Biological Chemistry最新文献_第7页

Synthesis of the ribosomal RNA precursor in human cells: mechanisms, factors and regulation. 人类细胞中核糖体RNA前体的合成:机制、因素和调控。

IF 3.7 4区生物学

Biological Chemistry Pub Date : 2023-07-17 Print Date: 2023-10-26 DOI: 10.1515/hsz-2023-0214

Julia L Daiß, Joachim Griesenbeck, Herbert Tschochner, Christoph Engel

引用次数: 0

The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression. DEAD-box RNA解旋酶Dbp5是一种在基因表达中结合多个步骤的关键蛋白。

IF 3.7 4区生物学

Biological Chemistry Pub Date : 2023-07-13 Print Date: 2023-07-26 DOI: 10.1515/hsz-2023-0130

Luisa Querl, Heike Krebber

引用次数: 0

The human long non-coding RNA LINC00941 and its modes of action in health and disease. 人类长链非编码RNA LINC00941及其在健康和疾病中的作用模式。

IF 3.7 4区生物学

Biological Chemistry Pub Date : 2023-07-10 Print Date: 2023-10-26 DOI: 10.1515/hsz-2023-0183

Eva Morgenstern, Markus Kretz

{"title":"The human long non-coding RNA LINC00941 and its modes of action in health and disease.","authors":"Eva Morgenstern, Markus Kretz","doi":"10.1515/hsz-2023-0183","DOIUrl":"10.1515/hsz-2023-0183","url":null,"abstract":"Long non-coding RNAs have gained attention in recent years as they were shown to play crucial roles in the regulation of cellular processes, but the understanding of the exact mechanisms is still incomplete in most cases. This is also true for long non-coding RNA LINC00941, which was recently found to be highly upregulated in various types of cancer influencing cell proliferation and metastasis. Initial studies could not elucidate the mode of action to understand the role and real impact of LINC00941 in tissue homeostasis and cancer development. However, recent analyses have demonstrated multiple potential modes of action of LINC00941 influencing the functionality of various cancer cell types. Correspondingly, LINC00941 was proposed to be involved in regulation of mRNA transcription and modulation of protein stability, respectively. In addition, several experimental approaches suggest a function of LINC00941 as competitive endogenous RNA, thus acting in a post-transcriptional regulatory fashion. This review summarizes our recent knowledge about the mechanisms of action of LINC00941 elucidated so far and discusses its putative role in miRNA sequestering processes. In addition, the functional role of LINC00941 in regulating human keratinocytes is discussed to also highlight its role in normal tissue homeostasis tissue aside from its involvement in cancer.","PeriodicalId":8885,"journal":{"name":"Biological Chemistry","volume":" ","pages":"1025-1036"},"PeriodicalIF":3.7,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10212032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Frontmatter 头版头条

4区生物学

Biological Chemistry Pub Date : 2023-07-01 DOI: 10.1515/hsz-2023-frontmatter8-9

引用次数: 0

Translation termination in human mitochondria - substrate specificity of mitochondrial release factors. 人线粒体翻译终止——线粒体释放因子的底物特异性。

IF 3.7 4区生物学

Biological Chemistry Pub Date : 2023-06-29 Print Date: 2023-07-26 DOI: 10.1515/hsz-2023-0127

Franziska Nadler, Ricarda Richter-Dennerlein

{"title":"Translation termination in human mitochondria - substrate specificity of mitochondrial release factors.","authors":"Franziska Nadler, Ricarda Richter-Dennerlein","doi":"10.1515/hsz-2023-0127","DOIUrl":"10.1515/hsz-2023-0127","url":null,"abstract":"Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to the descendance from a bacterial ancestor, some deviations regarding translation factors as well as mRNA characteristics and the applied genetic code are present in human mitochondria. Together, these features are certain challenges during translation the mitochondrion has to handle. Here, we discuss the current knowledge regarding mitochondrial translation focusing on the termination process and the associated quality control mechanisms. We describe how mtRF1a resembles bacterial RF1 mechanistically and summarize in vitro and recent in vivo data leading to the conclusion of mtRF1a being the major mitochondrial release factor. On the other hand, we discuss the ongoing debate about the function of the second codon-dependent mitochondrial release factor mtRF1 regarding its role as a specialized termination factor. Finally, we link defects in mitochondrial translation termination to the activation of mitochondrial rescue mechanisms highlighting the importance of ribosome-associated quality control for sufficient respiratory function and therefore for human health.","PeriodicalId":8885,"journal":{"name":"Biological Chemistry","volume":"404 8-9","pages":"769-779"},"PeriodicalIF":3.7,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10233378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of a Biocatalytic Flow Reactor Based on Hierarchically Structured Monolithic Silica for Producing Galactooligosaccharides (GOSs). 基于分层结构单片二氧化硅的低半乳糖生物催化流动反应器的设计

IF 1.2 4区生物学

Biological Chemistry Pub Date : 2023-06-28 DOI: 10.2533/chimia.2023.432

Riccardo Dejoma, Andrea Buscemi, Emilio Cutrona, Patrick Shahgaldian

引用次数: 0

Interactions of Na⁺/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy. Na+/牛磺胆酸共转运多肽与宿主细胞蛋白在乙型肝炎和丁型肝炎病毒感染中的相互作用:抗病毒治疗的新潜在靶点

IF 3.7 4区生物学

Biological Chemistry Pub Date : 2023-06-27 DOI: 10.1515/hsz-2022-0345

Dariusz Zakrzewicz, Joachim Geyer

{"title":"Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy.","authors":"Dariusz Zakrzewicz, Joachim Geyer","doi":"10.1515/hsz-2022-0345","DOIUrl":"https://doi.org/10.1515/hsz-2022-0345","url":null,"abstract":"Na+/taurocholate cotransporting polypeptide (NTCP) is a member of the solute carrier (SLC) family 10 transporters (gene symbol SLC10A1) and is responsible for the sodium-dependent uptake of bile salts across the basolateral membrane of hepatocytes. In addition to its primary transporter function, NTCP is the high-affinity hepatic receptor for hepatitis B (HBV) and hepatitis D (HDV) viruses and, therefore, is a prerequisite for HBV/HDV virus entry into hepatocytes. The inhibition of HBV/HDV binding to NTCP and internalization of the virus/NTCP receptor complex has become a major concept in the development of new antiviral drugs called HBV/HDV entry inhibitors. Hence, NTCP has emerged as a promising target for therapeutic interventions against HBV/HDV infections in the last decade. In this review, recent findings on protein-protein interactions (PPIs) between NTCP and cofactors relevant for entry of the virus/NTCP receptor complex are summarized. In addition, strategies aiming to block PPIs with NTCP to dampen virus tropism and HBV/HDV infection rates are discussed. Finally, this article suggests novel directions for future investigations evaluating the functional contribution of NTCP-mediated PPIs in the development and progression of HBV/HDV infection and subsequent chronic liver disorders.","PeriodicalId":8885,"journal":{"name":"Biological Chemistry","volume":"404 7","pages":"673-690"},"PeriodicalIF":3.7,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10146509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Lipid exchange among electroneutral Sulfo-DIBMA nanodiscs is independent of ion concentration. 电子中性硫- dibma纳米片之间的脂质交换与离子浓度无关。

IF 3.7 4区生物学

Biological Chemistry Pub Date : 2023-06-27 DOI: 10.1515/hsz-2022-0319

Loretta Eggenreich, Carolyn Vargas, Cenek Kolar, Sandro Keller

{"title":"Lipid exchange among electroneutral Sulfo-DIBMA nanodiscs is independent of ion concentration.","authors":"Loretta Eggenreich, Carolyn Vargas, Cenek Kolar, Sandro Keller","doi":"10.1515/hsz-2022-0319","DOIUrl":"https://doi.org/10.1515/hsz-2022-0319","url":null,"abstract":"Polymer-encapsulated nanodiscs enable membrane proteins to be investigated within a native-like lipid-bilayer environment. Unlike other bilayer-based membrane mimetics, these nanodiscs are equilibrium structures that permit lipid exchange on experimentally relevant timescales. Therefore, examining the kinetics and mechanisms of lipid exchange is of great interest. Since the high charge densities of existing anionic polymers can interfere with protein-protein and protein-lipid interactions as well as charge-sensitive analysis techniques, electroneutral nanodisc-forming polymers have been recently introduced. However, it has remained unclear how the electroneutrality of these polymers affects the lipid-exchange behavior of the nanodiscs. Here, we use time-resolved Förster resonance energy transfer to study the kinetics and the mechanisms of lipid exchange among nanodiscs formed by the electroneutral polymer Sulfo-DIBMA. We also examine the role of coulombic repulsion and specific counterion association in lipid exchange. Our results show that Sulfo-DIBMA nanodiscs exchange lipids on a similar timescale as DIBMA nanodiscs. In contrast with nanodiscs made from polyanionic DIBMA, however, the presence of mono- and divalent cations does not influence lipid exchange among Sulfo-DIBMA nanodiscs, as expected from their electroneutrality. The robustness of Sulfo-DIBMA nanodiscs against varying ion concentrations opens new possibilities for investigating charge-sensitive processes involving membrane proteins.","PeriodicalId":8885,"journal":{"name":"Biological Chemistry","volume":"404 7","pages":"703-713"},"PeriodicalIF":3.7,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9771992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schwann cells in neuromuscular in vitro models. 体外神经肌肉模型中的雪旺细胞。

IF 3.7 4区生物学

Biological Chemistry Pub Date : 2023-06-27 Print Date: 2024-01-29 DOI: 10.1515/hsz-2023-0172

Sarah Janice Hörner, Nathalie Couturier, Mathias Hafner, Rüdiger Rudolf

引用次数: 0

The Rauischholzhausen Transport Colloquium: membrane proteins from structure to function. Rauischholzhausen运输研讨会:膜蛋白从结构到功能。

IF 3.7 4区生物学

Biological Chemistry Pub Date : 2023-06-27 DOI: 10.1515/hsz-2023-0208

Joachim Geyer, Eckhard Hofmann, Lutz Schmitt

引用次数: 0