On the immunological theory of aging.

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI:10.1159/000358904

Tamas Fulop, Jacek M Witkowski, Graham Pawelec, Cohen Alan, Anis Larbi

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引用次数: 105

Abstract

Aging is a complex phenomenon the cause of which is not fully understood, despite the plethora of theories proposed to explain it. As we age, changes in essentially all physiological functions, including immunity, are apparent. Immune responses decrease with aging, contributing to the increased incidence of different chronic diseases with an inflammatory component (sometimes referred to as 'inflamm-aging'). It is clear from many studies that human longevity may be influenced by these changes in the immune system, but how they proceed is not clearly determined. In this chapter, we will review the age-related changes in the immune response and assess the validity of the immune theory of aging (i.e. that these changes in immune response are the primary cause of aging). Many data in humans support the notion that age-associated immune dysfunction may at least in part explain the aging process. Explanatory power may be enhanced by combination with other theories such as the free radical theory. More longitudinal studies are needed to corroborate the immune theory of aging.

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论衰老的免疫学理论。

衰老是一种复杂的现象，尽管提出了大量的理论来解释它，但其原因尚不完全清楚。随着年龄的增长，包括免疫力在内的所有生理功能都发生了明显的变化。免疫反应随着年龄的增长而下降，导致带有炎症成分(有时被称为“炎症老化”)的各种慢性疾病的发病率增加。从许多研究中可以清楚地看出，人类的寿命可能受到免疫系统这些变化的影响，但它们是如何进行的还不清楚。在本章中，我们将回顾免疫反应中与年龄相关的变化，并评估衰老免疫理论的有效性(即这些免疫反应的变化是衰老的主要原因)。许多人类数据支持这样一种观点，即与年龄相关的免疫功能障碍至少可以部分解释衰老过程。与自由基理论等其他理论相结合，可以增强解释力。需要更多的纵向研究来证实衰老的免疫理论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interdisciplinary topics in gerontology

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