Ernst Schering Foundation symposium proceedings最新文献_第9页

Interfering with the dynamics of estrogen receptor-regulated transcription. 干扰雌激素受体调控的转录动力学。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2006_013

S A Johnsen, S Kangaspeska, G Reid, F Gannon

引用次数: 8

Bone marrow niche and leukemia. 骨髓生态位和白血病。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2007_048

A D Ho, W Wagner

{"title":"Bone marrow niche and leukemia.","authors":"A D Ho, W Wagner","doi":"10.1007/2789_2007_048","DOIUrl":"https://doi.org/10.1007/2789_2007_048","url":null,"abstract":"Mounting evidence indicates that human cancers may originate from malignant transformation of stem cells. The most convincing proof is found in acute myeloid leukemia, where only a small subset of slowly dividing cells was able to induce transplantable acute myeloid leukemia. Normal hematopoietic stem cells (HSC) are characterized by their unlimited ability to self-renew, give rise to a multitude of cells that exhibit more differentiated features, and show slow division kinetics. Using human HSC and mesenchymal stromal cells (MSC) as models, we and others have demonstrated the vital role of the cellular niche in maintaining the self-renewing capacity, that is, \"stemness\" of HSC. Without direct contact with the cellular niche, HSC tend to differentiate and lose their stemness. Similar to their normal counterparts, leukemia stem cells divide slowly and maintain their self-renewal capacity through interaction with the niche. As a consequence, they are resistant to conventional chemotherapy strategies that target rapidly dividing cells. Thus it is of utmost importance to understand the interaction between cellular niche and normal HSC as well as between leukemia stem cells and the niche to provide a basis for more efficient treatment strategies.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 5","pages":"125-39"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2007_048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27050096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Niche for normal and cancer stem cells. 适合正常和癌症干细胞。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2007_041

S I Nishikawa, M Osawa

引用次数: 8

Nature's choice of genes controlling chronic inflammation. 自然选择控制慢性炎症的基因。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2007_036

R Holmdahl

{"title":"Nature's choice of genes controlling chronic inflammation.","authors":"R Holmdahl","doi":"10.1007/2789_2007_036","DOIUrl":"https://doi.org/10.1007/2789_2007_036","url":null,"abstract":"Inflammation is a physiological response that may go uncontrolled and thereby develop in a chronic way. This seems to happen in many common diseases of autoimmune, degenerative, or allergic character. Rheumatoid arthritis (RA) is by definition a chronic disease with an autoimmune inflammatory attack on diarthrodial cartilaginous joints. The development of new treatment neutralizing cytokines involved in the inflammatory attack has given relief and gives the promise of more effective treatment of already established disease. It is now time to set our eyes on a new vision to develop preventive and curative treatment based on knowledge of the unique and causative pathogenic mechanisms. To do this we believe it is important to identify the natural-selected polymorphisms that are associated with disease. These have proven to be extremely difficult to identify in complex diseases such as RA, but using animal models, this work is closer to reality. Animal models have recently been developed mimicking various aspects of the human disease. We will present an example in which a genetic polymorphism associated with the development of arthritis has been identified. On the basis of this finding, a new pathway involving control of immune tolerance by reactive oxidative species has been identified and a new class of antiinflammatory agents activating the induced oxidative burst protein complex is suggested.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 4","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2007_036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27006697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Microstructured reactors for development and production in pharmaceutical and fine chemistry. 用于制药和精细化学开发和生产的微结构反应器。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2007_035

V Hessel, P Löb, U Krtschil, H Löwe

引用次数: 9

Orphan seven transmembrane receptor screening. 孤儿7跨膜受体筛选。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2006_006

M J Wigglesworth, L A Wolfe, A Wise

{"title":"Orphan seven transmembrane receptor screening.","authors":"M J Wigglesworth, L A Wolfe, A Wise","doi":"10.1007/2789_2006_006","DOIUrl":"https://doi.org/10.1007/2789_2006_006","url":null,"abstract":"Drug discovery has successfully exploited the superfamily of seven transmembrane receptors (7TMR), with over 35% of clinically marketed drugs targeting them. However, it is clear that there remains an undefined potential within this protein family for successful drugs of the future. The human genome sequencing project identified approximately 720 genes that belong to the 7TMR superfamily. Around half of these genes encode sensory receptors, while the other half are potential drug targets. Natural ligands have been identified for approximately 215 of these, leaving 155 receptors classified as orphan 7TMRs having no known ligand. Deorphanisation of these receptors by identification of natural ligands has been the traditional method enabling target validation by use of these ligands as tools to define biological relevance and disease association. Such ligands have been paired with their cognate receptor experimentally by screening of small molecule and peptide ligands, reverse pharmacology and the use of bioinformatics to predict candidate ligands. In this manuscript, we review the methodologies developed for the identification of ligands at orphan 7TMRs and exemplify these with case studies.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 2","pages":"105-43"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2006_006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26892716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Virus-encoded G-protein-coupled receptors: constitutively active (dys)regulators of cell function and their potential as drug target. 病毒编码的g蛋白偶联受体:细胞功能的组成活性(日)调节剂及其作为药物靶点的潜力。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2006_009

H F Vischer, J W Hulshof, I J P de Esch, M J Smit, R Leurs

引用次数: 13

Modeling GPCRs. GPCR建模。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2006_002

A C M Paiva, L Oliveira, F Horn, R P Bywater, G Vriend

引用次数: 5

c-Myc and activated Ras during skin tumorigenesis: cooperation at the cancer stem cell level? 皮肤肿瘤发生过程中c-Myc和活化Ras:癌症干细胞水平上的合作?

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2007_042

A Trumpp

引用次数: 8

Preclinical characterization of selective estrogen receptor beta agonists: new insights into their therapeutic potential. 选择性雌激素受体激动剂的临床前特征:对其治疗潜力的新见解。

Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2006_021

H A Harris

引用次数: 26