Biochemical medicine最新文献

Hormone regulation of cardiac energy metabolism 心脏能量代谢的激素调节

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90088-2

E.K. Seppet , A.J. Adoyaan , A.P. Kallikorm , G.B. Chernousova , N.V. Lyulina , V.G. Sharov , V.V. Severin , M.I. Popovich , V.A. Saks

{"title":"Hormone regulation of cardiac energy metabolism","authors":"E.K. Seppet , A.J. Adoyaan , A.P. Kallikorm , G.B. Chernousova , N.V. Lyulina , V.G. Sharov , V.V. Severin , M.I. Popovich , V.A. Saks","doi":"10.1016/0006-2944(85)90088-2","DOIUrl":"https://doi.org/10.1016/0006-2944(85)90088-2","url":null,"abstract":"<div>Hyperthyroid rat heart was studied with the purpose of identifying the mechanism for the significant decrease in total creatine (free creatine plus phosphocreatine) observed in this pathology and its consequences on heart function. Administration of l-thyroxine in doses of <math><mtext>50–100 μ</mtext><mtext>g</mtext><mtext>100 </mtext><mtext>g</mtext></math> of body weight during a week resulted in a reversible decrease of the total creatine by 40–50%. Simultaneously, remarkable changes in the creatine transport system across the cardiac cell membranes were observed: both the maximal rate of its active uptake and its passive movement along its concentration gradient were enhanced. In euthyroid hearts, the parameters of creatine uptake (Km ⋍ 0.05 mm, Vmax = 20 nmole/min/g dry weight) were similar to those for skeletal muscle and the passive movement of creatine was negligible. In hyperthyroid hearts the latter rate was enhanced to 0.4 μmole min/g dry weight, this showing reversible damages in the cell membrane structure induced by l-thyroxine. This conclusion is consistent with observed penetration of colloidal lanthanum into the cells of hyperthyroid hearts. Perfusion of hyperthyroid rat hearts with 50 mm creatine significantly restored creatine content in the cells. Hyperthyroid hearts with decreased creatine content were found to develop ischemic contracture more rapidly and in higher extent than the euthyroid hearts. Increased sensitivity to ischemic damage may be related to decreased efficiency of energy channeling via phosphocreatine pathway.</div>","PeriodicalId":8781,"journal":{"name":"Biochemical medicine","volume":"34 3","pages":"Pages 267-279"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-2944(85)90088-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92069561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

A comparison of succinyladenylate lyase activity and serum sialic acid as markers of malignancy 琥珀酰腺酸裂解酶活性与血清唾液酸作为恶性肿瘤标志物的比较

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90095-X

Donald O. Mack, Ellen M. Lewis, E.Marie Butler, William H. Archer, Larry D. Smith

引用次数: 7

Separation of the intermediates of leucine catabolism by high-performance liquid chromatography 高效液相色谱法分离亮氨酸分解代谢中间体

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90091-2

Theodore Page, William L. Nyhan

引用次数: 6

Effect of swimming on protein degradation: 3-methylhistidine and creatinine excretion 游泳对蛋白质降解的影响:3-甲基组氨酸和肌酐排泄

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90101-2

E. Mussini, L. Colombo, G. De Ponte, M. Calzi, F. Marcucci

引用次数: 21

Author index for volume 34 第34卷的作者索引

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90103-6

引用次数: 0

Cumulative subject index volumes 33–34 累积主题索引卷33-34

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90104-8

引用次数: 0

Uptake of proline by brushborder vesicles isolated from human kidney cortex 人肾皮质毛刷缘囊泡对脯氨酸的摄取

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90092-4

John W. Foreman , Pamela D. McNamara , Louise M. Pepe , Kristina Ginkinger , Stanton Segal

引用次数: 4

Platelet phenylalanine hydroxylating activity in phenylketonurics and normal controls 苯丙酮尿症患者和正常人血小板苯丙氨酸羟化活性

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90102-4

Ralf Uebelhack, Leonora Franke, Dolphe Kutter, John Thoma, Karl Seidel

引用次数: 3

Lipid peroxidation in liver, plasma, and erythrocytes of rats chronically treated with ethanol 长期乙醇处理大鼠肝脏、血浆和红细胞的脂质过氧化

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90100-0

Müjdat Uysal, Gülçin Aykaç, Lecla Koçak-Toker, Ahmet Sivas, Suha Yalçin, Hikmet Oz

引用次数: 21

Prolonged refractoriness to the diabetogenic action of streptozotocin in mice 小鼠对链脲佐菌素致糖尿病作用的长期耐受性

Biochemical medicine Pub Date : 1985-12-01 DOI: 10.1016/0006-2944(85)90087-0

Y. Abramovici , M.K. Agarwal

{"title":"Prolonged refractoriness to the diabetogenic action of streptozotocin in mice","authors":"Y. Abramovici , M.K. Agarwal","doi":"10.1016/0006-2944(85)90087-0","DOIUrl":"10.1016/0006-2944(85)90087-0","url":null,"abstract":"<div>A single intraperitoneal injection of 5 mg (250 mg/kg body wt) streptozotocin induced overt diabetes within 48 hr in male, 6-week-old mice of <math><mtext>C57BL</mtext><mtext>6</mtext></math> and <math><mtext>C57BL</mtext><mtext>10</mtext></math> (sensitive) strains. The <math><mtext>C3H</mtext><mtext>HeJ</mtext></math> and <math><mtext>C3H</mtext><mtext>eb</mtext></math> (resistant) strains exhibited a progressive delayed-onset hyperglycemia which required 6 weeks to reach the level seen within only 48 hr in sensitive strains. Resistance to SZ-induced diabetes was not related to changes in body weights or different pharmacokinetics of the drug. <math><mtext>C3H</mtext><mtext>HeJ</mtext></math> (resistant) mice showed a smaller fall in immunoreactive insulin pancreatic content and less severe damage of pancreatic islets on histologic examination, when compared to <math><mtext>C57BL</mtext><mtext>6</mtext></math> (sensitive) mice during the first week post-SZ. These results suggest that strain-related resistance to SZ-induced diabetes may be mediated at the level of the β cell's responsiveness to the cytotoxic action of the drug. This very simple experimental tool may be of value in monitoring the period before the onset of overt insulin-deficient diabetes and for probing the nature of factors that constitute a genetically resistant pancreas, understanding of which could aid management of diabetes mellitus in humans.</div>","PeriodicalId":8781,"journal":{"name":"Biochemical medicine","volume":"34 3","pages":"Pages 259-266"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-2944(85)90087-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14071862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2