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Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference最新文献

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PDMS Substrates with tunable stiffness for cardiac mechanobiology investigation: A nanoindentation study 心脏力学生物学研究中硬度可调的PDMS基质:纳米压痕研究
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.192
Gianpaolo Serino, A. Lugas, Giacomo Bernava, S. Ragazzini, S. Gabetti, M. Terzini, U. Morbiducci, A. Audenino, M. Pesce, D. Massai
{"title":"PDMS Substrates with tunable stiffness for cardiac mechanobiology investigation: A nanoindentation study","authors":"Gianpaolo Serino, A. Lugas, Giacomo Bernava, S. Ragazzini, S. Gabetti, M. Terzini, U. Morbiducci, A. Audenino, M. Pesce, D. Massai","doi":"10.4081/bse.2021.192","DOIUrl":"https://doi.org/10.4081/bse.2021.192","url":null,"abstract":"Micromechanical characterization by nanoindentation of PDMS substrates for cardiac mechanobiology studies.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89372501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Promising 3D in vitro models for studying tumour heterogeneity and testing novel therapeutic approaches in pancreatic cancer 有希望的3D体外模型研究肿瘤异质性和测试胰腺癌的新治疗方法
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.169
S. Forciniti, M. Cavo, I. Dando, E. D. Pozza, M. Palmieri, L. L. Mercato
{"title":"Promising 3D in vitro models for studying tumour heterogeneity and testing novel therapeutic approaches in pancreatic cancer","authors":"S. Forciniti, M. Cavo, I. Dando, E. D. Pozza, M. Palmieri, L. L. Mercato","doi":"10.4081/bse.2021.169","DOIUrl":"https://doi.org/10.4081/bse.2021.169","url":null,"abstract":"In this study we produced 3D organotypic cultures and spheroids to mimic the complex microenvironment of pancreatic cancer and to test alternative therapeutic strategies.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84902173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IVTech: The next generation of in vitro models IVTech:下一代体外模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.139
Tommaso Sbrana
{"title":"IVTech: The next generation of in vitro models","authors":"Tommaso Sbrana","doi":"10.4081/bse.2021.139","DOIUrl":"https://doi.org/10.4081/bse.2021.139","url":null,"abstract":"In vitro cell cultures are often proposed as “Alternatives” to animal models, but they are still inadequate to reproduce the human pathophysiology. This is mainly due to the technological limitations of the standard equipment used in cell culture laboratories, such as the lack of a 3D micro-architecture, the static environment and the absence of cross talk between different tissues. These limitations cause the poor predictivity of a standard in-vitro model, if compared with the human reality.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75746861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a multiscale testing method for the reduction of soft biological tissues waste during mechanical characterization 在力学表征过程中减少软生物组织浪费的多尺度测试方法的开发
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.176
A. Lugas, Gianpaolo Serino, M. Terzini, C. Bignardi, A. Audenino
{"title":"Development of a multiscale testing method for the reduction of soft biological tissues waste during mechanical characterization","authors":"A. Lugas, Gianpaolo Serino, M. Terzini, C. Bignardi, A. Audenino","doi":"10.4081/bse.2021.176","DOIUrl":"https://doi.org/10.4081/bse.2021.176","url":null,"abstract":"Two biaxial mechanical test methods were devised to compare their suitability for the mechanical characterization of soft biological tissues with the least possible tissue waste. Nanoindentation was used to explore the microscopic properties of the tissue and to overcome the macroscopic test limitations.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76021553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of pathogens from environmental samples for the evaluation of the health status of laboratory animals 用于评价实验动物健康状况的环境样品中病原体的检测
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.159
A. Cacciamali, C. Romano, Martina Angela Checco, R. Villa
{"title":"Detection of pathogens from environmental samples for the evaluation of the health status of laboratory animals","authors":"A. Cacciamali, C. Romano, Martina Angela Checco, R. Villa","doi":"10.4081/bse.2021.159","DOIUrl":"https://doi.org/10.4081/bse.2021.159","url":null,"abstract":"Pathogens present in the environment are the biggest source of diseases and epidemics in the breeding of laboratory animals. The presence of microorganisms, in fact, can critically influence the animal health status and consequently the validity and reproducibility of experimental data. In accordance with the 3Rs principle, this study fits into the Refinement and Reduction concepts. The development of a health surveillance plan on environmental material from animal housing would have an important impact not only on maintaining an adequate state of health and on the generation of quality experimental data, but also on reducing the number of animals to be sacrificed.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81957306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro Multi-level Approaches to Study Cadmium Neurotoxicity 镉神经毒性的体外多层次研究方法
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.190
Marta Scrivani, M. Forcella, F. Bovio, A. Bogni, M. Fabbri, L. Gribaldo, S. Andó, P. Melchioretto, M. Tringali, P. Fusi, C. Urani
{"title":"In vitro Multi-level Approaches to Study Cadmium Neurotoxicity","authors":"Marta Scrivani, M. Forcella, F. Bovio, A. Bogni, M. Fabbri, L. Gribaldo, S. Andó, P. Melchioretto, M. Tringali, P. Fusi, C. Urani","doi":"10.4081/bse.2021.190","DOIUrl":"https://doi.org/10.4081/bse.2021.190","url":null,"abstract":"Epidemiological data have related cadmium exposure to neurotoxicity. The combination of multi-level and complementary approaches provides a comprehensive view of mechanistic processes in neurotoxicity.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76760951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coupling in silico and ex vivo porcine model for the evaluation of biomechanical impact of TEVAR 硅-离体耦合猪模型评价TEVAR的生物力学影响
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.152
D. Bianchi, D. Bissacco, M. Domanin, S. Trimarchi, Rodrigo M Romarowski, S. Marconi, F. Auricchio, M. Conti
{"title":"Coupling in silico and ex vivo porcine model for the evaluation of biomechanical impact of TEVAR","authors":"D. Bianchi, D. Bissacco, M. Domanin, S. Trimarchi, Rodrigo M Romarowski, S. Marconi, F. Auricchio, M. Conti","doi":"10.4081/bse.2021.152","DOIUrl":"https://doi.org/10.4081/bse.2021.152","url":null,"abstract":"The study couples the experimental and the computational approaches in an integrated in silico and ex vivo biomechanical analysis of porcine aorta. The aim of the presented work is to evaluate the mechanical impact of TEVAR on aortic structure.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"407 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84867656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Engineering magneto-responsive core-shell microbeads for mimicking peristalsis and alveolar breathing in vitro 工程磁响应核壳微珠在体外模拟蠕动和肺泡呼吸
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.173
N. Guazzelli, L. Cacopardo, A. Ahluwalia
{"title":"Engineering magneto-responsive core-shell microbeads for mimicking peristalsis and alveolar breathing in vitro","authors":"N. Guazzelli, L. Cacopardo, A. Ahluwalia","doi":"10.4081/bse.2021.173","DOIUrl":"https://doi.org/10.4081/bse.2021.173","url":null,"abstract":"The aim of this work is to integrate bioprinting technologies and smart materials to fabricate core-shell structures able to mimic 3D peristaltic and breathing movements.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81533459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Human tissue culture of osteochondral defect: An advanced in vitro model 人骨软骨缺损组织培养:一种先进的体外模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.177
M. Maglio, M. Tschon, S. Pagani, L. Vivarelli, M. Govoni, M. Rocchi, A. Mazzotta, L. Martini, D. Dallari, M. Fini
{"title":"Human tissue culture of osteochondral defect: An advanced in vitro model","authors":"M. Maglio, M. Tschon, S. Pagani, L. Vivarelli, M. Govoni, M. Rocchi, A. Mazzotta, L. Martini, D. Dallari, M. Fini","doi":"10.4081/bse.2021.177","DOIUrl":"https://doi.org/10.4081/bse.2021.177","url":null,"abstract":"The optimization of advanced in vitro models is essential for the development of alternative methods. The in vitro study of osteochondral regeneration still has numerous limitations and wide scope for exploration.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85279242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A programmable culture platform for stimulation and in situ sensing of lung epithelial cells 用于刺激和原位感应肺上皮细胞的可编程培养平台
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.160
N. Cacocciola, Matteo Parmeggiani, Matteo Segantini, A. Verna, Désirée Baruffaldi, Simona Villata, F. Frascella, S. Marasso, G. Canavese, M. Cocuzza, C. Pirri
{"title":"A programmable culture platform for stimulation and in situ sensing of lung epithelial cells","authors":"N. Cacocciola, Matteo Parmeggiani, Matteo Segantini, A. Verna, Désirée Baruffaldi, Simona Villata, F. Frascella, S. Marasso, G. Canavese, M. Cocuzza, C. Pirri","doi":"10.4081/bse.2021.160","DOIUrl":"https://doi.org/10.4081/bse.2021.160","url":null,"abstract":"A programmable dynamic cell culture chamber compatible with a standard multi-well plate was designed and characterized. The system is integrated with an array of OECT biosensors, in view of an in-situ monitoring of the dynamic cultures.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84136688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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