IEE proceedings. Nanobiotechnology最新文献

Dynamics of rotating paramagnetic particles simulated by lattice Boltzmann and particle dynamics methods. 用晶格玻尔兹曼和粒子动力学方法模拟旋转顺磁粒子动力学。

IEE proceedings. Nanobiotechnology Pub Date : 2006-12-01 DOI: 10.1049/ip-nbt:20060009

A Yadav, R Calhoun, P E Phelan, A K Vuppu, A A Garcia, M Hayes

{"title":"Dynamics of rotating paramagnetic particles simulated by lattice Boltzmann and particle dynamics methods.","authors":"A Yadav, R Calhoun, P E Phelan, A K Vuppu, A A Garcia, M Hayes","doi":"10.1049/ip-nbt:20060009","DOIUrl":"https://doi.org/10.1049/ip-nbt:20060009","url":null,"abstract":"Novel biochemical sensors consisting of rotating chains of microscale paramagnetic particles have been proposed that would enable convenient, sensitive analyte detection. Predicting the dynamics of these particles is required to optimise their design. The results of lattice Boltzmann (LB) and particle dynamics (PD) simulations are reported, where the LB approach provides a verified solution of the complete Navier-Stokes equations, including the hydrodynamic interactions among the particles. On the other hand, the simpler PD approach neglects hydrodynamic interactions, and does not compute the fluid motion. It is shown that macroscopic properties, like the number of aggregated particles, depend only on the drag force and not on the total hydrodynamic force, making PD simulations yield reasonably accurate predictions. Relatively good agreement between the LB and PD simulations, and qualitative agreement with experimental data, are found for the number of aggregated particles as a function of the Mason number. The drag force on a rotating cylinder is significantly different from that on particle chains calculated from both simulations, demonstrating the different dynamics between the two cases. For microscopic quantities like the detailed force distributions on each particle, the complete Navier-Stokes solution, here represented by the LB simulation, is required.","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"153 6","pages":"145-50"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20060009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26516905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Absorption detection of enzymatic reaction using optical microfluidics based intermittent flow microreactor system. 基于光学微流体间歇流微反应器系统的酶促反应吸收检测。

IEE proceedings. Nanobiotechnology Pub Date : 2006-12-01 DOI: 10.1049/ip-nbt:20060012

A Chandrasekaran, M Packirisamy

{"title":"Absorption detection of enzymatic reaction using optical microfluidics based intermittent flow microreactor system.","authors":"A Chandrasekaran, M Packirisamy","doi":"10.1049/ip-nbt:20060012","DOIUrl":"https://doi.org/10.1049/ip-nbt:20060012","url":null,"abstract":"The advantages of integrating microfluidics into photonics-based biosensing for fabricating microreactor type lab-on-a-chip devices carries a lot of advantages, such as smaller sample volume handling, controlled drug delivery and high throughput diagnosis, which is useful for in situ medical diagnosis and point-of-care (POC) testing. A hybrid integrated optical microfluidic system has been developed for the study of single molecules and enzymatic reactions. The method of optical absorption has been employed for biosensing and the feasibility of absorption-based detection on the microfluidic platform has been demonstrated using horseradish peroxidase and hydrogen peroxide, as an example. The results show that the device is useful for the analysis of both the individual chemical specimen and also the study of chemical and biological reaction between two reacting species. The hybrid integration of microfluidics and optical ensembles thus forms the basis for developing the microreactor type lab-on-a-chip device, which would have several important applications in the area of nanobiotechnology.","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"153 6","pages":"137-43"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20060012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26516904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Analysis of cellular structure by light scattering measurements in a new cytometer design based on a liquid-core waveguide. 基于液芯波导的新型细胞仪设计中的细胞结构光散射分析。

IEE proceedings. Nanobiotechnology Pub Date : 2006-10-01 DOI: 10.1049/ip-nbt:20060004

Y H Ji

引用次数: 10

Application of nano-indenter for investigation of the properties of the elytra cuticle of the dung beetle (Copris ochus Motschulsky). 纳米压头在屎壳虫鞘翅角质层特性研究中的应用。

IEE proceedings. Nanobiotechnology Pub Date : 2006-10-01 DOI: 10.1049/ip-nbt:20050050

J Y Sun, J Tong, J Zhou

引用次数: 17

Fast-scanning atomic force microscopy reveals the molecular mechanism of DNA cleavage by ApaI endonuclease. 快速扫描原子力显微镜揭示了ApaI内切酶裂解DNA的分子机制。

IEE proceedings. Nanobiotechnology Pub Date : 2006-08-01 DOI: 10.1049/ip-nbt:20050018

M Yokokawa, S H Yoshimura, Y Naito, T Ando, A Yagi, N Sakai, K Takeyasu

引用次数: 5

Microfluidic sensor for dynamic surface tension measurement. 用于动态表面张力测量的微流体传感器。

IEE proceedings. Nanobiotechnology Pub Date : 2006-08-01 DOI: 10.1049/ip-nbt:20050013

N-T Nguyen, S Lassemono, F A Chollet, C Yang

{"title":"Microfluidic sensor for dynamic surface tension measurement.","authors":"N-T Nguyen, S Lassemono, F A Chollet, C Yang","doi":"10.1049/ip-nbt:20050013","DOIUrl":"https://doi.org/10.1049/ip-nbt:20050013","url":null,"abstract":"A novel microfluidic sensor for measuring dynamic gas-liquid interfacial tension is reported. The device consists of a microfluidic chip with a microchannel network and an optical detection system. The sample is introduced into a main channel, while air is injected through a T-junction. Owing to the fixed flow rate ratio used for the sensor, surface tension is the only parameter determining bubble formation frequency, which can be measured by optical detection. Although the bubble is represented by a pulse in the output signal, the formation frequency is simply the frequency of the output signal. Measurements were carried out for aqueous solutions with different concentrations of the ionic surfactant cetyl trimethyl ammonium bromide. Surface tensions of these solutions were calibrated with a commercial tensiometer. The measurement results show a clear relationship between surface tension and formation frequency. The sensor can be used to identify the critical micelle concentration of the surfactant. The sensor potentially allows the use of a minute amount of sample compared with the relatively large amount required for existing commercial systems.","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"153 4","pages":"102-6"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20050013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26232927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Characterisation of pore structures in nanoporous materials for advanced bionanotechnology. 用于先进生物纳米技术的纳米多孔材料的孔隙结构表征。

IEE proceedings. Nanobiotechnology Pub Date : 2006-08-01 DOI: 10.1049/ip-nbt:20050020

K Heo, J Yoon, K S Jin, S Jin, M Ree

引用次数: 11

Paramagnetic capture mode magnetophoretic microseparator for blood cells. 顺磁捕获模式磁泳微血细胞分离器。

IEE proceedings. Nanobiotechnology Pub Date : 2006-08-01 DOI: 10.1049/ip-nbt:20050019

K-H Han, A B Frazier

引用次数: 40

Membrane channels as a tool to control nanoreactors. 膜通道作为控制纳米反应器的工具。

IEE proceedings. Nanobiotechnology Pub Date : 2006-08-01 DOI: 10.1049/ip-nbt:20050027

M Lindemann, M Winterhalter

{"title":"Membrane channels as a tool to control nanoreactors.","authors":"M Lindemann, M Winterhalter","doi":"10.1049/ip-nbt:20050027","DOIUrl":"https://doi.org/10.1049/ip-nbt:20050027","url":null,"abstract":"We present an example of the use of self-assembly of biomolecules to create nanostructured building blocks. The resulting individual compartments can be tailored to fulfil specific functions: catalysis of a chemical reaction in a confined environment, detection on a molecular level and feedback with the outside. For example, such individually designed components can be assembled to build up macroscopic chemically active filters. The main component is membrane channels acting as molecular sieves, able to control the permeation across the capsule wall. We introduce briefly a new microdevice to characterise membrane channels with a future potential for high-throughput screening of channel properties based on automation, parallelisation and the use of microfluidics. Subsequently, we outline a possible application for channel-forming proteins: encapsulation of charged polymers or proteins into liposomes and restriction of diffusion through transmembrane channels to small ions, creating a Donnan potential. This Donnan potential can be used for external manipulation of nanocontainers by coupling of the capsule to an external electric field, or for the selective uptake of small charged molecules into the capsule.","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"153 4","pages":"107-11"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20050027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26232928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Integration of microfluidics with biomedical infrared spectroscopy for analytical and diagnostic metabolic profiling. 集成微流体与生物医学红外光谱分析和诊断代谢谱。

IEE proceedings. Nanobiotechnology Pub Date : 2006-08-01 DOI: 10.1049/ip-nbt:20050028

C D Mansfield, A Man, R A Shaw

{"title":"Integration of microfluidics with biomedical infrared spectroscopy for analytical and diagnostic metabolic profiling.","authors":"C D Mansfield, A Man, R A Shaw","doi":"10.1049/ip-nbt:20050028","DOIUrl":"https://doi.org/10.1049/ip-nbt:20050028","url":null,"abstract":"We describe how infrared spectroscopy of dry films (IRDF) can provide diagnostic information, and how we expect integration with laminar fluid diffusion interface (LFDI) sample pre-processing to generate new analytical and diagnostic tests. LFDI pre-processing provides sample clean-up and analyte separation. The sensitivity of IRDF to certain analytes is enhanced through the depletion of sample constituents that otherwise obscure relevant spectral features, permitting the deposition of films with larger sample volumes and, hence, of greater effective optical pathlength for the targeted analytes. An integrated LFDI-IRDF technology holds promise both as a method for rapid point-of-care quantitative analysis of biological fluids and as the engine of discovery for a wide range of novel diagnostic methods based upon metabolic profiling. In particular, successful integration will provide a versatile and cost effective technology platform that will allow for the accurate quantification of low-concentration analytes that are otherwise inaccessible and will provide the basis for diagnostic and prognostic methods that would otherwise be impossible. The specific question addressed by the proof-of-concept study summarised here is whether the spectra of LFDI processed samples can provide analytical methods that are more accurate than otherwise possible without LFDI pre-processing. The enrichment of serum creatinine is accomplished, with subsequent enhancement of its spectral contribution permitting quantification of this clinically important analyte beyond that achievable with no pre-processing. Finally, to illustrate the potential in diagnostic applications, two recently initiated studies are outlined, one involving chronic kidney disease and the other for chronic and acute coronary artery disease.","PeriodicalId":87402,"journal":{"name":"IEE proceedings. Nanobiotechnology","volume":"153 4","pages":"74-80"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-nbt:20050028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26232925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9