LEAD DETERMINATION IN PAROTID AND SUBMANDIBULAR SALIVAS AND WHOLE BLOOD IN RAT

Abstract

The effects of lead acetate (100 mg/ kg) after repeated intraperitoneal (ip) injection were examined in parotid and submandibular saliva and blood in rats. Animals were treated with 1, 2, or 3 injections of lead acetate and were sacrificed 1 and 7 d after the last injection. Lead concentrations were determined by flame atomic absorption spectroscopy, in whole blood and in submandibular and parotid salivas. Lead concentrations in submandibular and parotid salivas were determined to be 50% and 22% of whole blood lead concentrations, respectively. Lead concentrations in whole blood and in submandibular and parotid salivas were determined to be significantly different from their respected controls. Submandibular saliva lead concentrations were correlated with whole blood lead concentrations ( r = .78) and parotid saliva lead concentrations were correlated ( r = .93) only on d 1 with respect to whole blood level after the first administration (acute poisoning).