Paediatric and perinatal drug therapy最新文献_第5页

Physiology-based versus allometric scaling of clearance in children; an eliminating process based comparison 儿童生理清除率与异速测量清除率的比较一种基于比较的消除过程

Paediatric and perinatal drug therapy Pub Date : 2006-11-01 DOI: 10.1185/146300906778876170

A. Edginton, S. Willmann

引用次数: 36

Prospective assessment of systemic side effects of topical ophthalmic drug administration for screening for retinopathy of prematurity 用于筛查早产儿视网膜病变的外用眼药全身性副作用的前瞻性评估

Paediatric and perinatal drug therapy Pub Date : 2006-11-01 DOI: 10.1185/146300906778876224

L. Willems, K. Allegaert, I. Casteels

引用次数: 11

Impact of a paediatric vial on the magnitude of systematic medication errors in neonates 儿科小瓶对新生儿系统性用药错误程度的影响

Paediatric and perinatal drug therapy Pub Date : 2006-07-01 DOI: 10.1185/146300906X105096

K. Allegaert, B. Anderson, M. Vrancken, A. Debeer, K. Desmet, K. Cosaert, D. Tibboel, H. Devlieger

引用次数: 32

Improving dose accuracy and reducing medication errors in neonates 提高剂量准确性，减少新生儿用药错误

Paediatric and perinatal drug therapy Pub Date : 2006-07-01 DOI: 10.1185/146300906X105104

I. Choonara, A. Nunn

引用次数: 3

Should labouring women take coffee with their steroids 待产女性应该在服用类固醇的同时喝咖啡吗

Paediatric and perinatal drug therapy Pub Date : 2006-07-01 DOI: 10.1185/146300906X105113

Amanda L. Potts, B. Anderson

引用次数: 1

A taste-testing study in healthy volunteers (children) to investigate children's preference for ibuprofen or placebo suspension 一项针对健康志愿者(儿童)的味觉测试研究，旨在调查儿童对布洛芬或安慰剂悬浮液的偏好

Paediatric and perinatal drug therapy Pub Date : 2006-07-01 DOI: 10.1185/146300906X105087

S. Reader, H. Shaw, S. Hails

引用次数: 9

Electrocardiographic observations in premature and term infants on cisapride therapy 西沙必利治疗早产儿和足月婴儿的心电图观察

Paediatric and perinatal drug therapy Pub Date : 2006-07-01 DOI: 10.1185/146300906X105131

C. Berul, R. Ward, G. Kearns, R. Kerstens, Patricia K. Robinson, F. Ouweland

引用次数: 2

Tranquilliser and hypnotic drug use in French children, adolescents and their families 法国儿童、青少年及其家庭使用镇静剂和催眠药物的情况

Paediatric and perinatal drug therapy Pub Date : 2006-05-01 DOI: 10.1185/146300905X65722

G. Michel, C. Chambaud-Peycher, D. Purper-Ouakil, C. Saurat, F. Pérez-Diaz, A. Bourillon, M. Mouren, É. Jacqz-Aigrain, M. Flament

引用次数: 3

Phenobarbital for childhood epilepsy: systematic review. 苯巴比妥治疗儿童癫痫:系统评价。

Paediatric and perinatal drug therapy Pub Date : 2006-05-01 DOI: 10.1185/146300905X75361

Deb K Pal

{"title":"Phenobarbital for childhood epilepsy: systematic review.","authors":"Deb K Pal","doi":"10.1185/146300905X75361","DOIUrl":"https://doi.org/10.1185/146300905X75361","url":null,"abstract":"<p><p>INTRODUCTION: Against a background of concern about the safety of new pharmaceutical products, there has been renewed interest in one of the oldest antiepileptic drugs (AEDs), phenobarbital. Although still in widespread use in developing countries, its popularity has slipped in Western countries over the past century, partly because of controversy about its adverse effect profile. This critical review examines the evidence supporting its effectiveness and its associated behavioural adverse effects for febrile convulsions and childhood epilepsy. METHODS: Relevant randomised controlled trials (RCTs) of phenobarbital vs other antiepileptic drugs or placebo between 1970-2005 were identified through a comprehensive manual and computer database search of the world biomedical literature. Eleven RCTs of febrile convulsions and nine RCTs of childhood epilepsy were systematically reviewed against a conventional set of quality criteria. RESULTS: With a few exceptions, the overall quality of clinical trial methodology, especially in the early studies conducted in the 1970s and 1980s, was poor. There is no evidence for a difference in antiepileptic efficacy between phenobarbital and any other compared AED, yet no evidence for absolute efficacy. No convincing evidence exists for an excess of behavioural adverse effects, over other AEDs, attributable to phenobarbital. Masked studies of phenobarbital in childhood epilepsy have shown no significant differences in behavioural or cognitive adverse effects compared to other AEDs. This is in contrast to the excess of such adverse effects reported in studies open to observer bias. However, the one finding of reduction in cognitive ability associated with phenobarbital treatment for febrile convulsions remains a concern. Future areas of clinical and genetic epidemiological research are outlined.</p>","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"31-42"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1185/146300905X75361","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26600999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Design of pharmacokinetic – pharmacodynamic (PK–PD) studies in children: a workshop for health professions involved in paediatric drug research 儿童药代动力学-药效学(PK-PD)研究的设计:为参与儿科药物研究的卫生专业人员举办的研讨会

Paediatric and perinatal drug therapy Pub Date : 2006-05-01 DOI: 10.1185/146300905X65731

T. Johnson, A. Thomson

引用次数: 1