Biology of the Cell最新文献

{"title":"The magic of MAGI-1: A scaffolding protein with multi signalosomes and functional plasticity","authors":"Katherine J. D. A. Excoffon,&nbsp;Christina L. Avila,&nbsp;Mahmoud S. Alghamri,&nbsp;Abimbola O. Kolawole","doi":"10.1111/boc.202300901","DOIUrl":"10.1111/boc.202300901","url":null,"abstract":"<p>Biology of the Cell, 114, 185−198. https://doi.org/10.1111/boc.202200014</p><p>The above article, which was published online on 7 April 2022 in Wiley Online Library, failed to specify that Figure 4 is adapted and reproduced with permission from Wörthmüller, J. and Rüegg, C., MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions. Cells <b>2021</b>, <i>10</i>(6), 1494. The authors apologize for this error.</p>","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"115 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/boc.202300901","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functions of actin-binding proteins in cilia structure remodeling and signaling","authors":"Siqi Wang,&nbsp;Xin Wang,&nbsp;Congbin Pan,&nbsp;Ying Liu,&nbsp;Min Lei,&nbsp;Xiying Guo,&nbsp;Qingjie Chen,&nbsp;Xiaosong Yang,&nbsp;Changhan Ouyang,&nbsp;Zhanhong Ren","doi":"10.1111/boc.202300026","DOIUrl":"10.1111/boc.202300026","url":null,"abstract":"<p>Cilia are microtubule-based organelles found on the surfaces of many types of cells, including cardiac fibroblasts, vascular endothelial cells, human retinal pigmented epithelial-1 (RPE-1) cells, and alveolar epithelial cells. These organelles can be classified as immotile cilia, referred to as primary cilia in mammalian cells, and motile cilia. Primary cilia are cellular sensors that detect extracellular signals; this is a critical function associated with ciliopathies, which are characterized by the typical clinical features of developmental disorders. Cilia are extensively studied organelles of the microtubule cytoskeleton. However, the ciliary actin cytoskeleton has rarely been studied. Clear evidence has shown that highly regulated actin cytoskeleton dynamics contribute to normal ciliary function. Actin-binding proteins (ABPs) play vital roles in filamentous actin (F-actin) morphology. Here, we discuss recent progress in understanding the roles of ABPs in ciliary structural remodeling and further downstream ciliary signaling with a focus on the molecular mechanisms underlying actin cytoskeleton-related ciliopathies.</p>","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"115 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/boc.202300026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria: At the crossroads between mechanobiology and cell metabolism","authors":"Émilie Su,&nbsp;Catherine Villard,&nbsp;Jean-Baptiste Manneville","doi":"10.1111/boc.202300010","DOIUrl":"10.1111/boc.202300010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Metabolism and mechanics are two key facets of structural and functional processes in cells, such as growth, proliferation, homeostasis and regeneration. Their reciprocal regulation has been increasingly acknowledged in recent years: external physical and mechanical cues entail metabolic changes, which in return regulate cell mechanosensing and mechanotransduction. Since mitochondria are pivotal regulators of metabolism, we review here the reciprocal links between mitochondrial morphodynamics, mechanics and metabolism. Mitochondria are highly dynamic organelles which sense and integrate mechanical, physical and metabolic cues to adapt their morphology, the organization of their network and their metabolic functions. While some of the links between mitochondrial morphodynamics, mechanics and metabolism are already well established, others are still poorly documented and open new fields of research. First, cell metabolism is known to correlate with mitochondrial morphodynamics. For instance, mitochondrial fission, fusion and cristae remodeling allow the cell to fine-tune its energy production through the contribution of mitochondrial oxidative phosphorylation and cytosolic glycolysis. Second, mechanical cues and alterations in mitochondrial mechanical properties reshape and reorganize the mitochondrial network. Mitochondrial membrane tension emerges as a decisive physical property which regulates mitochondrial morphodynamics. However, the converse link hypothesizing a contribution of morphodynamics to mitochondria mechanics and/or mechanosensitivity has not yet been demonstrated. Third, we highlight that mitochondrial mechanics and metabolism are reciprocally regulated, although little is known about the mechanical adaptation of mitochondria in response to metabolic cues. Deciphering the links between mitochondrial morphodynamics, mechanics and metabolism still presents significant technical and conceptual challenges but is crucial both for a better understanding of mechanobiology and for potential novel therapeutic approaches in diseases such as cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"115 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/boc.202300010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information","authors":"","doi":"10.1002/nafm.10785","DOIUrl":"https://doi.org/10.1002/nafm.10785","url":null,"abstract":"","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46664551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fostering innovation to solve the biomechanics of microbe–host interactions: Focus on the adhesive forces underlying Apicomplexa parasite biology","authors":"Luis Vigetti,&nbsp;Isabelle Tardieux","doi":"10.1111/boc.202300016","DOIUrl":"10.1111/boc.202300016","url":null,"abstract":"<p>The protozoa, <i>Toxoplasma gondii</i> and <i>Plasmodium</i> spp., are preeminent members of the Apicomplexa parasitic phylum in large part due to their public health and economic impact. Hence, they serve as model unicellular eukaryotes with which to explore the repertoire of molecular and cellular strategies that specific developmental morphotypes deploy to timely adjust to their host(s) in order to perpetuate. In particular, host tissue- and cell-invasive morphotypes termed zoites alternate extracellular and intracellular lifestyles, thereby sensing and reacting to a wealth of host-derived biomechanical cues over their partnership. In the recent years, biophysical tools especially related to real time force measurement have been introduced, teaching us how creative are these microbes to shape a unique motility system that powers fast gliding through a variety of extracellular matrices, across cellular barriers, in vascular systems or into host cells. Equally performant was this toolkit to start illuminating how parasites manipulate their hosting cell adhesive and rheological properties to their advantage. In this review, besides highlighting major discoveries along the way, we discuss the most promising development, synergy, and multimodal integration in active noninvasive force microscopy methods. These should in the near future unlock current limitations and allow capturing, from molecules to tissues, the many biomechanical and biophysical interplays over the dynamic host and microbe partnership.</p>","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"115 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/boc.202300016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special issue for biology of the cell “intracellular trafficking of viruses”","authors":"Raphael Gaudin,&nbsp;Maika S. Deffieu","doi":"10.1111/boc.202300046","DOIUrl":"10.1111/boc.202300046","url":null,"abstract":"In this special issue of Biology of the Cell, https:// onlinelibrary.wiley.com/doi/toc/10.1111/(ISSN)1768322X.viruses the authors explored the literature, describing how viruses exploit various host machineries to enter, replicate and exit from cells. The review by Gerber-Tichet & Kremer describes the variability in human adenoviruses immune response which is important for the design of virus-based vaccines. Focusing on skin cells, they outline the role of various adenovirus receptors for efficient infection of immune cells. They also highlight the importance of post-translational modifications of cell surface proteins in virus uptake (Gerber-Tichet Dienst & Kremer, 2022). Because virusreceptor interactions and subsequent viral fusion with host membrane cells are highly dynamic processes, advanced imaging tools are needed to shed light on virus entry. S. Padilla-Parra reviewed key microscopy approaches to study these steps in the context of HIV1 entry and fusion, including single particle tracking and spectral imaging (Padilla-Parra, 2023). The actin cytoskeleton plays a pivotal role during virus entry, but also exit from cells. The review by Serrano et al. describes how HIV-1 remodels the actin cytoskeleton during virus-receptor interactions, and proposes a model for the role of the actin cytoskeleton in HIV-1 assembly, budding, and release (Serrano et al., 2023). Viruses have evolved numerous strategies to travel within the cell from compartment-to-compartment. The review by Prasad & Bartenschlager describes how SARS-CoV-2 impacts intracellular trafficking pathways, including the hijacking of endosomal transport, modulation of ER/Golgi/endosomes membrane contact sites, inhibition of cellular mRNA nuclear export, perturba-","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"115 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9927162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forces exerted and transduced by cancer-associated fibroblasts during cancer progression","authors":"Madison E. Bates,&nbsp;Sarah Libring,&nbsp;Cynthia A. Reinhart-King","doi":"10.1111/boc.202200104","DOIUrl":"10.1111/boc.202200104","url":null,"abstract":"<p>Although it is well-known that cancer-associated fibroblasts (CAFs) play a key role in regulating tumor progression, the effects of mechanical tissue changes on CAFs are understudied. Myofibroblastic CAFs (myCAFs), in particular, are known to alter tumor matrix architecture and composition, heavily influencing the mechanical forces in the tumor microenvironment (TME), but much less is known about how these mechanical changes initiate and maintain the myCAF phenotype. Additionally, recent studies have pointed to the existence of CAFs in circulating tumor cell clusters, indicating that CAFs may be subject to mechanical forces beyond the primary TME. Due to their pivotal role in cancer progression, targeting CAF mechanical regulation may provide therapeutic benefit. Here, we will discuss current knowledge and summarize existing gaps in how CAFs regulate and are regulated by matrix mechanics, including through stiffness, solid and fluid stresses, and fluid shear stress.</p>","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"115 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9933163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do different exosome biogenesis pathways and selective cargo enrichment contribute to exosomal heterogeneity?","authors":"Shatakshi Shukla,&nbsp;Fatema Currim,&nbsp;Rajesh Singh","doi":"10.1111/boc.202200116","DOIUrl":"10.1111/boc.202200116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Exosomes are emerging intercellular communicators essential for cellular homeostasis during development and differentiation. The dysregulation in exosome-mediated communication alters cellular networking leads to developmental defects and chronic diseases. Exosomes are heterogeneous in nature depending on differences in size, membrane protein abundance, and differential cargo load. In this review, we have highlighted the latest developments in exosome biogenesis pathways, heterogeneity, and selective enrichment of various exosomal cargoes including proteins, nucleic acids, and mitochondrial DNA. Furthermore, the recent developments in the isolation techniques of exosome subpopulations have also been discussed. The comprehensive knowledge of extracellular vesicle (EV) heterogeneity and selective cargo enrichment during specific pathology may provide a clue for disease severity and early prognosis possibilities. The release of specific exosome subtypes is associated with the progression of specific disease type and hence a probable tool for therapeutics and biomarker development.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"115 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9793494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index des auteurs","authors":"Bernard Brusset","doi":"10.1017/S0395264900046254","DOIUrl":"https://doi.org/10.1017/S0395264900046254","url":null,"abstract":"ABÉLÈS Marc, 0989 AFFICHARD Joëlle, 0459 AGUIRRE ROJAS Carlos Antonio, 0001 AL AM Muzaffar, 0300 ALBERT Jean-Pierre, 0643, 0810, 0900 ALBERT-LLORCA Marlène, 0900 ALEXANDRE-BIDON Danièle, 0318, 0758, 0811, 0901, 0902, 1058, 1059, 1060 ALLEN Robert C , 0596 AMELANG James S., 0557 AMINO Yoshihiko, 0663 ANDREAU Jean, 0460, 0558 ANDRIEU Claire, 0371 Annales (Les), 0002, 0028, 0611 ANTOINE Jean-Philippe, 0029, 0812 ARABEYRE Patrick, 0059, 0319, 0903 ASSAYAG Jackie, 0030, 0208, 0248 ATTEN Michel, 0559 AURELL Martin, 0209, 0249, 0320 AUTRAND Françoise, 0372 AYÇOBERRY Pierre, 0117, 0177, 0182, 0210, 0301,0373,0374,0375,0753,0813","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"76 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0395264900046254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42565202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamin-2 controls actin remodeling for efficient complement receptor 3-mediated phagocytosis","authors":"Anna Mularski,&nbsp;Ryszard Wimmer,&nbsp;Floriane Arbaretaz,&nbsp;Gabriel Le Goff,&nbsp;Manon Depierre,&nbsp;Florence Niedergang","doi":"10.1111/boc.202300001","DOIUrl":"10.1111/boc.202300001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background information</h3>\u0000 \u0000 <p>Phagocytosis is the mechanism of the internalization of large particles, microorganisms and cellular debris. The complement pathway represents one of the first mechanisms of defense against infection and the complement receptor 3 (CR3), which is highly expressed on macrophages, is a major receptor for many pathogens and debris. Key to dissecting the mechanisms by which CR3-mediated phagocytosis occurs, is understanding how the complex actin binding protein machinery and associated regulators interact with actin during phagocytosis, from triggering of receptor, through to phagosome formation and closure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Here, we reveal that Dynamin-2 is recruited concomitantly with polymerized actin at the phagocytic cup and during phagosome formation and closure. Inhibition of Dynamin activity leads to stalled phagocytic cups and a decrease in the amount of F-actin at the site of phagocytosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dynamin-2 regulates the assembly of the F-actin phagocytic cup for successful CR3-mediated phagocytosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance</h3>\u0000 \u0000 <p>These results highlight an important role for Dynamin-2 in actin remodeling downstream of integrins.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8859,"journal":{"name":"Biology of the Cell","volume":"115 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/boc.202300001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}