{"title":"An Idea to Explore: A Project-Based Innovative Biology Laboratory Course Investigation of Chitin-Binding Domain Based Fused Protein and Its Use in Protein Immobilization on Chitin.","authors":"Jun-Wei Deng, Heng-Yun Zhao, Xiao-Ru Lin, Jing-Wen Ma, Ying-Jie Tang, Xiao-Chun Lin, Hui-Min Ye, Lan-Xin Zheng, Jian Li, Shi-Lin Cao, Xin-An Zeng","doi":"10.1002/bmb.70054","DOIUrl":"10.1002/bmb.70054","url":null,"abstract":"<p><p>This course investigates the theoretical and experimental aspects of protein immobilization technology based on chitin-binding domains (CHIBD). The design, expression, and purification of a CHIBD-fused protein were performed, and CHIBD-fused protein was subsequently immobilized onto chitin. By integrating computational and experimental approaches, the course aims to enhance the research skills among participating students, enabling them to proficiently perform basic calculations and experimental operations.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"308-318"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Stapfer, Ernestine Saumweber, Achim Schneider, Susanne J Kühl
{"title":"\"Bionopoly\" as a Gamechanger? Effects of Gamification on Learning Success, Motivation and Activation Among Medical Students in a Biochemistry Course.","authors":"Eva Stapfer, Ernestine Saumweber, Achim Schneider, Susanne J Kühl","doi":"10.1002/bmb.70045","DOIUrl":"10.1002/bmb.70045","url":null,"abstract":"<p><p>Gamification is characterized by the use of gaming elements in a non-gaming context. This concept is commonly applied in teaching to create a more meaningful and activating learning environment. The major aim of this study was to compare possible effects of gamification on a traditional interactive teaching concept in a biochemistry course on students' learning. This study was performed in summer semester 2024 with fourth semester medical students at Ulm University in Germany. Students were divided into two homogenous study groups that differed in the teaching concept. In the control group, students received instruction through traditional, interactive face-to-face lessons that included open-ended questions. In the gaming group, the quiz-game \"Bionopoly\" was introduced and the students were taught using a gamified didactic concept. Learning success was measured by a multiple-choice test at the beginning and the end of the course day. Satisfaction, motivation and a possible continuous activating effect were analyzed by an online evaluation and a handout questionnaire. Students of the gamified concept scored higher in the post-knowledge test. Furthermore, the gamified concept motivated the student's significantly more when compared to the traditional teaching concept. Measured throughout the entire course day, gamification had a stabilizing effect on students' concentration, motivation and interest in biochemistry. All in all our study provides evidence that gamification is an attractive teaching concept for practical courses with an accompanying seminar.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"243-253"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13206467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathan D Tivendale, Alyssa Van Dreumel, Peter G Arthur
{"title":"Introducing Experimental Design Concepts Improves Biochemistry Undergraduates' Experimental Laboratory Competence and Confidence.","authors":"Nathan D Tivendale, Alyssa Van Dreumel, Peter G Arthur","doi":"10.1002/bmb.70046","DOIUrl":"10.1002/bmb.70046","url":null,"abstract":"<p><p>Laboratory science education can provide a training ground for developing experimental design capabilities, the ability to critically assess a range of laboratory methods, and confidence in selecting, adapting, and performing laboratory techniques. However, traditional, fail-safe, protocol-based laboratories provide little opportunity for students to develop these cognitive abilities. We introduced experimental design elements into a second-year undergraduate biochemistry laboratory. Using a guided inquiry model, we show that students improve their self-perceived and externally measured ability to critically assess laboratory methods, design experiments, and adapt protocols (experimental laboratory competence) and gain confidence in adapting protocols and applying technical laboratory knowledge to new situations (experimental laboratory confidence). Furthermore, students on the whole reported enjoying engaging with experimental design.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"254-263"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13206386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Walter Novak, Paul Craig, Michael Foster, Chris Berndsen
{"title":"The Case for Building Faculty Capacity for Coding in BMB Education and What We Are Doing About It.","authors":"Walter Novak, Paul Craig, Michael Foster, Chris Berndsen","doi":"10.1002/bmb.70050","DOIUrl":"10.1002/bmb.70050","url":null,"abstract":"","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"223-225"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Exploratory Study of Undergraduate Students' Perceptions of Visualization and Visualization Ability in Biochemistry.","authors":"Andrew McVay, Suazette Mooring","doi":"10.1002/bmb.70052","DOIUrl":"10.1002/bmb.70052","url":null,"abstract":"<p><p>This qualitative study explored undergraduate biochemistry students' perceptions of visualization, their mindset beliefs, and challenges in engaging with visual representations. Ten student interviews and two instructor interviews were analyzed using thematic analysis. Students focused on external visualizations, while instructors emphasized internal mental imagery. Some students expressed growth mindset beliefs. However, fixed mindset beliefs about visualization were common among students with self-perceived aphantasia. Findings suggest the need for targeted instructional strategies to foster visual literacy, support diverse visualization abilities, and align student-instructor expectations.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"271-282"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Idea to Explore: From How to Why: Using Evolutionary Biochemistry to Inspire Biochemistry Education.","authors":"Alberto Vázquez-Salazar","doi":"10.1002/bmb.70048","DOIUrl":"10.1002/bmb.70048","url":null,"abstract":"<p><p>Traditional biochemistry instruction often emphasizes mechanistic detail, that is, how molecules and pathways function, without equally addressing why they have their present forms. This fact-centered approach can leave students overwhelmed and disconnected from the broader scientific narrative. Evolutionary biochemistry, which examines biomolecular properties through the combined lens of their historical origins and physical constraints, offers a framework to enrich biochemistry education at both undergraduate and graduate levels. By integrating concepts from molecular evolution, origins-of-life research, and historical biochemistry, instructors can connect isolated facts into coherent stories of adaptation, innovation, and contingency across deep time. This teaching perspective argues that embedding the why into the how promotes deeper engagement, improves retention, and encourages interdisciplinary thinking. Practical strategies are proposed for incorporating evolutionary framing into existing curricula without sacrificing core content coverage.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"264-270"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13206292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Teaching Bio-Layer Interferometry: Protein-Protein Versus Protein-Small Molecule Interaction Analysis on an Octet R8.","authors":"Wen Chen","doi":"10.1002/bmb.70049","DOIUrl":"10.1002/bmb.70049","url":null,"abstract":"<p><p>We describe a classroom-ready bio-layer interferometry protocol for upper-level undergraduates that contrasts a macromolecular interaction with a small-molecule interaction on an Octet R8. Biotinylated bovine serum albumin (BSA) is immobilized on Super Streptavidin sensors to enable two assays in parallel: (i) binding of a commercially available anti-BSA IgG (protein-protein) and (ii) binding of a long-chain fatty acid such as palmitate (protein-small molecule). The exercise emphasizes assay design decisions that differ by analyte class-sensor chemistry and loading density, solvent matching and reference subtraction, association/dissociation timing, and the choice of data-analysis pathway (global 1:1 kinetic fitting for IgG vs. steady-state isotherms for fatty acids). Representative data yield nanomolar K<sub>D</sub> values for BSA-IgG and micromolar apparent K<sub>D</sub> for BSA-fatty acid, with correspondingly larger response amplitudes and slower off-rates for the protein-protein case. The protocol fits into two 3-h sessions, leverages eight-channel parallel acquisition for efficient titrations, and includes safety notes, optional regeneration to demonstrate sensor reuse, and troubleshooting for non-ideal behaviors (drift, avidity, non-specific binding). Assessment artifacts (rubrics, short-answer prompts, and figure-quality criteria) support measurement of learning outcomes in experimental design and quantitative analysis. Because the same BSA surface underpins both assays, the module is cost effective, reproducible, and readily transferable across institutions, providing a practical framework for teaching how analyte size and mechanism shape biosensor strategy and interpretation.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"297-307"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Idea to Explore: Enhancing the Teaching of Genome Editing Through 3D Printed Models of CRISPR-Cas9 Technology.","authors":"Kevin Diao, Stephen M G Duff, Hong Li","doi":"10.1002/bmb.70047","DOIUrl":"10.1002/bmb.70047","url":null,"abstract":"<p><p>Innovative biological discoveries are crucial for addressing global challenges, yet teaching these complex concepts poses significant difficulties due to the complexity of the subject matter as well as limited educational resources and methodologies. Genome editing, specifically with CRISPR-Cas9, represents a convergence of technology, molecular biology, and engineering, enabling precise manipulation of DNA sequences in various organisms. It leverages advanced tools and a deep understanding of molecular biology to target specific genes while applying engineering principles to improve editing mechanisms. However, the complexity of this field poses educational challenges due to a scarcity of accessible resources. To enhance the accessibility of genome editing to scientists and students, we propose utilizing 3D modeling and printing to create tangible models of key components in the genome editing process. By visualizing these molecular structures, our goal is to simplify and enrich the educational experience, making the intricate principles of genome editing more comprehensible and engaging for students.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"292-296"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J S Sousa, B M P Gonçalves, C Ferreira, J M Rocha, S Faia, L C Simões, M Simões
{"title":"Impact of a One-Week Bioengineering Outreach Activity on the Academic Perceptions and Motivation of High School Students.","authors":"J S Sousa, B M P Gonçalves, C Ferreira, J M Rocha, S Faia, L C Simões, M Simões","doi":"10.1002/bmb.70053","DOIUrl":"10.1002/bmb.70053","url":null,"abstract":"<p><p>Many universities across Europe have developed outreach programs to bring high school students closer to science and help them make more informed decisions about their academic futures. At the University of Porto (Portugal), the Junior University is a summer school that offers research and development activities on specific topics, enabling students to experience university life and the research environment through representative hands-on programs. This report presents the impact of a one-week bioengineering program, conducted at the Faculty of Engineering of the University of Porto (FEUP) and repeated over 4 weeks, on the academic literacy and motivation of high school students. Throughout each week, students completed two questionnaires-one at the beginning and another at the end of the program. The results reveal clear improvements in their understanding of bioengineering concepts and applications. For some students, the experience reinforced their interest in the field, while for others, it helped clarify that bioengineering might not be their preferred area of study. Overall, the outcomes of this study highlight the value of university-led initiatives in enhancing high school students' academic literacy and supporting them in making more informed, thoughtful decisions regarding their future academic and professional paths.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"283-291"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13206384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147526038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meghan Kates, Alexa Fitzpatrick, Yupeng Zhang, Alison Gibbs, Qin Liu, Alan da Silveira Fleck, Leora Freedman, Stavroula Andreopoulos
{"title":"Effectiveness of Scientific Literacy and Communication E-Modules in a Molecular Biology Course: A Qualitative and Quantitative Analysis.","authors":"Meghan Kates, Alexa Fitzpatrick, Yupeng Zhang, Alison Gibbs, Qin Liu, Alan da Silveira Fleck, Leora Freedman, Stavroula Andreopoulos","doi":"10.1002/bmb.70043","DOIUrl":"10.1002/bmb.70043","url":null,"abstract":"<p><p>In previous work, we described the development and implementation of new pedagogical practices aimed at enhancing literacy, critical thinking, and communication skills development in a third-year undergraduate molecular biology course. The online nature and large size of the course presented challenges regarding student engagement and access to adequate support. To address these issues, we created four assignments (Journal Article, TED-style Talk, Reflective, and Concept Map) to build scientific literacy skills. To develop the intended skills, we designed interactive e-learning modules with active learning opportunities and practice activities to provide effective feedback. Here, we present an evaluation of the outcomes of this work by comparing student engagement in the modules with learning outcomes and academic performance indicators. The majority of students indicated that the e-modules were conducive to their learning and acquisition of scientific literacy skills. Additionally, most students found that all individual e-modules and associated assignments supported their learning, with somewhat lower agreeance among students regarding the Journal Article assignment. This feedback and student performance on the assignment supported our hypothesis that students lack practice developing these skills earlier in their education. Overall, there was a trend showing that higher student engagement with the e-modules was associated with higher assignment scores and final grades. Therefore, the e-modules and assignments supported the goals of improving targeted skills and contributed to an overall positive learning environment for students. These data demonstrate the utility of online e-modules for student learning and the usefulness of learning analytics data to better understand the student experience.</p>","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":" ","pages":"226-242"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13206462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147368806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}