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引用次数: 5
摘要
凋亡抑制蛋白(IAP)家族的成员是凋亡的关键调节因子，因为它们结合并抑制caspases和其他促凋亡因子。最近的研究结果表明，这些蛋白在细胞周期调节、血管生成和癌变中发挥着额外的作用。在这里，我们回顾了BRUCE (BIR repeat-containing ubiquitin-conjugating enzyme，含泛素偶联酶)的功能，并描述了它在细胞凋亡和细胞分裂中的作用。BRUCE是一种具有泛素连接酶活性的528 kda IAP。此外，我们还讨论了这些看似无关的功能是如何联系在一起的。
Regulation of apoptosis and cytokinesis by the anti-apoptotic E2/E3 ubiquitin-ligase BRUCE.
Members of the inhibitor of apoptosis protein (IAP) family are key regulators of apoptosis as they bind and inhibit caspases and other pro-apoptotic factors. Recent findings suggest that these proteins play additional roles, e.g., in cell cycle regulation, angiogenesis, and carcinogenesis. Here, we review the function of BRUCE (BIR repeat-containing ubiquitin-conjugating enzyme), an unusual 528-kDa IAP with ubiquitin ligase activity, and describe its role in apoptosis and cytokinesis. Additionally, we discuss how these seemingly unrelated functions might be linked.
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