The open vaccine journal最新文献_第3页

Microbiological Diagnosis of Mumps 流行性腮腺炎的微生物诊断

The open vaccine journal Pub Date : 2010-02-16 DOI: 10.2174/1875035401003020086

Josep Costa

引用次数: 0

Features of a Measles Outbreak in the Elimination Era 消除时代麻疹暴发的特征

The open vaccine journal Pub Date : 2010-02-16 DOI: 10.2174/1875035401003020042

A. Martínez, N. Torner, Á. Domínguez, I. Barrabeig, A. Rovira, C. Rius, J. Caylà, E. Plasència, S. Minguell, I. Parrón, M. Sala, C. Arias, J. Costa, M. Mosquera, C. Cabezas, A. Plasència

引用次数: 1

Mumps Virus Genotyping: Basis and Known Circulating Genotypes~!2009-11-20~!2009-11-26~!2010-02-16~! 流行性腮腺炎病毒基因分型:基础和已知的流行基因型

The open vaccine journal Pub Date : 2010-02-16 DOI: 10.2174/1875035401003020037

J. Echevarría, A. Castellanos, J. Sanz, M. Aragón, I. P. Rey, M. Mosquera, F. Ory, E. Royuela

{"title":"Mumps Virus Genotyping: Basis and Known Circulating Genotypes~!2009-11-20~!2009-11-26~!2010-02-16~!","authors":"J. Echevarría, A. Castellanos, J. Sanz, M. Aragón, I. P. Rey, M. Mosquera, F. Ory, E. Royuela","doi":"10.2174/1875035401003020037","DOIUrl":"https://doi.org/10.2174/1875035401003020037","url":null,"abstract":"Although mumps virus (MV) is considered antigenically monotypic, twelve different genotypes of MV based on genetic variation in the SH gene (A to L) are currently recognised by the WHO. Both dominance of a single genotype and co-circulation of different genotypes in the same geographical area, as well as temporal replacement of genotypes have been described in different countries. The different histories of genotype importation, variations in vaccine coverage and the use of different vaccine strains in each country results in a complex picture that could be the cause of the different geographical patterns of mumps virus genotype circulation observed in different countries. Lack of full cross-protection between different genotypes has been reported and has been suggested as a cause of vaccine failure, especially for vaccine strains belonging to genotype A, which is genetically distant to the remaining genotypes that include most of the currently circulating wild strains. Finally, a differential ability to invade the neural system has been suggested for some particular strains belonging to genotype D.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"3 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2010-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Improving Health through Elimination and Eradication of Vaccine Preventable Diseases 通过消除和根除疫苗可预防疾病改善健康

The open vaccine journal Pub Date : 2010-02-16 DOI: 10.2174/1875035401003020019

Á. Domínguez, E. Borràs, N. Torner, N. Soldevila

引用次数: 0

Community Outbreak of Measles in Madrid (Spain) Caused by an Imported Case 西班牙马德里由输入病例引起的社区麻疹暴发

The open vaccine journal Pub Date : 2010-02-16 DOI: 10.2174/1875035401003020048

Luis García Comas, M. Gavín, Juan Carlos Sanz Moreno, I. R. Garduño, Maria Rodriguez, M. Carbajo, A. A. Arnaez, R. F. Muñoz

引用次数: 3

Measles Epidemiology in Spain after Introduction of the National Indigenous Measles Elimination Plan~!2009-10-30~!2009-11-10~!2010-02-16~! 西班牙实施全国本土麻疹消灭计划后的麻疹流行病学研究2009-10-30 2009-11-10 2010-02-16

The open vaccine journal Pub Date : 2010-02-16 DOI: 10.2174/1875035401003020025

I. Peña-Rey, M. Aragón, O. T. Anchuela, J. Masa, Enrique Alcalde Cabero, M. T. Ruiz

引用次数: 2

Situation of Rubella in Spain in the Elimination Phase. Rubella and Congenital Rubella Syndrome, 1997-2007 西班牙风疹在消除阶段的情况。风疹和先天性风疹综合征，1997-2007

The open vaccine journal Pub Date : 2010-02-16 DOI: 10.2174/1875035401003020055

M. Aragón, I. Peña-Rey, J. Masa, F. Ory, J. Echevarría

{"title":"Situation of Rubella in Spain in the Elimination Phase. Rubella and Congenital Rubella Syndrome, 1997-2007","authors":"M. Aragón, I. Peña-Rey, J. Masa, F. Ory, J. Echevarría","doi":"10.2174/1875035401003020055","DOIUrl":"https://doi.org/10.2174/1875035401003020055","url":null,"abstract":"Summary: Objective: To analyze the situation and evolution of rubella and congenital rubella syndrome in Spain and to evaluate the objective of elimination proposed by the World Health Organization for the European Region. Methods: Analysis of the evolution of rubella incidence and vaccination coverages (l980 and 2007). Morbidity data were obtained from the National Epidemiological Surveillance Network and mortality and population data from the National Institute of Statistics. Results: In 1979, a policy of selective rubella vaccination was introduced in Spain, targeting 11-year-old girls. In 1981, immunisation with the measles-mumps-rubella vaccine was introduced, at 15 months of age and a second dose was introduced in 1995. Vaccination coverages since 1999 exceed 95% for the first dose and 90% for the second. The incidence of rubella has fallen drastically to < 1/100,000 since 2000 in all regions. Only small outbreaks or clusters have been detected, except for one large outbreak in Madrid that affected young adult males and fertile women from countries with low vaccination coverages. Since 1997, 13 cases of congenital rubella syndrome have been detected. Conclusions: The situation in Spain favours the elimination of rubella. However, pockets of susceptible subjects remain, mainly young adult males and immigrants, who have increased substantially in numbers in the last decade. Fertile women with high birth rates from countries with a high rubella incidence have a high risk of congenital rubella syndrome.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"95 1","pages":"55-59"},"PeriodicalIF":0.0,"publicationDate":"2010-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Mannose-Binding Protein Sm60 from Schistosoma mansoni Suppresses T Cell Proliferation via Inhibition of Interleukin-2 Production 曼氏血吸虫甘露糖结合蛋白Sm60通过抑制白细胞介素-2的产生抑制T细胞增殖

The open vaccine journal Pub Date : 2010-01-15 DOI: 10.2174/1875035401003010001

A. M. Coelho-Castelo, A. Panunto-Castelo, Alan Berlese, J. Silva, V. Rodrigues

{"title":"The Mannose-Binding Protein Sm60 from Schistosoma mansoni Suppresses T Cell Proliferation via Inhibition of Interleukin-2 Production","authors":"A. M. Coelho-Castelo, A. Panunto-Castelo, Alan Berlese, J. Silva, V. Rodrigues","doi":"10.2174/1875035401003010001","DOIUrl":"https://doi.org/10.2174/1875035401003010001","url":null,"abstract":"Adult worms of Schistosoma mansoni live in the bloodstream, employing immune evasion strategies and exposing few antigens to the immune system. The tegumental surface of adult worms presents Sm60, a mannose-binding protein, which induces neutrophil migration and mast cell degranulation. Here we demonstrated that Sm60 is able to block the in vitro antigen-specific or polyclonal spleen cell proliferation induced by keyhole limpet haemocyanin (KLH) or con- canavalin A (Con A), respectively. To address the mechanism of inhibition, we evaluated some cytokines in culture and observed that Sm60 decreased significantly the synthesis of interleukin (IL)-2 induced in response to KLH, but not other cytokines. To block the suppression triggered by Sm60, exogenous IL-2 or α-methyl-mannoside were added to KLH- stimulated cultures pulsed with Sm60. Only IL-2 abolished the Sm60 effect, suggesting that Sm60 blocked the lymphop- roliferation through the inhibition of IL-2 production, in a carbohydrate recognition domain (CRD)-independent mecha- nism. Our results suggest that Sm60 could participate in the immune evasion mechanisms of S. mansoni.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"3 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2010-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Designing the optimal vaccine: the importance of cytokines and dendritic cells. 设计最佳疫苗：细胞因子和树突状细胞的重要性。

The open vaccine journal Pub Date : 2010-01-01 DOI: 10.2174/1875035401003010007

Penelope A Morel, Michael S Turner

{"title":"Designing the optimal vaccine: the importance of cytokines and dendritic cells.","authors":"Penelope A Morel, Michael S Turner","doi":"10.2174/1875035401003010007","DOIUrl":"10.2174/1875035401003010007","url":null,"abstract":"<p><p>Many vaccines existing today provide strong protection against a wide variety of infectious organisms, and these consist of either live attenuated or inactivated microorganisms. Most of these vaccines were developed empirically and there has not been a clear understanding of the immunological principles that contribute to this success. Recent advances in systems biology are being applied to the study of vaccines in order to determine which immunological parameters are the best predictors of success. New approaches to vaccine development include the identification of peptide epitopes and the manipulation of the immune response to generate the most appropriate response. Vaccines are being developed to prevent and/or treat such conditions as cancer and autoimmunity in addition to infectious diseases. Vaccines targeting this diverse group of diseases may need to elicit very different types of immune responses. Recent advances in our understanding of the functions of dendritic cells (DC) and cytokines in orchestrating qualitatively different immune responses has allowed the design of vaccines that can elicit immune responses appropriate for cancer, autoimmunity or infectious organisms. This review will focus on recent advances in the ways DC and cytokines can be used to develop the most appropriate and effective vaccines.</p>","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"3 ","pages":"7-17"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149857/pdf/nihms-313881.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30061537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphosphazenes Enhance Mucosal and Systemic Immune Responses in Mice Immunized Intranasally with Influenza Antigens 多磷腈增强流感抗原鼻内免疫小鼠的粘膜和全身免疫反应

The open vaccine journal Pub Date : 2009-11-18 DOI: 10.2174/1875035400902010134

Nelson F. Eng, S. Garlapati, K. Lai, V. Gerdts, G. Mutwiri

{"title":"Polyphosphazenes Enhance Mucosal and Systemic Immune Responses in Mice Immunized Intranasally with Influenza Antigens","authors":"Nelson F. Eng, S. Garlapati, K. Lai, V. Gerdts, G. Mutwiri","doi":"10.2174/1875035400902010134","DOIUrl":"https://doi.org/10.2174/1875035400902010134","url":null,"abstract":"Polyphosphazenes are synthetic, biodegradable, water-soluble polymers with a great versatility for vaccine and drug delivery applications. We previously observed that polyphosphazenes enhance immune responses in mice when injected subcutaneously against X:31 influenza antigens. Here, we investigated the potential of polyphosphazenes as mucosal adjuvants for enhancing influenza-specific immune responses. Vaccine combinations with soluble polyphos- phazenes (PCPP or PCEP) and influenza X:31 antigen were administered to BALB/c mice intranasally. Antigen-specific antibody responses were assayed in serum and mucosal washes by ELISA, while antigen-specific cytokine production was assayed in spleen cells by ELISPOT assay. We observed that the formulation of either of the two polyphosphazenes with X:31 induced significant and prolonged serum IgG1 antibody responses as early as 2 weeks after primary immuniza- tion. Interestingly, only PCEP + X:31 induced a significant and prolonged serum IgG2a response. These results implied that the PCEP+X:31 formulation induced better Th1 immune responses, suggesting increased cell-mediated immunity. To confirm this, we determined that IFN-￻ , a Th1 cytokine, was produced at significantly higher levels in spleens from mice that were vaccinated with the PCEP+X:31 formulation, while IL-4, a Th2 cytokine, was produced at higher levels from both vaccinated groups. Finally, we determined that these polyphosphazenes were indeed effective as adjuvants in induc- ing mucosal immune responses, as IgA and IgG antibodies were detected in lung and vaginal washes. We conclude that polyphosphazenes increase mucosal immune responses effectively, and can be used to modulate the quality of Th1 and Th2 immune responses.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"2 1","pages":"134-143"},"PeriodicalIF":0.0,"publicationDate":"2009-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9