Procedia, social and behavioral sciences最新文献_第2页

A Pattern Processing Method to Map Nanoscale Phases by EBSD. 利用 EBSD 绘制纳米级相图的模式处理方法。

IF 2.8

Procedia, social and behavioral sciences Pub Date : 2022-04-08 DOI: 10.1017/S1431927622000526

Etienne Brodu, Aimo Winkelmann, Marc Seefeldt

{"title":"A Pattern Processing Method to Map Nanoscale Phases by EBSD.","authors":"Etienne Brodu, Aimo Winkelmann, Marc Seefeldt","doi":"10.1017/S1431927622000526","DOIUrl":"10.1017/S1431927622000526","url":null,"abstract":"The crystallographic analysis of nanoscale phases with dimensions well below the spatial probing volume of electron backscatter diffraction (EBSD) traditionally rely on electron microscopy in transmission (either in SEM or TEM), because EBSD patterns are invariably dominated by the matrix phase contribution and present seemingly no trace from such nanoscale phases. Yet, this study shows that such nanoscale features generate a very faint but valuable secondary diffraction signal which can be retrieved. A diffraction pattern postprocessing method is presented which focuses on the detection of such secondary signal emitted by nanoscale minority phases in overlapped patterns dominated by a dominant matrix signal. The predominant, majority phase contribution in EBSD patterns is removed by a close-neighbor pattern subtraction routine, after which both the conventional Hough indexing method as well as pattern matching methods can be used to reveal the crystallography, spatial distribution, morphology, and orientation of nanoscale minority phases initially absent from EBSD maps. Nanolamellar pearlitic steel, which has long been out of reach for EBSD, has been chosen as an application example.","PeriodicalId":89222,"journal":{"name":"Procedia, social and behavioral sciences","volume":"55 1","pages":"1-7"},"PeriodicalIF":2.8,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77434007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyan fluorescent proteins derived from mNeonGreen. 源自 mNeonGreen 的青色荧光蛋白。

Procedia, social and behavioral sciences Pub Date : 2022-02-17 DOI: 10.1093/protein/gzac004

Landon Zarowny, Damien Clavel, Ryan Johannson, Kévin Duarte, Hadrien Depernet, Jérôme Dupuy, Heather Baker, Alex Brown, Antoine Royant, Robert E Campbell

{"title":"Cyan fluorescent proteins derived from mNeonGreen.","authors":"Landon Zarowny, Damien Clavel, Ryan Johannson, Kévin Duarte, Hadrien Depernet, Jérôme Dupuy, Heather Baker, Alex Brown, Antoine Royant, Robert E Campbell","doi":"10.1093/protein/gzac004","DOIUrl":"10.1093/protein/gzac004","url":null,"abstract":"mNeonGreen, an engineered green fluorescent protein (GFP) derived from lancelet, is one of the most brightly fluorescent homologs of Aequorea victoria jellyfish GFP (avGFP) yet reported. In this work, we investigated whether this bright fluorescence might be retained in homologs of mNeonGreen with modified chromophore structures and altered fluorescent hues. We found mNeonGreen to be generally less tolerant than avGFP to chromophore modification by substitution of the key chromophore-forming tyrosine residue with other aromatic amino acids. However, we were ultimately successful in creating a variant, designated as NeonCyan1, with a tryptophan-derived cyan fluorescent protein (CFP)-type chromophore, and two additional mutants with distinct spectral hues. Structural, computational, and photophysical characterization of NeonCyan1 and its variants provided insight into the factors that control the fluorescence emission color. Though not recommended as replacements for contemporary CFP variants, we demonstrate that NeonCyan1 variants are potentially suitable for live cell imaging applications.","PeriodicalId":89222,"journal":{"name":"Procedia, social and behavioral sciences","volume":"143 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77444746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pfizer-biontech COVID-19 RNA vaccination induces phosphatidylserine autoantibodies, cryoglobulinemia, and digital necrosis in a patient with pre-existing autoimmunity. 辉瑞-生物技术公司的 COVID-19 RNA 疫苗接种会诱发一名已存在自身免疫的患者出现磷脂酰丝氨酸自身抗体、低温球蛋白血症和数字坏死。

Procedia, social and behavioral sciences Pub Date : 2021-12-01 Epub Date: 2021-09-27 DOI: 10.1016/j.clicom.2021.08.001

Sandy Nasr, Sara Khalil, Bernard J Poiesz, Katalin Banki, Andras Perl

引用次数: 0

The triple role of glutathione S-transferases in mammalian male fertility. 谷胱甘肽 S-转移酶在哺乳动物雄性生殖力中的三重作用。

IF 8

Procedia, social and behavioral sciences Pub Date : 2020-06-01 Epub Date: 2019-12-05 DOI: 10.1007/s00018-019-03405-w

Marc Llavanera, Yentel Mateo-Otero, Sergi Bonet, Isabel Barranco, Beatriz Fernández-Fuertes, Marc Yeste

{"title":"The triple role of glutathione S-transferases in mammalian male fertility.","authors":"Marc Llavanera, Yentel Mateo-Otero, Sergi Bonet, Isabel Barranco, Beatriz Fernández-Fuertes, Marc Yeste","doi":"10.1007/s00018-019-03405-w","DOIUrl":"10.1007/s00018-019-03405-w","url":null,"abstract":"Male idiopathic infertility accounts for 15-25% of reproductive failure. One of the factors that has been linked to this condition is oxidative stress (OS), defined as the imbalance between antioxidants and reactive oxygen species. Amongst the different factors that protect the cell against OS, the members of the glutathione S-transferase (GST) superfamily play an important role. Interestingly, reduction or lack of some GSTs has been associated to infertility in men. Therefore, and to clarify the relationship between GSTs and male fertility, the aim of this work is to describe the role that GSTs play in the male reproductive tract and in sperm physiology. To that end, the present review provides a novel perspective on the triple role of GSTs (detoxification, regulation of cell signalling and fertilisation), and reports their localisation in sperm, seminal plasma and the male reproductive tract. Furthermore, we also tackle the existing correlation between some GST classes and male fertility. Due to the considerable impact of GSTs in human pathology and their tight relationship with fertility, future research should address the specific role of these proteins in male fertility, which could result in new approaches for the diagnosis and/or treatment of male infertility.","PeriodicalId":89222,"journal":{"name":"Procedia, social and behavioral sciences","volume":"174 1","pages":"2331-2342"},"PeriodicalIF":8.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76909143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A De Novo Variant Identified in the PPP2R1A Gene in an Infant Induces Neurodevelopmental Abnormalities. 在一名婴儿体内发现的 PPP2R1A 基因新变异引发神经发育异常

IF 5.6

Procedia, social and behavioral sciences Pub Date : 2020-02-01 Epub Date: 2019-09-17 DOI: 10.1007/s12264-019-00430-4

Yanghui Zhang, Haoxian Li, Hua Wang, Zhengjun Jia, Hui Xi, Xiao Mao

引用次数: 0

Cross-sectional analysis of cognitive function using multivariate normative comparisons in men with HIV disease. 利用多变量常模比较法对男性艾滋病患者的认知功能进行横断面分析。

IF 3.8

Procedia, social and behavioral sciences Pub Date : 2019-11-15 DOI: 10.1097/QAD.0000000000002312

Zheng Wang, Samantha A Molsberry, Yu Cheng, Lawrence Kingsley, Andrew J Levine, Eileen Martin, Cynthia A Munro, Ann Ragin, Leah H Rubin, Ned Sacktor, Eric C Seaberg, James T Becker

{"title":"Cross-sectional analysis of cognitive function using multivariate normative comparisons in men with HIV disease.","authors":"Zheng Wang, Samantha A Molsberry, Yu Cheng, Lawrence Kingsley, Andrew J Levine, Eileen Martin, Cynthia A Munro, Ann Ragin, Leah H Rubin, Ned Sacktor, Eric C Seaberg, James T Becker","doi":"10.1097/QAD.0000000000002312","DOIUrl":"10.1097/QAD.0000000000002312","url":null,"abstract":"Background: Prevalence estimates of cognitive impairment in HIV disease vary widely. Here we used multivariate normative comparison (MNC) with identify individuals with impaired cognition, and to compare the results with those using the Frascati and Gisslén criteria.Methods: The current project used data collected before October 2014 from bisexual/gay men from the Multicenter AIDS Cohort Study. A total of 2904 men (mean age 39.7 years, 52.7% seropositive) had complete data in six cognitive domains at their first neuropsychological evaluation. T-scores were computed for each domain and the MNC was applied to detect impairment among seronegative and seropositive groups.Results: The MNC classified 6.26% of seronegative men as being impaired using a predetermined 5% false discovery rate. By contrast, the Frascati and the Gisslén criteria identified 24.54 and 11.36% of seronegative men as impaired. For seropositive men, the percentage impairment was 7.45, 25.73, and 11.69%, respectively, by the MNC, Frascati and Gisslén criteria. When we used seronegative men without medical comorbidities as the control group, the MNC, the Frascati and the Gisslén criteria identified 5.05, 27.07, and 4.21% of the seronegative men, and 4.34, 30.95, and 4.48% of the seropositive men as having cognitive impairment. For each method, serostatus was not associated with cognitive impairment.Conclusion: The MNC controls the false discovery rate and therefore avoids the low specificity that characterizes the Frascati and Gisslén criteria. More research is needed to evaluate the sensitivity of the MNC method in a seropositive population that may be sicker and older than the current study sample and that includes women.","PeriodicalId":89222,"journal":{"name":"Procedia, social and behavioral sciences","volume":"153 1","pages":"2115-2124"},"PeriodicalIF":3.8,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77505401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay of Objective Sleep Duration and Cardiovascular and Cerebrovascular Diseases on Cause-Specific Mortality. 客观睡眠时间与心脑血管疾病对特定病因死亡率的相互影响。

Procedia, social and behavioral sciences Pub Date : 2019-10-15 Epub Date: 2019-10-02 DOI: 10.1161/JAHA.119.013043

Julio Fernandez-Mendoza, Fan He, Alexandros N Vgontzas, Duanping Liao, Edward O Bixler

{"title":"Interplay of Objective Sleep Duration and Cardiovascular and Cerebrovascular Diseases on Cause-Specific Mortality.","authors":"Julio Fernandez-Mendoza, Fan He, Alexandros N Vgontzas, Duanping Liao, Edward O Bixler","doi":"10.1161/JAHA.119.013043","DOIUrl":"10.1161/JAHA.119.013043","url":null,"abstract":"Background Cardiovascular and cerebrovascular diseases (CBVDs) and cancer are leading causes of death. Short sleep is a potential contributor to health; however, its role in predicting mortality associated with cardiometabolic risk factors (CMRs) and CBVD remains poorly understood. We tested whether objective short sleep duration increases the risk of mortality associated with CMRs and CBVD. Methods and Results A total of 1654 adults (aged 20-74 years) from the Penn State Adult Cohort (47.5 years, 52.5% women, and 89.8% white) whose cause of death was determined after 19.2 years (5.2 years). CMR was defined as stage 2 hypertension and/or type 2 diabetes mellitus on the basis of blood pressure and glucose levels or a report of diagnosis or treatment for these conditions. CBVD was defined as a report of diagnosis or treatment for heart disease and/or stroke. Objective short sleep duration was defined as polysomnographic total sleep time <6 hours. Cox proportional hazard models estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs. Risk of all-cause mortality associated with CMR or CBVD was significantly modified by objective sleep duration (P<0.05), and it was significantly higher in subjects who slept <6 hours (HR, 2.14 [95% CI, 1.52-3.02] and HR, 3.17 [95% CI=2.16-4.65], respectively). In subjects who slept <6 hours, CMR was associated with a 1.83 higher (95% CI, 1.07-3.13) risk of CBVD mortality and CBVD with a 2.92 higher (95% CI, 1.28-6.65) risk of cancer mortality. In subjects who slept ≥6 hours, CMR was not significantly associated with CBVD mortality (HR, 1.35; 95% CI, 0.70-2.63) nor was CBVD significantly associated with cancer mortality (HR, 0.55; 95% CI, 0.18-1.64). Conclusions Objective short sleep duration predicts the all-cause mortality prognosis of middle-aged adults with CMR and the cancer-specific mortality prognosis of those with CBVD.","PeriodicalId":89222,"journal":{"name":"Procedia, social and behavioral sciences","volume":"176 1","pages":"e013043"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76914512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T cell engineering for adoptive T cell therapy: safety and receptor avidity. 用于收养性 T 细胞疗法的 T 细胞工程：安全性和受体亲和性。

IF 5.8

Procedia, social and behavioral sciences Pub Date : 2019-10-01 Epub Date: 2019-09-21 DOI: 10.1007/s00262-019-02395-9

Elvira D'Ippolito, Kilian Schober, Magdalena Nauerth, Dirk H Busch

{"title":"T cell engineering for adoptive T cell therapy: safety and receptor avidity.","authors":"Elvira D'Ippolito, Kilian Schober, Magdalena Nauerth, Dirk H Busch","doi":"10.1007/s00262-019-02395-9","DOIUrl":"10.1007/s00262-019-02395-9","url":null,"abstract":"Since the first bone marrow transplantation, adoptive T cell therapy (ACT) has developed over the last 80 years to a highly efficient and specific therapy for infections and cancer. Genetic engineering of T cells with antigen-specific receptors now provides the possibility of generating highly defined and efficacious T cell products. The high sensitivity of engineered T cells towards their targets, however, also bears the risk of severe off-target toxicities. Therefore, different safety strategies for engineered T cells have been developed that enable removal of the transferred cells in case of adverse events, control of T cell activity or improvement of target selectivity. Receptor avidity is a crucial component in the balance between safety and efficacy of T cell products. In clinical trials, T cells equipped with high avidity T cell receptor (TCR)/chimeric antigen receptor (CAR) have been mostly used so far because of their faster and better response to antigen recognition. However, over-activation can trigger T cell exhaustion/death as well as side effects due to excessive cytokine production. Low avidity T cells, on the other hand, are less susceptible to over-activation and could possess better selectivity in case of tumor antigens shared with healthy tissues, but complete tumor eradication may not be guaranteed. In this review we describe how 'optimal' TCR/CAR affinity can increase the safety/efficacy balance of engineered T cells, and discuss simultaneous or sequential infusion of high and low avidity receptors as further options for efficacious but safe T cell therapy.","PeriodicalId":89222,"journal":{"name":"Procedia, social and behavioral sciences","volume":"116 1","pages":"1701-1712"},"PeriodicalIF":5.8,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11028346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77251688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Venous thromboembolism and palliative care. 静脉血栓栓塞症与姑息治疗。

IF 4.4

Procedia, social and behavioral sciences Pub Date : 2019-07-01 DOI: 10.7861/clinmedicine.19-4-315

Simon Noble

引用次数: 0

Anger management instruction for mothers: a cognitive behavioural approach 母亲愤怒管理指导：一种认知行为方法

Procedia, social and behavioral sciences Pub Date : 2018-09-10 DOI: 10.1016/J.SBSPRO.2010.07.290

M. Shokoohi-yekta, A. Parand, N. Zamani

引用次数: 9