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CHANGES IN CONCENTRATION OF TRACE ELEMENTS IN URINE, SERUM, AND SALIVA AS INDICES OF GENTAMICIN NEPHROTOXICITY IN MALE WISTAR RATS 庆大霉素肾毒性雄性wistar大鼠尿液、血清和唾液微量元素浓度的变化
Toxic substance mechanisms Pub Date : 1998-01-01 DOI: 10.1080/107691898229431
Ahmad Reza Dehpour Seyed Shahabeddin Sadr, F. Shadan, A. Norouzy, Niloofar Rezvan Bagher Minaee
{"title":"CHANGES IN CONCENTRATION OF TRACE ELEMENTS IN URINE, SERUM, AND SALIVA AS INDICES OF GENTAMICIN NEPHROTOXICITY IN MALE WISTAR RATS","authors":"Ahmad Reza Dehpour Seyed Shahabeddin Sadr, F. Shadan, A. Norouzy, Niloofar Rezvan Bagher Minaee","doi":"10.1080/107691898229431","DOIUrl":"https://doi.org/10.1080/107691898229431","url":null,"abstract":"Male Wistar rats were treated with gentamicin in repeated doses (5 2 100 mg/kg) intraperitoneally. The concentrations of trace elements (zinc and copper) in urine, serum, and pure saliva obtained from submandibular glands were determined 24 h and 20 d after the last administration of the drug. At the same time, kidneys and submandibular glands were examined histopathologically by electron microscopy. Rats receiving gentamicin demonstrated phospholipidosis at the end of 5 d of administration. At the same time, elevated zinc and copper levels in urine, increased zinc levels in serum, and decreased copper levels in serum and zinc levels in saliva were observed. Twenty days after the last injection, the levels of these metals were comparable to the control group and none of the sections demonstrated phospholipidosis. Based on these results, it may be concluded that certain changes in the levels of these metals in serum and saliva could also be an indicator of acute gentamicin nephrotoxicity.","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86384393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACUTE TOXICITY OF TOLUENE IN MALE AND FEMALE RATS:A SINGLE ORAL DOSE EXPOSURE 2-WEEK STUDY 甲苯对雄性和雌性大鼠的急性毒性:单次口服剂量暴露2周的研究
Toxic substance mechanisms Pub Date : 1998-01-01 DOI: 10.1080/107691898229440
C. S. Mehta, P. Sun, A. Kuhn
{"title":"ACUTE TOXICITY OF TOLUENE IN MALE AND FEMALE RATS:A SINGLE ORAL DOSE EXPOSURE 2-WEEK STUDY","authors":"C. S. Mehta, P. Sun, A. Kuhn","doi":"10.1080/107691898229440","DOIUrl":"https://doi.org/10.1080/107691898229440","url":null,"abstract":"The Agency for Toxic Substances and Disease Registry (ATSDR) has identified the oral route as the primary route of exposure, and neurotoxicity as the endpoint of concern, in the priority data needs for toluene. The acute oral neurotoxicity of toluene was investigated in male and female Sprague-Dawley rats. Dose selection was made relative to a benchmark dose (BD). The BD was defined as the maximum nonlethal neurotoxic dose and was examined by range-finding studies. The 3 oral (gavage) doses were 3.0 ml/kg (50% BD), 4.5 ml/kg (75% BD), and 6.0 ml/kg (100% BD). To characterize its neurotoxicity, a functional observational battery (FOB) and spontaneous motor activity (SMA) were measured on d 1 (2-3 h and 4-7 h postexposure times for FOB and SMA, respectively), 7, and 14 following toluene administration. The data indicate that on d 1, when compared with the saline controls, toluene-exposed rats (males at 4.5- and 6.0-ml/kg doses and females at 6.0-ml/kg dose) exhibited significantly ( p <.05) greater horiz...","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90343735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
DISRUPTION OF EPIDERMAL GROWTH FACTOR SIGNALING IN THE MOUSE PALATE BY SECALONIC ADIC D: AN IN VIVO STUDY 小鼠上颚表皮生长因子信号的破坏:一项体内研究
Toxic substance mechanisms Pub Date : 1998-01-01 DOI: 10.1080/107691898229422
R. V. Reddy, Guy F. Bouchar
{"title":"DISRUPTION OF EPIDERMAL GROWTH FACTOR SIGNALING IN THE MOUSE PALATE BY SECALONIC ADIC D: AN IN VIVO STUDY","authors":"R. V. Reddy, Guy F. Bouchar","doi":"10.1080/107691898229422","DOIUrl":"https://doi.org/10.1080/107691898229422","url":null,"abstract":"","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83051888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
COMMENTARY:ALTERNATIVE MEASURES OF PESTICIDE USE 评论:农药使用的替代措施
Toxic substance mechanisms Pub Date : 1998-01-01 DOI: 10.1080/107691898229468
N. Uri, C. Barnard
{"title":"COMMENTARY:ALTERNATIVE MEASURES OF PESTICIDE USE","authors":"N. Uri, C. Barnard","doi":"10.1080/107691898229468","DOIUrl":"https://doi.org/10.1080/107691898229468","url":null,"abstract":"","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79579725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Issues in Drug Toxicity ALCOHOL AND DRUGS:A POTENTIALLY DANGEROUS COMBINATION 当前的药物毒性问题酒精和药物:一个潜在的危险组合
Toxic substance mechanisms Pub Date : 1997-10-01 DOI: 10.1080/107691897229559
Daniel J. Dugan, L. Knodel
{"title":"Current Issues in Drug Toxicity ALCOHOL AND DRUGS:A POTENTIALLY DANGEROUS COMBINATION","authors":"Daniel J. Dugan, L. Knodel","doi":"10.1080/107691897229559","DOIUrl":"https://doi.org/10.1080/107691897229559","url":null,"abstract":"","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74557317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LEAD DETERMINATION IN PAROTID AND SUBMANDIBULAR SALIVAS AND WHOLE BLOOD IN RAT 大鼠腮腺、下颌下唾液及全血铅的测定
Toxic substance mechanisms Pub Date : 1997-10-01 DOI: 10.1080/107691897229513
M. Ghazi-Khansari, Zahra Mortazapour, Nasrin Shayaganfar, M. Abdollahi, A. Dehpour
{"title":"LEAD DETERMINATION IN PAROTID AND SUBMANDIBULAR SALIVAS AND WHOLE BLOOD IN RAT","authors":"M. Ghazi-Khansari, Zahra Mortazapour, Nasrin Shayaganfar, M. Abdollahi, A. Dehpour","doi":"10.1080/107691897229513","DOIUrl":"https://doi.org/10.1080/107691897229513","url":null,"abstract":"The effects of lead acetate (100 mg/ kg) after repeated intraperitoneal (ip) injection were examined in parotid and submandibular saliva and blood in rats. Animals were treated with 1, 2, or 3 injections of lead acetate and were sacrificed 1 and 7 d after the last injection. Lead concentrations were determined by flame atomic absorption spectroscopy, in whole blood and in submandibular and parotid salivas. Lead concentrations in submandibular and parotid salivas were determined to be 50% and 22% of whole blood lead concentrations, respectively. Lead concentrations in whole blood and in submandibular and parotid salivas were determined to be significantly different from their respected controls. Submandibular saliva lead concentrations were correlated with whole blood lead concentrations ( r = .78) and parotid saliva lead concentrations were correlated ( r = .93) only on d 1 with respect to whole blood level after the first administration (acute poisoning).","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77345059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
ACUTE INHALATION PHARMACOKINETICS OF BIS[2-(DIMETHYLAMINO)ETHYL] ETHER VAPOR BY HEAD-ONLY EXPOSURE OF THE FISCHER 344 RAT fischer 344大鼠仅头部接触双[2-(二甲氨基)乙醚]蒸气的急性吸入药代动力学
Toxic substance mechanisms Pub Date : 1997-10-01 DOI: 10.1080/107691897229540
C. B. Jensen, Heather D. Burle
{"title":"ACUTE INHALATION PHARMACOKINETICS OF BIS[2-(DIMETHYLAMINO)ETHYL] ETHER VAPOR BY HEAD-ONLY EXPOSURE OF THE FISCHER 344 RAT","authors":"C. B. Jensen, Heather D. Burle","doi":"10.1080/107691897229540","DOIUrl":"https://doi.org/10.1080/107691897229540","url":null,"abstract":"","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75501380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
EFFECTS OF LEAD ON ACTIVITIES OF CATECHOLAMINE BIOSYNTHETIC ENZYMES AND ON TYROSINE HYDROXYLASE PROTEIN AND mRNA LEVELS 铅对儿茶酚胺生物合成酶活性和酪氨酸羟化酶蛋白及mRNA水平的影响
Toxic substance mechanisms Pub Date : 1997-10-01 DOI: 10.1080/107691897229522
R. Reams, A. Ndifor
{"title":"EFFECTS OF LEAD ON ACTIVITIES OF CATECHOLAMINE BIOSYNTHETIC ENZYMES AND ON TYROSINE HYDROXYLASE PROTEIN AND mRNA LEVELS","authors":"R. Reams, A. Ndifor","doi":"10.1080/107691897229522","DOIUrl":"https://doi.org/10.1080/107691897229522","url":null,"abstract":"","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80692350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STUDY ON QSAR FOR GENERAL POLLUTANTS IN ORGANIC INDUSTRIAL WASTE 有机工业废弃物中一般污染物的qsar研究
Toxic substance mechanisms Pub Date : 1997-10-01 DOI: 10.1080/107691897229504
Wang Guilian, Bai Naibin
{"title":"STUDY ON QSAR FOR GENERAL POLLUTANTS IN ORGANIC INDUSTRIAL WASTE","authors":"Wang Guilian, Bai Naibin","doi":"10.1080/107691897229504","DOIUrl":"https://doi.org/10.1080/107691897229504","url":null,"abstract":"The quantitative structure-activity relationships between acute toxicity of 88 general pollutants, such as phenols, alcohols, alkanes, alkenes and alkenes, in organic industrial waste to Daphnia magna (24-h IC50) and 8 molecular descriptors are studied by an expert system approach. It shows that the correct classification rate reaches 95% in a training set including 68 compounds, and the correct prediction rate is about 90% in predicting set including 20 compounds. Some rules used in the expert system are interpreted by calculating quantum chemistry parameters, E lumo and E homo.","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79455123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
METALLOTHIONEIN GENE EXPRESSION IN THE REPRODUCTIVE TISSUES OF THE MALE WISTAR RAT: EFFECTS OF TREATMENT WITH METALS OR GLUCOCORTICOIDS 金属硫蛋白基因在雄性wistar大鼠生殖组织中的表达:金属或糖皮质激素的影响
Toxic substance mechanisms Pub Date : 1997-10-01 DOI: 10.1080/107691897229531
T. P. Coogan, Noriyuki Shirais
{"title":"METALLOTHIONEIN GENE EXPRESSION IN THE REPRODUCTIVE TISSUES OF THE MALE WISTAR RAT: EFFECTS OF TREATMENT WITH METALS OR GLUCOCORTICOIDS","authors":"T. P. Coogan, Noriyuki Shirais","doi":"10.1080/107691897229531","DOIUrl":"https://doi.org/10.1080/107691897229531","url":null,"abstract":"","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76343649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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