Biochemical medicine最新文献_第10页

Effects of sugar on the incorporation of valine into protein of hypertrophied soleus muscle in rats 糖对缬氨酸掺入大鼠比目鱼肌肥大蛋白的影响

Biochemical medicine Pub Date : 1985-04-01 DOI: 10.1016/0006-2944(85)90051-1

引用次数: 0

Adrenal dysfunction in glycerol kinase deficiency 甘油激酶缺乏引起肾上腺功能障碍

Biochemical medicine Pub Date : 1985-04-01 DOI: 10.1016/0006-2944(85)90027-4

William K. Seltzer , Harlan Firminger , Jerod Klein , Adrian Pike , Paul Fennessey , Edward R.B. McCabe

{"title":"Adrenal dysfunction in glycerol kinase deficiency","authors":"William K. Seltzer , Harlan Firminger , Jerod Klein , Adrian Pike , Paul Fennessey , Edward R.B. McCabe","doi":"10.1016/0006-2944(85)90027-4","DOIUrl":"10.1016/0006-2944(85)90027-4","url":null,"abstract":"<div><p>The infantile form of glycerol kinase deficiency appears to be an X-linked disorder which is consistently characterized by developmental delay and adrenal cortical insufficiency and hypoplasia. We propose that the inherited deficiency of outer mitochondrial membrane-bound glycerol kinase restricts glycerophospholipid synthesis, and, hence, the activation of stereoidogenesis. This would limit the conversion of cholesterol to pregnenolone, the precursor for glucocorticoids in the adrenal cortex. The deficiency in cortisol production, with a lack of feedback to the pituitary, would result in increased ACTH production and hypertrophy of the fascicular zone at the same time that replication of the cells within this zone would be inhibited. Similarly, the decreased mineralocorticoid production by the sparse glomerulososal zone would limit the ability of the individual to respond to stress, and would result in development of potentially fatal hyponatremia and hyperkalemia. Organization of the pathway for glycerophospholipid synthesis at the outer mitochondrial membrane would make this pathway particularly vulnerable to mutations disrupting the compartmented production of the parent compound, glycerol 3-phosphate, by mitochondrial-bound glycerol kinase.</p></div>","PeriodicalId":8781,"journal":{"name":"Biochemical medicine","volume":"33 2","pages":"Pages 189-199"},"PeriodicalIF":0.0,"publicationDate":"1985-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-2944(85)90027-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14122083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Some observations on mitochondrial-bound hexokinase and creatine kinase of the heart 心肌线粒体结合己糖激酶和肌酸激酶的观察

Biochemical medicine Pub Date : 1985-04-01 DOI: 10.1016/0006-2944(85)90025-0

Borgar Borrebaek , June Taje Haviken

{"title":"Some observations on mitochondrial-bound hexokinase and creatine kinase of the heart","authors":"Borgar Borrebaek , June Taje Haviken","doi":"10.1016/0006-2944(85)90025-0","DOIUrl":"10.1016/0006-2944(85)90025-0","url":null,"abstract":"<div><p>A large part of the hexokinase activity of the rat brain 20,000<em>g</em> supernatant became mitochondrial bound when incubated with rat heart mitochondria which had been pretreated with glucose-6-phosphate. This binding was dependent on small-molecular compounds (as yet unidentified) of the brain supernatant. Divalent cations, spermine, and pentalysine strongly stimulated the binding of brain supernatant hexokinase to heart mitochondria. Inorganic phosphate, α-glycero-phosphate, and fructose-1,6-diphosphate showed some stimulatory effect. No effect was observed with insulin or glucose.</p><p>Mitochondria isolated from hearts of fasted rats had less specific hexokinase activity than mitochondria from fasted and then carbohydrate refed rats. This dietary treatment had no significant effect on the total heart hexokinase activity.</p><p>Oligomycin did not inhibit the formation of creatine phosphate or glucose-6-phosphate by isolated rabbit heart mitochondria incubated in the presence of phosphoenolpyruvate and pyruvate kinase. However, the presence of creatine inhibited the formation of glucose-6-phosphate when the <span><math><mtext>ATP</mtext><mtext>ADP</mtext></math></span> ratio was low, indicating that creatine kinase has a greater access to <span><math><mtext>ATP</mtext><mtext>ADP</mtext></math></span> translocation than has hexokinase.</p></div>","PeriodicalId":8781,"journal":{"name":"Biochemical medicine","volume":"33 2","pages":"Pages 170-179"},"PeriodicalIF":0.0,"publicationDate":"1985-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-2944(85)90025-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15117530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Blood manganese levels in children with convulsive disorder 惊厥障碍儿童血锰水平

Biochemical medicine Pub Date : 1985-04-01 DOI: 10.1016/0006-2944(85)90033-X

C.L. Dupont, Y. Tanaka

{"title":"Blood manganese levels in children with convulsive disorder","authors":"C.L. Dupont, Y. Tanaka","doi":"10.1016/0006-2944(85)90033-X","DOIUrl":"10.1016/0006-2944(85)90033-X","url":null,"abstract":"<div><p>Manganese deficiency syndromes have been well described in animals and include among a wide variety of metabolic aberrations the heightened susceptibility to convulsions induced by electroshock or drugs. We have measured manganese blood levels in two populations of children: (1) a reference group of 120 ambulatory patients without neurologic disease, (2) 197 patients with convulsive disorder. Blood manganese was found to be age related in infants under 1 year of age. Highly significant was the lower mean blood manganese found in the convulsive disorder group as compared to the reference group. There was also a slight trend in the convulsive group for blood manganese to decrease from 1 to 22 years of age. No significant differences in manganese levels were found related to sex, type of seizure disorder, type of anticonvulsant drug therapy, or serum level of drug. Although this study does not demonstate a causal relation between manganese and seizure disorder, and cannot be used as the basis for altering current approaches to therapy, it provides insight into the potentially important role of previously unrecognized factors in the pathophysiology of this syndrome.</p></div>","PeriodicalId":8781,"journal":{"name":"Biochemical medicine","volume":"33 2","pages":"Pages 246-255"},"PeriodicalIF":0.0,"publicationDate":"1985-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-2944(85)90033-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15117535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Deficiency in tyrosine, a nonessential amino acid, impairs brain development 酪氨酸（一种非必需氨基酸）缺乏会损害大脑发育

Biochemical medicine Pub Date : 1985-04-01 DOI: 10.1016/0006-2944(85)90047-X

引用次数: 0

An appreciation of Samuel P. Bessman Samuel P. Bessman的欣赏

Biochemical medicine Pub Date : 1985-04-01 DOI: 10.1016/0006-2944(85)90021-3

Nathan O. Kaplan

引用次数: 0

Sites of cleavage of rabbit muscle aldolase by purified cathepsin M from rabbit liver 纯化兔肝组织蛋白酶M对兔肌醛缩酶的裂解位点

Biochemical medicine Pub Date : 1985-04-01 DOI: 10.1016/0006-2944(85)90041-9

引用次数: 0

Organization of Krebs tricarboxylic acid cycle enzymes 克雷布斯三羧酸循环酶的组织