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Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference最新文献

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Drug-induced hepatotoxicity studied in a 3D, in vitro model of the liver 在体外肝脏三维模型中研究药物引起的肝毒性
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.172
G. Guagliano, Manuela Legnardim, Cristina Volpini, N. Bloise, S. Dotti, R. Villa, L. Visai, P. Petrini
{"title":"Drug-induced hepatotoxicity studied in a 3D, in vitro model of the liver","authors":"G. Guagliano, Manuela Legnardim, Cristina Volpini, N. Bloise, S. Dotti, R. Villa, L. Visai, P. Petrini","doi":"10.4081/bse.2021.172","DOIUrl":"https://doi.org/10.4081/bse.2021.172","url":null,"abstract":"Drug development is a high failure rate process; too many drugs fail during clinical trials because of severe hepatotoxicity. This situation can be significantly improved by redesigning preclinical trials, and privileging the use of high-throughput in vitro models, by combining cell-based in vitro models and material-based models.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88631661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward scalable in vitro models: a novel experimental and computational pipeline for the identification of cellular metabolic parameters 向可扩展的体外模型:一种新的实验和计算管道，用于识别细胞代谢参数
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.179
P. Mancini, Ermes Botte, C. Magliaro, A. Ahluwalia
{"title":"Toward scalable in vitro models: a novel experimental and computational pipeline for the identification of cellular metabolic parameters","authors":"P. Mancini, Ermes Botte, C. Magliaro, A. Ahluwalia","doi":"10.4081/bse.2021.179","DOIUrl":"https://doi.org/10.4081/bse.2021.179","url":null,"abstract":"Oxygen utilization by cells has a crucial role in the design of advanced in vitro models. The aim of this study is to develop an experimental and computational pipeline for identifying oxygen metabolism parameters. We applied the approach to HepG2 cell monolayer cultures, demonstrating that such parameters depend on cell density.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74978557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of primary hepatocyte isolation for the pharmacological characterization of metabotropic glutamate receptor (mGluR) s ubtype 5: A study on Reduction 代谢性谷氨酸受体(mGluR)亚型5药理学特征的原代肝细胞分离优化:还原研究
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.151
C. Berardo, A. Ferrigno, Veronica Siciliano, M. Cagna, P. Richelmi, M. Vairetti, L. G. Pasqua
{"title":"Optimization of primary hepatocyte isolation for the pharmacological characterization of metabotropic glutamate receptor (mGluR) s ubtype 5: A study on Reduction","authors":"C. Berardo, A. Ferrigno, Veronica Siciliano, M. Cagna, P. Richelmi, M. Vairetti, L. G. Pasqua","doi":"10.4081/bse.2021.151","DOIUrl":"https://doi.org/10.4081/bse.2021.151","url":null,"abstract":"To minimize the number of animals used during experiments, it is important to choose the suitable enzyme according to the final goal. In our work, we demonstrated the superiority of collagenase IV in the maintenance of functional transmembrane receptor, thus the pharmacological activity, in isolated rat hepatocytes.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76312161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cadmium elicits alterations in mitochondrial morphology and functionality in C3H10T1/2Cl8 mouse fibroblast cell 镉引起C3H10T1/2Cl8小鼠成纤维细胞线粒体形态和功能的改变
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.185
M. Oldani, C. Milani, F. Gaboardi, M. Manzoni, A. Villa, F. Stefanini, P. Melchioretto, E. Monti, M. Forcella, C. Urani, P. Fusi
{"title":"Cadmium elicits alterations in mitochondrial morphology and functionality in C3H10T1/2Cl8 mouse fibroblast cell","authors":"M. Oldani, C. Milani, F. Gaboardi, M. Manzoni, A. Villa, F. Stefanini, P. Melchioretto, E. Monti, M. Forcella, C. Urani, P. Fusi","doi":"10.4081/bse.2021.185","DOIUrl":"https://doi.org/10.4081/bse.2021.185","url":null,"abstract":"In this work we exploit the widely used, well known CTA, which allows following healthy cells transformation into a malignant phenotype, to understand the early metabolic deregulation and events in cadmium-induced carcinogenesis.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73599833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of manuka honey on 5-fluorouracil chemosensitivity in colonspheres enriched with cancer stem (-like) cells 麦卢卡蜂蜜对富含癌症干细胞样细胞的结肠球5-氟尿嘧啶化学敏感性的影响
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.163
Danila Cianciosi, L. Regolo, M. Battino, F. Giampieri
{"title":"Effect of manuka honey on 5-fluorouracil chemosensitivity in colonspheres enriched with cancer stem (-like) cells","authors":"Danila Cianciosi, L. Regolo, M. Battino, F. Giampieri","doi":"10.4081/bse.2021.163","DOIUrl":"https://doi.org/10.4081/bse.2021.163","url":null,"abstract":"Manuka honey (MH) has an in vitro chemosensitizing effect against 5-Fluorouracil (5-Fu) in colonspheres enriched with cancer stem (-like) cells (CSCs-like); these interesting findings, although preliminary, suggest a potential synergistic action of MH with 5-Fu, which could be useful in deepening the studies on natural compounds to be used in association with conventional medical therapies.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82833076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Novel 3D in vitro retina model to investigate mechanisms involved in age-related macular degeneration 新的3D体外视网膜模型研究与年龄相关的黄斑变性有关的机制
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.150
Beatrice Belgio, S. Mantero, F. Boschetti
{"title":"Novel 3D in vitro retina model to investigate mechanisms involved in age-related macular degeneration","authors":"Beatrice Belgio, S. Mantero, F. Boschetti","doi":"10.4081/bse.2021.150","DOIUrl":"https://doi.org/10.4081/bse.2021.150","url":null,"abstract":"RetinaIn the present study, we present a strategy to develop a 3R-compliant in vitro retina model to study age-related macular degeneration pathways.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91246372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An osteochondral bio-engineered model to in vitro mimicking osteoarthritis 体外模拟骨关节炎的骨软骨生物工程模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.162
G. Cerqueni, A. Scalzone, Xiao-Nong Wang, C. Licini, K. Dalgarno, A. k, P. Gentile, M. Belmonte
{"title":"An osteochondral bio-engineered model to in vitro mimicking osteoarthritis","authors":"G. Cerqueni, A. Scalzone, Xiao-Nong Wang, C. Licini, K. Dalgarno, A. k, P. Gentile, M. Belmonte","doi":"10.4081/bse.2021.162","DOIUrl":"https://doi.org/10.4081/bse.2021.162","url":null,"abstract":"To date, treatments of Osteoarthritis are not able to provide the pathology regression. In vitro models are therefore necessary to: i) investigate the mechanisms involved in the disease evolution, ii) identify pharmacological targets, and iii) perform predictive tests for new drug delivery strategies.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88034637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Video tracking analysis of behavioral scores: The Finnover experience 行为评分的视频跟踪分析:Finnover经验
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.197
Hanna Trebesova, F. Turrini, G. Olivero, Valentina Orlandi, D. Donno, G. Beccaro, R. Boggia, A. Pittaluga, M. Grilli
{"title":"Video tracking analysis of behavioral scores: The Finnover experience","authors":"Hanna Trebesova, F. Turrini, G. Olivero, Valentina Orlandi, D. Donno, G. Beccaro, R. Boggia, A. Pittaluga, M. Grilli","doi":"10.4081/bse.2021.197","DOIUrl":"https://doi.org/10.4081/bse.2021.197","url":null,"abstract":"The aim of this study was to reduce and refine the number of animals subjected to behavioral analysis by ToxTrac software during the European project Interreg-ALCOTRA “Finnover”.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"273 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86360443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recellularization of decellularized porcine caval veins 脱细胞猪腔静脉的再细胞化
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.181
Mariangela Massaro, R. Palek, J. Rosendorf, A. Malečková, L. Cervenkova, Roshan K. Singh, R. Polak, V. Liska, V. Moulisová
{"title":"Recellularization of decellularized porcine caval veins","authors":"Mariangela Massaro, R. Palek, J. Rosendorf, A. Malečková, L. Cervenkova, Roshan K. Singh, R. Polak, V. Liska, V. Moulisová","doi":"10.4081/bse.2021.181","DOIUrl":"https://doi.org/10.4081/bse.2021.181","url":null,"abstract":"Decellularized material has been reported to be more suitable for cells to grow when compared to synthetic materials because repopulating cells are provided with the structural environment of native tissue. The aim of this study is to prepare and to test porcine caval veins through their decellularization followed by repopulation with human endothelial cells.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"289 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77149526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
3D printed microfluidic devices for cell culture 用于细胞培养的3D打印微流体装置
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.161
M. Canta, Désirée Baruffaldi, I. Roppolo, A. Chiappone, C. Pirri, F. Frascella
{"title":"3D printed microfluidic devices for cell culture","authors":"M. Canta, Désirée Baruffaldi, I. Roppolo, A. Chiappone, C. Pirri, F. Frascella","doi":"10.4081/bse.2021.161","DOIUrl":"https://doi.org/10.4081/bse.2021.161","url":null,"abstract":"A successful application of the 3D printed materials in the biomedical field requires extensive studies to ensure their biocompatibility at every step of the process. Here, different components suitable for cell applications, including a microfluidic device, were 3D printed using common resins and a deep analysis of their biocompatibility and post printed protocols was conducted.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82766443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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