Interdisciplinary topics in gerontology最新文献_第2页

Applications to aging networks. 老化网络的应用。

Interdisciplinary topics in gerontology Pub Date : 2015-01-01 Epub Date: 2014-10-13 DOI: 10.1159/000364925

Christopher Wimble, Tarynn M Witten

引用次数: 2

Aging as a process of deficit accumulation: its utility and origin. 衰老是一个赤字积累的过程:它的效用和起源。

Interdisciplinary topics in gerontology Pub Date : 2015-01-01 Epub Date: 2014-10-13 DOI: 10.1159/000364933

Arnold Mitnitski, Kenneth Rockwood

{"title":"Aging as a process of deficit accumulation: its utility and origin.","authors":"Arnold Mitnitski, Kenneth Rockwood","doi":"10.1159/000364933","DOIUrl":"https://doi.org/10.1159/000364933","url":null,"abstract":"Individuals of the same age differ greatly with respect to their health status and life span. We have suggested that the health status of individuals can be represented by the number of health deficits that they accumulate during their life. We have suggested that this can be measured by a fitness-frailty index (or just a frailty index), which is the ratio of the deficits present in a person to the total number of deficits considered (e.g. available in a given database or experimental procedure). Further, we have proposed that the frailty index represents the biological age of the individual, and suggested an algorithm for its estimation. In investigations by many groups, the frailty index has shown reproducible properties such as: age-specific, nonlinear increase, higher values in women, strong association with mortality and other adverse outcomes, and universal limit to its increase. At the level of individual, the frailty index shows complex stochastic dynamics, reflecting both stochasticity of the environment and the ability to recover from various illnesses. Most recently, we have proposed that the origin of deficit accumulation lies in the interaction between the environment, the organism and its ability to recover. We apply a stochastic dynamics framework to illustrate that the average recovery time increases with age, mimicking the age-associated increase in deficit accumulation.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"40 ","pages":"85-98"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000364933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32768913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 83

Modulating mTOR in aging and health. 调节mTOR在衰老和健康中的作用。

Interdisciplinary topics in gerontology Pub Date : 2015-01-01 Epub Date: 2014-10-13 DOI: 10.1159/000364974

Simon C Johnson, Maya Sangesland, Matt Kaeberlein, Peter S Rabinovitch

引用次数: 85

Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention: do we really have an antiaging drug? 保守的生长激素/IGF-1和mTOR信号通路作为衰老和癌症预防的目标:我们真的有抗衰老药物吗?

Interdisciplinary topics in gerontology Pub Date : 2015-01-01 Epub Date: 2014-10-13 DOI: 10.1159/000364982

Vladimir N Anisimov

引用次数: 9

On the immunological theory of aging. 论衰老的免疫学理论。

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI: 10.1159/000358904

Tamas Fulop, Jacek M Witkowski, Graham Pawelec, Cohen Alan, Anis Larbi

引用次数: 105

Aging of cell membranes: facts and theories. 细胞膜老化:事实与理论。

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI: 10.1159/000358900

Imre Zs-Nagy

{"title":"Aging of cell membranes: facts and theories.","authors":"Imre Zs-Nagy","doi":"10.1159/000358900","DOIUrl":"https://doi.org/10.1159/000358900","url":null,"abstract":"This chapter is intended to outline the main results of a research trend realized by the author during the last 45 years, focused on the main role played by the cell membrane in the aging process. It is a very wide field; therefore, the reader cannot expect in this limited space a detailed description, but will be given a wide, interdisciplinary insight into the main facts and theories regarding cellular aging. The central idea described here is the concept called the membrane hypothesis of aging (MHA). The history, the chemical roots, physicochemical facts, biophysical processes, as well as the obligatory biochemical consequences are all touched in by indicating the most important sources of detailed knowledge for those who are more interested in the basic biology of the aging process. This chapter covers also the available anti-aging interventions on the cell membrane by means of the centrophenoxine treatment based on the MHA. It also briefly interprets the possibilities of a just developing anti-aging method by using the recombinant human growth hormone, essential basis of which is the species specificity, and the general presence of receptors of this hormone in the plasma membrane of all types of cells.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"39 ","pages":"62-85"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000358900","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32368934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Longevity and its regulation: centenarians and beyond. 长寿及其调控:百岁老人及以上。

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI: 10.1159/000358907

L Robert, T Fulop

引用次数: 8

Oxidative stress, mitochondrial dysfunction and the mitochondria theory of aging. 氧化应激，线粒体功能障碍和衰老的线粒体理论。

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI: 10.1159/000358901

Yahui Kong, Sally E Trabucco, Hong Zhang

引用次数: 97

Control of cell replication during aging. 衰老过程中细胞复制的控制。

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI: 10.1159/000358898

Alvaro Macieira-Coelho

{"title":"Control of cell replication during aging.","authors":"Alvaro Macieira-Coelho","doi":"10.1159/000358898","DOIUrl":"https://doi.org/10.1159/000358898","url":null,"abstract":"The observation that human ﬁbroblasts have a limited number of cell population doublings in vitro led to the proposal that it is the expression of cellular aging. In vitro, the proliferation of human ﬁbroblasts terminates with a postmitotic cell which was called senescent cell. Due to misinterpreted experiments, the latter was considered the hallmark of cellular aging, although obviously we do not age because our cells stop dividing. The so-called senescent cell has been the core of the investigation on cellular aging and of the theories proposed on the subject. The search for mechanisms responsible for the postmitotic state led to contradictory results, which accumulated when the term cell senescence was used to deﬁne the growth arrest due to a variety of causes. The mechanisms believed to be causing these multiple forms of cell senescence multiplied accordingly. This was disregarded claiming that there are multiple pathways to cell senescence. Since it was thought that aging favors malignant transformation, speculations were made to ﬁnd a relationship between 'cell senescence' and cancers, which led to several paradoxes. The contradictions and paradoxes should be cleared to reestablish logic and order in the ﬁeld and understand its relevance for human aging.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"39 ","pages":"24-44"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000358898","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32368932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Aging as alteration. 衰老即变化。

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI: 10.1159/000358906

Paul-Antoine Miquel

引用次数: 3