Belgorod State University Scientific bulletin Medicine Pharmacy最新文献_第5页

Approbation of the method of enzymatic hydrolysis on natural and dyed hair for the extraction of medicinal substances 天然和染色头发酶解法提取药用物质的研究

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-659-671

M. V. Krys'ko, Saint-Petersburg State Chemical, Yu. V. Slustovskaya, O. Strelova, V. Kuklin

{"title":"Approbation of the method of enzymatic hydrolysis on natural and dyed hair for the extraction of medicinal substances","authors":"M. V. Krys'ko, Saint-Petersburg State Chemical, Yu. V. Slustovskaya, O. Strelova, V. Kuklin","doi":"10.18413/2075-4728-2018-41-4-659-671","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-4-659-671","url":null,"abstract":"The objective of the present study was to test the developed methods of enzymatic hydrolysis on natural and dyed fur (hair) and analyze the effect of bleaching on the results of a chemical toxicological analysis. The experiments were carried out with the used laboratory animals (red hair and black hair female guinea pigs) that had been daily given a diphenhydramine solution per os during 6 months preceding the study. It was shown that natural black and red hair (fur) have a similar composition of endogenous substances. Bleaching is a process of gaining much lighter hair color than natural one. And along with this, there is a destruction of natural hair pigment. The effect of the bleaching does not affect the background level of endogenous substances and does not interfere with the further determination of the model drug substance. Methods of enzymatic hydrolysis can be used to isolate substances from both natural colored and dyed hair (fur). The degree of extraction of diphenhydramine, a model drug substance, from bleached fur was 1.5-2 times higher than the degree of extraction of it from natural colored, which should be take into consideration when interpreting the results. This study can be used to diagnose the use of narcotic drugs and psychotropic substances. It is planned to conduct further studies on sectional analysis of hair. of synthetic psychoactive substances and their metabolites in and nails by liquid chromatography methods with mass spec-trometric detection] Informacionnoe Стрелова О.Ю., Сивакова М.А. 2017. Применение методики","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73540817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Development and validation of spectrophotometric quantitative determination of terpene-indole alkaloids (for example, vincristine sulfate and vinblastine sulfate) 萜烯-吲哚类生物碱(如硫酸长春新碱和硫酸长春新碱)分光光度法定量测定方法的建立与验证

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-687-702

O. V. Trineeva, A. J. Halahakun, A. I. Slivkin

引用次数: 0

Analysis of hospital purchases of antimicrobial drugs in the framework of the pharmaceutical market the North-Western Federal District 西北联邦区医药市场框架下医院抗菌药物采购情况分析

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-672-686

D. D. Siukaeva, Saint-Petersburg State Chemical, I. Narkevich, O. D. Nemyatych, I. I. Basakina

{"title":"Analysis of hospital purchases of antimicrobial drugs in the framework of the pharmaceutical market the North-Western Federal District","authors":"D. D. Siukaeva, Saint-Petersburg State Chemical, I. Narkevich, O. D. Nemyatych, I. I. Basakina","doi":"10.18413/2075-4728-2018-41-4-672-686","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-4-672-686","url":null,"abstract":"The results of the analysis of the hospital segment of the national and regional markets in the period from 2013 to 2017 are presented in the paper. It was established that volume of the Russian pharmaceutical market for hospital purchases grew by 42 % in value terms and by 8 % in physical terms over the study period. At the same time, the share of drugs represented by foreign manufacturers decreased by 5 % in value terms and by 2 % in physical terms, respectively. It has been established that in the given research conditions the group J «Antimicrobial drugs of systemic action» is the leader in the overall structure of national procurement, covering more than 30.0-35.5 % in value and more than 26.0-30.0 than 50 % of the range of antibacterial drugs. It is shown that in the structure of procurement, leading positions in terms of value were noted for foreign manufacturers, in natural units, domestic two producers play a leading role (more than 40 % of the assortment) both in the national and regional markets. At the same time, the vaccine for the prevention of pneumococcal infections (6-8 %) leads in cost terms, in natural units, ceftriaxone (about 20 %).","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81313446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Novosibirsk as a center of regional medical tourism: potential and implementation aspects 新西伯利亚作为区域医疗旅游中心:潜力和实施方面

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-600-615

N. Goroshko, E. Emelyanova, N. Nikiforova, Biotechnology “Vector”

引用次数: 1

Analysis of the results of primary accreditation of the graduates in the field of general medicine in the center of simulation training and assessment of professional skills of Belgorod National Research Universit 别尔哥罗德国立研究型大学模拟培训和专业技能评估中心对全科医学领域毕业生的初步认证结果分析

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-584-590

V. F. Kulikovsky, Y. A. Khoschenko, T. A. Nachetova, A. Nagorny

{"title":"Analysis of the results of primary accreditation of the graduates in the field of general medicine in the center of simulation training and assessment of professional skills of Belgorod National Research Universit","authors":"V. F. Kulikovsky, Y. A. Khoschenko, T. A. Nachetova, A. Nagorny","doi":"10.18413/2075-4728-2018-41-4-584-590","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-4-584-590","url":null,"abstract":"There are the results of the second round of accreditation of the graduates in the field of general medicine in Belgorod National Research University. The article explains reasons for using such indicators in assessing of professional skills quality as the average score in the accredited group for each station, percentage of persons attaining the highest grades, identification of the nature of the most frequent errors. In 2018 the graduates have higher rates of correctly implemented procedures than received in 2017 at such stations as emergency medical care ((95.79±1.70 % VS 86.63±2.95 %, Р<0.05), urgent medical care (98.34±1.08 % VS 88.77±2.76 %, Р<0.05), physical examination of cardiovascular system (97.10±1.42 % VS 90.84±2.52 %, Р<0.05). This article illustrates that raised level of skills and knowledge in 2018 is due to increasing the time available for preparations which became possible through the development of tutoring movement, students' participation in practical training competitions and the opening of The Center For Simulation Training And Assessment Of Professional Qualifications Of The Department Of Medical And Pharmaceutical Supplementary Education, Certification And Accreditation. It is stressed the need to increase the number of systematic practical skills training in simulated conditions for students of the Medical Institute. аккредитация, качество образования, практикоориентированная","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73165964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of thiotriazoline on the state of cellular and humoral immunity in patients with community-acquired pneumonia 硫代三唑啉对社区获得性肺炎患者细胞和体液免疫状态的影响

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-558-567

V. I. Vishnevskij, I. I. Mironenko, O. Demyanenko

引用次数: 0

Complex evaluation of the effect of prevention of sexually transmitted infections among young people of Kursk Region 库尔斯克地区青少年预防性传播感染效果的综合评价

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-640-651

A. G. Lastovetsky, V. I. Timoshilov

{"title":"Complex evaluation of the effect of prevention of sexually transmitted infections among young people of Kursk Region","authors":"A. G. Lastovetsky, V. I. Timoshilov","doi":"10.18413/2075-4728-2018-41-4-640-651","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-4-640-651","url":null,"abstract":"Sexually transmitted infections (STI) are one of the main medical and social problems of young people. The base of their prevention is formed by educational events for youth. In 2014 it was conducted a study, which shows a positive preventive effects of lectures and consults of doctors, watching of educational video, reading of special literature, self-making of informational materials and medical screening. As kinds of activities with negative effect were marked Internet-projects, social advertising, volunteer’s activities and discussions. The results of this study were presented during educational courses for doctors and teachers. The aim of the study in 2017 year was evaluating the effectiveness of the implementation of this recommendations. The program of the research included the survey of teenagers and the study of epidemiological data. The results showed the raising of the coverage of teenagers by effective preventive НАУЧНЫЕ ВЕДОМОСТИ |\"Ъ Серия Медицина. Фармация. 2018. Том 41, No 4 641 activities, decreasing of incidence of STI and reducing the proportion of young people among newly diagnosed patients. Ключевые слова: половые инфекции, молодежь, профилактика, заболеваемость, оценка эффективности","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80961270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of value of blood-brain barrier of acute lymphoblastic leukemia and neuroleukemia 急性淋巴细胞白血病与神经细胞白血病血脑屏障的价值分析

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-568-575

I. A. Dzhanybekova

引用次数: 1

Modern aspects of pathogenesis acute hematogenous osteomyelitis 急性血液性骨髓炎发病机制的现代方面

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-539-546

S. V. Kostin, V. P. Gavriliuk, D. A. Severinov, M. I. Statina

引用次数: 1

The impact of communication doctor – patient's parents on the level of parental compliance in the treatment of children with chronic gastroduodenal pathology associated with Helicobacter pylori 医患父母沟通对幽门螺杆菌相关慢性胃十二指肠病理患儿治疗依从性的影响

Belgorod State University Scientific bulletin Medicine Pharmacy Pub Date : 2018-12-30 DOI: 10.18413/2075-4728-2018-41-4-616-624

A. Barinova, A. V. Nalyotov, S. V. Nalyotov

{"title":"The impact of communication doctor – patient's parents on the level of parental compliance in the treatment of children with chronic gastroduodenal pathology associated with Helicobacter pylori","authors":"A. Barinova, A. V. Nalyotov, S. V. Nalyotov","doi":"10.18413/2075-4728-2018-41-4-616-624","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-4-616-624","url":null,"abstract":"The aim of the study was to determine the influence of communication between the doctor - patient's parents on the level of parental compliance in families of children suffering from chronic gastroduodenal pathology associated with H. pylori. 103 children of school age suffering from chronicgastroduodenal pathology associated with H. pylori were examined. The anti-H. pylori therapy scheme was prescribed for all children. The decrease in parental compliance was noted in more than 2/3 of the surveyed families. The low level of communication between the doctor and the patient's parents was established. The doctor's dialogue with the parents of a sick child takes place in conditions of limited time provided to the specialist during the consultation. Establishment of interpersonal relationships in the \"doctor- patient's parents\" system, working with parents, aimed at explaining the essence of the disease, the consequences of the disease, treatment tactics are an important stage in the therapy of a sick child. дети, хроническая Helicobacter","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79192221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0