Ernst Schering Foundation symposium proceedings最新文献

New concepts for organocatalysis. 有机催化的新概念。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-06-23 DOI: 10.1007/2789_2008_084

S. Pan, Benjamin List

引用次数: 12

A tale of two giant proteases. 两个巨型蛋白酶的故事。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01 DOI: 10.1007/2789_2008_099

B Rockel, W Baumeister

引用次数: 5

Transcriptional control and the ubiquitin-proteasome system. 转录控制与泛素-蛋白酶体系统。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01

A Leung, F Geng, A Daulny, G Collins, P Guzzardo, W P Tansey

引用次数: 0

Molecular genetics of the ubiquitin-proteasome system: lessons from yeast. 泛素-蛋白酶体系统的分子遗传学:来自酵母的教训。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01 DOI: 10.1007/2789_2008_100

M Hochstrasser, M Deng, A R Kusmierczyk, X Li, S G Kreft, T Ravid, M Funakoshi, M Kunjappu, Y Xie

{"title":"Molecular genetics of the ubiquitin-proteasome system: lessons from yeast.","authors":"M Hochstrasser, M Deng, A R Kusmierczyk, X Li, S G Kreft, T Ravid, M Funakoshi, M Kunjappu, Y Xie","doi":"10.1007/2789_2008_100","DOIUrl":"https://doi.org/10.1007/2789_2008_100","url":null,"abstract":"Our studies with the yeast Saccharomyces cerevisiae have uncovered a number of general principles governing substrate selectivity and proteolysis by the ubiquitin-proteasome system. The initial work focused on the degradation of a transcription factor, the MATalpha2 repressor, but the pathways uncovered have a much broader range of targets. At least two distinct ubiquitination mechanisms contribute to alpha2 turnover. One of them depends on a large integral membrane ubiquitin ligase (E3) and a pair of ubiquitin-conjugating enzymes (E2s). The transmembrane E3 and E2 proteins must travel from their site of synthesis in the ER to the inner nuclear membrane in order to reach nuclear substrates such as alpha2. The 26S proteasome is responsible for alpha2 degradation, and several important features of proteasome assembly and active site formation were uncovered. Most recently, we have delineated major steps in 20S proteasome assembly and have also identified several novel 20S proteasome assembly factors. Surprisingly, alterations in 20S proteasome assembly lead to defects in the assembly of the proteasome regulatory particle (RP). The RP associates with the 20S proteasome to form the 26S proteasome. Our data suggest that the 20S proteasome can function as an assembly factor for the RP, which would make it the first such factor for RP assembly identified to date.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 1","pages":"41-66"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2008_100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27971305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The ubiquitin system in health and disease. Preface. 泛素系统在健康和疾病中的作用。前言。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01

Bernard Haendler, Stefan Jentsch

引用次数: 0

Less is more: how protein degradation regulates muscle development. 少即是多:蛋白质降解如何调节肌肉发育。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01 DOI: 10.1007/2789_2008_101

T Hoppe

引用次数: 2

Regulation of T cell differentiation and allergic responses by the E3 ubiquitin ligase itch. E3泛素连接酶对T细胞分化和过敏反应的调控。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01 DOI: 10.1007/2789_2008_106

Y C Liu

{"title":"Regulation of T cell differentiation and allergic responses by the E3 ubiquitin ligase itch.","authors":"Y C Liu","doi":"10.1007/2789_2008_106","DOIUrl":"https://doi.org/10.1007/2789_2008_106","url":null,"abstract":"Itch is an E3 ubiquitin ligase that is originally identified by genetic analysis of a mutant mouse with aberrant immunological phenotypes and constant itching in the skin. Itch(-/-) T cells are biased toward the differentiation of T helper type 2 cells with augmented interleukin-4 cytokine production and serum IgE level. One of the mechanisms for Itch E3 ligase to regulate T cell responses is the induction of T cell anergy in which T cells become unresponsive upon restimulation. However, the detailed mechanisms underlying Itch-mediated protein ubiquitination and allergic responses remain to be investigated. Here we provide evidence that Itch is involved in the regulation of transforming growth factor (TGF)-beta signaling in naïve T cells and TGF-beta-induced expression of the transcription factor Foxp3, a master regulator in regulatory T cells. Itch promotes ubiquitin conjugation to TGF-beta inducible early gene 1 product (TIEG1). Moreover, monoubiquitinated TIEG1 positively modulates the transcription of Foxp3 gene. The results suggest a novel mechanism by which Itch regulates regulatory T cells and subsequent allergic responses.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 1","pages":"137-52"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2008_106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27969171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Regulation of apoptosis and cytokinesis by the anti-apoptotic E2/E3 ubiquitin-ligase BRUCE. 抗凋亡E2/E3泛素连接酶对细胞凋亡和细胞分裂的调控。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01 DOI: 10.1007/2789_2008_104

C Pohl, S Jentsch

引用次数: 5

Crosstalk between the SUMO and ubiquitin pathways. SUMO和泛素通路之间的串扰。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01 DOI: 10.1007/2789_2008_098

T Hunter, H Sun

引用次数: 49

Dissecting roles of ubiquitination in the p53 pathway. 泛素化在p53通路中的解剖作用。

Ernst Schering Foundation symposium proceedings Pub Date : 2008-01-01 DOI: 10.1007/2789_2008_105

J Shan, C Brooks, N Kon, M Li, W Gu

{"title":"Dissecting roles of ubiquitination in the p53 pathway.","authors":"J Shan, C Brooks, N Kon, M Li, W Gu","doi":"10.1007/2789_2008_105","DOIUrl":"https://doi.org/10.1007/2789_2008_105","url":null,"abstract":"Posttranslational modification of proteins by mono- or polyubiquitination represents a central mechanism to modulate a wide range of cellular functions like protein stability, intracellular transport, protein interactions, and transcriptional activity. Analogous to other posttranslational modifications, ubiquitination is a reversible process counteracted by deubiquitinating enzymes (DUBs), which cleave the isopeptide linkage between protein substrate and the ubiquitin residue. The p53 tumor suppressor is a sequence-specific DNA-binding transcriptional factor that plays a central role in regulating growth arrest and apoptosis during the stress response. Notably, recent studies indicate that both the stability and the subcellular localization of p53 are tightly regulated by ubiquitination; p53 is mainly ubiquitinated by Mdm2 but other ubiquitin ligases such as ARF-BP1/HectH9/MULE are also involved in p53 regulation in vivo. Moreover, a deubiquitinase HAUSP was initially identified in p53 deubiquitination but more recent studies showed that both Mdm2 and Mdmx are also bona fide substrates of HAUSP. In this article, we review our latest understanding of ubiquitination in modulating the p53 tumor suppression pathway.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 1","pages":"127-36"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2008_105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27973167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16