可卡因的血管毒性

S. Bansal, J. Morgan
{"title":"可卡因的血管毒性","authors":"S. Bansal, J. Morgan","doi":"10.2174/1567270000906010030","DOIUrl":null,"url":null,"abstract":"Cocaine acts on the vascular system by a number of mechanisms including monoamine re-uptake inhibition, local anesthesia, anti-cholinergic activity, alpha-adrenergic stimulation, regulation of various vasoconstrictor and vasodi- lator agents and promotion of prothrombotic state. These effects lead to a number of clinical syndromes via vasoconstric- tion, platelet activation, thrombus formation and early atherosclerosis in almost every organ of the body. Many of these effects may be under appreciated. Furthermore, cocaine is commonly associated with the use of tobacco and alcohol which can lead to superadditive effects and/or prolonged toxicity.","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"6 1","pages":"30-35"},"PeriodicalIF":0.0000,"publicationDate":"2009-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Vascular Toxicity of Cocaine\",\"authors\":\"S. Bansal, J. Morgan\",\"doi\":\"10.2174/1567270000906010030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cocaine acts on the vascular system by a number of mechanisms including monoamine re-uptake inhibition, local anesthesia, anti-cholinergic activity, alpha-adrenergic stimulation, regulation of various vasoconstrictor and vasodi- lator agents and promotion of prothrombotic state. These effects lead to a number of clinical syndromes via vasoconstric- tion, platelet activation, thrombus formation and early atherosclerosis in almost every organ of the body. Many of these effects may be under appreciated. Furthermore, cocaine is commonly associated with the use of tobacco and alcohol which can lead to superadditive effects and/or prolonged toxicity.\",\"PeriodicalId\":88793,\"journal\":{\"name\":\"Vascular disease prevention\",\"volume\":\"6 1\",\"pages\":\"30-35\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vascular disease prevention\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1567270000906010030\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vascular disease prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1567270000906010030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

摘要

可卡因通过多种机制作用于血管系统,包括单胺再摄取抑制、局部麻醉、抗胆碱能活性、α -肾上腺素能刺激、调节各种血管收缩剂和血管舒张剂以及促进血栓形成前状态。这些作用通过血管收缩、血小板活化、血栓形成和身体几乎每个器官的早期动脉粥样硬化导致许多临床综合征。其中许多影响可能没有得到充分认识。此外,可卡因通常与烟草和酒精的使用有关,这可能导致超加和(或)长期毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vascular Toxicity of Cocaine
Cocaine acts on the vascular system by a number of mechanisms including monoamine re-uptake inhibition, local anesthesia, anti-cholinergic activity, alpha-adrenergic stimulation, regulation of various vasoconstrictor and vasodi- lator agents and promotion of prothrombotic state. These effects lead to a number of clinical syndromes via vasoconstric- tion, platelet activation, thrombus formation and early atherosclerosis in almost every organ of the body. Many of these effects may be under appreciated. Furthermore, cocaine is commonly associated with the use of tobacco and alcohol which can lead to superadditive effects and/or prolonged toxicity.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信