The open vaccine journal最新文献_第4页

The open vaccine journal Pub Date : 2009-08-27 DOI: 10.2174/1875035400902010123

A. Cid-Arregui

引用次数: 0

Policy Development for Human Papillomavirus Vaccine Introduction in Low- Resource Settings 低资源环境中人乳头瘤病毒疫苗引进的政策发展

The open vaccine journal Pub Date : 2009-08-13 DOI: 10.2174/1875035400902010113

Jennifer Tsui, D. LaMontagne, C. Levin, A. Bingham, L. Menezes

{"title":"Policy Development for Human Papillomavirus Vaccine Introduction in Low- Resource Settings","authors":"Jennifer Tsui, D. LaMontagne, C. Levin, A. Bingham, L. Menezes","doi":"10.2174/1875035400902010113","DOIUrl":"https://doi.org/10.2174/1875035400902010113","url":null,"abstract":"The objectives of this analysis are: (1) to describe the policy environment related to human papillomavirus (HPV) vaccine introduction; (2) to identify the policy processes and key stakeholders in HPV vaccine introduction; (3) to summarize specific characteristics about HPV vaccines and their introduction that may be barriers to introduction; and (4) to recommend advocacy strategies to achieve a positive environment for cervical cancer prevention. This descriptive qualitative study of HPV vaccine policy development used an iterative, inductive, theme-based approach to data analysis. The study was conducted in four developing countries—India, Peru, Uganda, and Vietnam. Study participants were comprised of a total of 237 national policymakers, legislators, officials, and senior managers from ministries of health, finance, and planning; leaders of medical and health professional associations; cancer institutes; heads of nongovernmental organizations; and women's health advocates. While differences existed among low-income countries in specific cervical cancer, women's health, adolescent health, or immunization policy environments, we found the policymaking process itself, specific concerns related to HPV vaccines, and the information needs of policymakers for HPV vaccine introduction to be strikingly similar. Data on burden of cervi- cal cancer, HPV vaccine safety and efficacy, and cost-effectiveness and vaccine affordability were top issues reported by policymakers. Advocacy strategies need to address these issues in order for HPV vaccine policy formulation and approval to be successful.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"2 1","pages":"113-122"},"PeriodicalIF":0.0,"publicationDate":"2009-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Salmonella Vaccines for Animals and Birds and Their Future Perspective 动物和鸟类沙门氏菌疫苗及其未来展望

The open vaccine journal Pub Date : 2009-07-28 DOI: 10.2174/1875035400902010100

B. R. Singh

{"title":"Salmonella Vaccines for Animals and Birds and Their Future Perspective","authors":"B. R. Singh","doi":"10.2174/1875035400902010100","DOIUrl":"https://doi.org/10.2174/1875035400902010100","url":null,"abstract":"Vaccines are the most powerful biologicals which have modulated the economic, social and cultural life of human beings. Certain diseases have haunted humanity for centuries but are now extinct due to vaccines. On the other hand, some diseases such as salmonellosis, that were uncontrollable in the past, still cause pandemics today. There are more than 2500 serovars of Salmonella and vaccines made from any one serovar do not confer cross-protection against another, no matter how much antigenic similarity there is between the two. Salmonella strains are able to cause disease and to adapt to different types of animals whilst still maintaining their zoonotic and interspecies transfer potential. Three major types of vaccines are being used to control salmonellosis: killed bacteria, subunit vaccines and live attenuated vaccines. Effective vaccines against some host adapted and common serovars have been developed but their use has led to the emergence of other serovars. The problem has become more complex because increased international trade and travel has helped Salmonella strains to cross continental boundaries. It seems unlikely that we will be able to develop an effective Salmonella vaccine in the near future that is able to control all forms of salmonellosis, even in a single animal species. Recent advances in Salmonella vaccines will be reviewed including the use of Salmonella as vector for delivery of multivalent DNA and recombinant vaccines for controlling salmonellosis and other infectious diseases as well as for the control of cancer.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"192 1","pages":"100-112"},"PeriodicalIF":0.0,"publicationDate":"2009-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Immune Response to Streptomyces lividans in Mice: A Potential Vaccine Vehicle Against TB 小鼠对lividans链霉菌的免疫反应:一种潜在的结核病疫苗载体

The open vaccine journal Pub Date : 2009-06-23 DOI: 10.2174/1875035400902010085

C. Vallín, Julio C. Ayala, D. García-Rivera, Jony Jones, C. Rodríguez, L. González, Ivones Hernández, E. Pimienta, Ailin Vila, M. Sarmiento, A. Acosta, J. Anné, L. Mellaert

{"title":"Immune Response to Streptomyces lividans in Mice: A Potential Vaccine Vehicle Against TB","authors":"C. Vallín, Julio C. Ayala, D. García-Rivera, Jony Jones, C. Rodríguez, L. González, Ivones Hernández, E. Pimienta, Ailin Vila, M. Sarmiento, A. Acosta, J. Anné, L. Mellaert","doi":"10.2174/1875035400902010085","DOIUrl":"https://doi.org/10.2174/1875035400902010085","url":null,"abstract":"The potentialities of Streptomyces lividans 1326 as new live vaccine vehicle strategy have been evaluated. Immunization of mice with the Streptomyces mycelium induced high levels of specific antibodies against proteins released in the culture supernatant of the analyzed strain. Splenocytes from the Streptomyces-immunized animals were able to secrete high levels of IFN-� (2103.9 pg/mL) and to proliferate in vitro on stimulation with proteins released by Streptomyces. The analysis of cross-reactivity against M. tuberculosis secreted proteins showed that the immunization of mice with Streptomyces led to a comparable level of cross-reacting antibodies as in the BCG immunized mice. Similarly sera antibodies from Streptomyces immunized group recognized whole BCG cells to the same degree as antibodies raised against BCG reacted with Streptomyces mycelium, indicating that these two actinobacteria cross-react immunologically. The Streptomyces lividans strain was highly immunogenic in mice showing an enduring Th1-dependent immune response. This is the first report demonstrating the potential of Streptomyces as an attractive vehicle for developing a live TB vaccine.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"2 1","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2009-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Trend of Mandatory Vaccination among Children in Egypt 埃及儿童强制接种疫苗的趋势

The open vaccine journal Pub Date : 2009-06-23 DOI: 10.2174/1875035400902010077

A. Saad, Ashwak Safi-El-Dine, Karima El-shamy

引用次数: 6

Functional reconstruction of structurally complex epitopes using CLIPS™ technology 利用CLIPS™技术对结构复杂的表位进行功能重建

The open vaccine journal Pub Date : 2009-06-12 DOI: 10.2174/1875035400902010056

P. Timmerman, W. Puijk, R. Boshuizen, P. V. Dijken, J. W. Slootstra, F. Beurskens, P. Parren, A. H. Huber, M. Bachmann, R. Meloen

引用次数: 25

Effect of Lentiviral Vectors on the Phenotypical and Functional Maturation of Human Dendritic Cells: Implications for Gene Therapy 慢病毒载体对人树突状细胞表型和功能成熟的影响:基因治疗的意义

The open vaccine journal Pub Date : 2009-06-12 DOI: 10.2174/1875035400902010068

R. Simone, D. Saverino

{"title":"Effect of Lentiviral Vectors on the Phenotypical and Functional Maturation of Human Dendritic Cells: Implications for Gene Therapy","authors":"R. Simone, D. Saverino","doi":"10.2174/1875035400902010068","DOIUrl":"https://doi.org/10.2174/1875035400902010068","url":null,"abstract":"Dendritic cells (DCs) play a pivotal role in orchestrating and bridging innate, adaptive, and memory immunity. For this reason, genetic modification of DCs functions is an attractive approach to treat disease, both using mature DCs (mDCs) to immunize patients, or immature DCs (iDCs) to induce tolerance. Viral vectors are efficient at transducing DCs, and we have investigated the effect of transduction with viral vectors on the phenotype and function of DCs. Adenovirus (Ad5), and Lentivirus (LV) are able to up-regulate costimulatory molecules and major histocompatibility complex (MHC) class II expression on DCs, as well as inducing production of Th1 and proinflammatory cytokines. Moreover, the function of virally infected DCs is altered. In fact, iDCs have an increased, and mDCs a decreased, ability to stimulate a mixed lymphocyte reaction (MLR). Similar results were observed when the capability of transduced-DCs to present recall- antigen was investigated. Of interest, in the context of vaccine design, these vectors were able to induce an antigen- independent T lymphocytes proliferative response. These data are relevant not only in the context of genetic manipulation of DCs for vaccine development and active immunotherapy, but also in our understanding of the response of DCs to viral infection.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"2 1","pages":"68-76"},"PeriodicalIF":0.0,"publicationDate":"2009-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prime-Boost Immunogenicity of Class 5C Protein from Neisseria meningitidis in Mice with Different Adjuvants 不同佐剂对小鼠脑膜炎奈瑟菌5C类蛋白免疫原性的增强作用

The open vaccine journal Pub Date : 2009-05-13 DOI: 10.2174/1875035400902010045

A. M. Carmo, A. S. Ferraz, A. Y. Yto, Simone Néri, T. N. Cunha, E. Gaspari

引用次数: 4

Varicella-Zoster Virus Subunit Vaccine 水痘带状疱疹病毒亚单位疫苗

The open vaccine journal Pub Date : 2009-04-20 DOI: 10.2174/1875035400902010017

A. Vafai

{"title":"Varicella-Zoster Virus Subunit Vaccine","authors":"A. Vafai","doi":"10.2174/1875035400902010017","DOIUrl":"https://doi.org/10.2174/1875035400902010017","url":null,"abstract":"Varicella-zoster virus (VZV) causes chickenpox (Varicella) in children and shingles (Zoster) in elderly and immunosuppressed individuals. An attenuated VZV vaccine has been approved for general immunization to prevent varicella and zoster in the United States. Although this vaccine provides a high degree of protection against virus infection, the virus becomes latent in dorsal root ganglia and will reactivate to produce zoster. Therefore, there is a need for developing additional VZV vaccines that are capable of eliciting immune response to the virus but will not establish viral latency. Our studies have been focused on the development of a truncated secretory VZV glycoprotein (VZVgE) subunit vaccine. The results from our studies have shown that the VZV subunit vaccine: (1) elicits the induction of neutralizing antibodies in animals as well as in humans; and (2) stimulates the induction of VZVgE-specic antibodies in VZV-seropositive human mononuclear cells. Such a VZV glycoprotein antigen, therefore, may have the potential to be used as a candidate VZV glycoprotein subunit vaccine for prevention of primary VZV infection (Varicella) or boosting immune response against VZV reactivation (Zoster) in adults, the elderly and immunosuppressed individuals.","PeriodicalId":88763,"journal":{"name":"The open vaccine journal","volume":"2 1","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"2009-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Approach to Formative Research in HPV Vaccine Introduction Planning in Low-Resource Settings 低资源环境下HPV疫苗引进计划的形成性研究方法

The open vaccine journal Pub Date : 2009-04-03 DOI: 10.2174/1875035400902010001

A. Bingham, A. Janmohamed, R. Bartolini, H. Creed-Kanashiro, Irfan Khan, L. Menezes, D. Murokora, N. N. Quy, V. Tsu

引用次数: 34