The open clinical cancer journal最新文献

{"title":"Metabolic profile of breast cancer in a population of women in southern Spain.","authors":"Juan-Bosco Lopez-Saez,&nbsp;Jose Antonio Martinez-Rubio,&nbsp;Maria Montes Alvarez,&nbsp;Carmen Gonzalez Carrera,&nbsp;Margarita Dominguez Villar,&nbsp;Antonio Garcia de Lomas Mier,&nbsp;Charo Doménech,&nbsp;Avelino Senra-Varela","doi":"10.2174/1874189400802010001","DOIUrl":"https://doi.org/10.2174/1874189400802010001","url":null,"abstract":"<p><strong>Background: </strong>There are indications that mortality in breast cancer is related with dietary factors, but no study has been large enough to characterise reliably how, this risk is influenced. To establish a logistic regression equation that would predict breast cancer from factors in the endocrinological and metabolic profile, we studied endocrinological and metabolic risk factors that are modified by the diet, in a population of women with breast cancer in southern Spain.</p><p><strong>Patients and methods: </strong>We carried out a simple a case-control study comparing 204 women with breast cancer (96 premenopausal and 108 postmenopausal women) and 250 healthy control subjects. The predictive variables were basal glycaemia, insulin, glycosylated haemoglobin (HbA1c), C-peptide, insulin-like growth factor-I (IGF-I), total cholesterol, triglycerides, high density lipoprotein-c (HDL-C), low density lipoprotein-c (LDL-C), selenium and Quetelet index (BMI).</p><p><strong>Results: </strong>The metabolic profile differed between pre- and postmenopausal patients, and metabolic alterations were greater in postmenopausal than in premenopausal women. The differences between healthy subjects and breast cancer patients were clearly significant.</p><p><strong>Conclusions: </strong>Our findings have several potential practical applications in the early detection of breast cancer, especially in premenopausal women; in primary prevention; and in the development of a mathematical model of breast carcinogenesis.</p>","PeriodicalId":87833,"journal":{"name":"The open clinical cancer journal","volume":"2 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2008-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27565186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Factors are Associated with Where Women Undergo Clinical Breast Examination? Results from the 2005 National Health Interview Survey.","authors":"Steven S Coughlin,&nbsp;Susan A Sabatino,&nbsp;Kate M Shaw","doi":"10.2174/1874189400802010032","DOIUrl":"https://doi.org/10.2174/1874189400802010032","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have suggested that clinical breast examination (CBE) rates may vary according to patient, provider and health care system characteristics.</p><p><strong>Objective: </strong>To examine the locations where U.S. women received a CBE and other general preventive health, and to examine predictors of location of receipt of general preventive health care (including a recent CBE).</p><p><strong>Design: </strong>Age-specific and age-adjusted rates of CBE use were calculated using Statistical Analysis Software (SAS) and SUDAAN. A multivariate analysis was carried out using logistic regression techniques.</p><p><strong>Participants: </strong>Women aged 40 years and older (n = 10,002) who participated in the 2005 National Health Interview Survey (NHIS).</p><p><strong>Measurements: </strong>Recent CBE use was defined as within the past two years.</p><p><strong>Results: </strong>Among all women, 65% reported a CBE within two years. The highest rate was found among women receiving routine care from doctors' offices and health maintenance organizations (HMOs) (68.5%). CBE use was somewhat lower among women receiving routine care from clinics or health centers (62.9%), and substantially lower among women receiving care from \"other\" locations (28.4%) or not reporting receiving preventive care (25.3%). Low income women (p < .01) and those with less than a high school education (p < .01) are more likely to go to a hospital than higher SES women. Women with health insurance are much more likely than women without health insurance to go to a doctor's office or HMO, and less likely to be seen at a clinic or health center (p < .01 in both instances). In multivariate analysis, women who received routine care in a location other than a clinic or health center, doctor's office or HMO, or hospital outpatient department (OPD) were less likely to have received a CBE within the past two years (adjusted OR = 0.4, 95% CI = 0.3, 0.7) compared to those at a doctor's office or HMO.</p><p><strong>Conclusions: </strong>After adjusting for patient factors, clinics/health centers and hospital OPDs performed as well as doctors' offices/HMOs in delivering CBE. However, women receiving care in other locations were less likely to report CBE.</p>","PeriodicalId":87833,"journal":{"name":"The open clinical cancer journal","volume":"2 ","pages":"32-43"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638069/pdf/nihms77865.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27981675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of CEA and VEGF as Diagnostic Markers of Colorectal Cancer in Lebanese Patients.","authors":"Hashem A Dbouk,&nbsp;Ayman Tawil,&nbsp;Fahd Nasr,&nbsp;Loucine Kandakarjian,&nbsp;Raghida Abou-Merhi","doi":"10.2174/1874189400701010001","DOIUrl":"https://doi.org/10.2174/1874189400701010001","url":null,"abstract":"<p><p>Carcinoembryonic antigen and vascular endothelial growth factors are among the most important prognostic markers of colorectal cancer. Testing for these markers independently has been of limited value in screening for this tumor. The aim of this study is to determine the importance of simultaneous blood CEA and VEGF level determinations in diagnosis of colorectal cancer. Thirty-six patients diagnosed with colorectal cancer along with eight healthy controls were tested by ELISA for CEA and VEGF levels in serum and plasma, respectively. The positive predictive value of these markers was 95.4% for CEA and 89.5% for VEGF, and for combined CEA and VEGF was also high at 88%. Combined CEA and VEGF blood level assay constitutes a useful panel in detecting patients with colorectal cancer. Positive results allow selection of a subgroup of patients with a high tumor risk; therefore, such tests comprise valuable tumor diagnostic tests to add to current detection methods.</p>","PeriodicalId":87833,"journal":{"name":"The open clinical cancer journal","volume":"1 ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2007-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27565185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}