Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference最新文献_第8页

In silico modeling of biochemical pathways 生化途径的计算机模拟

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2021-09-28 DOI: 10.4081/bse.2021.142

P. Milazzo, R. Gori, A. Micheli, Lucia Nasti, Marco Podda

{"title":"In silico modeling of biochemical pathways","authors":"P. Milazzo, R. Gori, A. Micheli, Lucia Nasti, Marco Podda","doi":"10.4081/bse.2021.142","DOIUrl":"https://doi.org/10.4081/bse.2021.142","url":null,"abstract":"We present in silico modeling methods for the investigation of dynamical properties of biochemical pathways, that are chemical reaction networks underlying cell functioning. Since pathways are (complex) dynamical systems, in-silico models are often studied by applying numerical integration techniques for Ordinary Differential Equations (ODEs), or stochastic simulation algorithms. However, these techniques require a rather accurate knowledge of the kinetic parameters of the modeled chemical reactions. Moreover, in the case of very complex reaction networks, in silico analysis can become unfeasible from the computational viewpoint. Consequently, in the last few years several approaches have been proposed that focus on estimating or predicting dynamical properties from the analysis of the structure of the biochemical pathway. This means that the analysis focuses more on the interaction patterns than on the kinetic parameters, and this usually makes it possible to deduce the role of each molecule and how each molecule qualitatively influences each other, by abstracting away from quantitative details about concentrations and reaction rates.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89405691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organoid culture systems: Products supporting one of the biggest revolutions in biological research 类器官培养系统:支持生物研究领域最大革命之一的产品

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2020-02-12 DOI: 10.4081/bse.2019.102

R. Conder, Leon H. Chew, Fisal Elstone, Marianne Lankhorst, Adam Añonuevo, S. Simmini, W. Chang, A. Eaves, T. Thomas, S. Louis

引用次数: 0

Hydrogel-based platforms to mimic in vivo drug diffusion: A multicenter research 水凝胶平台模拟体内药物扩散:一项多中心研究

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2020-02-12 DOI: 10.4081/bse.2019.101

P. Petrini, D. Pacheco, F. B. Vangosa, C. Butnarasu, L. Visai, O. Monticelli, L. Pastorino, S. Visentin

引用次数: 0

Injectable thermosensitive gels for the localized and controlled delivery of biomolecules in tissue engineering/regenerative medicine 可注射热敏凝胶，用于组织工程/再生医学中生物分子的定位和控制递送

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2019-07-09 DOI: 10.4081/bse.2019.67

M. Boffito, Arianna Grivet Brancot, Ornella Lima, S. Bronco, S. Sartori, G. Ciardelli

{"title":"Injectable thermosensitive gels for the localized and controlled delivery of biomolecules in tissue engineering/regenerative medicine","authors":"M. Boffito, Arianna Grivet Brancot, Ornella Lima, S. Bronco, S. Sartori, G. Ciardelli","doi":"10.4081/bse.2019.67","DOIUrl":"https://doi.org/10.4081/bse.2019.67","url":null,"abstract":"The characteristic poor stability and high fluid permeability of Poloxamer®- based gels have severely limited their biomedical application. In this work, Poloxamer 407 was used as building block to synthesize a poly(ether urethane) (PEU), which aqueous solutions formed gels with improved stability and mechanics compared to Poloxamer itself. PEU chains formed micelles in aqueous solution (diameter ~40 nm at 25°C) and systems with PEU content higher than 5±1% w/v underwent a temperature- driven gelation. Gel properties were tuned acting on PEU concentration in the starting solutions, with compositions within the range 8-18% w/v showing high potential for biomedical applications (gelation at 37°C within 3-10 minutes, residence time from few days to many weeks, injectability). Model proteins (bovine serum albumin, horseradish peroxidase) were encapsulated in mild conditions and their release was modulated by gel composition (on day 3, approx. 85, 65 and 55% of encapsulated payload released from gels with 8, 15 and 18% w/v concentration). Released peroxidase retained approx. 30-40% of its activity up to 2 days, a key aspect for biomolecules in the drug delivery field.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82240490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Phantoms in medicine: The case of ophthalmology 医学上的幻影:眼科的案例

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2019-07-08 DOI: 10.4081/bse.2019.61

C. Maria, S. Iorio, F. Montemurro, G. M. Fortunato, M. Ori, V. Raffa, G. Vozzi

引用次数: 1

Drug-Free Antibacterial Technology for Medical Applications - First Cambridge International Conference - December 14th, 2018 - Cambridge, UK 2018年12月14日，英国剑桥，第一届剑桥国际会议，医疗应用的无药物抗菌技术

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2019-02-25 DOI: 10.4081/BSE.2019.66

V. Chiono, J. Salber

引用次数: 0

Analysis of Online Social Networks to Understand Information Sharing Behaviors Through Social Cognitive Theory. 通过社会认知理论分析在线社会网络理解信息共享行为。

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2014-05-01 DOI: 10.1109/BSEC.2014.6867744

Hong-Jun Yoon, Georgia Tourassi

{"title":"Analysis of Online Social Networks to Understand Information Sharing Behaviors Through Social Cognitive Theory.","authors":"Hong-Jun Yoon, Georgia Tourassi","doi":"10.1109/BSEC.2014.6867744","DOIUrl":"https://doi.org/10.1109/BSEC.2014.6867744","url":null,"abstract":"Analyzing the contents of online social networks is an effective process for monitoring and understanding peoples' behaviors. Since the nature of conversation and information propagation is similar to traditional conversation and learning, one of the popular socio-cognitive methods, social cognitive theory was applied to online social networks to. Two major news topics about colon cancer were chosen to monitor traffic of Twitter messages. The activity of \"leaders\" on the issue (i.e., news companies or people will prior Twitter activity on topics related to colon cancer) was monitored. In addition, the activity of \"followers\", people who never discussed the topics before, but replied to the discussions was also monitored. Topics that produce tangible benefits such as positive outcomes from appropriate preventive actions received dramatically more attention and online social media traffic. Such characteristics can be explained with social cognitive theory and thus present opportunities for effective health campaigns.","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"2014 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/BSEC.2014.6867744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33303444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

A cost-effective, case-control study on the association between breast cancer and pregnancy through web mining. 通过网络挖掘对乳腺癌和怀孕之间关系的一项具有成本效益的病例对照研究。

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2013-05-01 DOI: 10.1109/BSEC.2013.6618493

Hong-Jun Yoon, Songhua Xu, Georgia Tourassi

引用次数: 1

Mathematical model of the effect of intercellular cooperative interactions in cancer during drug therapy. 肿瘤药物治疗过程中细胞间合作作用的数学模型。

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2013-05-01 DOI: 10.1109/BSEC.2013.6618486

Chanchala D Kaddi, May D Wang

引用次数: 1

Interfaces and Integration of Medical Image Analysis Frameworks: Challenges and Opportunities. 医学图像分析框架的接口与集成：挑战与机遇。

Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference Pub Date : 2010-05-25 DOI: 10.1109/BSEC.2010.5510850

Kelsie Covington, Evan S McCreedy, Min Chen, Aaron Carass, Nicole Aucoin, Bennett A Landman

{"title":"Interfaces and Integration of Medical Image Analysis Frameworks: Challenges and Opportunities.","authors":"Kelsie Covington, Evan S McCreedy, Min Chen, Aaron Carass, Nicole Aucoin, Bennett A Landman","doi":"10.1109/BSEC.2010.5510850","DOIUrl":"10.1109/BSEC.2010.5510850","url":null,"abstract":"Clinical research with medical imaging typically involves large-scale data analysis with interdependent software toolsets tied together in a processing workflow. Numerous, complementary platforms are available, but these are not readily compatible in terms of workflows or data formats. Both image scientists and clinical investigators could benefit from using the framework which is a most natural fit to the specific problem at hand, but pragmatic choices often dictate that a compromise platform is used for collaboration. Manual merging of platforms through carefully tuned scripts has been effective, but exceptionally time consuming and is not feasible for large-scale integration efforts. Hence, the benefits of innovation are constrained by platform dependence. Removing this constraint via integration of algorithms from one framework into another is the focus of this work. We propose and demonstrate a light-weight interface system to expose parameters across platforms and provide seamless integration. In this initial effort, we focus on four platforms Medical Image Analysis and Visualization (MIPAV), Java Image Science Toolkit (JIST), command line tools, and 3D Slicer. We explore three case studies: (1) providing a system for MIPAV to expose internal algorithms and utilize these algorithms within JIST, (2) exposing JIST modules through self-documenting command line interface for inclusion in scripting environments, and (3) detecting and using JIST modules in 3D Slicer. We review the challenges and opportunities for light-weight software integration both within development language (e.g., Java in MIPAV and JIST) and across languages (e.g., C/C++ in 3D Slicer and shell in command line tools).","PeriodicalId":89077,"journal":{"name":"Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference","volume":"2010 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998761/pdf/nihms199028.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29530371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0