The Possible Role of Mast Cells in the Odontogenic Cyst's Pathogenesis: A Comparative Study between Dentigerous Cyst and Keratocystic Odontogenic Tumor

Pathology research international Pub Date : 2016-02-24 DOI:10.1155/2016/8754567

S. Farhadi, F. Shahsavari, MirMahdi Davardan

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引用次数: 8

Abstract

Background. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. This study was aimed to evaluate and compare the density of mast cells in Dentigerous cyst (DC) and Keratocystic odontogenic tumor (KCOT) regarding their different clinical behavior. Method. This study was conducted on 23 and 26 cases of DC and KCOT, respectively. Four-micron sections were prepared for Toluidine blue staining and mast cell densities in two desired cysts were studied. Final data was analyzed via t-test and Mann-Whitney U test method regarding the significant level lower than 0.05. Results. Mast cell densities were significantly higher in KCOTs for deep and superficial layers and both layers (P < 0.05). The density of degranulated mast cells in the deeper layers and both layers was significantly higher in KCOTs (P < 0.05). However, the density of degranulated mast cells in the superficial layer had no significant difference (P > 0.05). Conclusion. It seems that mast cells may be involved in the pathogenesis of KCOT, but, regarding wide range of mast cell's biologic activities, further investigations are recommended to confirm the issue and prepare the details.

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肥大细胞在牙源性囊肿发病中的可能作用:牙源性囊肿与角化囊性牙源性肿瘤的比较研究

背景。最近，肥大细胞被认为是侵袭性病理病变的发病机制。本研究旨在评估和比较牙本质囊肿(DC)和角化囊性牙源性肿瘤(KCOT)中肥大细胞密度的不同临床行为。方法。本研究分别对23例DC和26例KCOT进行了研究。制备四微米切片进行甲苯胺蓝染色，并研究了两个所需囊肿的肥大细胞密度。最终数据采用t检验和Mann-Whitney U检验，显著性水平低于0.05。结果。深层、浅层及两层kcot的肥大细胞密度均显著增高(P < 0.05)。kcot组深层及两层脱颗粒肥大细胞密度均显著增高(P < 0.05)。浅层脱颗粒肥大细胞密度差异无统计学意义(P < 0.05)。结论。肥大细胞似乎可能参与了KCOT的发病机制，但由于肥大细胞的生物学活性范围广泛，建议进一步研究以证实这一问题并准备细节。

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Pathology research international

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