Biochemical medicine最新文献_第2页

Carl F. Cori and Sidney Colowick 卡尔·f·科里和西德尼·科洛维克

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90085-7

Samuel P. Bessman

引用次数: 0

Accumulation of hepatic collagen following long-term administration of sake to rats 大鼠长期服用清酒后肝胶原的积累

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90099-7

H. Nakatsukasa, M. Kobayashi, A. Watanabe, N. Hobara, M. Fujiwara, T. Shiota, Y. Yamauchi, T. Higashi, H. Nagashima

引用次数: 1

The influence of carbamazepine on the heme biosynthetic pathway 卡马西平对血红素生物合成途径的影响

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90089-4

Nili Schoenfeld , Yehudit Greenblat , Orit Epstein , Abraham Atsmon

引用次数: 6

Myoadenylate deaminase deficiency and malignant hyperthermia susceptibility: Is there a relationship? 肌腺苷酸脱氨酶缺乏与恶性高热易感性:有关系吗?

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90097-3

William N. Fishbein , Sheila M. Muldoon , Patricia A. Deuster , Vernon W. Armbrustmacher

{"title":"Myoadenylate deaminase deficiency and malignant hyperthermia susceptibility: Is there a relationship?","authors":"William N. Fishbein , Sheila M. Muldoon , Patricia A. Deuster , Vernon W. Armbrustmacher","doi":"10.1016/0006-2944(85)90097-3","DOIUrl":"10.1016/0006-2944(85)90097-3","url":null,"abstract":"<div><p>Muscle biopsies from 35 patients referred for possible malignant hyperthermia were subjected to contracture testing with halothane, caffeine, and the combined agents, histopathological and fiber-type-distribution analysis, and quantitative assay of three major muscle enzymes: adenylate deaminase, adenylate kinase, and creatine kinase. Adenylate kinase and creatine kinase were in the normal range in all biopsies and each averaged 92% of expected normal value when corrected for their fiber-type distribution. Of the 14 cases with a positive halothane test, 2 had primary myoadenylate deaminase deficiency, and 5 others had low levels of this enzyme (less than one-third normal). In contrast, only 3 of 21 cases negative to halothane testing had low adenylate deaminase levels, and none were deficient. This association was significant by several statistical tests, although it would not be highly predictive for an individual case. A positive halothane test also correlated wth a high type 2 fiber contribution, but this was probably secondary, since cases with low enzyme levels had significantly higher type 2 fiber areas. Caffeine contractures did not correlate with either low enzyme levels or with fiber-type distribution. Sixty percent of the biopsies were entirely normal histologically, and showed a significant correlation with a negative combined contracture test. Data on the one family included in this study suggest separate inheritance of the trait for myoadenylate deaminase deficiency and the trait for positive contracture tests. The present findings suggest that patients with myoadenylate deaminase deficiency (and the carrier state as well) may be at increased risk of malignant hyperthermia when subjected to anesthesia.</p></div>","PeriodicalId":8781,"journal":{"name":"Biochemical medicine","volume":"34 3","pages":"Pages 344-354"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-2944(85)90097-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15209407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Electrophoretic studies of human upper gastrointestinal mucosal acid proteinases 人上胃肠道粘膜酸性蛋白酶的电泳研究

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90093-6

Farhad Navab , Carlos E. Rubio , Michael D. Turner

引用次数: 0

The molecular weight-dependent distribution of urinary glycosaminoglycans in Werner's syndrome 尿糖胺聚糖在维尔纳综合征中的分子量依赖性分布

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90086-9

Katsumi Murata

引用次数: 3

The effect of dietary precursors on the excretion of amines and their metabolites in the rat 饮食前体对大鼠胺及其代谢物排泄的影响

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90094-8

M.L. Sedlock , Joshua Ravitch , David J. Edwards

引用次数: 4

Glycolytic and tricarboxylic acid cycle intermediates in dog livers during endotoxic shock 内毒素休克时狗肝脏中的糖酵解和三羧酸循环中间体

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90096-1

Maw-Shung Liu, Ji-Nan Zhang

{"title":"Glycolytic and tricarboxylic acid cycle intermediates in dog livers during endotoxic shock","authors":"Maw-Shung Liu, Ji-Nan Zhang","doi":"10.1016/0006-2944(85)90096-1","DOIUrl":"10.1016/0006-2944(85)90096-1","url":null,"abstract":"<div><p>The effects of endotoxin administration on glycolytic and tricarboxylic acid cycle intermediates in dog livers were studied. Changes in metabolite concentrations were expressed graphically as percentages of controls using “crossover” plots in order to identify transitory rate-controlling steps. The results show that endotoxin administration increased glycolytic flux through pyruvate kinase, inhibited gluconeogenic flux through phosphoenolpyruvate carboxykinase, decreased glycogen storage, shifted cytosolic and mitochondrial redox state from a relatively oxidized to a more reduced state, decreased the extra- and intramitochondrial malate-aspartate and glutamate-α-ketoglutarate shuttle activities, depleted ATP, ADP, and NADP concentrations, and decreased energy charge. Based on these data, it is concluded that pyruvate kinase plays the major role in the control of glycolysis, while phosphoenolpyruvate carboxykinase is the major controlling step for the regulation of gluconeogenesis in dog livers during endotoxic shock. In addition, the major factor in the regulation of metabolic pathways that produce and utilize high-energy phosphates in the livers was impaired in endotoxic shock.</p></div>","PeriodicalId":8781,"journal":{"name":"Biochemical medicine","volume":"34 3","pages":"Pages 335-343"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-2944(85)90096-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15209406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Editorial note 编辑注意

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90084-5

Samuel P. Bessman

引用次数: 0

A biochemical study on mothers of children with congenital neurodevelopmental abnormalities 先天性神经发育异常患儿母亲的生化研究

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90090-0

Gwilym Hosking , Jane Hosking , Pat Winstanley , Anne Green , Michael Grimsley

{"title":"A biochemical study on mothers of children with congenital neurodevelopmental abnormalities","authors":"Gwilym Hosking , Jane Hosking , Pat Winstanley , Anne Green , Michael Grimsley","doi":"10.1016/0006-2944(85)90090-0","DOIUrl":"10.1016/0006-2944(85)90090-0","url":null,"abstract":"<div><p>A biochemical study has been undertaken on the mothers of children with a major neurodevelopmental disability, without known etiology (study group), and an appropriate control group. Two hundred seventy-four mothers were studied, 137 in each group. Social and environmental details were recorded in earch of the two major groups.</p><p>Biochemical studies included the assay of plasma and urinary amino acids and appropriate screening tests for carbohydrate and organic acid abnormalities. To introduce an element of standardization and also to enhance the opportunities for identifying possible biochemical heterozygote states, a 50-g protein mean was given to all subjects approximately three-quarters of an hour before blood and urine samples were taken.</p><p>Difference of means tests on 22 amino acids revealed 9 significant <em>t</em> values at the 0.05 level and all means were significantly lower in the study groups. Because of the differences noted a discriminant analysis was carried out which demonstrated an extremely high proportion of correctly classified subjects (98%) when biochemical parameters were used to attempt to classify subjects into the study or control group.</p></div>","PeriodicalId":8781,"journal":{"name":"Biochemical medicine","volume":"34 3","pages":"Pages 287-296"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-2944(85)90090-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15209403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2