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Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference最新文献

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Towards reliable in vitro models – New bi-compartmental platforms for replicating tissue barriers 迈向可靠的体外模型——用于复制组织屏障的新的双室平台
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.166
L. Coppadoro, E. Pederzani, C. Foglieni, M. Lombardi, G. Fiore, M. Soncini
{"title":"Towards reliable in vitro models – New bi-compartmental platforms for replicating tissue barriers","authors":"L. Coppadoro, E. Pederzani, C. Foglieni, M. Lombardi, G. Fiore, M. Soncini","doi":"10.4081/bse.2021.166","DOIUrl":"https://doi.org/10.4081/bse.2021.166","url":null,"abstract":"In vitro cell cultures represent a widespread methodology for pathophysiology studies with a high benefit/cost ratio. We have developed and are validating TToP, a novel, versatile, and scalable culture system allowing compartmentalized cell/tissue cultures with the aim of mimicking the human pathophysiological microenvironment of tissue barriers.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91104221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico experiments as a tool to reduce preclinical tests of magnetic hyperthermia 硅片实验作为减少临床前磁热疗试验的工具
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.199
M. Vicentini, M. Vassallo, Riccardo Ferrero, A. Manzin
{"title":"In silico experiments as a tool to reduce preclinical tests of magnetic hyperthermia","authors":"M. Vicentini, M. Vassallo, Riccardo Ferrero, A. Manzin","doi":"10.4081/bse.2021.199","DOIUrl":"https://doi.org/10.4081/bse.2021.199","url":null,"abstract":"In silico models can be useful tools to guide preclinical tests of magnetic hyperthermia, which employs Magnetic Nanoparticles (MNPs) excited by AC magnetic fields, as heat mediators for cancer cure. We virtually reproduce the heating process induced by magnetic hyperthermia in murine models, as a function of field applicator features, properties and size of target tissue, MNP dose and animal size.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77243095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design of a contamination-free microfluidic device for Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) biosensors 用于电解门控有机场效应晶体管(EGOFET)生物传感器的无污染微流控装置设计
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.191
Matteo Segantini, Matteo Parmeggiani, A. Ballesio, F. Frascella, G. Palmara, M. Cocuzza, C. Pirri, S. Marasso
{"title":"Design of a contamination-free microfluidic device for Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) biosensors","authors":"Matteo Segantini, Matteo Parmeggiani, A. Ballesio, F. Frascella, G. Palmara, M. Cocuzza, C. Pirri, S. Marasso","doi":"10.4081/bse.2021.191","DOIUrl":"https://doi.org/10.4081/bse.2021.191","url":null,"abstract":"In this work a new microfluidic platform is designed and validated to remove analyte contamination problem in EGOFETs biosensors.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"607 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77351453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulated models for testing performance of a radiofrequency ablation device for spine tumors 脊柱肿瘤射频消融装置性能测试模拟模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.188
Federica Rusinà, Alice Ravizza, S. Pasquino, M. Muto
{"title":"Simulated models for testing performance of a radiofrequency ablation device for spine tumors","authors":"Federica Rusinà, Alice Ravizza, S. Pasquino, M. Muto","doi":"10.4081/bse.2021.188","DOIUrl":"https://doi.org/10.4081/bse.2021.188","url":null,"abstract":"Effectiveness of simulation models to assess performance a radiofrequency tumor ablation device.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90297564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative 3D proteome-wide scale identification of ALKBH5 target for MV1035 small molecule able to reduce migration and invasiveness in U87 glioblastoma cell lines by SPILLO-PBSS 利用SPILLO-PBSS技术，创新的3D蛋白组级鉴定ALKBH5靶点MV1035小分子能够降低U87胶质母细胞瘤细胞系的迁移和侵袭性
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.178
A. Malacrida, Mirko Rivara, Omar Ben Mariem, Alessandro Di Domizio, Giacomo Cislaghi, M. Miloso, V. Zuliani, G. Nicolini
{"title":"Innovative 3D proteome-wide scale identification of ALKBH5 target for MV1035 small molecule able to reduce migration and invasiveness in U87 glioblastoma cell lines by SPILLO-PBSS","authors":"A. Malacrida, Mirko Rivara, Omar Ben Mariem, Alessandro Di Domizio, Giacomo Cislaghi, M. Miloso, V. Zuliani, G. Nicolini","doi":"10.4081/bse.2021.178","DOIUrl":"https://doi.org/10.4081/bse.2021.178","url":null,"abstract":"The innovative in silico technologies developed at SPILLOproject,1 e.g., the SPILLO potential binding sites searcher (SPILLO-PBSS) software,2,3 allow to identify targets and off-targets of any small molecule on a multiple-organism proteomewide scale, and to perform an accurate multilevel cross-organism transferability analysis (MCOTA) aimed at rationalising animal testing. SPILLO-PBSS has been successfully used in several research projects, such as a study in which a compound (MV1035) was found to reduce migration and invasiveness in U87 glioblastoma (GBM) cell lines: the human structural proteome was analyzed and the RNA demethylase ALKBH5 has been identified as a target responsible for the observed effects (target experimentally validated). Another top-ranked target identified by SPILLO-PBSS, the DNA repair protein AlkB homolog 2 (ALKBH2), abundantly expressed in GBM cell lines, resulted particularly interesting for its pivotal role in the onset of resistance to Temozolomide (TMZ), the standard firstline treatment for GBM.2","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83489877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total and local experimental validation of a lumbar spine numerical model to enhance the orthopaedic management of spinal metastases 腰椎数值模型的整体和局部实验验证，以加强脊柱转移的骨科管理
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.155
Simone Borrelli, G. Putame, M. Terzini, A. Ferro, Stefano Marone, C. Bignardi, A. Audenino
{"title":"Total and local experimental validation of a lumbar spine numerical model to enhance the orthopaedic management of spinal metastases","authors":"Simone Borrelli, G. Putame, M. Terzini, A. Ferro, Stefano Marone, C. Bignardi, A. Audenino","doi":"10.4081/bse.2021.155","DOIUrl":"https://doi.org/10.4081/bse.2021.155","url":null,"abstract":"This work shows a full biomechanical validation of a multibody lumbar model with respect to an experimental phantom, fruitful for giving major insights on different surgical vertebral metastasis treatments.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"46 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83527381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimum performance level definition for bone plate testing according to standard: A preliminary study 根据标准进行骨板试验的最低性能水平定义:初步研究
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.154
F. A. Bologna, M. Terzini, A. Lugas, A. Audenino
{"title":"Minimum performance level definition for bone plate testing according to standard: A preliminary study","authors":"F. A. Bologna, M. Terzini, A. Lugas, A. Audenino","doi":"10.4081/bse.2021.154","DOIUrl":"https://doi.org/10.4081/bse.2021.154","url":null,"abstract":"In silico modeling of osteosynthesis medical devices allows the reduction of the time required for experimental tests and the introduction of “simulation-driven design”. Using a wise combination of these techniques and analytical calculations, it is possible to relate the experimental results, which are mandatory for regulatory purposes, to the plate physiological application and prevent the occurrence of complications in the early stages after the orthopedic device implantation on humans and animals.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"300 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83719199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
In silico investigation of molecular interactions of Volatile Anesthetics: Effects on phospholipid membranes and subcellular targets 挥发性麻醉药分子相互作用的计算机研究:对磷脂膜和亚细胞靶点的影响
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.202
E. A. Zizzi, M. Cavaglià, M. Deriu, J. Tuszynski
{"title":"In silico investigation of molecular interactions of Volatile Anesthetics: Effects on phospholipid membranes and subcellular targets","authors":"E. A. Zizzi, M. Cavaglià, M. Deriu, J. Tuszynski","doi":"10.4081/bse.2021.202","DOIUrl":"https://doi.org/10.4081/bse.2021.202","url":null,"abstract":"The ability of anesthetics to reversibly suppress consciousness must reside in the effects exerted onto specific molecular targets. Interactions between Volatile Anesthetics and the phospholipid membrane as well as intracellular tubulin, were investigated using Computational Molecular Modelling, which showed rapid ligand partitioning inside the membrane and significant effects on the mechanical characteristics thereof, while transient binding locations have been found on the tubulin dimer.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88825874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioprinting for osteosarcoma model: Methodological aspects and experimental applications 骨肉瘤模型的生物打印:方法方面和实验应用
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.168
Elena Delgrosso, Gaia Martina Sarcinelli, F. Riva, F. Scocozza, M. Conti, I. Postuma, S. Bortolussi, C. Ferrari
{"title":"Bioprinting for osteosarcoma model: Methodological aspects and experimental applications","authors":"Elena Delgrosso, Gaia Martina Sarcinelli, F. Riva, F. Scocozza, M. Conti, I. Postuma, S. Bortolussi, C. Ferrari","doi":"10.4081/bse.2021.168","DOIUrl":"https://doi.org/10.4081/bse.2021.168","url":null,"abstract":"The study aims at using the bioprinting technique to create an in vitro 3D construct of osteosarcoma, as an alternative model for studies related to Boron Neutron Capture Therapy (BNCT).","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90244611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting cancer drug resistance by modulation of ERCC1-XPF and p53 activity 通过调节ERCC1-XPF和p53活性靶向肿瘤耐药
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.164
G. Ciniero, Francesco Gentile, Ahmed H. Elmenoufy, Emeline Cros-Perrial, F. West, M. Weinfeld, M. Deriu, L. Jordheim, J. Tuszynski
{"title":"Targeting cancer drug resistance by modulation of ERCC1-XPF and p53 activity","authors":"G. Ciniero, Francesco Gentile, Ahmed H. Elmenoufy, Emeline Cros-Perrial, F. West, M. Weinfeld, M. Deriu, L. Jordheim, J. Tuszynski","doi":"10.4081/bse.2021.164","DOIUrl":"https://doi.org/10.4081/bse.2021.164","url":null,"abstract":"New disruptors of the ERCC1-XPF interaction interaction have a synergistic effect with traditional NER inhibitors, in p53 positive cells. Furthermore, the synergy can be resumed in p53 negative cells upon reactivation of the TP53 gene.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"295 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74153536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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