Medical devices & sensors最新文献

{"title":"Hollow fibre membrane bioreactor functionalized with GO-cryogel 3D matrix promotes liver cell anchoring and their functional maintenance","authors":"Surendra Kumar Verma,&nbsp;Akshay Modi,&nbsp;Jayesh Bellare","doi":"10.1002/mds3.10128","DOIUrl":"10.1002/mds3.10128","url":null,"abstract":"<p>The liver support system (bioartificial liver, BAL) is a potentially efficient treatment during reversible acute liver disease or while waiting for a liver transplant. The main challenge in implementing BAL is a bioreactor, which can fulfil the needs of hepatocyte culture, mass transfer and immunobarriers. In the present study, polymer nanocomposite hollow fibre membranes (HFMs) were fabricated using polyethersulphone (P) as a base polymer, vitamin E TPGS (T) as an additive and carboxylated carbon nanotubes (C) as a filler. These PTC HFMs were functionalized with cryogel (Cr), with or without carboxylated graphene oxide (G), known as PTC-Cr or PTC-CrG HFMs, respectively. These HFM substrates were characterized and evaluated for hemocompatibility, cytotoxicity and cellular functionality. Among all the HFM substrates, PTC-CrG HFMs showed superior hemocompatibility and minimal cytotoxicity. Furthermore, a liver cell bioreactor was developed and studied using PTC-CrG HFMs. The goat primary liver cells were seeded in a bioreactor and cultured in continuous mode. The cell functionality was better maintained in the continuous mode as compared to that in the batch culture. The three-dimensional PTC-CrG HFMs-based bioreactor can be used for liver cell bioreactor, bioartificial liver system, drug testing/toxicology metabolic study and mass cell culture.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42728796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diamond in medical devices and sensors: An overview of diamond surfaces","authors":"Nour Mani,&nbsp;Aaqil Rifai,&nbsp;Shadi Houshyar,&nbsp;Marsilea A. Booth,&nbsp;Kate Fox","doi":"10.1002/mds3.10127","DOIUrl":"10.1002/mds3.10127","url":null,"abstract":"<p>Significant challenges arise when the human body is damaged, diseased and unable to repair itself. Current biomaterials for biomedical devices have limitations to restore function, while materials for implants and sensors often invoke a large foreign body response. Therefore, there is a need to develop suitable biomaterials in the fields of medical devices and sensors. Diamond is emerging due to its many favourable properties including biocompatibility, antimicrobial capability, antifouling properties, electrical conductivity and chemical functionalization capability. Thin film coatings of diamond can be fabricated by chemical vapour deposition, or by particle coatings with nanodiamond materials. Hybrid/composite diamond materials include soft materials such as those processed by electrospinning and melt extrusion, as well as hard materials such as those processed by additive manufacturing. Additive manufacturing is a developing area for diamond biomaterial fabrication and can include both hard and soft materials. The fabrication method used will depend on the properties required of the biomaterial, as well as the application. In this mini-review, recent progress on using diamond in medical devices and sensors is outlined, with particular emphasis on fabrication methods. We highlight selected applications from recent literature and, in closing, make comments and suggestions to advance the field and direction of diamond application in medical devices and sensors.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42961182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive technologies for diagnostics of orthopaedic implant fixation","authors":"Sara Hosseini,&nbsp;Rafael Claramunt,&nbsp;Antonio Ros","doi":"10.1002/mds3.10125","DOIUrl":"10.1002/mds3.10125","url":null,"abstract":"<p>One of the most important human intervention is a total hip replacement (THR) that has the goal of pain relief and performance restoration. From early 1960, THR comes a long way and now more than one million patients all around the world every year have THR. Against all these facts, 4%–10% of all THR are failed mostly due to loosening. Precise and fast detection is vital for both surgeons and patients. The diagnosis approaches are generally classified into two groups: conventional non-imaging and imaging approaches. Imaging approaches are the most widely used because they are most cost-effective, convenient and available. However, some shortcomings are obvious in the conventional imaging methods of diagnosing prosthesis loosening. Consequently, new techniques have been further developed and recommended based on non-destructive analysis such as vibrometery, telemetry and acoustic.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"110533859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of a multi-disease biomarker in saliva with graphene field effect transistors","authors":"Narendra Kumar,&nbsp;Mason Gray,&nbsp;Juan C. Ortiz-Marquez,&nbsp;Andrew Weber,&nbsp;Cameron R. Desmond,&nbsp;Avni Argun,&nbsp;Tim van Opijnen,&nbsp;Kenneth S. Burch","doi":"10.1002/mds3.10121","DOIUrl":"https://doi.org/10.1002/mds3.10121","url":null,"abstract":"<p>Human carbonic anhydrase 1 (CA1) has been suggested as a biomarker for identification of several diseases including cancers, pancreatitis, diabetes and Sjogren's syndrome. However, the lack of a rapid, cheap, accurate and easy-to-use quantification technique has prevented widespread utilization of CA1 for practical clinical applications. To this end, we present a label-free electronic biosensor for detection of CA1 utilizing highly sensitive graphene field effect transistors (G-FETs) as a transducer and specific RNA aptamers as a probe. The binding of CA1 with aptamers resulted in a positive shift in Dirac voltage <i>V_D</i> of the G-FETs, the magnitude of which depended on target concentration. These aptameric G-FET biosensors showed the binding affinity (<i>K_D</i>) of ~2.3 ng/ml (70 p<span>M</span>), which is four orders lower than that reported using a gel shift assay. This lower value of <i>K_D</i> enabled us to achieve a detection range (10 pg/ml –100 ng/ml) which is well in line with the clinically relevant range. These highly sensitive devices allowed us to further prove their clinical relevance by successfully detecting the presence of CA1 in human saliva samples. Utilization of this label-free biosensor could facilitate the early-stage identification of various diseases associated with changes in concentration of CAs.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137539603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends in the development of complex, personalized, biomedical, surgical implant devices using 3D printing/additive manufacturing: A review","authors":"Lawrence E. Murr","doi":"10.1002/mds3.10126","DOIUrl":"10.1002/mds3.10126","url":null,"abstract":"<p>With the advent and proliferation of commercial 3D printing/additive manufacturing systems for laser and electron beam powder bed fusion fabrication of complex, open-cellular metal and alloy biomedical implant devices over the past decade, custom manufacture of personalized and patient-specific devices has become popularized. In-hospital, point-of-care surgical service centres have been established around the world, which include surgical modelling and planning, and surgical model fabrication, as well as the production of complex, open-cellular, patient-specific implants; especially of Ti-6Al-4 V alloy. The selective production of open-cellular, porous mesh and foam biomedical devices provides for optimal biomechanical compatibility with bone as well as bone cell ingrowth, which assures implant fixation and the reduction of revision surgeries. This review discusses these issues in the context of globalization of custom implant device fabrication.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41628167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of prostate cancer DNA using tetrapods based disposable paper ecofriendly biosensor device","authors":"Aarti Gautam,&nbsp;Chaitali Singhal,&nbsp;Annu Mishra,&nbsp;Alishba T. John,&nbsp;Uttam K. Gautam,&nbsp;Reza Abolhassani,&nbsp;Rainer Adelung,&nbsp;Devesh Kumar Avasthi,&nbsp;Yogendra Kumar Mishra","doi":"10.1002/mds3.10122","DOIUrl":"10.1002/mds3.10122","url":null,"abstract":"<p>The present work reports an enhancement in early diagnosis of DNA of prostate cancer by a rapid and sensitive biosensor. The genosensor platform was designed and fabricated using cost-effective and disposable paper-based electrodes. Herein, the bio-nano-interface was developed by immobilization of probe DNA of prostate cancer on the zinc oxide tetrapods modified paper electrode. The genosensor was characterized by scanning electron microscopy, transmission electron microscopy, synchrotron X-ray photoelectron spectroscopy, cyclic voltammetry and impedance spectroscopy. The nano-engineered genosensor was tested and found to be selective to prostate cancer. The sensor could detect as low as 1 pM of prostate cancer DNA with the linear detection range from 50 µM to 1 pM. The paper-based genosensor also proved to be advantageous in terms of easy preparation, low specimen volume, homogenous distribution of nanostructures onto the surface and cost-effectiveness. The present work demonstrates the enormous potential of DNA biosensor as a rapid and specific diagnostic tool to be used for the detection of prostate cancer DNA.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43126347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Q-VENT—A novel device for emergency ventilation of the lungs in patients with respiratory failure due to diseases such as COVID-19","authors":"Patrik Palacka,&nbsp;Samuel Furka,&nbsp;Daniel Furka,&nbsp;Tibor Huzevka,&nbsp;Dalibor Gallik,&nbsp;Marian Janek","doi":"10.1002/mds3.10124","DOIUrl":"10.1002/mds3.10124","url":null,"abstract":"<p>Since the end of 2019, a novel coronavirus (SARS-CoV-2) causing pneumonia, often progressing to rapid deterioration with acute respiratory distress syndrome (ARDS) requiring advanced life support, has been spreading worldwide. The humanitarian crisis we are currently witnessing across the globe is threatening access to artificial ventilation of the lungs (AVL) for patients with respiratory failure. Q-vent is a multi-way air valve system with filters and heater/humidifier module produced by 3D printer from a new composite material based on Phloxine B, Saponite and Polylactic acid that prevents the formation of bacterial biofilms. This automated device, which can be fitted with commercially available Ambu^® Breathing Bags or similar, provides a high degree of controllability along with one-box complexity. A built-in cough sensor warns of patient's awakening. In the case of power failure, Q-vent switches to battery reserve. The developed device was tested on an intubated model (Gaumard^® Scientific - UNI^®) corresponding to a patient (80 kg) with lung compliance 50 ml/cm H2O to simulate ARDS for 24 hours. The inspiration-to-expiration (I:E) ratio, tidal volume set to 8 ml/kg PBW (L-type pneumonia) and 6 ml/kg PBW (H-type Pneumonia), and frequency of inspiration were adjusted to test Q-Vent operation at a range of different conditions. All functions performed reliably throughout the testing procedure. Q-Vent successfully passed the Rapidly Manufactured Ventilator System (RMVS001) validation issued by MHRA and is awaiting clinical trials to determine its value in overcoming crises caused by the lack of conventional AVL.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"108284762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19: Facemasks, healthcare policies and risk factors in the crucial initial months of a global pandemic","authors":"Jubair Ahmed,&nbsp;Anthony Harker,&nbsp;Mohan Edirisinghe","doi":"10.1002/mds3.10120","DOIUrl":"10.1002/mds3.10120","url":null,"abstract":"<p>Previous pandemics have shown that facemask use becomes highly popular in public settings due to fear of the disease spreading. There is, however, a lack of strong scientific evidence that facemasks can significantly reduce the spread of respiratory diseases and as such, most governing policies do not mandate these coverings. There is a stark contrast between the policies and acceptance of facemasks across different geographies. In this work, several data sources have been thoroughly analysed to elucidate how viral diseases are transmitted and spread with particular emphasis on the novel SARS-CoV-2 virus which is causing an outbreak of COVID-19. The different types of facemasks and respirators are also explained, the nature of their design and their efficacy is also examined. Several key factors which have been hypothesised to contribute to the spread of viral infections are elaborated in detail including the effect of temperature and humidity, public transportation systems, population density, socio-economics and sociology. In this work, data are analysed to explain how the disease is spread, how facemasks function and the differences in the number of initial cases based on several contributing factors to the spread of disease. There are also some dangers in automatically recommending community facemask wearing, such as a reduction in the immune system functionality from the reduced exposure to microbes and the disposal issues which result from the large-scale use of such materials. The questions of whether facemasks are useful in a community setting or if they divert valuable material away from critical healthcare providers are discussed.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"93933598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in medical sensors","authors":"Steve Binion,&nbsp;Roger J. Narayan","doi":"10.1002/mds3.10118","DOIUrl":"10.1002/mds3.10118","url":null,"abstract":"<p>According to data from the Centers for Medicare and Medicaid Services (CMS), the United States spent 13.6 trillion dollars on health care in 2018, with annual increases trending at 4.6 per cent (Lehr, <span>2013</span>). Concerns over burgeoning healthcare expenditures have increased pressure on healthcare providers and payers to reduce overall costs through a variety of approaches, including increasing focus on the development of novel rapid diagnostics for both point of care (POC) testing by healthcare professionals and in home use by patients (Elder, <span>2012</span>; Lehr, <span>2013</span>). Although testing with POC diagnostics is generally more expensive than testing in a clinical laboratory on a cost-per-test basis, it is anticipated that the use of rapid diagnostics provides offsetting advantages. For example, continuous monitoring of a chronic medical condition will enable better patient involvement and capture ongoing patient-specific data, which can lead to improved patient care, thus reducing incidents requiring physician intervention, including emergency room visits and hospital admissions.</p><p>A more rigorous analysis of the value proposition for diagnostics information as a component in the healthcare ecosystem was recently reviewed by Wurcel et al. (<span>2019</span>). The authors discuss the ongoing struggle that governments face to balance sustainable health care spending against the goal of high-quality health care, pointing out that the impact of diagnostics information has not typically been analysed with the same rigour as direct medical interventions. They highlight the value of readily accessible diagnostics information for patients—empowerment and knowing/deciding—as well as for healthcare professionals and payers who can evaluate the impact of diagnostics on healthcare system management and outcomes.</p><p>Increasingly, one of the drivers of the POC diagnostics market is the growing number of older adults, who not only require proportionately greater amounts of health care but also expect more rapid medical results as well as short turnaround times (Elder, <span>2012</span>; Lehr, <span>2013</span>). The National Institute of Aging expects there to be nearly one billion individuals over the age of 65 in the year 2030 (Lehr, <span>2013</span>). The number of individuals with chronic diseases such as hypertension, diabetes and chronic kidney disease is anticipated to increase globally, with a surge in global diabetes that is already staggering. These trends will be exacerbated by a shortage of skilled healthcare workers, both in the developing and developed world, reducing the number of healthcare providers available to perform conventional hospital- or clinic-based diagnostic procedures.</p><p>Despite the attractiveness of the market for POC diagnostics, developers must overcome multiple technical, regulatory and reimbursement challenges to successfully introduce a novel product. Considerations when commercializing","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44331963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of bile acids for biomedical devices and sensors","authors":"Kayla Baker,&nbsp;Rebecca Sikkema,&nbsp;Igor Zhitomirsky","doi":"10.1002/mds3.10119","DOIUrl":"10.1002/mds3.10119","url":null,"abstract":"<p>The objective of this mini-review is to describe the recent advances and applications of bile acids (BAs) for manufacturing biomedical devices and sensors. The biological origin and unique multifunctional properties of BAs are key factors for novel biomedical applications. BAs are used for solubilization of drugs and the development of advanced devices for controlled drug delivery. BAs outperform many commercial dispersants in the dispersion of carbon nanotubes and hydrophobic polymers. They also exhibit unique gel-forming and film-forming properties, which are used for the development of biosensors and functionalization of implant materials. Especially important is the possibility of bile acid gel synthesis for controlled release of drugs and other functional molecules. Electrodeposition of BAs films and composites is emerging as a new area of technological interest. The discovery of BAs mediating the biomineralization phenomena allows the development of biomedical implants with enhanced bioactivity and biocompatibility. Bile acids are used as efficient biocompatible reducing and capping agents for the synthesis of inorganic particles and their functionalization for application in biosensors and antimicrobial coatings. The progress in the modification of biopolymers with BAs and development of BAs derivatives paves the way for the fabrication of advanced implants and sensors.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"103699912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}