International journal of diabetes mellitus最新文献

{"title":"Fluctuations in glycosylated hemoglobin (HbA1C) as a predictor for the development of diabetic nephropathy in type 1 diabetic patients","authors":"Jocelyn Eid Fares ,&nbsp;Mona Kanaan ,&nbsp;Monique Chaaya ,&nbsp;Sami T. Azar","doi":"10.1016/j.ijdm.2009.12.012","DOIUrl":"10.1016/j.ijdm.2009.12.012","url":null,"abstract":"<div><h3>Objective</h3><p>The incidence of diabetic nephropathy is higher in type 1 diabetic patients with associated risk factors. The within individual fluctuations in HbA1C and its effect on the development of nephropathy was not previously studied. The purpose of this study is to examine whether HbA1C fluctuations are a predictor of the development of diabetic nephropathy independent of mean HbA1C and other risk factors.</p></div><div><h3>Methods</h3><p>One hundred and seventeen patients (64 females and 53 males) were recruited and followed up regularly at least every 3<!--> <!-->months. The “fluctuations” in HbA1C over time was assessed. HbA1C fluctuation was defined as an increase in HbA1C of more than 2% between two consecutive measurements, or an increase of more than 1% at 2 points in time.</p></div><div><h3>Results</h3><p>Incipient nephropathy was present in 18 and absent in 99 patients. Mean HbA1C was significantly higher in nephropathy than in non-nephropathy patients. The effect of fluctuations on nephropathy appeared to be more significant in patients with poor metabolic control (HbA1C<!--> <!-->⩾<!--> <!-->8%).</p></div><div><h3>Conclusion</h3><p>T1D patients who have a similar mean HbA1C may progressively behave differently in terms of developing nephropathy, depending on the fluctuations in HbA1C. This effect seems to be more pronounced among those who have higher values of HbA1C.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 10-14"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"I27L Polymorphism in hepatocyte nuclear factor-1α gene and type 2 diabetes mellitus: A meta-analysis of studies about orient population (Chinese and Japanese)","authors":"Tao Chen ,&nbsp;Xu Cao ,&nbsp;Yang Long ,&nbsp;Xiangxun Zhang ,&nbsp;Honglin Yu ,&nbsp;Jin Xu ,&nbsp;Ting Yu ,&nbsp;Haoming Tian","doi":"10.1016/j.ijdm.2009.12.011","DOIUrl":"10.1016/j.ijdm.2009.12.011","url":null,"abstract":"<div><h3>Aims</h3><p>The aim of the study was to investigate the relationship between I27L variant of HNF-1α gene and type 2 diabetes mellitus (T2DM) in an/the oriental population.</p></div><div><h3>Methods</h3><p>We recruited 149 T2DM patients and 96 non-diabetes controls from China. The I27L polymorphism in HNF-1α gene was detected by PCR–RFLP analysis. A mete-analysis of previously published studies on I27L and T2DM of orient population and our new study was performed. Databases of MEDLINE, CBM, and the Cochrane Library (CD-ROM) were electronically searched from January 1980 to April 2008. Analysis was performed by RevMan 4.2 software which was downloaded from website of Cochrane collaboration.</p></div><div><h3>Results</h3><p>(1). The genotype distribution of I27L/exon1 polymorphism in the HNF-1α gene was in Hardy–Weinberg equilibrium (<em>χ</em>² <!-->=<!--> <!-->2.34, 0.05<!--> <!-->&lt;<!--> <em>P</em> <!-->&lt;<!--> <!-->0.1). The IL, LL genotype frequencies and <em>L</em> allelic frequency were slightly higher in T2DM group than in controls (0.52, 0.14 and 0.40 in T2DM vs. 0.49, 0.08 and 0.33 in controls), but the difference were not statistically significant, which indicated that 27L variant did not increase the risk of T2DM in our small sample Chinese population. (2). Three published studies concerning the Chinese population, two studies involving the Japanese population and our present study, providing information on a total of 1225 unique subjects, were included in the meta-analysis. The results showed that the 27L variant increased the prevalence of T2DM (OR 1.22, 95% CI 1.03–1.44, <em>p</em> <!-->=<!--> <!-->0.02).</p></div><div><h3>Conclusion</h3><p>I27L polymorphism in the HNF-1α gene increases the risk of T2DM in the orient population (Chinese and Japanese).</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 28-31"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diphenylhydantoin and insulinoma","authors":"Viroj Wiwanitkit","doi":"10.1016/j.ijdm.2009.12.001","DOIUrl":"10.1016/j.ijdm.2009.12.001","url":null,"abstract":"","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Page 67"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic complications of diabetes mellitus in newly diagnosed patients","authors":"Iraj Heydari ,&nbsp;Vida Radi ,&nbsp;Sara Razmjou ,&nbsp;Afsaneh Amiri","doi":"10.1016/j.ijdm.2009.08.001","DOIUrl":"10.1016/j.ijdm.2009.08.001","url":null,"abstract":"<div><p>The prevalence of Diabetes Mellitus (DM) has increased in recent decades. This study was designed to determine retinopathy, neuropathy, nephropathy, hypertension and hyperlipidemia and their interdependence in newly diagnosed diabetic patients. In this study, 200 consecutive newly diagnosed patients were evaluated and screening tests for retinopathy, neuropathy, nephropathy, hypertension and hyperlipidemia were undertaken.</p><p>The frequency of positive screening tests for hyperlipidemia, hypertension, neuropathy, nephropathy and retinopathy was found to be 73.5%, 58.5%, 52%, 10%, and 6% respectively.</p><p>A significant proportion of newly diagnosed diabetic patients have signs of these chronic complications.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 61-63"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenge of undiagnosed pre-diabetes, diabetes and associated cardiovascular disease","authors":"Ved V. Gossain,&nbsp;Saleh Aldasouqi","doi":"10.1016/j.ijdm.2009.10.004","DOIUrl":"10.1016/j.ijdm.2009.10.004","url":null,"abstract":"<div><h3>Objective</h3><p>To present the challenges of undiagnosed pre-diabetes, diabetes and associated cardiovascular disease.</p></div><div><h3>Results</h3><p>A substantial number of people with diabetes and pre-diabetes remain undiagnosed worldwide. Without preventive measures, pre-diabetes progresses to overt diabetes at the rate of approximately 5% per year. Both diabetes and pre-diabetes are associated with vascular complications.</p></div><div><h3>Conclusion</h3><p>Undiagnosed pre-diabetes and diabetes is a major health problem, and we recommend widespread screening for diabetes. An international expert committee has recommended that HbA1c be used for the diagnosis of diabetes. Further studies are needed before HbA1c can be used as a diagnostic test for gestational diabetes.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 43-46"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author response: Diphenylhydantoin and insulinoma","authors":"Lara Al-Khoury Nabbout","doi":"10.1016/j.ijdm.2009.12.004","DOIUrl":"10.1016/j.ijdm.2009.12.004","url":null,"abstract":"","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Page 68"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome in type 1 diabetes","authors":"Sujoy Ghosh ,&nbsp;Andrew Collier ,&nbsp;Mario Hair ,&nbsp;Iqbal Malik ,&nbsp;Tarik Elhadd","doi":"10.1016/j.ijdm.2009.10.005","DOIUrl":"10.1016/j.ijdm.2009.10.005","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of this study was to assess the prevalence and effects of the presence of metabolic syndrome in patients with type 1 diabetes.</p></div><div><h3>Research design and methods</h3><p>Retrospective analysis of data from a one year period of patients attending annual review clinic was undertaken. Body weight, height and blood pressure were measured along with assessment of micro-/macro-vascular complications. HbA1c, urea, cholesterol, triglyceride, urinary albumin: creatinine ratios were also measured. Patients were divided into those with and those without metabolic syndrome.</p></div><div><h3>Results</h3><p>Data from 365 type 1 diabetic patients was analysed. Hundred and twelve had metabolic syndrome. There was no difference according to gender or smoking. Type 1 diabetic patients with metabolic syndrome had longer duration of diabetes, were significantly older, heavier, had higher blood pressure, higher triglyceride and lower HDL cholesterol levels. There were significant increases in mean BMI, urea, serum creatinine, urinary albumin: creatinine ratio, cholesterol and triglyceride in the group with metabolic syndrome even after controlling for both age and duration of diabetes. Neuropathy and macro-vascular complications were commoner in patients with metabolic syndrome. Patients with metabolic syndrome were more likely to be on statins, ACE inhibitors and angiotensin receptor blockers and had a significantly higher mean insulin dosage requirement per kg.</p></div><div><h3>Conclusions</h3><p>This study highlights the importance of the presence of the metabolic syndrome in patients with type 1 diabetes. It shows that metabolic syndrome is associated with a higher incidence of diabetes-related complications, a need for higher insulin doses and a more aggressive multifactorial intervention.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 38-42"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical assessment of insulin action during late pregnancy in women at risk for gestational diabetes: Association of maternal glycemia with perinatal outcome","authors":"Karen E. Elkind-Hirsch ,&nbsp;Beverly W. Ogden ,&nbsp;Carmen J. Darensbourg ,&nbsp;Brett L. Schelin","doi":"10.1016/j.ijdm.2009.12.006","DOIUrl":"10.1016/j.ijdm.2009.12.006","url":null,"abstract":"<div><h3>Objective</h3><p>We prospectively evaluated differences in fasting- and oral glucose tolerance test (OGTT)-derived indices of insulin action in Caucasian (Cau) and African-American (AA) pregnant women and compared them with obstetric outcomes.</p></div><div><h3>Study design</h3><p>IRB-approved prospective study in 171 pregnant women undergoing a 3-h OGTT. Mathematical modeling was used to evaluate insulin response, insulin activity and glucose tolerance in fasting and postglucose ingestion state. Insulin sensitivity indices derived from fasting (HOMA-IR) and glucose-stimulated values (SIOGTT) were compared. An insulin sensitivity-secretion index (IS-SI) was calculated from the product of the SIOGTT and early-phase insulin secretion.</p></div><div><h3>Results</h3><p>Forty-nine patients had gestational diabetes (GDM), 28 had gestational impaired glucose tolerance (GIGT) and 94 had normal glucose tolerance after an abnormal glucose challenge test (NGT-abnGCT). Insulin sensitivity was lowest in women with GDM. In all groups, pregnant AA women were significantly more insulin resistant than Cau women, based on both HOMA-IR and SIOGTT, but had enhanced insulin secretion compared to their Cau counterparts. The mean IS-SI progressively improved for all women from GDM to GIGT to NGT-abnGCT. Women with NGT-abnGCT had a higher prevalence of large-for-gestational age (LGA) newborns and significantly higher cesarean section rate.</p></div><div><h3>Discussion</h3><p>Insulin measures along with glucose determinations during OGTT testing in pregnant women at risk for diabetes provide valuable information that varies according to race. We observed that pregnant women with a lesser degree of glucose tolerance abnormality during pregnancy who receive no intervention have a higher risk for LGA infants and significantly increased C-section rate (ClinicalTrials.gov number, NCT006874791).</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 3-9"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of urinary Monocyte Chemoattractant Protein-1 (uMCP-1) in Indian type 2 diabetic patients at different stages of diabetic nephropathy","authors":"Priyanka Tilak,&nbsp;Zenith Khashim,&nbsp;Satyavani Kumpatla,&nbsp;Mary Babu,&nbsp;Vijay Viswanathan","doi":"10.1016/j.ijdm.2009.10.003","DOIUrl":"10.1016/j.ijdm.2009.10.003","url":null,"abstract":"<div><h3>Objective</h3><p>Monocyte Chemoattractant Protein-1 (MCP-1) is the strongest known chemotactic factor for monocytes and is upregulated in diabetic nephropathy. So measuring urinary MCP-1 is of great significance in the diagnosis and intervention of early diabetic nephropathy. This study aims at determining the levels of urinary MCP-1 (uMCP-1) at different stages of diabetic nephropathy and to see its correlation with other parameters in Indian type2 diabetic subjects.</p></div><div><h3>Materials and methods</h3><p>A total of 64 (M:F; 40:24) type 2 diabetic subjects were divided into three groups based on their renal function and were compared with non-diabetic controls (Group 1) <em>n</em> <!-->=<!--> <!-->20 (M:F; 13:7). The study groups were Group 2 (normoalbuminuria) <em>n</em> <!-->=<!--> <!-->16, Group 3 (microalbuminuria) <em>n</em> <!-->=<!--> <!-->23 and Group 4 (macroalbuminuria) <em>n</em> <!-->=<!--> <!-->25. Demographic, anthropometric and biochemical details were recorded for all the subjects. Urinary MCP-1 levels were measured by using solid phase ELISA method.</p></div><div><h3>Results</h3><p>Mean levels of uMCP-1 in subjects with type 2 diabetes were significantly higher than in controls (<em>p</em> <!-->&lt;<!--> <!-->0.05). The levels of uMCP-1 in type 2 diabetic subjects increased gradually with deteriorating renal function (<em>p</em> <!-->=<!--> <!-->0.006). There was a significant difference in urinary MCP-1 levels between Group 2 and Group 1 (<em>p</em> <!-->&lt;<!--> <!-->0.001). Levels of uMCP-1 were significantly higher in subjects with eGFR &lt;60<!--> <!-->ml/min compared to eGFR &gt;60<!--> <!-->ml/min (<em>p</em> <!-->=<!--> <!-->0.008). uMCP-1 levels correlated positively with uACR or uPCR (<em>r</em> <!-->=<!--> <!-->0.551, <em>p</em> <!-->&lt;<!--> <!-->0.0001), urea (<em>r</em> <!-->=<!--> <!-->0.43, <em>p</em> <!-->&lt;<!--> <!-->0.0001) and creatinine (<em>r</em> <!-->=<!--> <!-->0.478, <em>p</em> <!-->&lt;<!--> <!-->0.0001). A negative correlation between uMCP-1 and eGFR (<em>r</em> <!-->=<!--> <!-->−0.338, <em>p</em> <!-->=<!--> <!-->0.006) was noted.</p></div><div><h3>Conclusion</h3><p>Our study demonstrated that urinary MCP-1 levels increased gradually in type 2 diabetic subjects with deteriorating renal function. It is significantly associated with the other risk factors of diabetic nephropathy.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 15-19"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dealing with anxiety: A pilot cognitive behavioural therapy program for diabetic clinic outpatient attendees","authors":"Gillian Evans,&nbsp;Terry J. Lewin,&nbsp;Kerry Bowen,&nbsp;Julia Lowe","doi":"10.1016/j.ijdm.2009.12.010","DOIUrl":"10.1016/j.ijdm.2009.12.010","url":null,"abstract":"<div><h3>Aims</h3><p>To assess a group-based cognitive behaviour therapy [CBT] program in diabetes.</p></div><div><h3>Methods</h3><p>Sixty people with diabetes were randomly allocated to either immediate (29) or 3<!--> <!-->months delayed (31) CBT groups.</p></div><div><h3>Results</h3><p>DASS scores were reduced by 0.37 standardised [effect-size] units [<em>P</em> <!-->&lt;<!--> <!-->0.01], with a tendency for more marked reductions in anxiety and stress [0.60] among those for whom treatment had been delayed whose HbA1C fell by 0.93% . ADDQoL scores also improved in the short-term but these changes did not persist at 6<!--> <!-->months.</p></div><div><h3>Conclusions</h3><p>The CBT program led to short-term improvements in anxiety, depression, stress and quality of life.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 51-55"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}