International journal of diabetes mellitus最新文献

{"title":"Diabetes epigenetics: Fact or fiction","authors":"Khalid Al-Rubeaan","doi":"10.1016/j.ijdm.2010.06.001","DOIUrl":"10.1016/j.ijdm.2010.06.001","url":null,"abstract":"","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 2","pages":"Pages 71-72"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-cell protein tyrosine phosphatase: A role in inflammation and autoimmunity","authors":"Dimitry A. Chistiakov ,&nbsp;Emma I. Chistiakova","doi":"10.1016/j.ijdm.2010.05.012","DOIUrl":"10.1016/j.ijdm.2010.05.012","url":null,"abstract":"<div><p>A cDNA of <em>PTPN2</em> encoding for T-cell protein tyrosine phosphate (TC-PTP) was isolated and characterized as long as 20<!--> <!-->years ago. However, findings suggesting a potentially exciting role of this enzyme in general autoimmunity have only recently been obtained. Genome-wide association scans of the human genome revealed the involvement of <em>PTPN2</em> in susceptibility to a several autoimmune disorders such as Crohn’s disease, type 1 diabetes, and Graves’ disease. Functional studies in immune cells revealed a key role of this enzyme in down-regulation of cytokine expression and inflammatory response, which provides an essential background to explaining the pathophysiological role of TC-PTP in autoimmunity. Thus, in addition to <em>PTPN22</em>, <em>PTPN2</em> is likely to represent a second member of the broad family of non-receptor PTPs contributing to general autoimmunity.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 2","pages":"Pages 114-118"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.05.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fiber psyllium based hydrogels for use in insulin delivery","authors":"Baljit Singh,&nbsp;Nirmala Chauhan","doi":"10.1016/j.ijdm.2009.12.014","DOIUrl":"10.1016/j.ijdm.2009.12.014","url":null,"abstract":"<div><p>The present article is related to the development of psyllium based oral insulin delivery systems that could release insulin in a controlled and sustained manner. Psyllium is a medicinally important gel, forming glucose lowering dietary fiber and drug delivery system developed by its functionalization will have the double potential of curing diabetes. Psyllium and acrylamide/methacrylamide based hydrogels were prepared, and the effect of pH on the release dynamics of insulin from drug loaded hydrogels has been studied to evaluate the drug release mechanism. Non-Fickian diffusion mechanism has been observed for the release of insulin in the pH 7.4 buffer.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 32-37"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should capillary blood glucose measurements be used in population surveys?","authors":"R. Tirimacco ,&nbsp;P.A. Tideman ,&nbsp;J. Dunbar ,&nbsp;P.A. Simpson ,&nbsp;B. Philpot ,&nbsp;T. Laatikainen ,&nbsp;E. Janus","doi":"10.1016/j.ijdm.2009.12.002","DOIUrl":"10.1016/j.ijdm.2009.12.002","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the accuracy and appropriateness of capillary blood glucose testing in population surveys.</p></div><div><h3>Materials and methods</h3><p>Capillary blood glucose using the Rochec ACCU-CHEK instrument and Advantage 11 Test Strips was compared to a laboratory instrument. Three independent cross-sectional risk factor surveys (<em>n</em> <!-->=<!--> <!-->1432) and baseline individuals from the Greater Green Triangle Diabetes Prevention Project (<em>n</em> <!-->=<!--> <!-->341) provided both fasting plasma and capillary blood glucose measurements. Accuracy of capillary glucoses was assessed using the ISO 15197 standard. The median age of the participants was 71<!--> <!-->years, ranging from 25 to 84<!--> <!-->years. There were 799 males and 974 females.</p></div><div><h3>Results</h3><p>Capillary glucose method had poorer precision at lower concentrations (CV: 9.50%, mean<!--> <!-->=<!--> <!-->3.09<!--> <!-->mmol/L, CV: 4.90%, mean<!--> <!-->=<!--> <!-->16.78<!--> <!-->mmol/L, <em>n</em> <!-->=<!--> <!-->233 replicates). Individual discrepancies were seen across the measuring range (2.8–19.9<!--> <!-->mmol/L, <em>n</em> <!-->=<!--> <!-->1773). In total, 94.5% of results fell within the minimum acceptable accuracy standards. This was slightly short of the 95% of results required to meet the ISO 15197 standard. The prevalence of diabetes in the study population using glucose ⩾7.0<!--> <!-->mmol/L was 2.4% (95%CI 1.8–3.3%) according to fasting plasma glucose and 2.8% (2.1–3.8%) according to fasting capillary glucose. The lower WHO-defined cut-off of 6.1<!--> <!-->mmol/L for capillary blood glucose testing gave a prevalence of 10.7% (9.0–12.5%).</p></div><div><h3>Conclusions</h3><p>This study of matched capillary and plasma glucose results concludes that while it is appropriate to use fasting capillary glucose levels to determine the prevalence of diabetes in populations, it should not be used to reliably diagnose diabetes in individuals.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 24-27"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial tRNALeu(UUR) gene mutation and maternally inherited diabetes mellitus in Pakistan population","authors":"Khalid Siddiqui","doi":"10.1016/j.ijdm.2009.12.007","DOIUrl":"10.1016/j.ijdm.2009.12.007","url":null,"abstract":"","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Page 69"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous endophthalmitis secondary to pyogenic liver abscess","authors":"Musleh Saleh Al-Amri","doi":"10.1016/j.ijdm.2009.12.005","DOIUrl":"10.1016/j.ijdm.2009.12.005","url":null,"abstract":"<div><p>A 55<!--> <!-->year old male presented with abdominal pain and vomiting, followed by a sudden onset of left eye pain, with decreased visual acuity. After clinical and laboratory examinations, the patient was diagnosed with endogenous endophthalmitis, secondary to pyogenic liver abscess, secondary to <em>Klebsiella pneumonia</em>.</p><p>The patient was managed with intravitreal injection of vancomycin and ceftazidime for 2<!--> <!-->weeks, which afforded a resolution.</p><p>Cases of endogenous endophthalmitis pyogenic liver abscess are more commonly reported in the Far East. <em>K. pneumonia</em> primary liver abscess, particularly those associated with metastatic infection, are more commonly reported in Taiwan and are community acquired <span>[1]</span>, <span>[2]</span>, <span>[3]</span>. This paper reports the first case of endogenous endophthalmitis pyogenic liver abscess in the Middle East.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 64-66"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of spirometry in diabetic patients","authors":"Sultan Ayoub Meo","doi":"10.1016/j.ijdm.2009.12.003","DOIUrl":"10.1016/j.ijdm.2009.12.003","url":null,"abstract":"<div><p>Spirometry is a widely used pulmonary function test (PFT), ideally suited to describing the effects of obstruction or restriction on lung function. It is a powerful diagnostic tool that plays a significant role in the early diagnosis of lung damage and its associated structures. It is also used to monitor the therapeutic efficacy of various treatment regimes and the course of the disease. The spirometric parameters have gained more popularity when it has been reported that impaired Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 s (FEV1) are emerging novel risk factors for type 2 diabetes mellitus. These spirometric parameter derangements have been evident on spirometry long before the clinical diagnosis of diabetes mellitus or insulin resistance. In spite of this, spirometry is not used routinely as part of a management system in diabetic patients. Its role is neither fully explored, nor fully utilized to achieve quality of life when managing diabetes mellitus. The aim of the present review is to highlight the evidence based significance of spirometry in the light of peer reviewed published literature. It may serve as a brief reference for diabetes management teams to enable spirometry to be included in the algorithm of the routine assessment of diabetic patients.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 47-50"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 diabetes mellitus red zone","authors":"Khalid Al-Rubeaan","doi":"10.1016/j.ijdm.2009.12.009","DOIUrl":"10.1016/j.ijdm.2009.12.009","url":null,"abstract":"","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.12.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in animal models","authors":"S.K. Mastan ,&nbsp;K. Eswar Kumar","doi":"10.1016/j.ijdm.2009.10.001","DOIUrl":"10.1016/j.ijdm.2009.10.001","url":null,"abstract":"<div><h3>Background</h3><p>The objective of this study was to investigate the effect of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in rats (normal and diabetic) and rabbits to evaluate the safety and effectiveness of the combination.</p></div><div><h3>Methods</h3><p>Blood samples were analysed for blood glucose by GOD/POD method, serum gliclazide levels by HPLC method and insulin by Radio Immuno Assay method.</p></div><div><h3>Results</h3><p>In combination, atazanavir significantly enhanced the pharmacodynamic activity and altered the pharmacokinetic parameters of gliclazide in animal models.</p></div><div><h3>Conclusions</h3><p>The interaction between atazanavir and gliclazide appears to be pharmacokinetic interaction at metabolic level in animal models.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Pages 56-60"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Page","authors":"","doi":"10.1016/S1877-5934(10)00005-6","DOIUrl":"https://doi.org/10.1016/S1877-5934(10)00005-6","url":null,"abstract":"","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 1","pages":"Page ii"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1877-5934(10)00005-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137054983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}