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Nuclear receptor modulators: Catching information by machine learning 核受体调节剂:通过机器学习捕捉信息
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.198
C. Valsecchi, F. Grisoni, V. Consonni, D. Ballabio, R. Todeschini
{"title":"Nuclear receptor modulators: Catching information by machine learning","authors":"C. Valsecchi, F. Grisoni, V. Consonni, D. Ballabio, R. Todeschini","doi":"10.4081/bse.2021.198","DOIUrl":"https://doi.org/10.4081/bse.2021.198","url":null,"abstract":"Nuclear receptors (NRs) are involved in fundamental human health processes and are a relevant target for toxicological risk assessment. To help prioritize chemicals that can mimic natural hormones and be endocrine disruptors, computational models can be a useful tool.1,2 In this work we i) created an exhaustive collection of NR modulators and ii) applied machine learning methods to fill the data-gap and prioritize NRs modulators by building predictive models.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90186707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing genomic profiles of tumour and peritumoral biopsies to find new possible biomarkers for glioblastoma therapy. 比较肿瘤和肿瘤周围活检的基因组图谱，寻找新的可能的胶质母细胞瘤治疗的生物标志物。
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.170
Martina Giambra, Eleonora Messuti, S. Redaelli, A. Cristofori, A. Bentivegna
{"title":"Comparing genomic profiles of tumour and peritumoral biopsies to find new possible biomarkers for glioblastoma therapy.","authors":"Martina Giambra, Eleonora Messuti, S. Redaelli, A. Cristofori, A. Bentivegna","doi":"10.4081/bse.2021.170","DOIUrl":"https://doi.org/10.4081/bse.2021.170","url":null,"abstract":"The study of glioblastoma genomic profiles permits the use of CNAs load to identify patients with poor prognosis and the understanding of the genomic signatures essential for the disease maintenance and the identification of new potential biomarkers.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74908791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel in silico tool for dose assessment in cell culture nanotoxicology 一种用于细胞培养纳米毒理学剂量评估的新型硅工具
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.156
Ermes Botte, Pietro Vagaggini, Joana Costa, Lara Faccani, I. Zanoni, A. Costa, A. Ahluwalia
{"title":"A novel in silico tool for dose assessment in cell culture nanotoxicology","authors":"Ermes Botte, Pietro Vagaggini, Joana Costa, Lara Faccani, I. Zanoni, A. Costa, A. Ahluwalia","doi":"10.4081/bse.2021.156","DOIUrl":"https://doi.org/10.4081/bse.2021.156","url":null,"abstract":"Dose assessment is essential for understanding the mechanisms triggering nanomaterial toxicity in vitro and for meaningful translations to in vivo. We propose a novel computational approach for improving the accuracy of biological dose-response characterization, demonstrating its robustness for insoluble Engineered Nanomaterials (ENMs).","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77252518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Differentiated neuroblastoma F-11 cells as an alternative in-vitro model to dorsal root ganglion neurons 分化神经母细胞瘤F-11细胞作为背根神经节神经元的替代体外模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.153
Stefania Blasa, V. Pastori, A. D’Aloia, M. Lecchi
{"title":"Differentiated neuroblastoma F-11 cells as an alternative in-vitro model to dorsal root ganglion neurons","authors":"Stefania Blasa, V. Pastori, A. D’Aloia, M. Lecchi","doi":"10.4081/bse.2021.153","DOIUrl":"https://doi.org/10.4081/bse.2021.153","url":null,"abstract":"We induced differentiation in F-11 cells to verify if they could show similarities with sensory neurons, in order to develop an alternative to animal models for research studies in the biomedical field.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76509330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An in vitro lung biomimetic model 体外肺仿生模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.174
Michela Licciardello, G. Ciardelli, C. Tonda-Turo
{"title":"An in vitro lung biomimetic model","authors":"Michela Licciardello, G. Ciardelli, C. Tonda-Turo","doi":"10.4081/bse.2021.174","DOIUrl":"https://doi.org/10.4081/bse.2021.174","url":null,"abstract":"The design and fabrication of a system to both mimic the multicellular composition of the lung and its vascular network, as well as the composition and structure of extracellular matrix (ECM) was developed.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81247913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyvinyl alcohol/cellulose hydrogel as possible corneal stroma substitute in drug permeation tests 聚乙烯醇/纤维素水凝胶可作为药物渗透试验中角膜基质的替代品
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.203
Erica Zucchetti, Leonardo Ling, D. Monti, P. Chetoni, S. Tampucci, S. Burgalassi
{"title":"Polyvinyl alcohol/cellulose hydrogel as possible corneal stroma substitute in drug permeation tests","authors":"Erica Zucchetti, Leonardo Ling, D. Monti, P. Chetoni, S. Tampucci, S. Burgalassi","doi":"10.4081/bse.2021.203","DOIUrl":"https://doi.org/10.4081/bse.2021.203","url":null,"abstract":"The permeation studies of active compounds and formulations are necessary to verify the capability of molecules to pass through the physiological barrier of our body. In order to develop a 3D model of the cornea, preparation and characterization of different hydrogels as corneal stroma substitutes were tested.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77678661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of different hydrogels for the bioprinting of 3D in vitro skeletal muscle models 不同水凝胶用于体外3D骨骼肌模型生物打印的比较分析
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.146
Flaminia Aliberti, Lorenza Rinvenuto, Giada Loi, L. Benedetti, F. Scocozza, F. Ronzoni, M. Sampaolesi, G. Cusella, M. Conti, G. Ceccarelli
{"title":"Comparative analysis of different hydrogels for the bioprinting of 3D in vitro skeletal muscle models","authors":"Flaminia Aliberti, Lorenza Rinvenuto, Giada Loi, L. Benedetti, F. Scocozza, F. Ronzoni, M. Sampaolesi, G. Cusella, M. Conti, G. Ceccarelli","doi":"10.4081/bse.2021.146","DOIUrl":"https://doi.org/10.4081/bse.2021.146","url":null,"abstract":"In this study we demonstrated an application of 3D Bioprinting using different commercially available hydrogels (CELLINK AB, Sweden) with the aim to identify the most suitable biomaterial for the proliferation and differentiation of murine muscle cells (C2C12).","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77878797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of in vitro 3D culture system to mimic lung cancer tissue 模拟肺癌组织体外三维培养系统的研制
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.149
Désirée Baruffaldi, M. Canta, C. Pirri, F. Frascella
{"title":"Development of in vitro 3D culture system to mimic lung cancer tissue","authors":"Désirée Baruffaldi, M. Canta, C. Pirri, F. Frascella","doi":"10.4081/bse.2021.149","DOIUrl":"https://doi.org/10.4081/bse.2021.149","url":null,"abstract":"A 3D culture system based on a photocurable matrix has been developed. The aim is to create a 3D printable platform mimicking lung cancer tissue, to study tumor microenvironment evolution, in terms of structural (architecture) and molecular (signalling) components.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90539751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light-based 3D printing of functional polydimethylsiloxane- based microfluidic chips 基于光的3D打印功能聚二甲基硅氧烷微流控芯片
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.171
Gustavo A. Gonzalez, A. Chiappone, K. Dietliker, P. C. Fabrizio, I. Roppolo
{"title":"Light-based 3D printing of functional polydimethylsiloxane- based microfluidic chips","authors":"Gustavo A. Gonzalez, A. Chiappone, K. Dietliker, P. C. Fabrizio, I. Roppolo","doi":"10.4081/bse.2021.171","DOIUrl":"https://doi.org/10.4081/bse.2021.171","url":null,"abstract":"The objective of the work is to fabricate and functionalize 3D printed PDMS-based microfluidic chips through digital light processing DLP-3D printing.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89854279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How systems biology of cancer signaling pathways can inform optimized combination chemotherapy design 癌症信号通路的系统生物学如何为优化的联合化疗设计提供信息
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.143
J. Tuszynski, E. Rietman
{"title":"How systems biology of cancer signaling pathways can inform optimized combination chemotherapy design","authors":"J. Tuszynski, E. Rietman","doi":"10.4081/bse.2021.143","DOIUrl":"https://doi.org/10.4081/bse.2021.143","url":null,"abstract":"This talk presents an overview of the systems biology of cancer applied to specific protein-protein interaction signaling pathways. We argue that network analysis augmented with thermodynamics measures such as Gibbs free energy can lead to optimized design of drug combinations for cancer chemotherapy.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88635398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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