Beyoglu Eye Journal最新文献

Long-term Outcomes of Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Vitrectomized Eyes. 玻璃体切除术后小梁切除术与Ahmed青光眼瓣膜植入术的远期疗效。

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.04378

Gulsah Gumus Akgun, Nese Alagoz, Ihsan Cakir, Cigdem Altan, Ali Safa Balci, Yavuz Selim Dogan, Tekin Yasar, Gizem Taskin

{"title":"Long-term Outcomes of Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Vitrectomized Eyes.","authors":"Gulsah Gumus Akgun, Nese Alagoz, Ihsan Cakir, Cigdem Altan, Ali Safa Balci, Yavuz Selim Dogan, Tekin Yasar, Gizem Taskin","doi":"10.14744/bej.2025.04378","DOIUrl":"10.14744/bej.2025.04378","url":null,"abstract":"Objectives: This study compares the long-term outcomes and success rates of trabeculectomy and Ahmed glaucoma valve (AGV) implantation in vitrectomized eyes.Methods: This study included 58 eyes of 58 patients who had undergone pars plana vitrectomy and subsequently received either trabeculectomy (25 eyes) or AGV implantation (33 eyes) at our hospital between March 01, 2017 and April 01, 2023 and had at least 1-year follow-up. Complete success was defined as maintaining an intraocular pressure (IOP) between 5 and 21 mmHg without medication, whereas overall success was defined as achieving the same IOP range with or without medication. Failure was defined as an IOP exceeding 21 mmHg or falling below 5 mmHg, visual deterioration to light perception due to glaucoma progression or complications from glaucoma surgery, or the need for further glaucoma surgery.Results: The complete success was higher in the trabeculectomy group. Whereas both groups' overall success rates were similar at the last follow-up (p=0.04). Both groups demonstrated a comparable failure rate (p=0.44). The probability of success in the trabeculectomy group was 92.0% at 12 months, 88.0% at 24 months, and 84.0% at 36 months, whereas in the AGV group, it was 87.8% at 12 months, 81.8% at 24 months, and 75.7% at 36 months. There was no difference in terms of post-operative complication rate in both groups. (p=0.36).Conclusion: Both AGV implantation and trabeculectomy yield comparable outcomes in vitrectomized eyes. However, trabeculectomy reduced the requirement for antiglaucoma medications postoperatively. Consequently, trabeculectomy may be a viable option in carefully selected vitrectomized eyes.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"218-225"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Botulinum Toxin in Dry Eye Disease and Meibomian Gland Dysfunction Associated with Hemifacial Spasm. 肉毒杆菌毒素在干眼病和面肌痉挛相关睑板腺功能障碍中的作用。

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.03764

Meryem Altin Ekin

{"title":"The Role of Botulinum Toxin in Dry Eye Disease and Meibomian Gland Dysfunction Associated with Hemifacial Spasm.","authors":"Meryem Altin Ekin","doi":"10.14744/bej.2025.03764","DOIUrl":"10.14744/bej.2025.03764","url":null,"abstract":"Objectives: To investigate the signs and symptoms of dry eye disease (DED) in patients with hemifacial spasm (HFS) through the evaluation of ocular surface measurements and meibomian gland function, and to assess the effects of botulinum toxin type A (BTX-A) injection on ocular surface health.Methods: This prospective study included patients with unilateral HFS who underwent BTX-A injection as treatment. Eyes on the same side as the spasm were defined as the HFS group, whereas the contralateral, unaffected eyes were used as controls. Ocular surface assessments included the ocular surface disease ındex (OSDI) score, Schirmer's I test, tear break-up time (TBUT), corneal surface staining, eyelid margin abnormalities, and meibomian gland function. All evaluations were repeated at 1, 3, and 6 months following BTX-A injection.Results: Compared to the control group, the HFS group demonstrated significantly higher OSDI scores, corneal surface staining, eyelid margin abnormalities, meibomian gland expression scores, meibography scores, and meibomian gland loss, whereas TBUT and Schirmer's I test values were significantly lower (p<0.05). A significant correlation was observed between the severity of HFS and ocular surface dysfunction, including meibomian gland dysfunction (MGD) (p<0.05). Following BTX-A injection, ocular surface parameters showed significant improvement at 1 month (p<0.05) and 3 months (p<0.05) compared to pre-injection values.Conclusion: We found an association between HFS and DED, which was correlated with the severity of HFS. In addition, BTX-A injection led to a temporary improvement in dry eye signs and symptoms, including MGD.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"235-243"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compatibility Between the Intraocular Lens Master and Pentacam Devices in White-to-White Measurements Used in Phakic Intraocular Lens Calculations. 人工晶状体Master和Pentacam设备在晶状体计算中白对白测量的兼容性。

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.50133

Mine Koru Toprak, Aydin Toprak, Bekir Ayyildiz, Mutluay Bozoklu, Deniz Kilic

{"title":"Compatibility Between the Intraocular Lens Master and Pentacam Devices in White-to-White Measurements Used in Phakic Intraocular Lens Calculations.","authors":"Mine Koru Toprak, Aydin Toprak, Bekir Ayyildiz, Mutluay Bozoklu, Deniz Kilic","doi":"10.14744/bej.2025.50133","DOIUrl":"10.14744/bej.2025.50133","url":null,"abstract":"Objectives: Measurement of white-to-white (WtW) distance is essential in the pre-operative evaluation of candidates for cataract or refractive surgery, and in determining the appropriate haptic size of newly developed phakic intraocular lenses (IOLs). This distance can be measured quickly and easily using various methods. However, inconsistencies among reported results raise concerns about whether these measurements can be used interchangeably. Although previous studies have analyzed the agreement between different devices, there has been no such study conducted at the national level. Based on this, our study aimed to analyze the agreement between WtW measurements obtained by the IOLMaster 500 and Pentacam devices for use in phakic IOL (pIOL) calculations.Methods: A total of 66 eyes from 66 candidates for cataract or refractive surgery were included in the study. WtW distance measurements obtained from both devices were recorded and analyzed. A one-sample t-test was used to compare the mean WtW values. Bland-Altman analysis was performed to assess the agreement between the two devices.Results: The mean age of the participants was 63.42±18.27 years, and 20 (60.6%) were male. The mean WtW distances measured by the IOLMaster 500 and Pentacam were 11.80±0.48 mm and 11.50±0.56 mm, respectively (p<0.001) (limits of agreement: Lower limit 0.19, upper limit 0.41; 95% confidence interval).Conclusion: Our study showed that the IOLMaster 500 measured significantly higher WtW distances compared to the Pentacam. Therefore, these two devices should not be used interchangeably for WtW measurements. We recommend using the devices endorsed by the chosen pIOL manufacturer.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"206-210"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Two Techniques in Phacoemulsification: Hydroimplantation and Viscoimplantation. 两种超声乳化术的比较：水植入术和粘胶植入术。

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.56833

Yusuf Ayaz, Hatice Deniz Ilhan, Cisil Erkan Pota, Mustafa Unal, Yusuf Samet Atlihan

{"title":"Comparison of Two Techniques in Phacoemulsification: Hydroimplantation and Viscoimplantation.","authors":"Yusuf Ayaz, Hatice Deniz Ilhan, Cisil Erkan Pota, Mustafa Unal, Yusuf Samet Atlihan","doi":"10.14744/bej.2025.56833","DOIUrl":"10.14744/bej.2025.56833","url":null,"abstract":"Objectives: The aim of this study was to compare hydroimplantation and viscoimplantation techniques in phacoemulsification surgery by analyzing corneal tomography parameters and changes in intraocular pressure (IOP).Methods: This retrospective study included 74 eyes of 74 consecutive patients who underwent phacoemulsification surgery and implantation of a foldable intraocular lens (IOL). Each eye was assigned to either the viscoelastic material (VEM) group (VEM(+); (n=39) or the VEM (-) group (n=35). Accordingly, IOL implantation was performed with VEM (1.4% sodium hyaluronate; Protectalon, VSY, Turkey) in the VEM(+) group, whereas hydroimplantation without VEM was used in the VEM (-) group. Post-operative examinations were performed on post-operative days 1, 3, and 7, and at 1 month.Results: There was no statistically significant difference in IOP between the VEM(+) and VEM(-) groups before surgery or at any post-operative time point except at 24 h. At 24 h postoperatively, the VEM(+) group had a significantly higher IOP compared to the VEM(-) group (p=0.010). In addition, the central corneal thickness at 1 month was significantly higher in the VEM(+) group than in the VEM(-) group (p=0.027). No statistically significant differences were found between the groups in best corrected visual acuity, anterior chamber depth, and axial length. There was no posterior capsule rupture or zonular dialysis in either group.Conclusion: Phacoemulsification using the hydroimplantation technique appears to be a safe and feasible approach that may help mitigate early post-operative IOP elevation; however, assessing corneal endothelial cell function by specular microscopy would be important for a more comprehensive safety comparison between techniques.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"211-217"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Ophthalmic Entity More Than Liver Disease, Alagille Syndrome: A Genetically Confirmed Case Report. 一种比肝脏疾病更严重的眼科疾病，Alagille综合征：一份遗传确诊病例报告。

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.45762

Tulin Ogreden

{"title":"An Ophthalmic Entity More Than Liver Disease, Alagille Syndrome: A Genetically Confirmed Case Report.","authors":"Tulin Ogreden","doi":"10.14744/bej.2025.45762","DOIUrl":"10.14744/bej.2025.45762","url":null,"abstract":"Alagille syndrome (ALGS) is a rare autosomal dominant disease that mainly affects the bile ducts and the liver. This syndrome may be associated with ophthalmic anomalies, but systemic diseases are often so obvious compared to ocular findings that many patients are referred to eye clinics after diagnosis. The diagnosis of ALGS is based on medical history and clinical findings. In this report, we describe and present a systemic disease of an undiagnosed ALGS based on eye findings. Papilledema and posterior embryotoxon were detected in the patient who was investigated due to headache. The diagnosis was made based on ophthalmological findings and was confirmed by genetic consultation. Missense mutations of the jagged canonical Notch ligand 1 gene located on chromosome 20p12.2 were detected. The patient benefited from treatment aimed at increasing intracranial pressure, and the etiology of symptoms related to other systems was clarified. The aim of this report is to support a clinical approach that evaluates possible common and rare comorbidities in ALGS from an ophthalmic perspective. We also emphasize the diversity of clinical presentation. ALGS affects multiple systems, so an integrative approach is important.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"258-261"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Inferior Rectus Recession without Lower Eyelid Retraction in Thyroid Eye Disease. 甲状腺眼病患者下直肌大收缩无下眼睑挛缩。

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.25932

Birsen Gokyigit, Asli Inal, Ceren Gurez

{"title":"Large Inferior Rectus Recession without Lower Eyelid Retraction in Thyroid Eye Disease.","authors":"Birsen Gokyigit, Asli Inal, Ceren Gurez","doi":"10.14744/bej.2025.25932","DOIUrl":"10.14744/bej.2025.25932","url":null,"abstract":"Objectives: In this study, a new technique that does not cause lower eyelid retraction in patients with excessive limitation of movement and vertical strabismus due to inferior rectus (IR) fibrosis in thyroid eye disease was introduced.Methods: There were six patients with their six eyes with their mid-term results.Operation technique: According to the deviation amount, a 7-14 mm length bovine pericardium (Tutopatch®) was inserted between the distal end of the tendon and the beginning of the muscle fibers, which are located between the tendon's distal end and the tendon muscle junction to the IR with 6/0 non-absorbable suture.Results: There were six cases with a mean 19.5±5.2 PD (PD: prism diopters) (14-26 PD) vertical deviation and severe up-gaze limitations with a mean -4.1±0.75. The post-operative vertical deviation was a mean of 3.5±1.22 PD, and the limitation of upgaze was a mean of -1.3±0.4.Conclusion: This procedure provides effective results in reducing gaze limitation and vertical deviation in thyroid patients without causing any problems in the eyelids.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"250-253"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Topical Insulin Eye Drops for Corneal Epithelial Defects: A Systematic Review, Meta-Analysis, and Grading of Recommendations Assessment, Development, and Evaluation Assessment. 局部胰岛素滴眼液治疗角膜上皮缺陷的疗效和安全性：系统回顾、meta分析和推荐评估、开发和评价评估的分级。

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.00821

Muhammad Alfatih, Christina Wunardi, Alfiani Zukhruful Fitri Rifa'i

{"title":"Efficacy and Safety of Topical Insulin Eye Drops for Corneal Epithelial Defects: A Systematic Review, Meta-Analysis, and Grading of Recommendations Assessment, Development, and Evaluation Assessment.","authors":"Muhammad Alfatih, Christina Wunardi, Alfiani Zukhruful Fitri Rifa'i","doi":"10.14744/bej.2025.00821","DOIUrl":"10.14744/bej.2025.00821","url":null,"abstract":"Objectives: The aim of this study was to review and meta-analyze the efficacy and safety of topical insulin eye drops (TIED) in treating corneal epithelial defects (CED).Methods: We registered the protocol in PROSPERO (CRD420251051879). A systematic literature search on PubMed, Cochrane, ScienceDirect, Scopus, and Google Scholar until May 2025 was done to identify controlled comparative studies. Outcomes of interest include time to complete re-epithelialization, re-epithelialization rate, treatment failure, recurrence, and adverse events. We performed meta-analysis using a random-effects model and assessed the certainty of evidence for each result using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment.Results: Seven studies involving 238 patients were included in the analysis. TIED significantly shortened re-epithelialization time (mean difference [MD] -1.20 days [-1.71--0.69], p<0.0001) and accelerated the healing rate (MD +0.26 mm2/h [0.10-0.42], p=0.002). In addition, TIED significantly reduced the risk of treatment failure (risk ratio [RR] 0.30 [0.16-0.57], p=0.003) and recurrence (RR 0.25 [0.11-0.56], p=0.0007) compared to conventional treatments, with no adverse events reported. GRADE assessments indicated very low to low certainty of evidence.Conclusion: TIED may speed corneal healing, cut failures and recurrences, and is well-tolerated and inexpensive. Robust randomized controlled trials are still needed to nail down the optimal dosing, long-term safety, and its role in CED management.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"195-205"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tamoxifen Retinopathy and Macular Telangiectasia Type 2: Case-Based Differential Diagnosis. 视网膜病变和黄斑毛细血管扩张2型：基于病例的鉴别诊断。

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.97355

Abdullah Erdem, Sule Acar Duyan

引用次数: 0

A 5-Year Analysis of Optical Coherence Tomography Biomarkers in The Visual Outcomes of an As-Needed Treatment Algorithm for Neovascular Age-Related Macular Degeneration. 光学相干断层扫描生物标志物在新血管性年龄相关性黄斑变性按需治疗算法的视觉结果中的5年分析

Beyoglu Eye Journal Pub Date : 2026-01-19 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.42068

Ozlem Candan, Guner Uney, Dicle Hazirolan, Nurten Unlu, Mehmet Akif Acar

{"title":"A 5-Year Analysis of Optical Coherence Tomography Biomarkers in The Visual Outcomes of an As-Needed Treatment Algorithm for Neovascular Age-Related Macular Degeneration.","authors":"Ozlem Candan, Guner Uney, Dicle Hazirolan, Nurten Unlu, Mehmet Akif Acar","doi":"10.14744/bej.2025.42068","DOIUrl":"10.14744/bej.2025.42068","url":null,"abstract":"Objectives: This study aimed to predict the visual course of patients with neovascular age-related macular degeneration by analyzing data from a 5-year observational study and to identify biomarkers that have an impact on visual prognosis.Methods: The present study comprised a total of 104 patients who received the PRN treatment regimen between March 2015 and March 2021. Best-corrected visual acuity (BCVA) and optical coherence tomography findings were evaluated. Multinomial logistic regression models were used to determine predictors of BCVA at 12, 24, and 60 months.Results: Better BCVA and thicker macula at baseline, decreased BCVA at month 3, and persistence of IRF at month 3 were correlated with decreased BCVA at month 12 (all p<0.05). At 24 month, a decline in BCVA was associated with specific baseline characteristics, including better BCVA, absence of pigment epithelial detachment (PED), and presence of intraretinal cystoid fluid (IRF) (all p<0.01). Similarly, decreased BCVA and thicker macula in the 3rd month were associated with worse BCVA. At the 60-month visit, better baseline BCVA, absence of PED, presence of IRF at baseline, and persistence of IRF at month 3 were associated with a reduction in BCVA (all p<0.05). The visual prognosis had no correlation with the number of injections.Conclusion: This 5-year real-life study identified prognostic markers that cause a decline in visual acuity. The use of these markers has the potential to be valuable in preserving visual gain, irrespective of the number of injections.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"226-234"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Multimodal Large Language Model for Interpreting Image-Based Ophthalmology Case Questions: Comparative Analysis of Multiple-Choice and Open-Ended Response. 一种新的多模态大语言模型用于解释基于图像的眼科病例问题：选择题与开放式回答的比较分析。

Beyoglu Eye Journal Pub Date : 2025-10-08 eCollection Date: 2025-01-01 DOI: 10.14744/bej.2025.06332

Pelin Kiyat, Hazan Gul Kahraman

{"title":"A Novel Multimodal Large Language Model for Interpreting Image-Based Ophthalmology Case Questions: Comparative Analysis of Multiple-Choice and Open-Ended Response.","authors":"Pelin Kiyat, Hazan Gul Kahraman","doi":"10.14744/bej.2025.06332","DOIUrl":"10.14744/bej.2025.06332","url":null,"abstract":"Objectives: The objective of the study is to evaluate the performance of Claude 3.5 Sonnet, a novel multimodal large language model, in interpreting image-based ophthalmology case questions.Methods: A total of 174 image-based ophthalmology questions from a comprehensive ophthalmology education platform were analyzed by Claude 3.5 Sonnet. Each question was presented in both multiple-choice and open-ended formats. Questions were categorized into six subspecialties: Retina and uveitis; external eye and cornea; orbit and oculoplastics; neuroophthalmology; glaucoma and cataract; and strabismus, pediatric ophthalmology, and genetics. Performance was evaluated by two board-certified ophthalmologists.Results: Claude 3.5 Sonnet demonstrated an overall accuracy rate of 89.65% in multiple-choice questions and a comparable 87.93% in open-ended questions, with no statistically significant difference between formats (p=0.72). Performance showed slight variations among subspecialties, with the highest accuracy in external eye and cornea cases (95.65% in both formats) and lower accuracy in strabismus, pediatric ophthalmology, and genetics (87.50% in multiple-choice and 84.38% in open-ended).Conclusion: Claude 3.5 Sonnet showed strong capabilities in interpreting image-based ophthalmology questions across all subspecialties, with consistent performance between different question formats. These findings suggest potential applications in ophthalmology education and board examination preparation; however, validation of its utility in real-world clinical scenarios needs further evaluation.","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"10 4","pages":"244-249"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0