The open clinical cancer journal最新文献

Human Papillomavirus Integration and its Role in Cervical Malignant Progression 人乳头瘤病毒整合及其在宫颈恶性进展中的作用

The open clinical cancer journal Pub Date : 2011-01-25 DOI: 10.2174/1874189401105010001

R. Raybould, A. Fiander, S. Hibbitts

引用次数: 20

Psoas Abscess after Radical Abdominal Hysterectomy: A Case Report and Review of the Literature 腹部子宫根治性切除术后腰肌脓肿1例报告及文献复习

The open clinical cancer journal Pub Date : 2010-10-29 DOI: 10.2174/1874189401004010015

D. Spiliopoulos, K. Galaal, K. Godfrey, R. Naik

引用次数: 1

Oral Mucositis, Pain and Xerostomia in Patients with Head and Neck Cancer who Received Chemoradiotherapy with or without Cetuximab 接受西妥昔单抗或不含西妥昔单抗放化疗的头颈癌患者的口腔黏膜炎、疼痛和口干

The open clinical cancer journal Pub Date : 2010-08-26 DOI: 10.2174/1874189401004010006

O. Nicolatou‐Galitis, T. Sarri, K. Dardoufas, V. Kouloulias, Xenophon Vakalis, A. Polychronopoulou, D. Demenagas, A. Sotiropoulou-Lontou

{"title":"Oral Mucositis, Pain and Xerostomia in Patients with Head and Neck Cancer who Received Chemoradiotherapy with or without Cetuximab","authors":"O. Nicolatou‐Galitis, T. Sarri, K. Dardoufas, V. Kouloulias, Xenophon Vakalis, A. Polychronopoulou, D. Demenagas, A. Sotiropoulou-Lontou","doi":"10.2174/1874189401004010006","DOIUrl":"https://doi.org/10.2174/1874189401004010006","url":null,"abstract":"Goal of work: To compare the severity of oral mucositis, pain and xerostomia in head and neck cancer patients, who received radiotherapy with cisplatin and cetuximab to that of patients who received radiotherapy with cisplatin alone. Patients: Forty-nine head and neck cancer patients entered the study. Twenty-five patients (Group A) received radiotherapy and cisplatin. Twenty-four patients (Group B) received radiotherapy, cisplatin, and cetuximab. Methods: Oral mucositis was recorded weekly, according to EORTC/RTOG criteria. Pain and xerostomia were assessed using a 10cm visual analogue scale. Antifungal and antiviral treatment and prophylaxis were administered during RT to both groups. Results: During chemoradiotherapy, severe mucositis, pain and xerostomia were observed in 60%, 64% and 52% respectively in Group A, while the same symptoms were observed in 79%, 58% and 29% respectively in Group B. The differences between the two groups were not statistically significant. At the end of chemoradiotherapy, severe mucositis, pain and xerostomia were recorded in 24%, 32% and 32% in Group A and 37%, 21% and 17% respectively in Group B. The differences between the two groups were, again, statistically not significant. Neither significant differences were found between the two groups with respect to the use of antifungal and antiviral treatment, radiotherapy interruptions and weight loss. In both groups, oral mucositis, pain and xerostomia were significantly reduced at the end of radiotherapy as compared to those during RT, following the anti-infectious treatment and prophylaxis. Conclusion: Cetuximab, added to cisplatin/radiotherapy, did not increase the severity of oral mucositis, pain and xerostomia, in head and neck cancer patients, with limitations of the study design and its limited number of patients.","PeriodicalId":87833,"journal":{"name":"The open clinical cancer journal","volume":"20 77 1","pages":"6-14"},"PeriodicalIF":0.0,"publicationDate":"2010-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80753658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Rare Tumors: An Appeal for Justice 罕见肿瘤:对正义的呼吁

The open clinical cancer journal Pub Date : 2010-08-24 DOI: 10.2174/1874189401004010003

E. Bloustein

引用次数: 0

Redox Status and Ascorbic Acid in Carcinoma of Head and Neck is Correlated to Clinical Response 头颈部癌的氧化还原状态和抗坏血酸与临床反应相关

The open clinical cancer journal Pub Date : 2010-05-13 DOI: 10.2174/1874189401004010001

Aashita Gupta, J. Verma, M. Bhatt, M. K. Misra

引用次数: 1

Oncolytic Effects of the E Variant of Encephalomyocarditis Virus to Human Neuroblastoma in in Vitro and in Vivo 脑心肌炎病毒E型变异对人神经母细胞瘤的体外和体内溶瘤作用

The open clinical cancer journal Pub Date : 2009-11-26 DOI: 10.2174/1874189400903010001

M. Adachi, S. Brooks, M. R. Stein, B. E. Franklin, F. Caccavo

{"title":"Oncolytic Effects of the E Variant of Encephalomyocarditis Virus to Human Neuroblastoma in in Vitro and in Vivo","authors":"M. Adachi, S. Brooks, M. R. Stein, B. E. Franklin, F. Caccavo","doi":"10.2174/1874189400903010001","DOIUrl":"https://doi.org/10.2174/1874189400903010001","url":null,"abstract":"The oncolytic effects of encephalomyocarditis (EMC) virus on of human neuroblastoma (NB) were studied in vitro employing NB cell cultures and in vivo employing tumors grown in nude mice and nude rats. In short-term studies, human NB cell (HTB10) cultures were exposed to the virus 10 4 Tissue Culture Infectious Doses (TCIDs). The TCIDs were used to titer the maximum effect of EMC virus on L-929 cells. In vitro studies showed 100% Cytopathic Effect (CPE) at 48 hours. The CPE was used to observe pathologic effects of the cells. The in vivo studies showed necrosis and degeneration in the tumors grown in nude mice at 7 days following treatment with the virus. The nude mice exhibited a high mortality rate after exposure to the virus. The long-term studies were performed on tumors grown in nude rats, since they were more tolerant to the viral treatment. On the 58th day after the viral treatment of tumor bearing rats, 8 out of the 12 tumors had disappeared, and the remaining 4 tumors were grossly necrotic. The average size of the infected tumors was 2.13 cm 2 as compared with 30.5 cm 2 in the control. Microscopically the treated tumors showed severe necrosis and microcystic degeneration. The observed gross decrease in treated tumor size together with the presented light and electron microscopic studies, support the potential value of viral treatment of neuroblastoma.","PeriodicalId":87833,"journal":{"name":"The open clinical cancer journal","volume":"33 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2009-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80407149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individualized Survival and Treatment Response Predictions in Breast Cancer Patients: Involvements of Phospho-EGFR and Phospho-Her2/neu Proteins. 乳腺癌患者的个体化生存和治疗反应预测:磷酸化- egfr和磷酸化- her2 /neu蛋白的参与

The open clinical cancer journal Pub Date : 2008-05-27 DOI: 10.2174/1874189400802010018

Lan Guo, Jame Abraham, Daniel C Flynn, Vincent Castranova, Xianglin Shi, Yong Qian

{"title":"Individualized Survival and Treatment Response Predictions in Breast Cancer Patients: Involvements of Phospho-EGFR and Phospho-Her2/neu Proteins.","authors":"Lan Guo, Jame Abraham, Daniel C Flynn, Vincent Castranova, Xianglin Shi, Yong Qian","doi":"10.2174/1874189400802010018","DOIUrl":"https://doi.org/10.2174/1874189400802010018","url":null,"abstract":"Our robust prediction system for individual breast cancer patients combines three well-known machine-learning classifiers to provide stable and accurate clinical outcome prediction (N=269). The average performance of the selected classifiers is used as the evaluation criterion in breast cancer outcome predictions. A profile (incorporating histology, lymph node status, tumor grade, tumor stage, ER, PR, Her2/neu, patient's age and smoking status) generated over 95% accuracy in individualized disease-free survival and treatment response predictions. Furthermore, our analysis demonstrated that the measurement of phospho-EGFR and phospho-Her2/neu is more powerful in breast cancer survival prediction than that of total EGFR and total Her2/neu (p < 0.05). The incorporation of hormone receptor status, Her2/neu, patient's age and smoking status into the traditional pathologic markers creates a powerful standard to perform individualized survival and treatment outcome predictions for breast cancer patients.","PeriodicalId":87833,"journal":{"name":"The open clinical cancer journal","volume":"2 ","pages":"18-31"},"PeriodicalIF":0.0,"publicationDate":"2008-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282131/pdf/nihms650818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32950166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Changing Management of Esophageal Carcinoma: Survival in a Population Cohort 1985-1994 食管癌治疗方法的改变:1985-1994年人群队列的生存率

The open clinical cancer journal Pub Date : 2008-04-01 DOI: 10.2174/1874189400802010044

T. Bates, A. Antoniou, R. Marshall, M. Harrison, E. Bassett

引用次数: 0

Expression of Nuclear β-Catenin in Rectal Versus Colonic Cancers 核β-连环蛋白在直肠癌和结肠癌中的表达

The open clinical cancer journal Pub Date : 2008-03-18 DOI: 10.2174/1874189400802010013

R. Aamodt, J. Bondi, S. Andersen, G. Bukholm, I. Bukholm

引用次数: 6

Epithelial ovarian cancer: the role of cell cycle genes in the different histotypes. 上皮性卵巢癌:细胞周期基因在不同组织型中的作用。

The open clinical cancer journal Pub Date : 2008-02-06 DOI: 10.2174/1874189400802010007

Giuseppina D'Andrilli, Antonio Giordano, Alessandro Bovicelli

引用次数: 21