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New developments in enantioselective Brønsted acid catalysis: chiral ion pair catalysis and beyond. 对映选择性Brønsted酸催化的新进展:手性离子对催化及其他。
Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_085
M. Rueping, E. Sugiono
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引用次数: 3
Nucleophilic carbenes as organocatalysts. 亲核羰基作为有机催化剂。
Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_081
F. Glorius, K. Hirano
{"title":"Nucleophilic carbenes as organocatalysts.","authors":"F. Glorius, K. Hirano","doi":"10.1007/2789_2008_081","DOIUrl":"https://doi.org/10.1007/2789_2008_081","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":"21 1","pages":"159-81"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79937280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Controlling the selectivity and stability of proteins by new strategies in directed evolution: the case of organocatalytic enzymes. 定向进化中的新策略控制蛋白质的选择性和稳定性:以有机催化酶为例。
Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2007_068
M. Reetz
{"title":"Controlling the selectivity and stability of proteins by new strategies in directed evolution: the case of organocatalytic enzymes.","authors":"M. Reetz","doi":"10.1007/2789_2007_068","DOIUrl":"https://doi.org/10.1007/2789_2007_068","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":"321 1","pages":"321-40"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82916525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Systems biology of T cell activation. T细胞活化的系统生物学。
Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2007_070
J. Lindquist, B. Schraven
{"title":"Systems biology of T cell activation.","authors":"J. Lindquist, B. Schraven","doi":"10.1007/2789_2007_070","DOIUrl":"https://doi.org/10.1007/2789_2007_070","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":"23 1","pages":"43-61"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81887831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Asymmetric organocatalysis on a technical scale: current status and future challenges. 技术规模上的不对称有机催化:现状与未来挑战。
Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_082
H. Gröger
{"title":"Asymmetric organocatalysis on a technical scale: current status and future challenges.","authors":"H. Gröger","doi":"10.1007/2789_2008_082","DOIUrl":"https://doi.org/10.1007/2789_2008_082","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":"10 1","pages":"141-58"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88332317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
High content screening to monitor G protein-coupled receptor internalisation. 高含量筛选监测G蛋白偶联受体内化。
Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2006_011
R Heilker
{"title":"High content screening to monitor G protein-coupled receptor internalisation.","authors":"R Heilker","doi":"10.1007/2789_2006_011","DOIUrl":"https://doi.org/10.1007/2789_2006_011","url":null,"abstract":"<p><p>G protein-coupled receptors (GPCRs) fulfil a broad diversity of physiological functions in areas such as neurotransmission, respiration, cardiovascular action, pain and more. Consequently, they are considered as the most successful group of therapeutic targets on the pharmaceutical market, and the search for compounds that interfere with GPCR function in a specific and selective way is a major focus of the pharmaceutical industry. High Content Screening (HCS), a combination of fluorescence microscopic imaging and automated image analysis, has become a frequently employed tool to study test compound effects in cellular disease modelling systems. One way to functionally analyse the effect of test compounds on GPCRs by HCS relies on the broadly observed phenomenon of desensitisation. Agonist stimulation of most GPCRs leads to their intracellular phosphorylation and subsequent internalisation, resulting in the termination of receptor signalling and the seclusion of the GPCR from further extracellular stimulation. Complementary to other functional GPCR drug discovery assays, GPCR internalisation assays enable a desensitisation-focussed pharmacological analysis of test compounds.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 2","pages":"229-47"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2006_011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26892680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
G-proteins and GPCrs: from the beginning. g蛋白和gpcr:从头开始。
Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2006_001
H R Bourne
{"title":"G-proteins and GPCrs: from the beginning.","authors":"H R Bourne","doi":"10.1007/2789_2006_001","DOIUrl":"https://doi.org/10.1007/2789_2006_001","url":null,"abstract":"<p><p>From the point of view of a participant observer, I tell the discovery stories of trimeric G-proteins and GPCRs, beginning in the 1970s. As in most such stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting. Because these pivotally important signaling molecules were discovered before the recombinant DNA revolution, today's well-trained molecular biologist may find it amazing that we learned anything at all.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 2","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2006_001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26893491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Microreactors as tools in the hands of synthetic chemists. 微反应器作为合成化学家手中的工具。
Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2007_025
P H Seeberger, K Geyer, J D C Codée
{"title":"Microreactors as tools in the hands of synthetic chemists.","authors":"P H Seeberger,&nbsp;K Geyer,&nbsp;J D C Codée","doi":"10.1007/2789_2007_025","DOIUrl":"https://doi.org/10.1007/2789_2007_025","url":null,"abstract":"<p><p>Recent developments in the construction of microstructured reaction devices and their wide-ranging applications in many different areas of chemistry suggest that microreactors may significantly impact the way chemists conduct experiments. Miniaturizing reactions offers many advantages for the synthetic organic chemist: high-throughput scanning of reaction conditions, precise control of reaction variables, the use of small quantities of reagents, increased safety parameters, and ready scale-up of synthetic procedures. A wide range of single and multiphase reactions has been performed in microfluidic-based devices. Certainly, microreactors cannot be applied to all chemistries yet and microfluidic systems also have disadvantages. Limited reaction time ranges, high sensitivity to precipitating products, and analytical challenges have to be overcome. An overview of microfluidic devices available for chemical synthesis is provided and some specific examples, mainly from our laboratory, are discussed to illustrate the potential of microreactors.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 3","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2007_025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26885442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Applying homogeneous catalysis for the synthesis of pharmaceuticals. 均相催化在药物合成中的应用。
Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2007_030
M Beller
{"title":"Applying homogeneous catalysis for the synthesis of pharmaceuticals.","authors":"M Beller","doi":"10.1007/2789_2007_030","DOIUrl":"https://doi.org/10.1007/2789_2007_030","url":null,"abstract":"<p><p>This article describes recent achievements of my research group in the Leibniz-Institut für Katalyse e.V. in the area of applied homogeneous catalysis for the synthesis of biologically active compounds. Special focus is given on the development of novel and practical palladium and copper catalysts for the functionalization of haloarenes and haloheteroarenes.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 3","pages":"99-116"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2007_030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26887567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Solid-phase supported synthesis: a possibility for rapid scale-up of chemical reactions. 固相支持合成:快速放大化学反应的可能性。
Ernst Schering Foundation symposium proceedings Pub Date : 2006-01-01 DOI: 10.1007/2789_2007_034
M Meisenbach, T Allmendinger, C P Mak
{"title":"Solid-phase supported synthesis: a possibility for rapid scale-up of chemical reactions.","authors":"M Meisenbach,&nbsp;T Allmendinger,&nbsp;C P Mak","doi":"10.1007/2789_2007_034","DOIUrl":"https://doi.org/10.1007/2789_2007_034","url":null,"abstract":"<p><p>The direct scale-up of a solid-phase synthesis has been demonstrated with 4-(2-amino-6-phenylpyrimidin-4-yl)benzamide and an arylsulfonamido-substituted hydroxamic acid derivative as examples. These compounds were obtained through combinatorial chemistry and solution-phase synthesis was used in parallel to provide a comparison. By applying highly loaded polystyrene-derived resins as the solid support, a good ratio between the product and the starting resin is achieved. We have demonstrated that the synthesis can be scaled up directly on the solid support, successfully providing the desired compounds easily and quickly in sufficient quantities for early development demands.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 3","pages":"187-203"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2007_034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26887571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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