{"title":"甲苯对雄性和雌性大鼠的急性毒性:单次口服剂量暴露2周的研究","authors":"C. S. Mehta, P. Sun, A. Kuhn","doi":"10.1080/107691898229440","DOIUrl":null,"url":null,"abstract":"The Agency for Toxic Substances and Disease Registry (ATSDR) has identified the oral route as the primary route of exposure, and neurotoxicity as the endpoint of concern, in the priority data needs for toluene. The acute oral neurotoxicity of toluene was investigated in male and female Sprague-Dawley rats. Dose selection was made relative to a benchmark dose (BD). The BD was defined as the maximum nonlethal neurotoxic dose and was examined by range-finding studies. The 3 oral (gavage) doses were 3.0 ml/kg (50% BD), 4.5 ml/kg (75% BD), and 6.0 ml/kg (100% BD). To characterize its neurotoxicity, a functional observational battery (FOB) and spontaneous motor activity (SMA) were measured on d 1 (2-3 h and 4-7 h postexposure times for FOB and SMA, respectively), 7, and 14 following toluene administration. The data indicate that on d 1, when compared with the saline controls, toluene-exposed rats (males at 4.5- and 6.0-ml/kg doses and females at 6.0-ml/kg dose) exhibited significantly ( p <.05) greater horiz...","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"ACUTE TOXICITY OF TOLUENE IN MALE AND FEMALE RATS:A SINGLE ORAL DOSE EXPOSURE 2-WEEK STUDY\",\"authors\":\"C. S. Mehta, P. Sun, A. Kuhn\",\"doi\":\"10.1080/107691898229440\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The Agency for Toxic Substances and Disease Registry (ATSDR) has identified the oral route as the primary route of exposure, and neurotoxicity as the endpoint of concern, in the priority data needs for toluene. The acute oral neurotoxicity of toluene was investigated in male and female Sprague-Dawley rats. Dose selection was made relative to a benchmark dose (BD). The BD was defined as the maximum nonlethal neurotoxic dose and was examined by range-finding studies. The 3 oral (gavage) doses were 3.0 ml/kg (50% BD), 4.5 ml/kg (75% BD), and 6.0 ml/kg (100% BD). To characterize its neurotoxicity, a functional observational battery (FOB) and spontaneous motor activity (SMA) were measured on d 1 (2-3 h and 4-7 h postexposure times for FOB and SMA, respectively), 7, and 14 following toluene administration. The data indicate that on d 1, when compared with the saline controls, toluene-exposed rats (males at 4.5- and 6.0-ml/kg doses and females at 6.0-ml/kg dose) exhibited significantly ( p <.05) greater horiz...\",\"PeriodicalId\":87425,\"journal\":{\"name\":\"Toxic substance mechanisms\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxic substance mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/107691898229440\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxic substance mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/107691898229440","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ACUTE TOXICITY OF TOLUENE IN MALE AND FEMALE RATS:A SINGLE ORAL DOSE EXPOSURE 2-WEEK STUDY
The Agency for Toxic Substances and Disease Registry (ATSDR) has identified the oral route as the primary route of exposure, and neurotoxicity as the endpoint of concern, in the priority data needs for toluene. The acute oral neurotoxicity of toluene was investigated in male and female Sprague-Dawley rats. Dose selection was made relative to a benchmark dose (BD). The BD was defined as the maximum nonlethal neurotoxic dose and was examined by range-finding studies. The 3 oral (gavage) doses were 3.0 ml/kg (50% BD), 4.5 ml/kg (75% BD), and 6.0 ml/kg (100% BD). To characterize its neurotoxicity, a functional observational battery (FOB) and spontaneous motor activity (SMA) were measured on d 1 (2-3 h and 4-7 h postexposure times for FOB and SMA, respectively), 7, and 14 following toluene administration. The data indicate that on d 1, when compared with the saline controls, toluene-exposed rats (males at 4.5- and 6.0-ml/kg doses and females at 6.0-ml/kg dose) exhibited significantly ( p <.05) greater horiz...