Effect of manuka honey on 5-fluorouracil chemosensitivity in colonspheres enriched with cancer stem (-like) cells

Abstract

Manuka honey (MH) has an in vitro chemosensitizing effect against 5-Fluorouracil (5-Fu) in colonspheres enriched with cancer stem (-like) cells (CSCs-like); these interesting findings, although preliminary, suggest a potential synergistic action of MH with 5-Fu, which could be useful in deepening the studies on natural compounds to be used in association with conventional medical therapies.