Pathology research international最新文献_第3页

Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep. 间日锥虫对实验感染绵羊红细胞的粘附。

Pathology research international Pub Date : 2016-01-01 Epub Date: 2016-05-16 DOI: 10.1155/2016/4503214

Alpidio A Boada-Sucre, Marcello Salvatore Rossi Spadafora, Lucinda M Tavares-Marques, Héctor J Finol, Armando Reyna-Bello

{"title":"Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep.","authors":"Alpidio A Boada-Sucre, Marcello Salvatore Rossi Spadafora, Lucinda M Tavares-Marques, Héctor J Finol, Armando Reyna-Bello","doi":"10.1155/2016/4503214","DOIUrl":"https://doi.org/10.1155/2016/4503214","url":null,"abstract":"Trypanosomosis, a globally occurring parasitic disease, poses as a major obstacle to livestock production in tropical and subtropical regions resulting in tangible economic losses. In Latin America including Venezuela, trypanosomosis of ruminants is mainly caused by Trypanosoma vivax. Biologically active substances produced from trypanosomes, as well as host-trypanosome cellular interactions, contribute to the pathogenesis of anemia in an infection. The aim of this study was to examine with a scanning electron microscope the cellular interactions and alterations in ovine red blood cells (RBC) experimentally infected with T. vivax. Ovine infection resulted in changes of RBC shape as well as the formation of surface holes or vesicles. A frequent observation was the adhesion to the ovine RBC by the trypanosome's free flagellum, cell body, or attached flagellum in a process mediated by the filopodia emission from the trypanosome surface. The observed RBC alterations are caused by mechanical and biochemical damage from host-parasite interactions occurring in the bloodstream. The altered erythrocytes are prone to mononuclear phagocytic removal contributing to the hematocrit decrease during infection. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2016 ","pages":"4503214"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4503214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34474135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Evaluation of Various Nuclear Cytological Changes in Normal Buccal Mucosa and Peritumoural Area in Patients with Oral Squamous Cell Carcinoma Receiving Concomitant Chemoradiotherapy. 接受放化疗的口腔鳞状细胞癌患者正常颊黏膜及瘤周核细胞学变化的评价。

Pathology research international Pub Date : 2016-01-01 Epub Date: 2016-04-11 DOI: 10.1155/2016/6293795

Sadia Minhas, Muhammad Kashif, A H Nagi

{"title":"Evaluation of Various Nuclear Cytological Changes in Normal Buccal Mucosa and Peritumoural Area in Patients with Oral Squamous Cell Carcinoma Receiving Concomitant Chemoradiotherapy.","authors":"Sadia Minhas, Muhammad Kashif, A H Nagi","doi":"10.1155/2016/6293795","DOIUrl":"https://doi.org/10.1155/2016/6293795","url":null,"abstract":"Objectives. To evaluate the role of serial cytological assay in calculating the nuclear response of contralateral normal buccal mucosa and peritumoural area of squamous cell carcinoma of oral cavity in patients receiving fractionated radiotherapy (RT) and chemotherapy. Materials and Methods. This prospective, nonrandomized study was comprised of 76 histologically confirmed cases of oral squamous cell carcinoma on cyclical chemoradiation treatment. Chemoradiosensitivity was evaluated using serial scrape smears taken before and after immediate exposure to CCRT, at 17th day of CCRT (mid of treatment), and at the end of treatment. The nuclear changes, such as multinucleation, micronucleation, karyorrhexis, karyolysis, nuclear budding, prominent nucleoli, and binucleation occurring in both irradiated cancer cells and contralateral normal buccal mucosa, had a statistically significant dose related increase with concomitant chemoradiotherapy (p < 0.05). Conclusion. We recommend regular use of serial cytological assay during CCRT as it may prove to be a valuable tool for assessment of chemoradiosensitivity and persistence of tumour/dysplastic cells after radiotherapy. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2016 ","pages":"6293795"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6293795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34521543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Histomorphological Pattern Analysis of Pulmonary Tuberculosis in Lung Autopsy and Surgically Resected Specimens. 肺解剖和手术切除标本中肺结核的组织形态学分析。

Pathology research international Pub Date : 2016-01-01 Epub Date: 2016-03-21 DOI: 10.1155/2016/8132741

Mamta Gupta, Flora D Lobo, Deepa Sowkur Anandarama Adiga, Abhishek Gupta

{"title":"A Histomorphological Pattern Analysis of Pulmonary Tuberculosis in Lung Autopsy and Surgically Resected Specimens.","authors":"Mamta Gupta, Flora D Lobo, Deepa Sowkur Anandarama Adiga, Abhishek Gupta","doi":"10.1155/2016/8132741","DOIUrl":"https://doi.org/10.1155/2016/8132741","url":null,"abstract":"Background. Tuberculosis (TB) is a major cause of morbidity and mortality globally. Many cases are diagnosed on autopsy and a subset of patients may require surgical intervention either due to the complication or sequelae of TB. Materials and Methods. 40 cases of resected lung specimens following surgery or autopsy in which a diagnosis of pulmonary tuberculosis was made were included. Histopathological pattern analysis of pulmonary tuberculosis along with associated nonneoplastic changes and identification of Mycobacterium tuberculosis bacilli was done. Results. The mean age of diagnosis was 41 years with male predominance (92.5%). Tuberculosis was suspected in only 12.1% of cases before death. Seven cases were operated upon due to associated complications or suspicion of malignancy. Tubercular consolidation was the most frequent pattern followed by miliary tuberculosis. The presence of necrotizing granulomas was seen in 33 cases (82.5%). Acid fast bacilli were seen in 57.5% cases on Ziehl-Neelsen stain. Conclusion. Histopathology remains one of the most important methods for diagnosing tuberculosis, especially in TB prevalent areas. It should be considered in the differential diagnosis of all respiratory diseases because of its varied clinical presentations and manifestations. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2016 ","pages":"8132741"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8132741","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34411040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

FAP Associated Papillary Thyroid Carcinoma: A Peculiar Subtype of Familial Nonmedullary Thyroid Cancer FAP相关乳头状甲状腺癌:家族性非髓样甲状腺癌的一个特殊亚型

Pathology research international Pub Date : 2015-12-01 DOI: 10.1155/2015/309348

F. Cetta

{"title":"FAP Associated Papillary Thyroid Carcinoma: A Peculiar Subtype of Familial Nonmedullary Thyroid Cancer","authors":"F. Cetta","doi":"10.1155/2015/309348","DOIUrl":"https://doi.org/10.1155/2015/309348","url":null,"abstract":"Familial Nonmedullary Thyroid Carcinoma (FNMTC) makes up to 5–10% of all thyroid cancers, also including those FNMTC occurring as a minor component of familial cancer syndromes, such as Familial Adenomatous Polyposis (FAP). We give evidence that this extracolonic manifestation of FAP is determined by the same germline mutation of the APC gene responsible for colonic polyps and cancer but also shows some unusual features (F : M ratio = 80 : 1, absence of LOH for APC in the thyroid tumoral tissue, and indolent biological behaviour, despite frequent multicentricity and lymph nodal involvement), suggesting that the APC gene confers only a generic susceptibility to thyroid cancer, but perhaps other factors, namely, modifier genes, sex-related factors, or environmental factors, are also required for its phenotypic expression. This great variability is against the possibility of classifying all FNMTC as a single entity, not only with a unique or prevalent causative genetic factor, but also with a unique or common biological behavior and a commonly dismal prognosis. A new paradigm is also suggested that could be useful (1) for a proper classification of FAP associated PTC within the larger group of FNMTC and (2) for making inferences to sporadic carcinogenesis, based on the lesson from FAP.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/309348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64897504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Prognostic Significance of N-Glycolyl GM3 Ganglioside Expression in Non-Small Cell Lung Carcinoma Patients: New Evidences n-糖基GM3神经节苷脂在非小细胞肺癌患者中的表达及其预后意义:新证据

Pathology research international Pub Date : 2015-11-08 DOI: 10.1155/2015/132326

Rancés Blanco, E. Domínguez, O. Morales, D. Blanco, Darel Martínez, Charles E. Rengifo, C. Viada, M. Cedeño, E. Rengifo, A. Carr

{"title":"Prognostic Significance of N-Glycolyl GM3 Ganglioside Expression in Non-Small Cell Lung Carcinoma Patients: New Evidences","authors":"Rancés Blanco, E. Domínguez, O. Morales, D. Blanco, Darel Martínez, Charles E. Rengifo, C. Viada, M. Cedeño, E. Rengifo, A. Carr","doi":"10.1155/2015/132326","DOIUrl":"https://doi.org/10.1155/2015/132326","url":null,"abstract":"The prognostic role of N-glycolyl GM3 ganglioside (NeuGcGM3) expression in non-small cell lung carcinoma (NSCLC) still remains controversial. In this study, the NeuGcGM3 expression was reevaluated using an increased number of NSCLC cases and the 14F7 Mab (a highly specific IgG1 raised against NeuGcGM3). An immunohistochemical score integrating the percentage of 14F7-positive cells and the intensity of reaction was applied to reassess the relationship between NeuGcGM3 expression, some clinicopathological features, and the overall survival (OS) of NSCLC patients. The double and the triple expression of NeuGcGM3 with the epidermal growth factor receptor (EGFR) and/or its ligand, the epidermal growth factor (EGF), were also evaluated. NeuGcGM3 expression correlates with both S-Phase fraction (p = 0.006) and proliferation index (p = 0.000). Additionally, NeuGcGM3 expression was associated with a poor OS of patients in both univariate (p = 0.020) and multivariate (p = 0.010) analysis. Moreover, the double and/or the triple positivity of tumors to NeuGcGM3, EGFR, and/or EGF permitted us to identify phenotypes of NSCLC with a more aggressive biological behavior. Our results are in agreement with the negative prognostic significance of NeuGcGM3 expression in NSCLC patients. However, standardization of techniques to determine the expression of NeuGcGM3 in NSCLC as well as the implementation of a universal scoring system is recommended.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/132326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64797279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Morphological and chemical study of pathological deposits in human aortic and mitral valve stenosis: a biomineralogical contribution. 人类主动脉瓣和二尖瓣狭窄病理沉积物的形态学和化学研究:生物矿物学的贡献。

Pathology research international Pub Date : 2015-01-01 Epub Date: 2015-01-19 DOI: 10.1155/2015/342984

Valentina Cottignoli, Elena Cavarretta, Loris Salvador, Carlo Valfré, Adriana Maras

{"title":"Morphological and chemical study of pathological deposits in human aortic and mitral valve stenosis: a biomineralogical contribution.","authors":"Valentina Cottignoli, Elena Cavarretta, Loris Salvador, Carlo Valfré, Adriana Maras","doi":"10.1155/2015/342984","DOIUrl":"https://doi.org/10.1155/2015/342984","url":null,"abstract":"Aim of this study was to investigate heart valve calcification process by different biomineralogical techniques to provide morphological and chemical features of the ectopic deposit extracted from patients with severe mitral and aortic valve stenosis, to better evaluate this pathological process. Polarized light microscopy and scanning electron microscopy analyses brought to light the presence of nodular and massive mineralization forms characterized by different levels of calcification, as well as the presence of submicrometric calcified globular cluster, micrometric cavities containing disorganized tissue structures, and submillimeter pockets formed by organic fibers very similar to amyloid formations. Electron microprobe analyses showed variable concentrations of Ca and P within each deposit and the highest content of Ca and P within calcified tricuspid aortic valves, while powder X-ray diffraction analyses indicated in the nanometer range the dimension of the pathological bioapatite crystals. These findings indicated the presence of highly heterogeneous deposits within heart valve tissues and suggested a progressive maturation process with continuous changes in the composition of the valvular tissue, similar to the multistep formation process of bone tissue. Moreover the micrometric cavities represent structural stages of the valve tissue that immediately precedes the formation of heavily mineralized deposits such as bone-like nodules. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2015 ","pages":"342984"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/342984","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33383531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Leishmaniasis in central morocco: seasonal fluctuations of phlebotomine sand fly in aichoun locality, from sefrou province. 摩洛哥中部的利什曼病：塞夫鲁省艾丘恩地区沙蝇的季节性波动。

Pathology research international Pub Date : 2015-01-01 Epub Date: 2015-02-08 DOI: 10.1155/2015/438749

Fatima Zahra Talbi, Abdelhakim El Ouali Lalami, Abdellatif Janati Idrissi, Faiza Sebti, Chafika Faraj

{"title":"Leishmaniasis in central morocco: seasonal fluctuations of phlebotomine sand fly in aichoun locality, from sefrou province.","authors":"Fatima Zahra Talbi, Abdelhakim El Ouali Lalami, Abdellatif Janati Idrissi, Faiza Sebti, Chafika Faraj","doi":"10.1155/2015/438749","DOIUrl":"10.1155/2015/438749","url":null,"abstract":"Cutaneous leishmaniases (CL) are endemic in Morocco. They are common in the human population in different localities such as Aichoun in Sefrou province, Morocco. This study was carried out in Aichoun locality from April to October 2012 in order to study the spatiotemporal trends of the main Leishmania phlebotomine vectors in this focus. Overall, 1171 sand flies, belonging to four species, were collected by sticky traps. Phlebotomus sergenti was the predominant species (78.4%) followed by Ph. perniciosus (10.5%), Ph. papatasi (7.94%), and Ph. longicuspis (3.16%). Sandflies were active during 6 months (May-October). Ph. sergenti, Ph. perniciosus, and Ph. papatasi displayed a bimodal distribution with a first peak in July and a second peak in September, while Ph. longicuspis showed a monophasic trend with a peak in August. The high abundance and the lengthy period of activity of Ph. sergenti and Ph. perniciosus, vectors of L. tropica and L. infantum, respectively, are a cause for concern as they indicate the high potential risk of Leishmania transmission in the studied areas. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2015 ","pages":"438749"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33104314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Prostanoid EP3 Receptors in Oral Squamous Epithelium and Oral Squamous Cell Carcinoma. 前列腺素EP3受体在口腔鳞状上皮和口腔鳞状细胞癌中的表达。

Pathology research international Pub Date : 2015-01-01 Epub Date: 2015-02-09 DOI: 10.1155/2015/602929

Muhammad Kashif, Muhammad Ishfaq, A H Nagi

{"title":"Expression of Prostanoid EP3 Receptors in Oral Squamous Epithelium and Oral Squamous Cell Carcinoma.","authors":"Muhammad Kashif, Muhammad Ishfaq, A H Nagi","doi":"10.1155/2015/602929","DOIUrl":"https://doi.org/10.1155/2015/602929","url":null,"abstract":"Objectives. To carry out a descriptive analysis of the expression of the EP3 receptors of PGE2 in different histological grades of OSCC and adjacent normal epithelium. Material and Methods. A total of 46 patients presenting with various histological subtypes and grades of OSCC were recruited from Maxillofacial Surgery Department of Nishtar Institute of Dentistry Multan. Microscopically tumour subtyping and histological grading according to Anneroth's grading system were carried out. Immunohistochemical staining with rabbit polyclonal EP3 receptor antibody was performed and sections were scored for intensity and proportion of positive adjacent squamous epithelial and tumour cells. Results. Out of 46 patients n = 28 (60.9%) were well differentiated, n = 15 (32.6%) were moderately differentiated, and only n = 3 (6.5%) were poorly differentiated. All n = 46 cases of OSCC were positive for EP3 receptor antibody, n = 14 (30.4%) cases had strong intensity of anti EP3 antibody staining in tumour tissue, n = 17 (37%) cases showed moderate intensity, and n = 15 (32.6%) cases showed weak intensity. Conclusion. Prostanoid EP3 receptors are widely but variably expressed in OSCC. Most of well differentiated OSCC cases show a moderate to strong expression of EP3 receptors. However, insignificant statistical relation to histological grades of OSCC has been observed. This might be due to small sample size of the study. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2015 ","pages":"602929"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/602929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33104315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Thyroid cytopathology reporting by the bethesda system: a two-year prospective study in an academic institution. bethesda系统报告的甲状腺细胞病理学:一个学术机构为期两年的前瞻性研究。

Pathology research international Pub Date : 2015-01-01 Epub Date: 2015-01-22 DOI: 10.1155/2015/240505

Payal Mehra, Anand Kumar Verma

{"title":"Thyroid cytopathology reporting by the bethesda system: a two-year prospective study in an academic institution.","authors":"Payal Mehra, Anand Kumar Verma","doi":"10.1155/2015/240505","DOIUrl":"https://doi.org/10.1155/2015/240505","url":null,"abstract":"Background. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has attempted to standardize reporting and cytological criteria in aspiration smears. Aims. The objective of this study was to analyze the thyroid cytology smears by TBSRTC, to determine the distribution of diagnostic categories and subcategories, to analyze cytological features, and to correlate the cytopathology with histopathology, wherever surgery was done. Materials and Methods. This was a prospective study of 225 fine needle aspirations (FNA) of thyroid nodules. All fine needle aspiration cytology (FNAC) diagnoses were classified according to the features given in the monograph of TBSRTC into nondiagnostic/unsatisfactory (ND/UNS), benign, atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS), follicular neoplasm/suspicious of a follicular neoplasm (FN/SFN), suspicious for malignancy (SFM), and malignant. Cytohistological correlation was done, when surgical material was available. Results. The distribution of various categories from 225 evaluated thyroid nodules was as follows: 7.2% ND/UNS, 80.0% benign, 4.9% AUS/FLUS, 2.2% FN, 3.5% SFM, and 2.2% malignant. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated. Conclusions. TBSRTC is an excellent reporting system for thyroid FNA. It also provides clear management guidelines to clinicians to go for follow-up FNA or surgery and also the extent of surgery. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2015 ","pages":"240505"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/240505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33391102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Comparison of Immunohistochemical Expression of Antiapoptotic Protein Survivin in Normal Oral Mucosa, Oral Leukoplakia, and Oral Squamous Cell Carcinoma. 抗凋亡蛋白Survivin在正常口腔黏膜、口腔白斑和口腔鳞状细胞癌中免疫组化表达的比较。

Pathology research international Pub Date : 2015-01-01 Epub Date: 2015-09-20 DOI: 10.1155/2015/840739

Amita Negi, Abhiney Puri, Rakhi Gupta, Rajat Nangia, Alisha Sachdeva, Megha Mittal

{"title":"Comparison of Immunohistochemical Expression of Antiapoptotic Protein Survivin in Normal Oral Mucosa, Oral Leukoplakia, and Oral Squamous Cell Carcinoma.","authors":"Amita Negi, Abhiney Puri, Rakhi Gupta, Rajat Nangia, Alisha Sachdeva, Megha Mittal","doi":"10.1155/2015/840739","DOIUrl":"https://doi.org/10.1155/2015/840739","url":null,"abstract":"Background. Oral squamous cell carcinoma is the sixth most frequent malignant tumor worldwide and the third most common cancers in developing countries. Oral leukoplakia is the best-known precursor lesion of oral squamous cell carcinoma. The aim of the present study was to compare immunohistochemical expression of antiapoptotic protein survivin in normal oral mucosa, oral leukoplakia, and oral squamous cell carcinoma. Method. Total 45 specimens of formalin fixed paraffin embedded tissue blocks, 15 in each of the following: normal oral mucosa, leukoplakia, and oral squamous cell carcinoma were used for the study. Immunohistochemical reaction for survivin protein was performed for the 4 µm thick histological sections taken on positively charged slides. Results. 20% normal mucosa cases, 53.33% cases of leukoplakia, and 80% of oral squamous cell carcinoma were found out to be survivin positive. One way ANOVA test indicated statistically significant difference of survivin expression between the three different groups (p < 0.001). Conclusion. A high incidence of survivin protein expression in oral epithelial dysplasia and squamous cell carcinoma samples indicate that survivin protein expression may be an early event in initiation and progression of oral squamous cell carcinoma. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2015 ","pages":"840739"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/840739","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31