Paediatric and perinatal drug therapy最新文献

Paediatric infliximab therapy: Patients' and parents' perspectives on treatment options 儿科英夫利昔单抗治疗:患者和家长对治疗方案的看法

Paediatric and perinatal drug therapy Pub Date : 2008-08-20 DOI: 10.1185/146300908X292097

A. Hazen, F. Smith, K. Taylor, C. Rawcliffe, L. Medcalf, S. Keady

{"title":"Paediatric infliximab therapy: Patients' and parents' perspectives on treatment options","authors":"A. Hazen, F. Smith, K. Taylor, C. Rawcliffe, L. Medcalf, S. Keady","doi":"10.1185/146300908X292097","DOIUrl":"https://doi.org/10.1185/146300908X292097","url":null,"abstract":"Aim: To assess patients' and parents' perspectives on the impact of infliximab treatment on daily life and the acceptability and feasibility of (infliximab or adalimumab) home treatment, in the light of the perceived value of hospital services. Methods: A descriptive qualitative study was conducted at University College Hospital London. Data were collected via 25 semi-structured interviews with patients (aged 14-19) from both gastroenterology and rheumatology specialties, prescribed infliximab, and their parents. Results: The majority of participants preferred to continue infliximab treatment at their current hospital, rather than be treated in their local hospital or at home. The main reasons were the specialised care in their current hospital, the continuity of care and hospital staff, resistance to the method of adalimumab administration and expected problems with compliance. Hospital services were highly valued and current infliximab treatment at the hospital was considered to have either no impact on family and school life, or to have improved it. Conclusion: Infliximab is an effective therapy for inflammatory bowel diseases and rheumatology conditions in young people, bringing either no negative impact on, or improvement of school and family life. In association with patients' and parents' positive appraisal for hospital services and their confidence in the clinical team, patients and parents do not express a preference for infliximab or adalimumab home treatment, despite current health policy aimed towards therapy closer to, or at, home.","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"8 1","pages":"177-181"},"PeriodicalIF":0.0,"publicationDate":"2008-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65625283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Working with the pharmaceutical industry in relation to paediatric clinical trials. A British perspective 在儿科临床试验方面与制药行业合作。英国人的视角

Paediatric and perinatal drug therapy Pub Date : 2008-06-01 DOI: 10.1185/146300908X254198

O. Dewit, R. Tiner

引用次数: 1

Improving research and access to children's medicines worldwide 改善全球儿童药物的研究和可及性

Paediatric and perinatal drug therapy Pub Date : 2008-06-01 DOI: 10.1185/146300908X254189

Matityahu Berkovitch, I. Choonara, É. Jacqz-Aigrain, B. Kalikstad, G. Pons, A. Rane, J. Anker, B. Overmeire

引用次数: 3

A new partnership for drug therapy in children 儿童药物治疗的新伙伴关系

Paediatric and perinatal drug therapy Pub Date : 2008-06-01 DOI: 10.1185/146300908X292079

I. Choonara, A. Nunn

引用次数: 0

Delayed respiratory depression after accidental risperidone overdose 意外过量利培酮后延迟呼吸抑制

Paediatric and perinatal drug therapy Pub Date : 2008-06-01 DOI: 10.1185/146300908X254224

H. Satish, H. Payne, F. Potter, A. Nunn, K. Brodbelt

引用次数: 1

Hydroxurea treatment in sickle cell children 氢脲治疗镰状细胞儿童

Paediatric and perinatal drug therapy Pub Date : 2008-06-01 DOI: 10.1185/146300908X292060

M. Odièvre, M. Benkerrou, M. Belloy, J. Elion

{"title":"Hydroxurea treatment in sickle cell children","authors":"M. Odièvre, M. Benkerrou, M. Belloy, J. Elion","doi":"10.1185/146300908X292060","DOIUrl":"https://doi.org/10.1185/146300908X292060","url":null,"abstract":"Sickle cell anaemia, the most prevalent genetic disease in the black population, is characterised by the polymerisation of the abnormal haemoglobin S, which leads to vascular occlusion and severe painful crisis. Hydroxyurea is the fi rst drug that has been shown to reduce the clinical severity of sickle cell anaemia in adults. Several trials have been carried out in more than 400 children in the last decade, using different therapeutic schedules. Enrolment was based on clinical vasoocclusive severity and few studies included children with cerebrovascular events. Hydroxyurea enhanced fetal haemoglobin expression in almost all the children, despite a large interindividual variability. Hydroxyurea signifi cantly reduces the number of vasoocclusive crises, hospitalisations, the frequency of the acute chest syndrome and the rate of transfusion. Long-term tolerance to hydroxyurea is good. However, clinical response does not correlate consistently with the degree and with the time of increment in fetal haemoglobin, suggesting that hydroxyurea may mediate some of its clinical benefi ts through other mechanisms such as the reduction of sickle erythrocytes – endothelial cells adherence and of the vasoconstrictive stimulus.","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"8 1","pages":"158-170"},"PeriodicalIF":0.0,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65625212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Paediatric asthma severity score and length of stay in patients presenting to a paediatric emergency department 儿科哮喘严重程度评分和儿科急诊科患者的住院时间

Paediatric and perinatal drug therapy Pub Date : 2008-06-01 DOI: 10.1185/146300908X254215

S. Chu, J. Tan, J. Seabrook, M. Rieder

引用次数: 4

How long does it take to administer oral medicines to children 给儿童口服药物需要多长时间

Paediatric and perinatal drug therapy Pub Date : 2008-06-01 DOI: 10.1185/146300908X254206

Claire Skwierczynski, S. Conroy

引用次数: 24

Comparison of amethocaine gel versus 1% lidocaine infiltration on wound healing. A pilot study in animals 阿美索卡因凝胶与1%利多卡因浸润对伤口愈合的影响比较。对动物的初步研究

Paediatric and perinatal drug therapy Pub Date : 2007-11-01 DOI: 10.1185/146300907X199939

R. Lim, B. García, M. Rieder, Priya Iyer, J. Seabrook

引用次数: 1

Dioxins in children 儿童中的二恶英

Paediatric and perinatal drug therapy Pub Date : 2007-11-01 DOI: 10.1185/146300908X254161

Meg Sears, C. Walker, R. Jagt

引用次数: 0