotrypsin-like protease in SARS-CoV-2.","authors":"Kenana Al Adem, Juliana C Ferreira, Adrian J Villanueva, Samar Fadl, Farah El-Sadaany, Imen Masmoudi, Yugmee Gidiya, Tariro Gurudza, Thyago H S Cardoso, Nitin K Saksena, Wael M Rabeh","doi":"10.1042/BSR20231395","DOIUrl":"10.1042/BSR20231395","url":null,"abstract":"<p><p>Coronaviruses constitute a significant threat to the human population. Severe acute respiratory syndrome coronavirus-2, SARS-CoV-2, is a highly pathogenic human coronavirus that has caused the coronavirus disease 2019 (COVID-19) pandemic. It has led to a global viral outbreak with an exceptional spread and a high death toll, highlighting the need for effective antiviral strategies. 3-Chymotrypsin-like protease (3CLpro), the main protease in SARS-CoV-2, plays an indispensable role in the SARS-CoV-2 viral life cycle by cleaving the viral polyprotein to produce 11 individual non-structural proteins necessary for viral replication. 3CLpro is one of two proteases that function to produce new viral particles. It is a highly conserved cysteine protease with identical structural folds in all known human coronaviruses. Inhibitors binding with high affinity to 3CLpro will prevent the cleavage of viral polyproteins, thus impeding viral replication. Multiple strategies have been implemented to screen for inhibitors against 3CLpro, including peptide-like and small molecule inhibitors that covalently and non-covalently bind the active site, respectively. In addition, allosteric sites of 3CLpro have been identified to screen for small molecules that could make non-competitive inhibitors of 3CLpro. In essence, this review serves as a comprehensive guide to understanding the structural intricacies and functional dynamics of 3CLpro, emphasizing key findings that elucidate its role as the main protease of SARS-CoV-2. Notably, the review is a critical resource in recognizing the advancements in identifying and developing 3CLpro inhibitors as effective antiviral strategies against COVID-19, some of which are already approved for clinical use in COVID-19 patients.</p>","PeriodicalId":8926,"journal":{"name":"Bioscience Reports","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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