Paediatric and perinatal drug therapy最新文献

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Registering paediatric clinical trials 注册儿科临床试验
Paediatric and perinatal drug therapy Pub Date : 2006-12-01 DOI: 10.1185/146300906X148567
M. Bonati, C. Pandolfini, V. Rossi, E. Santoro, J. M. A. D. Bolós, I. D. Carreras, I. F. Camps, JM Llobet, É. Jacqz-Aigrain, S. Zarrabian, I. Choonara, H. Sammons, Coral Smith
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引用次数: 1
Reducing inter-individual variability in amikacin clearance in preterm neonates 减少早产儿阿米卡星清除率的个体差异
Paediatric and perinatal drug therapy Pub Date : 2006-12-01 DOI: 10.1185/146300906X148558
K. Allegaert, J. Hoon, M. Rayyan, J. Anker
{"title":"Reducing inter-individual variability in amikacin clearance in preterm neonates","authors":"K. Allegaert, J. Hoon, M. Rayyan, J. Anker","doi":"10.1185/146300906X148558","DOIUrl":"https://doi.org/10.1185/146300906X148558","url":null,"abstract":"The bactericidal efficacy of amikacin mainly relates to intermittent, discontinuous peak concentrations due to the post-antibiotic effect, while renal side effects and oto-toxicity relate to the average plasma concentration, based on saturation of renal and cochlear cell binding sites. This combination of efficacy and safety has resulted in the concept of administration of relative larger doses with extended dosing intervals between consecutive administrations. However, the important interindividual variability in amikacin pharmacokinetics (PK) due to renal maturation makes it difficult to achieve a safe and effective dosing regimen in the individual premature neonate, most prominent in extremely preterm neonates and at birth. We report on the consecutive steps we took over a period of 7 years to reduce inter-individual variability in order to achieve a safe and effective dosing regimen in preterm neonates at birth. Individual amikacin pharmacokinetics were calculated in 273 preterm neonates (546 paired observations, <31 weeks postmenstrual age (PMA), on respiratory support). Based on different dosing regimes used during consecutive time intervals, we were able to illustrate the PMA-dependent clearance, the negative effect of co-administration of a non-selective cyclo-oxygenase inhibitor on amikacin clearance and the impact of implementation of these observations on the amikacin trough levels observed. However, still important unexplained interindividual variability was observed. The subsequent introduction of a paediatric vial in a more recently treated cohort further reduced the variability in amikacin clearance observed. We have illustrated (i) the influence of perinatal renal function on amikacin clearance and (ii) the impact of a paediatric vial on the further reduction of the observed variability in amikacin clearance to dosing regimens.","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"163-169"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
New publisher, new opportunities 新的发行商,新的机遇
Paediatric and perinatal drug therapy Pub Date : 2006-12-01 DOI: 10.1185/146300906X148549
I. Choonara, P. Garner
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引用次数: 0
Drug metabolism studies in the newborn infant and children using an oral erythromycin breath test 新生儿和儿童口服红霉素呼吸试验的药物代谢研究
Paediatric and perinatal drug therapy Pub Date : 2006-12-01 DOI: 10.1185/146300906X148576
C. Cocking, E. Webster, J. McIntyre, T. Preston, I. Choonara
{"title":"Drug metabolism studies in the newborn infant and children using an oral erythromycin breath test","authors":"C. Cocking, E. Webster, J. McIntyre, T. Preston, I. Choonara","doi":"10.1185/146300906X148576","DOIUrl":"https://doi.org/10.1185/146300906X148576","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"172-177"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A single-dose, randomised, crossover study to compare the rate and extent of absorption of lisinopril solution versus tablets in healthy volunteers 一项单剂量、随机、交叉研究,比较健康志愿者赖诺普利溶液和片剂的吸收率和程度
Paediatric and perinatal drug therapy Pub Date : 2006-12-01 DOI: 10.1185/146300906X148585
A. Leary, M. Dowling, A. Wilson, B. McKenna, J. Rothwell
{"title":"A single-dose, randomised, crossover study to compare the rate and extent of absorption of lisinopril solution versus tablets in healthy volunteers","authors":"A. Leary, M. Dowling, A. Wilson, B. McKenna, J. Rothwell","doi":"10.1185/146300906X148585","DOIUrl":"https://doi.org/10.1185/146300906X148585","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"178-182"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Paediatric Clinical Pharmacology in Europe 欧洲儿科临床药理学
Paediatric and perinatal drug therapy Pub Date : 2006-11-01 DOI: 10.1185/146300906778876198
M. Bonati, J. Breitkreutz, I. Choonara, K. Hoppu, É. Jacqz-Aigrain, J. Langhendries, G. Pons, A. Rane, H. Seyberth, J. Anker
{"title":"Paediatric Clinical Pharmacology in Europe","authors":"M. Bonati, J. Breitkreutz, I. Choonara, K. Hoppu, É. Jacqz-Aigrain, J. Langhendries, G. Pons, A. Rane, H. Seyberth, J. Anker","doi":"10.1185/146300906778876198","DOIUrl":"https://doi.org/10.1185/146300906778876198","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"134-137"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Generalised oedema in an extremely low birthweight infant during treatment with dexamethasone for chronic lung disease 地塞米松治疗慢性肺部疾病期间极低出生体重婴儿的全身性水肿
Paediatric and perinatal drug therapy Pub Date : 2006-11-01 DOI: 10.1185/146300906778876215
S. Iijima, N. Uga
{"title":"Generalised oedema in an extremely low birthweight infant during treatment with dexamethasone for chronic lung disease","authors":"S. Iijima, N. Uga","doi":"10.1185/146300906778876215","DOIUrl":"https://doi.org/10.1185/146300906778876215","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"138-142"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal valproate syndrome: a review 胎儿丙戊酸综合征:综述
Paediatric and perinatal drug therapy Pub Date : 2006-11-01 DOI: 10.1185/146300906778876233
U. Kini
{"title":"Fetal valproate syndrome: a review","authors":"U. Kini","doi":"10.1185/146300906778876233","DOIUrl":"https://doi.org/10.1185/146300906778876233","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"123-130"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Adenosine in paediatric arrhythmias 腺苷在小儿心律失常中的作用
Paediatric and perinatal drug therapy Pub Date : 2006-11-01 DOI: 10.1185/146300906778876189
C. Wren
{"title":"Adenosine in paediatric arrhythmias","authors":"C. Wren","doi":"10.1185/146300906778876189","DOIUrl":"https://doi.org/10.1185/146300906778876189","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"114-117"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Can paediatric junior hospital doctors prescribe competently 儿科初级医院的医生能胜任开处方吗
Paediatric and perinatal drug therapy Pub Date : 2006-11-01 DOI: 10.1185/146300906778876260
L. Menon, Z. Taylor, D. Tuthill
{"title":"Can paediatric junior hospital doctors prescribe competently","authors":"L. Menon, Z. Taylor, D. Tuthill","doi":"10.1185/146300906778876260","DOIUrl":"https://doi.org/10.1185/146300906778876260","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"7 1","pages":"118-120"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
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