Pathology research international最新文献_第2页

Pathologic and Radiologic Correlation of Adult Cystic Lung Disease: A Comprehensive Review. 成人囊性肺疾病的病理与影像学相关性综述

Pathology research international Pub Date : 2017-01-01 Epub Date: 2017-02-08 DOI: 10.1155/2017/3502438

Prajwal Boddu, Vamsi Parimi, Michale Taddonio, Joshua Robert Kane, Anjana Yeldandi

{"title":"Pathologic and Radiologic Correlation of Adult Cystic Lung Disease: A Comprehensive Review.","authors":"Prajwal Boddu, Vamsi Parimi, Michale Taddonio, Joshua Robert Kane, Anjana Yeldandi","doi":"10.1155/2017/3502438","DOIUrl":"https://doi.org/10.1155/2017/3502438","url":null,"abstract":"The presence of pulmonary parenchymal cysts on computed tomography (CT) imaging presents a significant diagnostic challenge. The diverse range of possible etiologies can usually be differentiated based on the clinical setting and radiologic features. In fact, the advent of high-resolution CT has facilitated making a diagnosis solely on analysis of CT image patterns, thus averting the need for a biopsy. While it is possible to make a fairly specific diagnosis during early stages of disease evolution by its characteristic radiological presentation, distinct features may progress to temporally converge into relatively nonspecific radiologic presentations sometimes necessitating histological examination to make a diagnosis. The aim of this review study is to provide both the pathologist and the radiologist with an overview of the diseases most commonly associated with cystic lung lesions primarily in adults by illustration and description of pathologic and radiologic features of each entity. Brief descriptions and characteristic radiologic features of the various disease entities are included and illustrative examples are provided for the common majority of them. In this article, we also classify pulmonary cystic disease with an emphasis on the pathophysiology behind cyst formation in an attempt to elucidate the characteristics of similar cystic appearances seen in various disease entities.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2017 ","pages":"3502438"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3502438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34792279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach. igg4相关疾病患者中半乳糖凝集素-3的高表达:蛋白质组学方法

Pathology research international Pub Date : 2017-01-01 Epub Date: 2017-05-16 DOI: 10.1155/2017/9312142

Adeeb Salah, Hajime Yoshifuji, Shinji Ito, Koji Kitagori, Kaori Kiso, Norishige Yamada, Toshiki Nakajima, Hironori Haga, Tatsuaki Tsuruyama, Aya Miyagawa-Hayashino

{"title":"High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach.","authors":"Adeeb Salah, Hajime Yoshifuji, Shinji Ito, Koji Kitagori, Kaori Kiso, Norishige Yamada, Toshiki Nakajima, Hironori Haga, Tatsuaki Tsuruyama, Aya Miyagawa-Hayashino","doi":"10.1155/2017/9312142","DOIUrl":"https://doi.org/10.1155/2017/9312142","url":null,"abstract":"Objectives: Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan condition manifesting itself in different forms. This study aimed to investigate protein expression profiles and to find the possible biomarker for IgG4-RD by liquid chromatography mass spectrometry (LC-MS) using tissue sections in IgG4-RD patients.Methods: Protein expression profiles in five IgG4-related pancreatitis and three normal pancreatic samples were compared using LC-MS and were validated by quantitative real-time PCR (qRT-PCR), immunoblotting, and immunohistochemistry. ELISA was employed in the serum of 20 patients with systemic IgG4-RD before and during steroid treatment.Results: LC-MS indicated that the levels of 17 proteins were significantly higher and 12 others were significantly lower in IgG4-related pancreatitis patients compared to controls. Among these proteins, galectin-3 levels were 13-fold higher in IgG4-related pancreatitis (P < 0.01). These results were confirmed by immunoblotting and qRT-PCR. The average number of galectin-3 + cells in various organs of IgG4-RD patients, including salivary glands, lungs, and lymph nodes, was higher than in controls. Galectin-3 was detectable in macrophages, dendritic cells, and stromal myofibroblast-like cells, but not in lymphocytes by immunofluorescence staining. Serum galectin-3 levels were higher in patients with IgG4-RD compared with healthy donors and remained high during steroid therapy.Conclusion: Galectin-3 was overexpressed in IgG4-RD and the levels were indirectly related to clinical activity.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2017 ","pages":"9312142"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9312142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35070492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: An Evidence-Based Nomenclature Change. 具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤:一种基于证据的命名变化。

Pathology research international Pub Date : 2017-01-01 Epub Date: 2017-02-09 DOI: 10.1155/2017/1057252

Rachel Jug, Xiaoyin Jiang

{"title":"Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: An Evidence-Based Nomenclature Change.","authors":"Rachel Jug, Xiaoyin Jiang","doi":"10.1155/2017/1057252","DOIUrl":"https://doi.org/10.1155/2017/1057252","url":null,"abstract":"A consensus panel recently used clinical evidence and pathologic parameters to rename noninvasive encapsulated follicular variant of papillary thyroid carcinoma to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to better reflect the indolent course of this tumor. NIFTP has stringent histopathologic diagnostic criteria established by the panel, including papillary-like nuclear features, and submission of the entire tumor capsule to exclude invasion. From a molecular standpoint, NIFTP is often characterized by RAS-type mutations, similar to other follicular-patterned lesions. While there has been prior evidence in the literature for the low malignant potential of these tumors, projects moving forward will help to independently reinforce the reliability of these criteria and nomenclature. With planned inclusion of NIFTP into the latest World Health Organization endocrine tumor classification scheme, this nomenclature shift provides a model for pathology efforts to refine diagnostic classifications to better guide treatment. In this review we discuss this nomenclature change and review the current literature.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2017 ","pages":"1057252"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1057252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34800815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Development of Neurological Mouse Model for Toxoplasmosis Using Toxoplasma gondii Isolated from Chicken in Kenya. 利用从肯尼亚鸡体内分离的弓形虫开发弓形虫病神经小鼠模型。

Pathology research international Pub Date : 2017-01-01 Epub Date: 2017-05-24 DOI: 10.1155/2017/4302459

John Mokua Mose, David Muchina Kamau, John Maina Kagira, Naomi Maina, Maina Ngotho, Adele Njuguna, Simon Muturi Karanja

{"title":"Development of Neurological Mouse Model for Toxoplasmosis Using Toxoplasma gondii Isolated from Chicken in Kenya.","authors":"John Mokua Mose, David Muchina Kamau, John Maina Kagira, Naomi Maina, Maina Ngotho, Adele Njuguna, Simon Muturi Karanja","doi":"10.1155/2017/4302459","DOIUrl":"10.1155/2017/4302459","url":null,"abstract":"Animal models for the toxoplasmosis are scarce and have limitations. In this study, a neurological mouse model was developed in BALB/c mice infected intraperitoneally with 15 cysts of a Toxoplasma gondii isolate. The mice were monitored for 42 days and euthanized at different time points. Another group of mice were orally treated with dexamethasone (DXM: 2.66 mg/kg daily, 5.32 mg/kg daily) at 42 days after infection and monitored for a further 42 days. A mortality rate of 15% and 28.6% was observed in mice given 2.66 mg/kg/day and 5.32 mg/kg/day of DXM, respectively. The mean cyst numbers in the brain of DXM treated mice increased up to twofold compared with chronically infected untreated mice. Infections up to 42 days were associated with an increase in both IgM and IgG levels but following dexamethasone treatment, IgM levels declined but IgG levels continued on rising. The brain of toxoplasmosis infected mice showed mononuclear cellular infiltrations, neuronal necrosis, and cuffing. The severity of pathology was higher in mice treated with dexamethasone compared to the positive control groups. The findings of this study demonstrate that DXM-induced reactivation of chronic toxoplasmosis may be a useful development of laboratory animal model in outbred mice used for in vivo studies.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2017 ","pages":"4302459"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35101433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Attempt to Establish a Common Animal Model for Hepatorenal Fibrosis in Rats. 建立大鼠肝肾纤维化通用动物模型的尝试。

Pathology research international Pub Date : 2017-01-01 Epub Date: 2017-08-01 DOI: 10.1155/2017/8260508

Manoj Hang Limbu, Liu Lei, Cheng Zhengyuan, Liu Jing, Zhang Xiaoyi, Chen Pingsheng

{"title":"An Attempt to Establish a Common Animal Model for Hepatorenal Fibrosis in Rats.","authors":"Manoj Hang Limbu, Liu Lei, Cheng Zhengyuan, Liu Jing, Zhang Xiaoyi, Chen Pingsheng","doi":"10.1155/2017/8260508","DOIUrl":"https://doi.org/10.1155/2017/8260508","url":null,"abstract":"It is already a proven fact that there exists a relationship between CLD (chronic liver disease) and kidney disease but still there is no available combined animal model of liver and kidney fibrosis on the same animal. An animal model is one of the important research tools in the field of medical science because it is important to build a model that can simulate the disease condition so that the particular disease can be studied. Therefore, the aim of this study is to build a less expensive, less time consuming, and reproducible model of hepatorenal fibrosis on rats. We administered combined intraperitoneal injection of CCl4 (Carbon Tetrachloride) and BSA (Bovine Serum Albumin) on a female Wistar rats. At the end, the liver and kidney tissues were examined under microscope to see whether we were successful in establishing the model or not. The results show that liver fibrosis was marked but the changes on the kidneys were mild. In this study, we were able to induce significant fibrosis in the liver and early stages of fibrosis in the kidneys. The result also demonstrated that the addition of BSA conferred a liver protective effect against CCl4 induced hepatotoxicity, whereas combination of CCl4 and BSA proved to be detrimental for kidneys.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2017 ","pages":"8260508"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8260508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35343092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Possible Role of Mast Cells in the Odontogenic Cyst's Pathogenesis: A Comparative Study between Dentigerous Cyst and Keratocystic Odontogenic Tumor 肥大细胞在牙源性囊肿发病中的可能作用:牙源性囊肿与角化囊性牙源性肿瘤的比较研究

Pathology research international Pub Date : 2016-02-24 DOI: 10.1155/2016/8754567

S. Farhadi, F. Shahsavari, MirMahdi Davardan

{"title":"The Possible Role of Mast Cells in the Odontogenic Cyst's Pathogenesis: A Comparative Study between Dentigerous Cyst and Keratocystic Odontogenic Tumor","authors":"S. Farhadi, F. Shahsavari, MirMahdi Davardan","doi":"10.1155/2016/8754567","DOIUrl":"https://doi.org/10.1155/2016/8754567","url":null,"abstract":"Background. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. This study was aimed to evaluate and compare the density of mast cells in Dentigerous cyst (DC) and Keratocystic odontogenic tumor (KCOT) regarding their different clinical behavior. Method. This study was conducted on 23 and 26 cases of DC and KCOT, respectively. Four-micron sections were prepared for Toluidine blue staining and mast cell densities in two desired cysts were studied. Final data was analyzed via t-test and Mann-Whitney U test method regarding the significant level lower than 0.05. Results. Mast cell densities were significantly higher in KCOTs for deep and superficial layers and both layers (P < 0.05). The density of degranulated mast cells in the deeper layers and both layers was significantly higher in KCOTs (P < 0.05). However, the density of degranulated mast cells in the superficial layer had no significant difference (P > 0.05). Conclusion. It seems that mast cells may be involved in the pathogenesis of KCOT, but, regarding wide range of mast cell's biologic activities, further investigations are recommended to confirm the issue and prepare the details.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8754567","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64586027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Salivary and Urinary Total Antioxidant Capacity as Biomarkers of Oxidative Stress in Humans 唾液和尿液总抗氧化能力作为人类氧化应激的生物标志物

Pathology research international Pub Date : 2016-02-07 DOI: 10.1155/2016/5480267

I. Peluso, A. Raguzzini

{"title":"Salivary and Urinary Total Antioxidant Capacity as Biomarkers of Oxidative Stress in Humans","authors":"I. Peluso, A. Raguzzini","doi":"10.1155/2016/5480267","DOIUrl":"https://doi.org/10.1155/2016/5480267","url":null,"abstract":"Total Antioxidant Capacity (TAC) is a biomarker often used in order to investigate oxidative stress in many pathological conditions. Saliva and urine can be collected noninvasively and represent attractive diagnostic fluids for detecting biomarkers of various pathological conditions. The reviewed case-control and intervention studies that measured salivary or urinary TAC revealed that diseases, antioxidant foods, or supplements and age, gender, and lifestyle factors influenced salivary or urinary TAC. Salivary and urinary TAC were particularly affected by oral or renal status, respectively, as well as by infection; therefore these factors must be taken into account in both case-control and intervention studies. Furthermore, some considerations on sample collection and normalization strategies could be made. In particular, unstimulated saliva could be the better approach to measure salivary TAC, whereas 24 h or spontaneous urine collection should be chosen on the basis of the study outcome and of the creatinine clearance. Finally, the uric acid-independent TAC could be the better approach to evaluate red-ox status of body, in particular after nutritional interventions and in diseases associated with hyperuricaemia.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5480267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64429447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 89

Immunohistochemical Expression of Ki67 and p53 in Wilms Tumor and Its Relationship with Tumor Histology and Stage at Presentation Wilms肿瘤中Ki67和p53的免疫组织化学表达及其与肿瘤组织学和发病分期的关系

Pathology research international Pub Date : 2016-01-20 DOI: 10.1155/2016/6123951

O. R. Krishna, Geetha Kayla, Mohammed Abdul Aleem, Ramani Malleboyina, Ramesh Reddy Kota

{"title":"Immunohistochemical Expression of Ki67 and p53 in Wilms Tumor and Its Relationship with Tumor Histology and Stage at Presentation","authors":"O. R. Krishna, Geetha Kayla, Mohammed Abdul Aleem, Ramani Malleboyina, Ramesh Reddy Kota","doi":"10.1155/2016/6123951","DOIUrl":"https://doi.org/10.1155/2016/6123951","url":null,"abstract":"Aim. Evaluate tumor proliferation marker (Ki67) and p53 tumor suppressor marker in Wilms tumor and correlate with histology, anaplasia, and staging. Design. Prospective, hospital based study conducted at a tertiary pediatric referral centre in south India. Setting. Wilms tumor is the most common childhood renal malignancy worldwide. Anaplasia on histology is associated with treatment resistance but not with aggressiveness clinical presentation. Chemotherapy for Wilms tumor is based on histology and staging. Most patients respond to current chemotherapy protocol. However, a small fraction relapses or metastasizes. Affordable prognostic markers are needed for histopathological evaluation of this tumor. Subjects. Cases of histologically confirmed Wilms tumor over five years. Cases after chemotherapy were excluded as the immunostaining was inconsistent in necrotic areas. Methods. The clinical and radiological findings of 31 cases of Wilms tumor were documented at a tertiary pediatric referral hospital over five years. In addition to Hematoxylin and Eosin staining, Ki67 proliferation index and p53 expression were correlated with tumor histology and staging. Results. Age incidence was 3–8 years with female preponderance. Significant correlation was noted between Ki67 proliferation index and tumor staging. p53 expression was not useful in stratification of Wilms tumor. Conclusion. Ki67 was cost-effective immunohistochemical marker for prognostication of pediatric Wilms tumor.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6123951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64458868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Predictive Response Value of Pre- and Postchemoradiotherapy Variables in Rectal Cancer: An Analysis of Histological Data 直肠癌放化疗前后变量的预测反应价值:组织学数据分析

Pathology research international Pub Date : 2016-01-18 DOI: 10.1155/2016/2164609

Marisa D. Santos, Cristina Silva, A. Rocha, C. Nogueira, Eduarda Matos, C. Lopes

{"title":"Predictive Response Value of Pre- and Postchemoradiotherapy Variables in Rectal Cancer: An Analysis of Histological Data","authors":"Marisa D. Santos, Cristina Silva, A. Rocha, C. Nogueira, Eduarda Matos, C. Lopes","doi":"10.1155/2016/2164609","DOIUrl":"https://doi.org/10.1155/2016/2164609","url":null,"abstract":"Background. Neoadjuvant chemoradiotherapy (nCRT) followed by curative surgery in locally advanced rectal cancer (LARC) improves pelvic disease control. Survival improvement is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. Potential predictive factors for Mandard response are analyzed. Materials and Methods. 167 patients with LARC were treated with nCRT and curative surgery. Tumor biopsies and surgical specimens were reviewed and analyzed regarding mitotic count, necrosis, desmoplastic reaction, and inflammatory infiltration grade. Surgical specimens were classified according to Mandard TRG. The patients were divided as “good responders” (Mandard TRG1-2) and “bad responders” (Mandard TRG3-5). According to results from our previous data, good responders have better prognosis than bad responders. We examined predictive factors for Mandard response and performed statistical analysis. Results. In univariate analysis, distance from anal verge and ten other postoperative variables related with nCRT tumor response had predictive value for Mandard response. In multivariable analysis only mitotic count, necrosis, and differentiation grade in surgical specimen had predictive value. Conclusions. There is a lack of clinical and pathological preoperative variables able to predict Mandard response. Only postoperative pathological parameters related with nCRT response have predictive value.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2164609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64264258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Retracted: Oral Carcinogenesis and Oral Cancer Chemoprevention: A Review. 撤回：口腔癌发生与口腔癌化学预防：综述。

Pathology research international Pub Date : 2016-01-01 Epub Date: 2016-06-28 DOI: 10.1155/2016/9267585

Pathology Research International

引用次数: 0