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Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference最新文献

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Angiogenesis biomarkers detection on a polymeric 3D printed device 聚合物3D打印设备上血管生成生物标志物检测
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.186
G. Palmara, A. Chiadò, A. Chiappone, F. Pirri, I. Roppolo, F. Frascella
{"title":"Angiogenesis biomarkers detection on a polymeric 3D printed device","authors":"G. Palmara, A. Chiadò, A. Chiappone, F. Pirri, I. Roppolo, F. Frascella","doi":"10.4081/bse.2021.186","DOIUrl":"https://doi.org/10.4081/bse.2021.186","url":null,"abstract":"Polymeric 3D printed chips with intrinsic tuned functionalities were produced and employed for the detection of angiogenesis biomarkers.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84662514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chilled storage of zebrafish embryos: Development of an efficient protocol 冷冻储存斑马鱼胚胎:一个有效的方案的发展
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.189
M. Sampieri, Erika Molica Colella, S. Dotti
{"title":"Chilled storage of zebrafish embryos: Development of an efficient protocol","authors":"M. Sampieri, Erika Molica Colella, S. Dotti","doi":"10.4081/bse.2021.189","DOIUrl":"https://doi.org/10.4081/bse.2021.189","url":null,"abstract":"Making the zebrafish embryo available to be able to share it between different laboratories groups could pave the way for this animal model with the aim of disseminating and promoting the use and application of zebrafish in scientific research.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77120308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine learning approaches as an alternative to traditional statistical methods in cardiovascular risk prediction 机器学习方法作为传统统计方法在心血管风险预测中的替代方法
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.195
M. Sperti, F. D’Ascenzo, L. Navarini, G. Benedetto, A. Afeltra, R. Giacomelli, M. Deriu
{"title":"Machine learning approaches as an alternative to traditional statistical methods in cardiovascular risk prediction","authors":"M. Sperti, F. D’Ascenzo, L. Navarini, G. Benedetto, A. Afeltra, R. Giacomelli, M. Deriu","doi":"10.4081/bse.2021.195","DOIUrl":"https://doi.org/10.4081/bse.2021.195","url":null,"abstract":"Machine Learning (ML) algorithms have proven promising methodologies in improving Cardiovascular (CV) risk predictors based on traditional statistics. In the present work, two case studies are reported: CV risk prediction in patients affected by Inflammatory Arthritis (IA), with attention to Psoriatic Arthritis (PsA), and patients who experienced Acute Coronary Syndrome (ACS).","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"70 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90955826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrostimulation of a 3D in vitro skin model to activate wound healing 电刺激3D体外皮肤模型以激活伤口愈合
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.200
Simona Villata, L. Napione, Désirée Baruffaldi, C. Nardini, F. Frascella, F. Pirri
{"title":"Electrostimulation of a 3D in vitro skin model to activate wound healing","authors":"Simona Villata, L. Napione, Désirée Baruffaldi, C. Nardini, F. Frascella, F. Pirri","doi":"10.4081/bse.2021.200","DOIUrl":"https://doi.org/10.4081/bse.2021.200","url":null,"abstract":"The aim of the work is to propose a methodology for the stimulation of a 3D in vitro skin model to activate wound healing. The presented work is in the frame of the national research project, CronXCov, “Checking the CHRONIC to prevent COVID-19”, devoted to understand how physiologic and inflamed skin on chip 3D models evolve upon a range of physical (e.g., electrical, mechanical, optical) stimulations, over time. Thanks to the 3D modelling, using Next Generation Sequencing and the network medicine frame of analysis to process the data, we will systematically characterize the effects of the applied stimuli, offering new insight for the exploitation of wound healing.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83394173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ink-jet printed chitosan precise patterning for engineered 2D neuronal networks 喷墨打印壳聚糖用于工程二维神经网络的精确图案
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.148
A. Andolfi, P. Arnaldi, D. D. Lisa, S. Martinoia, L. Pastorino
{"title":"Ink-jet printed chitosan precise patterning for engineered 2D neuronal networks","authors":"A. Andolfi, P. Arnaldi, D. D. Lisa, S. Martinoia, L. Pastorino","doi":"10.4081/bse.2021.148","DOIUrl":"https://doi.org/10.4081/bse.2021.148","url":null,"abstract":"The aim of this work was to demonstrate chitosan micropatterning effectiveness to realize spatially guided 2D neuronal networks of primary rat neurons and neurons derived from human induced pluripotent stem cells (h-iNeurons). Morphological characterizations were carried out to validate the formation of a well-defined neuronal networks.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73711813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An in vitro enterocyte cell-like model to study Group B streptococci internalization 体外肠细胞样模型研究B组链球菌内化
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.167
Giuseppe Valerio De Gaetano, G. Lentini, R. Galbo, F. Coppolino, Agata Famà, G. Teti
{"title":"An in vitro enterocyte cell-like model to study Group B streptococci internalization","authors":"Giuseppe Valerio De Gaetano, G. Lentini, R. Galbo, F. Coppolino, Agata Famà, G. Teti","doi":"10.4081/bse.2021.167","DOIUrl":"https://doi.org/10.4081/bse.2021.167","url":null,"abstract":"We used a 2D in vitro growth model of Caco2 cells to study invasion of Streptococcus agalactiae. This model can be useful for evaluating the virulence of the most relevant enteric pathogens.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74341305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
View the meniscus: MicroCT strategies for enhancing microstructure visualization 观察半月板:增强显微结构可视化的MicroCT策略
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.180
G. Marchiori, M. Maglio, L. Martini, A. Visani, S. Zaffagnini, M. Fini
{"title":"View the meniscus: MicroCT strategies for enhancing microstructure visualization","authors":"G. Marchiori, M. Maglio, L. Martini, A. Visani, S. Zaffagnini, M. Fini","doi":"10.4081/bse.2021.180","DOIUrl":"https://doi.org/10.4081/bse.2021.180","url":null,"abstract":"The optimization of imaging protocols for soft tissue visualization is mandatory in the musculoskeletal field. Combining these techniques with histology and mechanics can provide a comprehensive structural and functional assessment of the tissue.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76746875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-specific modelling for the assessment of the hemodynamics risk of failure in endovascular aneurysm repair 评估血管内动脉瘤修复失败的血流动力学风险的患者特异性模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.175
M. L. Rizzini, P. Tasso, A. Raptis, M. Matsagkas, D. Gallo, M. Xenos, U. Morbiducci
{"title":"Patient-specific modelling for the assessment of the hemodynamics risk of failure in endovascular aneurysm repair","authors":"M. L. Rizzini, P. Tasso, A. Raptis, M. Matsagkas, D. Gallo, M. Xenos, U. Morbiducci","doi":"10.4081/bse.2021.175","DOIUrl":"https://doi.org/10.4081/bse.2021.175","url":null,"abstract":"Endovascular aneurysm repair (EVAR), despite its advantages over abdominal aortic aneurysm (AAA) open surgery, still presents risks of failure linked to Endograft (EG) migration. We here explore the link between intravascular blood flow features and Displacement Forces (DFs) acting on the EG. DFs are inversely associated with the amount of helical flow within the EG.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83273070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating molecular connetion between IAHSP onset and Alsin protein by means of Homology Modelling and Molecular Dynamics 利用同源性建模和分子动力学方法阐明IAHSP发病与Alsin蛋白之间的分子联系
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.183
Marcello Miceli, C. Exertier, B. Vallone, M. Cavaglià, M. Deriu
{"title":"Elucidating molecular connetion between IAHSP onset and Alsin protein by means of Homology Modelling and Molecular Dynamics","authors":"Marcello Miceli, C. Exertier, B. Vallone, M. Cavaglià, M. Deriu","doi":"10.4081/bse.2021.183","DOIUrl":"https://doi.org/10.4081/bse.2021.183","url":null,"abstract":"The Infantile-onset Ascending Hereditary Spastic Paralysis (IAHSP) is an incurable rare neurodegerative disease related to a mutation-driven aberrant behaviour of the Alsin protein. The lack of information on Alsin atomic structure limits a complete understanding on pathology mechanisms. In this work, molecular modelling techniques have been applied to shed lights on Alsin folding dynamics and misfunction induced by aberrant mutations.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84666444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and characterization of a novel human 3D model of bone metastasis from breast carcinoma in vitro cultured 体外培养的新型乳腺癌骨转移三维模型的建立与表征
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.165
D. Contartese, F. Salamanna, V. Borsari, S. Pagani, M. Sartori, L. Martini, G. B. Bròdano, A. Gasbarrini, M. Fini
{"title":"Development and characterization of a novel human 3D model of bone metastasis from breast carcinoma in vitro cultured","authors":"D. Contartese, F. Salamanna, V. Borsari, S. Pagani, M. Sartori, L. Martini, G. B. Bròdano, A. Gasbarrini, M. Fini","doi":"10.4081/bse.2021.165","DOIUrl":"https://doi.org/10.4081/bse.2021.165","url":null,"abstract":"Breast cancer frequently metastasizes to the skeleton causing significant morbidity. Here, we set-up a novel and advanced ex vivo model by using fresh tissue from human vertebral bone metastasis from breast carcinoma patients able to retain the tumor microenvironment and tumor cells heterogeneity.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88394375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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