{"title":"Fabrication of metal complex phthalocyanine and porphyrin nanoparticle aqueous colloids by pulsed laser fragmentation in liquid and their potential application to a photosensitizer for photodynamic therapy.","authors":"Taisei Himeda, Risako Kunitomi, Ryosuke Nabeya, Tamotsu Zako, Tsuyoshi Asahi","doi":"10.3762/bjnano.16.80","DOIUrl":"10.3762/bjnano.16.80","url":null,"abstract":"<p><p>We prepared stable nanoparticle dispersions of metal complex phthalocyanines (MPcs; M = AlCl, Fe, Co, Zn) and Pt complex octaethylporphyrin (PtOEP) by nanosecond laser fragmentation of the corresponding microcrystalline powders in an aqueous solution of the amphiphilic polymer Pluronic<sup>®</sup> F-127. All nanoparticles dispersed stably in phosphate-buffered saline and cell culture media without any precipitation for longer than one week. The aqueous F-127 solution at 0.1 wt % concentration, which is about one tenth of the critical micelle concentration, was enough to fabricate nanoparticles with excellent dispersion stability and high production efficiency. We examined the photosensitized generation of reactive oxygen species by AlClPc, ZnPc, and PtOEP nanoparticles and the photocytotoxicity for PC12 and HeLa cells, and demonstrated that the nanoparticles can be used as photosensitizers for photodynamic therapy.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"1088-1096"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Single-layer graphene oxide film grown on α-Al<sub>2</sub>O<sub>3</sub>(0001) for use as an adsorbent.","authors":"Shiro Entani, Mitsunori Honda, Masaru Takizawa, Makoto Kohda","doi":"10.3762/bjnano.16.79","DOIUrl":"10.3762/bjnano.16.79","url":null,"abstract":"<p><p>Graphene oxide (GO) is expected to be one of the most promising adsorbents for metal ions, including radioactive nuclides in aqueous solutions. Large-area and single-layer graphene oxide (SLGO) grown on α-Al<sub>2</sub>O<sub>3</sub>(0001) was used as a model structure of GO since the aggregation and re-stacking of the GO sheets prevent the adequate analysis of the adsorption state. The SLGO film was obtained by oxidizing monolayer graphene grown by metal-free chemical vapor deposition on the α-Al<sub>2</sub>O<sub>3</sub>(0001) surface, and the adsorption state was determined by surface analytical techniques. It was clarified that Cs adsorbs on oxygen functional groups by substituting with H atoms from carboxyl and hydroxy groups. It is also estimated that the weight adsorption capacity of SLGO in the 1.0 mol/L-Cs aqueous solution is as much as approximately 70 wt %. It has been demonstrated that GO has great potential to be a promising adsorbent for Cs in aqueous solutions.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"1082-1087"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sevin Adiguzel, Nilay Cicek, Zehra Cobandede, Feray B Misirlioglu, Hulya Yilmaz, Mustafa Culha
{"title":"Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts.","authors":"Sevin Adiguzel, Nilay Cicek, Zehra Cobandede, Feray B Misirlioglu, Hulya Yilmaz, Mustafa Culha","doi":"10.3762/bjnano.16.78","DOIUrl":"10.3762/bjnano.16.78","url":null,"abstract":"<p><p>Bone tissue, also known as bone, is a hard and specialized connective tissue consisting of various bone cells. Internally, it has a honeycomb-like matrix providing rigidity to the bone and a piezoelectric feature contributing to bone remodeling. Bone remodeling is a crucial process involving osteoblastic replacement and resorption by osteoclastic cells to maintain structural integrity and mechanical properties of the bone tissue as it grows. However, in cases of fracture or degeneration, the natural self-regeneration process or inherent piezoelectricity of the body may not be sufficient to repair the damage. To address this, the use of piezoelectric nanomaterials (NMs) in bone tissue engineering was investigated. In this study, the influence of the piezoelectric hexagonal boron nitrides (hBNs) and barium titanate (BaTiO<sub>3</sub>) on human osteoblasts (HOb) was comparatively evaluated. The synthesized hBNs and purchased BaTiO<sub>3</sub> were used after their full characterization by imaging and spectroscopic techniques. The piezoelectric behavior of both NMs was evaluated using piezoresponse force microscopy (PRFM). During in vitro studies, the piezoelectricity of the NMs was stimulated with ultrasound (US) exposure. The results showed that the NMs are not cytotoxic at the concentrations tested and the migration ability and calcium deposit formation of the cells treated with the NMs and upon US exposure were significantly increased. These results demonstrate that the hBNs have the potential to accelerate bone tissue regeneration and promote bone healing. These findings offer a promising avenue for developing new therapies for bone-related injuries and conditions requiring significant bone remodeling.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"1068-1081"},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others.","authors":"Katsuhiko Ariga","doi":"10.3762/bjnano.16.77","DOIUrl":"10.3762/bjnano.16.77","url":null,"abstract":"<p><p>The concept of nanoarchitecture, as a post-nanotechnology methodology, can be defined as the construction of functional materials from nanometer-sized units using a variety of materials processes. It is believed to be particularly well suited to the assembly of soft materials that exhibit flexible and diverse structures and properties. To demonstrate its effectiveness, this review takes typical soft materials, including liquid crystals, polymers, gels, and biological materials, as examples. The aims are to extract the properties that emerge from them and to highlight the challenges that lie ahead. The examples also illustrate the potential applications, including organic semiconductor devices, electrochemical catalysts, thin-film sensors, solar energy generation, plastic crystal electrolytes, microactuators, smart light-responsive materials, self-repairing materials, enzyme cascade sensors, healing materials for diabetic bone defects, and bactericidal materials. As can be seen from these examples, soft materials nanoarchitectonics offers a wide range of material designs, specific functions, and potential applications. In addition, this review examines the current state and future of soft materials nanoarchitectonics. As an overall conclusion, it is highly anticipated that soft materials nanoarchitectonics will continue to develop significantly in the future.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"1025-1067"},"PeriodicalIF":2.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Volodymyr Krasinskyi, Krzysztof Bajer, Ludmila Dulebova, Nickolas Polychronopoulos, Oksana Krasinska, Daniel Kaczor
{"title":"Multifunctional properties of bio-poly(butylene succinate) reinforced with multiwalled carbon nanotubes.","authors":"Volodymyr Krasinskyi, Krzysztof Bajer, Ludmila Dulebova, Nickolas Polychronopoulos, Oksana Krasinska, Daniel Kaczor","doi":"10.3762/bjnano.16.76","DOIUrl":"10.3762/bjnano.16.76","url":null,"abstract":"<p><p>Recent advances in nanocomposite technology, particularly the incorporation of carbon nanotubes, have shown promise in enhancing the properties of biodegradable polymers. This study investigated the effect of a 0.5 wt % addition of multiwalled carbon nanotubes (MWCNTs) on the properties of bio-poly(butylene succinate) (BioPBS) using a masterbatch-based melt compounding method. The incorporation of MWCNTs enhanced the mechanical strength and stiffness, improved the tribological properties by reducing friction, and increased the crystallization temperature. However, it also resulted in a decrease in elasticity. Morphological analysis confirmed the uniform dispersion of the nanotubes. These findings underscore the potential of MWCNTs to tailor the properties of BioPBS for specific applications, such as in the packaging, automotive, and biomedical industries, where both biodegradability and enhanced material performance are desirable.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"1014-1024"},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A calix[4]arene-based supramolecular nanoassembly targeting cancer cells and triggering the release of nitric oxide with green light.","authors":"Cristina Parisi, Loredana Ferreri, Tassia J Martins, Francesca Laneri, Samantha Sollima, Antonina Azzolina, Antonella Cusimano, Nicola D'Antona, Grazia Maria Letizia Consoli, Salvatore Sortino","doi":"10.3762/bjnano.16.75","DOIUrl":"10.3762/bjnano.16.75","url":null,"abstract":"<p><p>We have designed and synthesized a novel calix[4]arene derivative bearing four choline appendages as recognition targeting ligands and one amino-nitrobenzofurazan as a fluorescent labelling unit at the opposite sides of the calixarene molecular scaffold. Due to its amphiphilic character, this compound is well soluble in water, forming supramolecular assemblies that are ca. 170 nm in diameter. The nanoassembly selectively targets cancer cells that overexpress the choline transporters, and it can be visualized thanks to the fluorescent tag. The fluorogenic unit also acts as a green light harvesting center, making the nanoassembly a photo-nanoreactor able to encapsulate a hydrophobic nitric oxide (NO) photodonor, otherwise activatable with blue light, and encouraging the NO release with the more biocompatible green light probably by an intra-cage photoinduced electron transfer.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"1003-1013"},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maximilian Spellauge, David Redka, Mianzhen Mo, Changyong Song, Heinz Paul Huber, Anton Plech
{"title":"Time-resolved probing of laser-induced nanostructuring processes in liquids.","authors":"Maximilian Spellauge, David Redka, Mianzhen Mo, Changyong Song, Heinz Paul Huber, Anton Plech","doi":"10.3762/bjnano.16.74","DOIUrl":"10.3762/bjnano.16.74","url":null,"abstract":"<p><p>Laser synthesis and processing of colloids (LSPC) in liquids has gained widespread applications in producing nanomaterials of different classes of solids. While the technical processes in different cases of ablation, fragmentation or colloidal fusion may look macroscopically different in each application, the underlying fundamental mechanisms are always the same cascade of laser interaction with matter, non-thermal or thermal energy deposition, phase transitions, and the subsequent structure formation processes. Disentangling these mechanisms represents a veritable challenge, as ultrafast and structurally sensitive experimental methods are required. This review presents a discussion of how state-of-the-art experimental protocols using ultrafast lasers and sensitive structural probes, such as electrons or X-rays are able to address this challenge. In particular, it is possible to investigate LSPC on single objects using single probe pulses and avoid accumulation effects in a heterogeneous sample. The presented results capture structure formation with femtosecond and atomic scale resolution. Ultrafast time-resolved probing approaches are key to revealing the transient states and pathways that govern material transformation in LSPC.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"968-1002"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric Lieberwirth, Anja Schaeper, Regina Lange, Ingo Barke, Simone Baltrusch, Sylvia Speller
{"title":"Shape, membrane morphology, and morphodynamic response of metabolically active human mitochondria revealed by scanning ion conductance microscopy.","authors":"Eric Lieberwirth, Anja Schaeper, Regina Lange, Ingo Barke, Simone Baltrusch, Sylvia Speller","doi":"10.3762/bjnano.16.73","DOIUrl":"10.3762/bjnano.16.73","url":null,"abstract":"<p><p>Mitochondrial network dynamics play a key role in enabling cells to adapt to environmental changes. Fusion and fission of mitochondria, as well as their contact with other organelles, are central processes. Consequently, the outer membrane, which separates the mitochondrion from the cytoplasm, has become a focus of investigation. We analysed metabolically active mitochondria from HeLa cells using scanning ion conductance microscopy to generate nanoscopically resolved, three-dimensional topographies. Our measurements reveal the diversity of mitochondrial shapes. Moreover, a morphodynamic effect was identified, the magnitude of which depends on mitochondrial viability. This method, applied for the first time to mitochondria, shows potential for visualising the morphodynamic responses of mitochondria to their local environment. The similarities between the nanopipette in the measurement setup and the microtubules in the cellular context are discussed as the basis for the hypothesis.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"951-967"},"PeriodicalIF":2.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tendency in tip polarity changes in non-contact atomic force microscopy imaging on a fluorite surface.","authors":"Bob Kyeyune, Philipp Rahe, Michael Reichling","doi":"10.3762/bjnano.16.72","DOIUrl":"10.3762/bjnano.16.72","url":null,"abstract":"<p><p>We investigate the impact of tip changes on atomic-scale non-contact atomic force microscopy (NC-AFM) contrast formation when imaging a CaF<sub>2</sub>(111) surface. A change of the atomic contrast is explained by a polarity change of the tip-terminating cluster or by a polarity-preserving tip change via the re-arrangement of the foremost atoms. Based on the established understanding of the unique contrast patterns on CaF<sub>2</sub>(111), polarity-preserving and polarity-changing tip changes can be identified unambiguously. From analyzing a large set of images, we find that the vast majority of tip changes tend to result in negative tip termination. This analysis delivers hints for tip configurations suitable for stable imaging of CaF<sub>2</sub>(111) surfaces.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"944-950"},"PeriodicalIF":2.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of biowaste-derived carbon-dot-mediated silver nanoparticles and the evaluation of electrochemical properties for supercapacitor electrodes.","authors":"Navya Kumari Tenkayala, Chandan Kumar Maity, Md Moniruzzaman, Subramani Devaraju","doi":"10.3762/bjnano.16.71","DOIUrl":"10.3762/bjnano.16.71","url":null,"abstract":"<p><p>Herein, biowaste- (from <i>Pongammia pinnata</i> leaves) derived carbon dots (CDs) have been utilized as a mediator for the production of silver nanoparticles (PG-CDs-AgNPs) as a superior supercapacitor electrode. The methodology presented here is inexpensive and environmentally friendly as CDs play a role as capping, reducing, and stabilizing agent without addition of any chemicals. PG-CDs-AgNPs showed a particle size of 10 nm having excellent fluorescence emission in the blue region, and it has been explored as an electrode material for supercapacitor applications. The as-synthesized PG-CDs-AgNPs electrode exhibited the maximum specific capacitance of 540 F/g in a three-electrode study. The asymmetric supercapacitor (ASC) device with PG-CDs-AgNPs as the positive electrode reached the maximum specific capacitance of 200 F/g having a superior energy density of 71 W·h/kg at 1.5 A/g. Even at a high current density of 4 A/g, the ASC device reached a specific capacitance of 175 F/g, reinforcing its capability. The method described here provides a straightforward green approach towards biowaste-derived CD-mediated synthesis of AgNPs to produce efficient supercapacitor electrodes for energy storing.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"933-943"},"PeriodicalIF":2.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}