Vascular disease prevention最新文献_第2页

Cardiovascular Risk During the Menopause 绝经期的心血管风险

Vascular disease prevention Pub Date : 2009-03-25 DOI: 10.2174/1567270000906010103

M. J. Cancelo, C. Castelo-Branco

{"title":"Cardiovascular Risk During the Menopause","authors":"M. J. Cancelo, C. Castelo-Branco","doi":"10.2174/1567270000906010103","DOIUrl":"https://doi.org/10.2174/1567270000906010103","url":null,"abstract":"Although initial experimental data and results of observational studies suggest that hormone replacement ther- apy (HRT) is associated with a reduction in the risk of heart disease, the results for events such as stroke or thromboem- bolism are less clear. Randomized secondary and primary prevention studies have found that HRT is not protective against the risk of coronary heart disease, stroke or progression of atherosclerosis. Therefore, HRT therapy should not be initiated to prevent vascular disease among postmenopausal women. There are numerous explanations for the divergent findings of observational and randomized clinical trials of HRT. For example, study design and differing biological effects of HRT on vascular risk factors. The use of HRT for young postmenopausal women with moderate to severe menopausal vasomotor symptoms appears to be safe. The absolute risk of vascular event associated with HRT is low and varies depending on factors like age or years since the menopause. The presence or absence of cardiovascular risk factors determines the differences in vascular risk linked to HRT. Further studies should identify the mechanisms involved and determine whether and how different regimens of HRT in- fluence vascular risk as well as the influence of individual patient characteristics.","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"233 1","pages":"103-108"},"PeriodicalIF":0.0,"publicationDate":"2009-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67888868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Percutaneous Endovascular Repair and Savage of Vascular Stream After Spontaneous and/or Iatrogenic Complications of Kidney Transplantation 肾移植术后自发性和/或医源性并发症的经皮血管内修复和血管流恢复

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010047

E. D. Cillis, A. Bortone, P. Ditonno, L. Garofalo, C. Cicala, M. Battaglia, L. D. Schinosa

{"title":"Percutaneous Endovascular Repair and Savage of Vascular Stream After Spontaneous and/or Iatrogenic Complications of Kidney Transplantation","authors":"E. D. Cillis, A. Bortone, P. Ditonno, L. Garofalo, C. Cicala, M. Battaglia, L. D. Schinosa","doi":"10.2174/1567270000906010047","DOIUrl":"https://doi.org/10.2174/1567270000906010047","url":null,"abstract":"Background: Vascular complications are uncommon (1-3%) in kidney transplantation. Recipient morbidities may result in loss of the allograft. Early and middle-term vascular complications include external iliac artery iatrogenic or spontaneous lesions and drainage vein thrombosis. Percutaneous transluminal angioplasty (PTA) is proposed as a valid, less invasive and alternative treatment to surgical repair. Material and Methods: Three patients, in the last two years, referred to our Institute: one affected by dissection secondary to the site clamp and suture stenosis of the external iliac artery, one spontaneous pseudoaneurysm with uncontained rup- ture of the same artery and another with pseudoaneurysm at the site of previous transplantation. All patients were treated by endovascular PTA approach. Patients with pseudo-aneurysm were treated by self-expandable stent-graft PTFE endo- prostheses (Hemobahn-Gore) release whereas in the other a balloon-expandable covered stent (Advanta V12 Boston Sci- entific) was used. Results: After treatment clinical, ultrasonographic and Doppler parameters showed a complete functional recovery of ileo- femoral axis as well renal function. All patients were discharged 5 days after the procedure. At an average follow-up of 12 months, by angio-CT scan, no recurrence of stenoses or aneurysms were found. Conclusion: PTA followed by stent placement is safe, effective and less invasive than surgical repair. Short and middle- term follow-up showed the benefit of the procedure, moreover the hospital stay is dramatically reduced. All renal allograft recipients, with vascular complications, should undergo to PTA procedure as a first option.","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"6 1","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"2009-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67888674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Effects of Nutrients and the Promise for Refined Cardiovascular Disease Prevention 营养物质的表观遗传效应和精细心血管疾病预防的前景

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010097

G. Lund, S. Zaina

引用次数: 0

Mitochondria-Targeted Vitamin E Antioxidant: An Agent for Cardiovascular Protection 线粒体靶向维生素E抗氧化剂:心血管保护剂

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010036

M. Rocha, Remedios Garcia-Bou, N. Enguix, A. Hernández-Mijares, J. Esplugues, V. M. Víctor

引用次数: 3

Anti-CD105 Inhibits Primary Cancer Growth and Secondary Hematogenous Metastasis in a Xenograft Model 抗cd105在异种移植瘤模型中抑制原发肿瘤生长和继发血液转移

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010091

Rahmawati Minhajat, Lili Hou, K. Kai, Yukari Takase, D. Mori, O. Tokunaga

{"title":"Anti-CD105 Inhibits Primary Cancer Growth and Secondary Hematogenous Metastasis in a Xenograft Model","authors":"Rahmawati Minhajat, Lili Hou, K. Kai, Yukari Takase, D. Mori, O. Tokunaga","doi":"10.2174/1567270000906010091","DOIUrl":"https://doi.org/10.2174/1567270000906010091","url":null,"abstract":"CD105, a receptor for TGF-b1 and -b-3 modulates TGF-b signaling by interacting with TGF-bRI and/or II. It is now emerging as a prime vascular target of antiangiogenetic cancer therapy. In the present study, we investigate the efficacy of CD105 in colorectal cancer models. We found decreases in tumor size and in the number of metastatic foci to lung in a xenograft cancer model in scid mouse that was treated with Anti-CD105 antibody. The necrotic area in the tumor was greater in the anti-CD105 antibody group than that of the control group. The number of metastatic foci and the area of metastasis were also lesser in the anti-CD105 group than those of the control group. A direct effect of anti-CD105 antibody to the cultured colon cancer cell line was not detected in respect to morphology and proliferation. Decreased vasculature by an antiangiogenic effect of anti-CD105 antibody was confirmed by an immunohistochemical assessment of CD105 expression on frozen tumor tissue. These findings demonstrated that CD105 was specifically expressed in vascular endothelial cells in a xenograft colon cancer model, and anti-CD-105 antibody inhibited both tumor growth and hematogenous metastasis by blocking the vascular network. CD105 is a useful target and anti-CD105 antibody is a candidate for antiangiogenic colorectal cancer therapy.","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"30 1","pages":"91-96"},"PeriodicalIF":0.0,"publicationDate":"2009-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67888846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The GNAS 393 T>C Polymorphism and the Blood Pressure Response Immediately Following Aerobic Exercise Among Men with Elevated Blood Pressure 高血压男性有氧运动后GNAS 393 T bbbbc多态性与血压反应

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010056

L. Pescatello, B. Blanchard, G. Tsongalis, C. Maresh, B. J. Griffiths, P. Thompson

{"title":"The GNAS 393 T>C Polymorphism and the Blood Pressure Response Immediately Following Aerobic Exercise Among Men with Elevated Blood Pressure","authors":"L. Pescatello, B. Blanchard, G. Tsongalis, C. Maresh, B. J. Griffiths, P. Thompson","doi":"10.2174/1567270000906010056","DOIUrl":"https://doi.org/10.2174/1567270000906010056","url":null,"abstract":"A common silent single nucleotide polymorphism (393 T>C) in exon 5 of the guanine nucleotide-binding pro- tein systemsubunit (GNAS) gene associates with hypertension, and altered autonomic nervous system function and re- sponse to � -blockade. We examined the effects of GNAS 393 T>C on the acute post-exercise BP response among 48 Caucasian men (mean ± SEM, 43.7±1.4 yr) with hypertension (145.1±1.5/85.5±1.1 mmHg). Subjects self disclosed a fam- ily history of hypertension. Experiments were non-exercise control and 2 exercise bouts at 40% (LIGHT) and 60% (MODERATE) of peak oxygen uptake. Subjects left the laboratory with an ambulatory BP monitor. Genotypes were de- tected using polymerase chain reaction and restriction enzyme digestion. Repeated measure ANCOVA tested if BP dif- fered over time among experiments and GNAS genotypes (n=37, TT/TC; n=11, CC). Systolic BP increased 8.0+3.6 mmHg less (p 0.05). Most men with the GNAS T 393 allele and a family history of hyperten- sion had lower BP after LIGHT (18/20) vs. non-exercise control; whereas 64% of men with the GNAS CC genotype did not have lower BP after LIGHT (7/11), independent of family history of hypertension (p<0.01). Men with the GNAS T 393 allele, a family history of hypertension, and high BP appear to experience the antihypertensive effects of lower intensity, aerobic exercise more so than men with the GNAS CC genotype.","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"6 1","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2009-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67888737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Novel Strategies in Anti-Platelet Treatment for Coronary Artery Disease 冠状动脉疾病抗血小板治疗新策略

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010075

A. Schäfer, J. Bauersachs, M. Eigenthaler

{"title":"Novel Strategies in Anti-Platelet Treatment for Coronary Artery Disease","authors":"A. Schäfer, J. Bauersachs, M. Eigenthaler","doi":"10.2174/1567270000906010075","DOIUrl":"https://doi.org/10.2174/1567270000906010075","url":null,"abstract":"Treatment with oral anti-platelet agents constitutes a cornerstone in the therapy of coronary artery disease. Coronary angioplasty and stent implantation improved the therapy of coronary artery disease and especially the treatment of acute myocardial infarction. Implementation of glycoprotein IIb/IIIa inhibition further advanced anti-platelet therapy as a central component in the treatment of acute coronary syndromes. Sustained prevention of reocclusion was achieved when dual anti-platelet therapy had been introduced and reduced the risk of stent thrombosis to ~1% following elective stenting in stable coronary artery disease. However, targeting more complex lesions or performing the intervention in states of increased platelet reactivity such as in acute coronary syn- dromes or in diabetic patients is still associated with a higher risk of stent thrombosis. Additionally, incomplete ADP- receptor inhibition by thienopyridine treatment contributes to increased cardiovascular events and mortality after coronary intervention. This review describes the underlying pathophysiology leading to coronary atherothrombosis and contributing to stent thrombosis as well as the pharmacological approach to prevent it by dual anti-platelet therapy. It summarizes the assess- ment of anti-platelet therapy by different analytical methods such as platelet aggregation, platelet function analyzers, and the platelet reactivity index. Impaired clopidogrel responsiveness and its implication for adverse cardiovascular events and stent thrombosis are discussed. Current strategies in improving the efficacy of clopidogrel treatment as well as the next generation of anti-platelet substances such as novel thienopyridines and non-thienopyridine P2Y12-receptor blocking agents are addressed. Finally, we discuss the potential of von-Willebrand factor aptamers compared to glycoprotein IIb/IIIa inhibitors in acute coronary syndromes.","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"90 1","pages":"75-84"},"PeriodicalIF":0.0,"publicationDate":"2009-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67888791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Vascular Effects of Diabetes Mellitus 糖尿病对血管的影响

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010085

A. Kampoli, D. Tousoulis, K. Marinou, G. Siasos, C. Stefanadis

引用次数: 8

Vascular Toxicity of Cocaine 可卡因的血管毒性

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010030

S. Bansal, J. Morgan

引用次数: 5

The Renin-Angiotensin-Aldosterone System as a Therapeutic Target for Endothelial Dysfunction 肾素-血管紧张素-醛固酮系统作为内皮功能障碍的治疗靶点

Vascular disease prevention Pub Date : 2009-03-20 DOI: 10.2174/1567270000906010065

T. Imanishi, M. Goto, T. Akasaka

引用次数: 3