{"title":"可卡因的血管毒性","authors":"S. Bansal, J. Morgan","doi":"10.2174/1567270000906010030","DOIUrl":null,"url":null,"abstract":"Cocaine acts on the vascular system by a number of mechanisms including monoamine re-uptake inhibition, local anesthesia, anti-cholinergic activity, alpha-adrenergic stimulation, regulation of various vasoconstrictor and vasodi- lator agents and promotion of prothrombotic state. These effects lead to a number of clinical syndromes via vasoconstric- tion, platelet activation, thrombus formation and early atherosclerosis in almost every organ of the body. Many of these effects may be under appreciated. Furthermore, cocaine is commonly associated with the use of tobacco and alcohol which can lead to superadditive effects and/or prolonged toxicity.","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"6 1","pages":"30-35"},"PeriodicalIF":0.0000,"publicationDate":"2009-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Vascular Toxicity of Cocaine\",\"authors\":\"S. Bansal, J. Morgan\",\"doi\":\"10.2174/1567270000906010030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cocaine acts on the vascular system by a number of mechanisms including monoamine re-uptake inhibition, local anesthesia, anti-cholinergic activity, alpha-adrenergic stimulation, regulation of various vasoconstrictor and vasodi- lator agents and promotion of prothrombotic state. These effects lead to a number of clinical syndromes via vasoconstric- tion, platelet activation, thrombus formation and early atherosclerosis in almost every organ of the body. Many of these effects may be under appreciated. Furthermore, cocaine is commonly associated with the use of tobacco and alcohol which can lead to superadditive effects and/or prolonged toxicity.\",\"PeriodicalId\":88793,\"journal\":{\"name\":\"Vascular disease prevention\",\"volume\":\"6 1\",\"pages\":\"30-35\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vascular disease prevention\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1567270000906010030\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vascular disease prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1567270000906010030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cocaine acts on the vascular system by a number of mechanisms including monoamine re-uptake inhibition, local anesthesia, anti-cholinergic activity, alpha-adrenergic stimulation, regulation of various vasoconstrictor and vasodi- lator agents and promotion of prothrombotic state. These effects lead to a number of clinical syndromes via vasoconstric- tion, platelet activation, thrombus formation and early atherosclerosis in almost every organ of the body. Many of these effects may be under appreciated. Furthermore, cocaine is commonly associated with the use of tobacco and alcohol which can lead to superadditive effects and/or prolonged toxicity.