Beyoglu Eye JournalPub Date : 2026-10-01eCollection Date: 2026-01-01DOI: 10.14744/bej.2026.38802
Fevzi Akkan, Ersin Akbulut
{"title":"Outcomes and Safety of Femtosecond Laser-Assisted Phacovitrectomy Using 25-Gauge Pars Plana Vitrectomy.","authors":"Fevzi Akkan, Ersin Akbulut","doi":"10.14744/bej.2026.38802","DOIUrl":"https://doi.org/10.14744/bej.2026.38802","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the safety, visual outcomes, and complication profile of femtosecond laser-assisted cataract surgery (FLACS) combined with 25-gauge pars plana vitrectomy (PPV) in patients with concurrent cataract and vitreoretinal disease.</p><p><strong>Methods: </strong>This retrospective study included 57 eyes of 57 patients who underwent FLACS with a standardized 4.8-mm capsulotomy followed by 25-gauge PPV at a tertiary referral center in Istanbul, Turkey, between August 2020 and May 2025. Data collected included intraoperative events, postoperative best-corrected visual acuity (BCVA, Snellen converted to logMAR for analysis), intraocular pressure (IOP), and complication rates over a mean follow-up of 15.8±1.8 months.</p><p><strong>Results: </strong>Mean BCVA significantly improved from 0.68±0.34 logMAR preoperatively to 0.28±0.14 logMAR at 1 month, 0.19±0.11 logMAR at 3 months, and 0.15±0.14 logMAR at the final visit (all p<0.001). All eyes achieved meaningful visual recovery with stable and well-centered intraocular lenses and attached retinas. On postoperative day 1, post-hoc pairwise analysis revealed a significantly lower IOP in the air tamponade group compared with the SF6 and BSS groups (MD=-4.24, p<0.001); no significant IOP differences were found between groups at week 1, month 1, or month 3. Intraoperative complications included loss of cone suction (n=2, 3.5%) and incomplete capsulorhexis (n=2, 3.5%). Miosis occurred in 6 eyes (10.5%), and sclerotomy leakage requiring suturing in 7 eyes (12.3%).</p><p><strong>Conclusions: </strong>Combined FLACS and 25-gauge PPV is a safe and effective option for the management of coexisting cataract and vitreoretinal pathologies. The procedure provides favorable anatomical and visual outcomes with a low incidence of intraoperative and postoperative complications, supporting its use in appropriately selected patients. Prospective controlled studies are warranted to confirm these findings.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"244-251"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyoglu Eye JournalPub Date : 2026-10-01eCollection Date: 2026-01-01DOI: 10.14744/bej.2026.77528
Yasin Çimen, Habibullah Saltuk Songür, Mukaddes Kübra Uçar, Alper Can Yılmaz
{"title":"Cidofovir-Induced Bilateral Uveitis, Hypotony and Choroidal Effusion: A Case Report.","authors":"Yasin Çimen, Habibullah Saltuk Songür, Mukaddes Kübra Uçar, Alper Can Yılmaz","doi":"10.14744/bej.2026.77528","DOIUrl":"https://doi.org/10.14744/bej.2026.77528","url":null,"abstract":"<p><p>Cidofovir is an antiviral agent used in the treatment of viral infections but is associated with ocular toxicities. We report a case of a 71-year-old immunocompromised woman who developed bilateral anterior uveitis, marked hypotony, and choroidal effusion following intravenous cidofovir treatment for refractory herpes simplex virus type 2 infection. Ophthalmic examination and multimodal imaging, including optical coherence tomography and ocular ultrasonography, confirmed bilateral choroidal folds and effusion. Extensive systemic evaluation excluded infectious, inflammatory, and autoimmune etiologies. The close temporal relationship between cidofovir administration and symptom onset supported a diagnosis of cidofovir-induced ocular toxicity. Discontinuation of cidofovir and initiation of intensive topical corticosteroid therapy resulted in clinical improvement. This case highlights the importance of early recognition of cidofovir-related ocular adverse effects and the need for close ophthalmic monitoring during therapy.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"277-280"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Histopathologically Proven Tarsal Lacrimal Gland Choristoma.","authors":"Ezgi Tatlici, Eratilgan Nihat Furkan, Banu Yaman, Melis Palamar","doi":"10.14744/bej.2026.94758","DOIUrl":"https://doi.org/10.14744/bej.2026.94758","url":null,"abstract":"<p><p>Ectopic lacrimal glands, also known as lacrimal gland choristomas, are seen in various areas of the eyes and are characterized by their placement outside of their typical anatomical position. While tarsal lacrimal gland choristomas are uncommon, the bulbar conjunctiva and limbal area have been identified as the most frequent sites. Herein, we report a 32-year-old female with a mass on the left lower eyelid conjunctiva that is histopathologically proved to be a lacrimal gland choristoma.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"281-284"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyoglu Eye JournalPub Date : 2026-10-01eCollection Date: 2026-01-01DOI: 10.14744/bej.2026.75391
Muhammer Özgür Çevik
{"title":"Molecular Diagnostic Yield and Genotype-Phenotype Spectrum of Inherited Eye Diseases in a Tertiary Health Center in Türkiye.","authors":"Muhammer Özgür Çevik","doi":"10.14744/bej.2026.75391","DOIUrl":"https://doi.org/10.14744/bej.2026.75391","url":null,"abstract":"<p><strong>Objectives: </strong>To describe ophthalmic phenotypes prompting genetic testing and to calculate the molecular diagnostic yield retrospectively in a real-world tertiary health center cohort.</p><p><strong>Methods: </strong>This retrospective observational study employed a phenotype-first review of archived clinical genetic testing records. Unique individuals with documented ocular manifestations were identified and deduplicated using demographic and phenotype consistency rather than laboratory patient number alone. Patients were assigned one primary molecular outcome: Phenotype-concordant pathogenic or likely pathogenic diagnosis, candidate/variant of uncertain significance/partial finding, unresolved, or secondary/non-diagnostic pathogenic or likely pathogenic finding. Variants of uncertain significance, single pathogenic alleles for recessive disorders, and unphased biallelic variants were not counted as definitive diagnoses.</p><p><strong>Results: </strong>Among 33 unique individuals, phenotype-concordant molecular diagnoses were established in 18.2% (6/33), while candidate, variant of uncertain significance, or partial findings were more frequent at 54.5% (18/33). Diagnoses involved <i>REEP6, TYR, PTEN, BRPF1</i>, and <i>CACNA1F</i>. An additional patient with albinism carried two heterozygous <i>TYR</i> pathogenic or likely pathogenic variants, but phase was not established; confirmation in trans would increase the yield to 21.2%. Excluding a <i>CACNA1F</i> case with a nonspecific archived phenotype reduced the yield to 15.2%.</p><p><strong>Conclusion: </strong>The conservative molecular diagnostic yield was 18.2%, with candidate and partial findings substantially outnumbering definitive diagnoses. This gap underscores the importance of phenotype concordance, inheritance-aware interpretation, and segregation analysis in real-world ophthalmic genetics, where unresolved cases represent a reanalysis cohort rather than a diagnostic dead end.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"266-271"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyoglu Eye JournalPub Date : 2026-10-01eCollection Date: 2026-01-01DOI: 10.14744/bej.2026.46343
Metehan Simsek, Husna Topcu, Kubra Serefoglu Cabuk, Pelin Ozyavuz Cubuk, Erva Bengu Balaban, Alp Peker, Mehmet Goksel Ulas, Ayse Cetin Efe
{"title":"A Rare Homozygous Synonymous Variant in the ECM1 Gene in a Lipoid Proteinosis Patient.","authors":"Metehan Simsek, Husna Topcu, Kubra Serefoglu Cabuk, Pelin Ozyavuz Cubuk, Erva Bengu Balaban, Alp Peker, Mehmet Goksel Ulas, Ayse Cetin Efe","doi":"10.14744/bej.2026.46343","DOIUrl":"https://doi.org/10.14744/bej.2026.46343","url":null,"abstract":"<p><p>Lipoid proteinosis (LP) is a rare autosomal recessive disorder resulting from mutations in the <i>ECM1</i> gene and characterized by mucocutaneous thickening and deposition of hyaline material. We present a 10-year-old male with hoarseness, moniliform blepharosis, oral mucosal nodules, and cutaneous lesions. Histopathology showed PAS-positive hyaline material deposition. Genetic analysis by next-generation sequencing identified a homozygous synonymous variation, <i>ECM1</i> c.879G>A (p.Ser293=), which has not been previously reported in a homozygous form. Segregation analysis showed heterozygosity in both parents. In accordance with ACMG guidelines, the variant meets criteria PS4, PM2, PM3, PP3, and PP4, supporting its reclassification as pathogenic. This case highlights the diagnostic value of combining clinical, histological, and genomic data, especially in the evaluation of variations of uncertain significance. Genotyping in patients clinically and histopathologically compatible with LP is crucial to inform disease management and enhance understanding of its genetic background.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"272-276"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyoglu Eye JournalPub Date : 2026-10-01eCollection Date: 2026-01-01DOI: 10.14744/bej.2026.75318
Ismail Evgin, Mete Guler, Gokhan Kokusari
{"title":"Effect of Internal Limiting Membrane Peeling on Macular and Optic Disc Vascular Density Following Epiretinal Membrane Surgery.","authors":"Ismail Evgin, Mete Guler, Gokhan Kokusari","doi":"10.14744/bej.2026.75318","DOIUrl":"https://doi.org/10.14744/bej.2026.75318","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of internal limiting membrane peeling on vascular density of macula and optic disc in idiopathic epiretinal membrane surgery.</p><p><strong>Methods: </strong>Thirty-six eyes of 36 patients who underwent combined phacoemulsification with intraocular lens implantation followed by pars plana vitrectomy and epiretinal membrane (ERM) removal were prospectively included in this study. Based on the intraoperative status of the internal limiting membrane (ILM) after ERM removal, the eyes were classified into two groups: The ILM-peeled group (n=22) and the ILM-unpeeled group (n=14). Vascular density of superficial capillary plexus, deep capillary plexus, optic nerve head and radial peripapillary capillary plexus were obtained by optical coherence tomography angiography before and up to 3 months after surgery.</p><p><strong>Results: </strong>After surgery, superficial capillary plexus fovea vascular density and foveal thickness decreased significantly in the internal limiting membrane unpeeled group. (p=0.016; p=0.048 respectively). There was no significant change in superficial capillary plexus paravofea (p=0.257), deep capillary plexus fovea (p=0.569), deep capillary plexus parafovea (p=0.457), optic nerve head (p=0.545) and radial peripapillary capillary plexus (p=0.975) vascular density comparison between groups.</p><p><strong>Conclusion: </strong>Internal limiting membrane peeling has no significant effect on deep capillary plexus and the optic disc vascular density, but can reduce vascular density in the superficial capillary plexus after idiopathic epiretinal membrane peeling surgery.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"252-260"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyoglu Eye JournalPub Date : 2026-10-01eCollection Date: 2026-01-01DOI: 10.14744/bej.2026.89896
Ali Safa Balci, Husna Topcu, Merve Emul, Mehmet Goksel Ulas, Ayse Cetin Efe, Fatma Poslu Karademir, Kubra Serefoglu Cabuk
{"title":"Twenty Years of Anophthalmic Surgery in a Tertiary Referral Center: Etiologies, Surgical Trends, and Clinical Findings.","authors":"Ali Safa Balci, Husna Topcu, Merve Emul, Mehmet Goksel Ulas, Ayse Cetin Efe, Fatma Poslu Karademir, Kubra Serefoglu Cabuk","doi":"10.14744/bej.2026.89896","DOIUrl":"https://doi.org/10.14744/bej.2026.89896","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the etiological causes, demographic characteristics, surgical procedures, implant features, complications, and additional surgical interventions in patients undergoing anophthalmic surgery over a 20-year period.</p><p><strong>Methods: </strong>The records of patients who underwent evisceration, enucleation, sphere exchange, secondary sphere implantation, and anophthalmic socket reconstruction at our institution between 2003 and 2023 were reviewed. Etiologic and demographic data, surgical procedures, orbital implant diameter and material, postoperative complications, additional surgical procedures, and follow-up periods were recorded. Female patients were classified as group 1 and male patients as group 2, and both groups were subjected to comparative analysis.</p><p><strong>Results: </strong>A total of 603 patients were divided into two groups: Group 1 (female, 32.2%) and Group 2 (male, 67.8%). The mean age at the time of surgery was comparable between the two groups (p=0.830). Trauma was the most common etiology, malignancy the least common. Evisceration was the most frequently performed procedure, and enucleation the least. The mean diameter of implanted spheres was significantly smaller in Group 1 (p=0.001). No significant difference in implant materials was observed (p=0.590). Conjunctival suture dehiscence and infection were the most common complications, showing similar profiles in both groups.</p><p><strong>Conclusion: </strong>Trauma was the leading cause in both groups, with evisceration as the most frequently performed procedure. These procedures addressed the underlying ocular pathologies and contributed to orbital volume restoration when indicated.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"205-212"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyoglu Eye JournalPub Date : 2026-10-01eCollection Date: 2026-01-01DOI: 10.14744/bej.2026.79095
Bora Yüksel, Nurullah Berk Açar, Tuncay Kusbeci, Erel Icel
{"title":"Endothelial Safety After Phacoemulsification in Patients with Fuchs Dystrophy: Short Term Outcomes and Predictors of Corneal Edema.","authors":"Bora Yüksel, Nurullah Berk Açar, Tuncay Kusbeci, Erel Icel","doi":"10.14744/bej.2026.79095","DOIUrl":"https://doi.org/10.14744/bej.2026.79095","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the clinical outcomes of phacoemulsification combined with intraocular lens implantation in patients with Fuchs endothelial corneal dystrophy (FECD) and individuals with healthy corneas.</p><p><strong>Methods: </strong>This retrospective study included eyes that underwent phacoemulsification and intraocular lens (IOL) implantation between January 2021 and September 2022. Phacoemulsification was performed using a contemporary oscillatory ultrasound mode; device-logged energy and fluidics metrics were recorded. Best corrected visual acuity (BCVA) and specular microscopy (CEM-530™; Nidek) were evaluated preoperatively and at postoperative week 1, month 1, and month 3. Endothelial cell density (ECD) and central corneal thickness (CCT) were recorded. The primary outcome measures were postoperative BCVA, ECD, and CCT changes. The study included 32 eyes with FECD and 29 control eyes with healthy corneas.</p><p><strong>Results: </strong>In both groups, mean BCVA improved significantly from 0.7 LogMAR preoperatively to 0.15 LogMAR at 1 month postoperatively (p=0.000). The endothelial cell loss at 3 months was significantly higher in the FECD group compared to controls (20.9% vs. 17.9%, p=0.022). Baseline ECD was 2065.5 cells/mm<sup>2</sup> in the FECD group and 2289.4 cells/mm<sup>2</sup> in the control group, decreasing to 1633.1 and 1878.9 cells/mm<sup>2</sup>, respectively, at 3 months. CCT increased from 564.5 µm to 584.1 µm in the FECD group (p=0.006), and from 550.5 µm to 557.7 µm in the control group (p=0.124). No cases of postoperative corneal decompensation were observed.</p><p><strong>Conclusion: </strong>Phacoemulsification yielded meaningful visual improvement in FECD eyes without early corneal decompensation. Endothelial loss as higher and CCT recovery slower than in controls, supporting energy-minimizing techniques and closer early follow-up in FECD.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"181-187"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical Outcomes of Pediatric Blepharoptosis.","authors":"Mehmet Göksel Ulaş, İlkay Semizoğlu, Ayse Cetin Efe, Fatma Poslu Karademir","doi":"10.14744/bej.2026.46667","DOIUrl":"https://doi.org/10.14744/bej.2026.46667","url":null,"abstract":"<p><strong>Objectives: </strong>The results of ptosis surgery and revision surgery performed in blepharoptosis of different etiologies in the paediatric age group were evaluated.</p><p><strong>Methods: </strong>The 78 eyes of 66 patients followed up at our clinic between 2020 and 2024 were retrospectively examined. The patient's age, gender, etiology, preoperative and postoperative Best Corrected Visual Acuity (BCVA), levator function, Margin Reflex Distance-1 (MRD-1), surgical techniques and revisions performed, amount of lagophthalmos, Bell's phenomenon, strabismus and amblyopia status were evaluated.</p><p><strong>Results: </strong>The mean age of the patients was 9.05±4.18 years, and the follow-up period was 21.19±12.90 months. The etiology of ptosis was congenital myogenic in 49 (74.4%) patients, congenital neurogenic in 13 (19.6%) patients, and acquired in 4 (6%) patients. Strabismus was detected in 12 patients (18%), and amblyopia was detected in 35 eyes (44.9%). The most frequently used surgical techniques were frontal suspension with silicone (30.8%), müller muscle conjunctival resection (28.2%), and levator surgery (25.6%). Revision surgery was performed in 29 eyes (37.2%). The preoperative MRD-1 (0.72±1.26 mm) showed a significant increase at 6 months postoperatively (2.20±1.42 mm) (p<0.001). A positive correlation was found between final BCVA and preoperative BCVA (r=0.579, p<0.001). A low to moderate significant correlation was found between postoperative lagophthalmos and punctate staining (r=0.308, p=0.012). Lagophthalmos was more pronounced in the silicone sling group.</p><p><strong>Conclusions: </strong>In pediatric ptosis surgery, a high rate of functional and aesthetic success is achieved through the selection of surgery appropriate to the etiology and careful postoperative follow-up.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"219-226"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Clinical Study of Retinal Nerve Fibre Layer and Ganglion Cell Layer changes in patients with Migraine at a Tertiary Care Hospital.","authors":"Tanvi Shetty, Thanuja Gopal Pradeep, Pradeep Rangaiah","doi":"10.14744/bej.2026.82652","DOIUrl":"https://doi.org/10.14744/bej.2026.82652","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess and compare retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) thickness in migraine patients versus controls and to analyze differences between chronic and episodic migraine.</p><p><strong>Methods: </strong>A cross-sectional, case-control study was conducted from June 2022 to December 2023. A total of 100 migraine patients (33 chronic, 67 episodic) and 102 controls underwent detailed ocular evaluation using OCT. RNFL and GCL parameters were compared between cases and controls using an independent t-test. Paired t-tests assessed differences between chronic and episodic migraine, as well as between the right and left eyes.</p><p><strong>Results: </strong>Photophobia (90%) and ocular pain (85%) were the most common symptoms. Migraine patients showed a significant reduction in average (106 µm), superior (129 µm), and nasal (80 µm) RNFL thickness compared to controls. Chronic migraine patients exhibited significant thinning in the temporal (67 µm) and nasal (72 µm) RNFL quadrants and superotemporal (67 µm) and superonasal (70 µm) GCL quadrants in the right eye. Episodic migraine patients had reduced superotemporal GCL thickness (71 µm) in the left eye.</p><p><strong>Conclusion: </strong>The retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) thickness is reduced in chronic and episodic type of migraine patients. Hence, ophthalmologists should consider the potential impact of migraine headaches on the thickness of RNFL and GCL.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"11 3","pages":"236-243"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}