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IEE proceedings. Nanobiotechnology最新文献

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Adaptive, integrated sensor processing to compensate for drift and uncertainty: a stochastic 'neural' approach. 自适应集成传感器处理补偿漂移和不确定性:随机“神经”方法。
IEE proceedings. Nanobiotechnology Pub Date : 2004-02-01 DOI: 10.1049/ip-nbt:20040213
T B Tang, H Chen, A F Murray
{"title":"Adaptive, integrated sensor processing to compensate for drift and uncertainty: a stochastic 'neural' approach.","authors":"T B Tang,&nbsp;H Chen,&nbsp;A F Murray","doi":"10.1049/ip-nbt:20040213","DOIUrl":"https://doi.org/10.1049/ip-nbt:20040213","url":null,"abstract":"<p><p>An adaptive stochastic classifier based on a simple, novel neural architecture--the Continuous Restricted Boltzmann Machine (CRBM) is demonstrated. Together with sensors and signal conditioning circuits, the classifier is capable of measuring and classifying (with high accuracy) the H+ ion concentration, in the presence of both random noise and sensor drift. Training on-line, the stochastic classifier is able to overcome significant drift of real incomplete sensor data dynamically. As analogue hardware, this signal-level sensor fusion scheme is therefore suitable for real-time analysis in a miniaturised multisensor microsystem such as a Lab-in-a-Pill (LIAP).</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"151 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20040213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25854382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Modelling muscle motor conformations using low-angle X-ray diffraction. 用低角x射线衍射模拟肌肉运动构象。
IEE proceedings. Nanobiotechnology Pub Date : 2003-12-01 DOI: 10.1049/ip-nbt:20031094
J M Squire, H A Al-Khayat, J J Harford, L Hudson, T Irving, C Knupp, M K Reedy
{"title":"Modelling muscle motor conformations using low-angle X-ray diffraction.","authors":"J M Squire,&nbsp;H A Al-Khayat,&nbsp;J J Harford,&nbsp;L Hudson,&nbsp;T Irving,&nbsp;C Knupp,&nbsp;M K Reedy","doi":"10.1049/ip-nbt:20031094","DOIUrl":"https://doi.org/10.1049/ip-nbt:20031094","url":null,"abstract":"<p><p>New results on myosin head organization using analysis of low-angle X-ray diffraction patterns from relaxed insect flight muscle (IFM) from a giant waterbug, building on previous studies of myosin filaments in bony fish skeletal muscle (BFM), show that the information content of such low-angle diffraction patterns is very high despite the 'crystallographically low' resolution limit (65 A) of the spacings of the Bragg diffraction peaks being used. This high information content and high structural sensitivity arises because: (i) the atomic structures of the domains of the myosin head are known from protein crystallography; and (ii) myosin head action appears to consist mainly of pivoting between domains which themselves stay rather constant in structure, thus (iii) the intensity distribution among diffraction peaks in even the low resolution diffraction pattern is highly determined by the high-resolution distribution of atomically modelled domain mass. A single model was selected among 5000+ computer-generated variations as giving the best fit for the 65 reflections recorded within the selected resolution limit of 65 A. Clear evidence for a change in shape of the insect flight muscle myosin motor between the resting (probably like the pre-powerstroke) state and the rigor state (considered to mimic the end-of-powerstroke conformation) has been obtained. This illustrates the power of the low-angle X-ray diffraction method. The implications of these new results about myosin motor action during muscle contraction are discussed.</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 3","pages":"103-10"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20031094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Nanometre resolution tracking of myosin-1b motility. 肌球蛋白-1b运动的纳米分辨率跟踪。
IEE proceedings. Nanobiotechnology Pub Date : 2003-12-01 DOI: 10.1049/ip-nbt:20031169
M I Wallace, C Batters, L M Coluccio, J E Molloy
{"title":"Nanometre resolution tracking of myosin-1b motility.","authors":"M I Wallace, C Batters, L M Coluccio, J E Molloy","doi":"10.1049/ip-nbt:20031169","DOIUrl":"10.1049/ip-nbt:20031169","url":null,"abstract":"<p><p>The movement produced by a small number of myosin molecular motors was measured with nanometre precision using single-molecule fluorescence localisation methods. The positional precision of the measurements was sufficient to reveal fluctuations in sliding velocity due to stochastic interactions between individual myosin motors and the actin filament. Dependence of sliding velocity upon filament length was measured and fluctuations in velocity were quantified by autocorrelation analysis. Optical tweezers-based nanometry was used to measure the myosin-1b step-size directly. The 10 nm power-stroke and its duty cycle ratio were consistent with values derived from in vitro sliding assays.</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 3","pages":"134-40"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidation of the separate roles of myosins IIA and IIB during neurite outgrowth, adhesion and retraction. 阐明肌球蛋白IIA和IIB在神经突生长、粘连和收缩中的作用。
IEE proceedings. Nanobiotechnology Pub Date : 2003-12-01 DOI: 10.1049/ip-nbt:20031076
P D Chantler, S R Wylie
{"title":"Elucidation of the separate roles of myosins IIA and IIB during neurite outgrowth, adhesion and retraction.","authors":"P D Chantler,&nbsp;S R Wylie","doi":"10.1049/ip-nbt:20031076","DOIUrl":"https://doi.org/10.1049/ip-nbt:20031076","url":null,"abstract":"<p><p>The functions of nonmuscle myosin isoforms are key to an understanding of process outgrowth from nerve cells during animal development. Despite considerable structural similarity, myosin IIA and myosin IIB play distinct and complementary roles during the actin-based mechanisms of nerve process extension. An overview is given of evidence that implicates myosin IIB as the motor essential for nerve process outgrowth and myosin IIA both as the motor required to maintain cell adhesion to the substrate as well as the motor required to power retraction of the nerve cell process. These actions are placed in context within a model for nerve process extension that is consistent with many observations in the literature and provides testable hypotheses regarding possible roles for these nonmuscle myosin motors. The relevance of a fundamental understanding of the mechanisms underpinning nerve cell process extension to the application of nanotechnology in this area is also discussed.</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 3","pages":"111-25"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20031076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Molecular motors: nature's nanomachines. 分子马达:自然界的纳米机器。
IEE proceedings. Nanobiotechnology Pub Date : 2003-12-01 DOI: 10.1049/ip-nbt:20031172
M J A Tyreman, J E Molloy
{"title":"Molecular motors: nature's nanomachines.","authors":"M J A Tyreman,&nbsp;J E Molloy","doi":"10.1049/ip-nbt:20031172","DOIUrl":"https://doi.org/10.1049/ip-nbt:20031172","url":null,"abstract":"<p><p>Molecular motors are protein-based machines that convert chemical potential energy into mechanical work. This paper aims to introduce the non-specialist reader to molecular motors, in particular, acto-myosin, the prototype system for motor protein studies. These motors produce their driving force from changes in chemical potential arising directly from chemical reactions and are responsible for muscle contraction and a variety of other cell motilities.</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 3","pages":"95-102"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20031172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Mathematical theory of molecular motors and a new approach for uncovering motor mechanism. 分子马达的数学理论与揭示马达机理的新途径。
IEE proceedings. Nanobiotechnology Pub Date : 2003-12-01 DOI: 10.1049/ip-nbt:20031075
H Wang
{"title":"Mathematical theory of molecular motors and a new approach for uncovering motor mechanism.","authors":"H Wang","doi":"10.1049/ip-nbt:20031075","DOIUrl":"https://doi.org/10.1049/ip-nbt:20031075","url":null,"abstract":"<p><p>Molecular motors operate in an environment dominated by thermal fluctuations. A molecular motor may produce an active force at the reaction site to directly move the motor forward. Alternatively a molecular motor may generate a unidirectional motion by rectifying thermal fluctuations. In this case, the chemical reaction establishes free energy barriers to block the backward fluctuations. The effect of the chemical reaction on the motor motion can be represented by the motor potential profile (rectifying barrier andor active driving force). Different motor mechanisms are characterised by different motor potential profiles. The mathematical theory and properties of molecular motors are discussed and a mathematical framework is developed for extracting the motor potential profile from measured time series of motor position. As an example, we discuss the binding zipper model for the F(1) ATPase, which was motivated mainly by the fact that the motor potential profile of the F(1) ATPase is nearly a constant slope.</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 3","pages":"127-33"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20031075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Editorial: Molecular motors. 社论：分子马达。
IEE proceedings. Nanobiotechnology Pub Date : 2003-12-01 DOI: 10.1049/ip-nbt:20031216
J E Molloy, C Veigel
{"title":"Editorial: Molecular motors.","authors":"J E Molloy, C Veigel","doi":"10.1049/ip-nbt:20031216","DOIUrl":"10.1049/ip-nbt:20031216","url":null,"abstract":"","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 3","pages":"93"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of scale on electrostatic forces and torques in AC particulate electrokinetics. 交流微粒电动力学中尺度对静电力和力矩的影响。
IEE proceedings. Nanobiotechnology Pub Date : 2003-11-01 DOI: 10.1049/ip-nbt:20031101
T B Jones
{"title":"Influence of scale on electrostatic forces and torques in AC particulate electrokinetics.","authors":"T B Jones","doi":"10.1049/ip-nbt:20031101","DOIUrl":"https://doi.org/10.1049/ip-nbt:20031101","url":null,"abstract":"<p><p>Dielectrophoretic forces and torques move and manipulate biological cells, typically of the order of 10 mum ( approximately 10(-5) m) in diameter and ordinarily suspended in aqueous liquids, using electrodes with dimensions around 100 mum ( approximately 10(-4) m). The ability to exploit these same electromechanical effects for particles below 1 mum, that is, <10(-6) m, creates opportunities for remote manipulation and handling of subcellular components, biological macromolecules, and DNA. In this paper, Trimmer's bracket notation is adapted for systematic examination of the scaling laws governing electrokinetic behaviour. The purpose is to shed light on how critical performance measures relevant to the laboratory on a chip are affected by reducing particle sizes and electrode dimensions into the nanometre range. The scaling methodology facilitates consideration of the effect of electrode structure and particle size reduction on voltage, electric field, heating, and response time. Particles with induced moments, dipolar and quadrupolar, as well as permanent dipoles are examined. Separate consideration is given to electrical torque and its application in electrorotation and particle alignment. An eventual goal of these scaling studies is to identify the lower limit on the size of particles that can be manipulated effectively using electrokinetic phenomena.</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 2","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20031101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Dielectrophoresis of microbioparticles in water with planar and capillary quadrupole electrodes. 平面四极电极和毛细管四极电极对水中微生物微粒的电泳研究。
IEE proceedings. Nanobiotechnology Pub Date : 2003-11-01 DOI: 10.1049/ip-nbt:20031031
S Tsukahara, H Watarai
{"title":"Dielectrophoresis of microbioparticles in water with planar and capillary quadrupole electrodes.","authors":"S Tsukahara,&nbsp;H Watarai","doi":"10.1049/ip-nbt:20031031","DOIUrl":"https://doi.org/10.1049/ip-nbt:20031031","url":null,"abstract":"<p><p>Dielectrophoresis of single microbioparticles was measured in a planar quadrupole microelectrode (50 mum or 65 mum in working area radius) with a microscope. Carbon and polystyrene microparticles, yeast cells and DNA molecules (about 40 kbp) were adopted as a sample. Their dielectrophoretic mobilities were analysed quantitatively with their intrinsic and surface conductivity, their permittivities and their sizes as well as the conductivity and permittivity of aqueous media. Using the dielectrophoretic mobilities obtained with the planar quadrupole microelectrode, some instances of the separation performance between the microparticles were demonstrated with a fabricated capillary quadrupole microelectrode (82.5 mum in bore radius) under the field flow fractionation regime.</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 2","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20031031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dielectrophoretic manipulation of DNA. DNA的介电泳操作。
IEE proceedings. Nanobiotechnology Pub Date : 2003-11-01 DOI: 10.1049/ip-nbt:20031006
R Hölzel, F F Bier
{"title":"Dielectrophoretic manipulation of DNA.","authors":"R Hölzel,&nbsp;F F Bier","doi":"10.1049/ip-nbt:20031006","DOIUrl":"https://doi.org/10.1049/ip-nbt:20031006","url":null,"abstract":"<p><p>The characterisation and spatial manipulation of cells by AC electrokinetic methods such as dielectrophoresis and electrorotation is well established. However, applications to submicroscopical objects like viruses and molecules have been rare. Only recently has the number of such studies risen more quickly due to the availability of suitable electrodes and a growing need for single molecule techniques. Of special interest is the spatial control of single DNA molecules for genetic investigations as well as for the building of well defined structures with nanometre resolution. Here a review is given of dielectrophoretic studies dealing with single and double stranded DNA emphasising single molecule aspects.</p>","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"150 2","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20031006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25848125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
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