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V-ATPase as a mediator of treatment resistance in Glioblastoma Multiforme: an in vitro study to investigate new therapeutic strategies v - atp酶作为多形性胶质母细胞瘤治疗耐药的中介:一项探讨新的治疗策略的体外研究
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.182
Eleonora Messuti, Martina Giambra, S. Redaelli, A. Cristofori, C. Giussani, A. Bentivegna
{"title":"V-ATPase as a mediator of treatment resistance in Glioblastoma Multiforme: an in vitro study to investigate new therapeutic strategies","authors":"Eleonora Messuti, Martina Giambra, S. Redaelli, A. Cristofori, C. Giussani, A. Bentivegna","doi":"10.4081/bse.2021.182","DOIUrl":"https://doi.org/10.4081/bse.2021.182","url":null,"abstract":"Recent evidences suggest the involvement of the Vacuolar H+ ATPase (V-ATPase) in the development and/or progression of Glioblastoma Multiforme (GBM). This proton pump could be a valid therapeutic target but more in-depth studies are necessary. The aim of this study is to better define the in vitro effects on Glioma Stem Cell (GSC) primary cultures viability of single and combined treatment with Bafilomycin-A1 (Baf-A1), a V-ATPase inhibitor, and Temozolomide (TMZ), the chemotherapeutic agent currently used to treat GBM patients. We found out that GSC were resistant to TMZ and more sensitive to treatments with Baf-A1 and that the two drugs exerted a synergistic effect when administered together.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77093629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3F(eature)s model: modularity, heterogeneity and three-dimensionality to design in vitro neuronal model 3F(nature)s模型:模块化、非均质性和三维性设计体外神经元模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.158
Martina Brofiga, M. Pisano, M. Tedesco, F. Callegari, P. Massobrio
{"title":"3F(eature)s model: modularity, heterogeneity and three-dimensionality to design in vitro neuronal model","authors":"Martina Brofiga, M. Pisano, M. Tedesco, F. Callegari, P. Massobrio","doi":"10.4081/bse.2021.158","DOIUrl":"https://doi.org/10.4081/bse.2021.158","url":null,"abstract":"In this work, we present a novel experimental platform to build in vitro interconnected (i.e., modular) heterogeneous (e.g., cortical-hippocampal) and three-dimensional (3D) neuronal cultures plated on Micro-Electrode Arrays (MEAs) to extracellularly record the electrophysiological activity continuously.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88407540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel in vitro culture system for the generation of controlled hydrodinamic stimuli 一种用于产生受控流体动力刺激的新型体外培养系统
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.187
E. Pederzani, L. Coppadoro, C. Foglieni, M. Lombardi, M. Soncini, G. Fiore
{"title":"A novel in vitro culture system for the generation of controlled hydrodinamic stimuli","authors":"E. Pederzani, L. Coppadoro, C. Foglieni, M. Lombardi, M. Soncini, G. Fiore","doi":"10.4081/bse.2021.187","DOIUrl":"https://doi.org/10.4081/bse.2021.187","url":null,"abstract":"A novel device to analyze the correlation between hydrodinamic stimuli and atherosclerosis advancement.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88512334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A compact in vitro test bench for cardiovascular flow analysis 一个紧凑的体外测试平台，用于心血管血流分析
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-29 DOI: 10.4081/bse.2021.196
E. Torta, G. Caridi, Claudio Chiastra, D. Gallo, U. Morbiducci
{"title":"A compact in vitro test bench for cardiovascular flow analysis","authors":"E. Torta, G. Caridi, Claudio Chiastra, D. Gallo, U. Morbiducci","doi":"10.4081/bse.2021.196","DOIUrl":"https://doi.org/10.4081/bse.2021.196","url":null,"abstract":"A low-cost particle image velocimetry set-up that allows to investigate the fluid dynamics inside realistic coronary artery phantoms has been implemented. The proposed smart test bench for experimental characterization of arterial hemodynamics also in the presence of implanted devices represents a low-cost equipment that can be easily implemented in non-expert laboratories for research as well as educational applications.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84125992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A viability study of 3D tumor spheroids after their mass-density characterization via an innovative flow-based biophysical method 通过创新的基于流动的生物物理方法对三维肿瘤球体进行质量密度表征后的生存能力研究
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-28 DOI: 10.4081/bse.2021.140
Francesco Bacchi, A. Sargenti, F. Musmeci, Simone Pasqua, Simone Bonetti, D. Gazzola, D. A. Cristaldi
{"title":"A viability study of 3D tumor spheroids after their mass-density characterization via an innovative flow-based biophysical method","authors":"Francesco Bacchi, A. Sargenti, F. Musmeci, Simone Pasqua, Simone Bonetti, D. Gazzola, D. A. Cristaldi","doi":"10.4081/bse.2021.140","DOIUrl":"https://doi.org/10.4081/bse.2021.140","url":null,"abstract":"The simple measurement of mass density, size and weight of sphere-like 3D cell models has been recently enabled by a specifically conceived flow-based method. Here we demonstrate that such technique also allows the post-analysis collection of live 3D tumor spheroids, without compromising their viability.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76458532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rigenera protocol: Elucidation of the mechanisms involved in wound healing Rigenera方案:阐明涉及伤口愈合的机制
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-28 DOI: 10.4081/bse.2021.133
G. Ceccarelli, Martina Balli, R. Bellazzi, M. Sampaolesi, G. Cusella
{"title":"Rigenera protocol: Elucidation of the mechanisms involved in wound healing","authors":"G. Ceccarelli, Martina Balli, R. Bellazzi, M. Sampaolesi, G. Cusella","doi":"10.4081/bse.2021.133","DOIUrl":"https://doi.org/10.4081/bse.2021.133","url":null,"abstract":"In this study, we show an approach that follow 3R guidelines in order to demonstrate how Autologous Micrografts (AMG) modulates primary fibroblast migration and accelerates skin re-epithelialization without affecting cell proliferation.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82068132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beating organs-on-chip as technological platforms in drug screening: Advanced in vitro models of human physiology and pathology 跳动器官芯片作为药物筛选的技术平台:先进的人体生理和病理体外模型
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-28 DOI: 10.4081/bse.2021.141
P. Occhetta, R. Visone, S. Piazza, Ferran Lozano, M. Rasponi
{"title":"Beating organs-on-chip as technological platforms in drug screening: Advanced in vitro models of human physiology and pathology","authors":"P. Occhetta, R. Visone, S. Piazza, Ferran Lozano, M. Rasponi","doi":"10.4081/bse.2021.141","DOIUrl":"https://doi.org/10.4081/bse.2021.141","url":null,"abstract":"Taking advantages of uBeat® technology, 3D beating Organs-on-Chip integrates the native complexity of human mechanical microenvironment into clinically relevant in vitro models of human organs and diseases.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87303548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new brain organoid model to study Parkinson’s Disease 一个新的脑类器官模型来研究帕金森病
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-28 DOI: 10.4081/bse.2021.137
S. Bolognin, Lisa M. Smits, S. Nickels, S. Magni, Paul M. A. Antony, K. Grzyb, R. Krüger, A. Skupin, J. Schwamborn
{"title":"A new brain organoid model to study Parkinson’s Disease","authors":"S. Bolognin, Lisa M. Smits, S. Nickels, S. Magni, Paul M. A. Antony, K. Grzyb, R. Krüger, A. Skupin, J. Schwamborn","doi":"10.4081/bse.2021.137","DOIUrl":"https://doi.org/10.4081/bse.2021.137","url":null,"abstract":"Human midbrain organoid models represent a new tool to study the underlaying etiology of Parkinson’s disease in physiological conditions.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77785380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A millifluidic-based 3D-platform as a useful tool for the efficacy of glaucoma therapeutic strategies 基于微流体的3d平台作为青光眼治疗策略有效性的有用工具
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-28 DOI: 10.4081/bse.2021.135
A. Bassi, S. Tirendi, S. Scarfì, M. Passalacqua, Vanessa Almonti, S. Vernazza
{"title":"A millifluidic-based 3D-platform as a useful tool for the efficacy of glaucoma therapeutic strategies","authors":"A. Bassi, S. Tirendi, S. Scarfì, M. Passalacqua, Vanessa Almonti, S. Vernazza","doi":"10.4081/bse.2021.135","DOIUrl":"https://doi.org/10.4081/bse.2021.135","url":null,"abstract":"The aim of this present study is to investigate the role of damaged Trabecular Meshwork (TM) in triggering neuron-like cell apoptosis. Preliminary results showed that stressed TM releases harmful signals to neuron-like cells, suggesting its pivotal role in glaucoma cascade.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84974815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone and gut microbiota crosstalk: A novel 3D in vitro approach 骨和肠道菌群串扰:一种新的3D体外方法
Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-28 DOI: 10.4081/bse.2021.134
M. Belmonte, G. Cerqueni, Francesco Biagini, Marco Calvigioni, Emanuele Russello, Nunzia Paglione, F. Montemurro, E. Ghelardi, G. Vozzi
{"title":"Bone and gut microbiota crosstalk: A novel 3D in vitro approach","authors":"M. Belmonte, G. Cerqueni, Francesco Biagini, Marco Calvigioni, Emanuele Russello, Nunzia Paglione, F. Montemurro, E. Ghelardi, G. Vozzi","doi":"10.4081/bse.2021.134","DOIUrl":"https://doi.org/10.4081/bse.2021.134","url":null,"abstract":"The present research aimed at shedding light on the interplay between the composition of the human gut microbiota and bone cells.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82957177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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