Medical devices & sensors最新文献_第6页

Setting behaviour, mechanical properties and heat generation under alternate current magnetic fields of Fe3O4/TiO2/PMMA composite bone cement Fe3O4/TiO2/PMMA复合骨水泥交变磁场下的固化行为、力学性能和产热

Medical devices & sensors Pub Date : 2020-08-07 DOI: 10.1002/mds3.10114

Moe Kubota, Taishi Yokoi, Tomoyuki Ogawa, Shin Saito, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka, Balachandran Jeyadevan, Masakazu Kawashita

{"title":"Setting behaviour, mechanical properties and heat generation under alternate current magnetic fields of Fe3O4/TiO2/PMMA composite bone cement","authors":"Moe Kubota, Taishi Yokoi, Tomoyuki Ogawa, Shin Saito, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka, Balachandran Jeyadevan, Masakazu Kawashita","doi":"10.1002/mds3.10114","DOIUrl":"10.1002/mds3.10114","url":null,"abstract":"Poly(methyl methacrylate) (PMMA) bone cement has excellent mechanical properties and is injectable; therefore, it is widely used as a filler for bone defects. To realize further effective treatment of bone defects, the design of PMMA cement containing magnetite (Fe3O4) and titania (TiO2), with good bone-bonding properties and potential for application in magnetic hyperthermia treatment, is proposed. The ceramic content of the PMMA composite bone cements was varied from 20 mass% to 45 mass%. The setting behaviour, microstructure, compressive strength and heat generation under alternate current (AC) magnetic fields of the PMMA composite bone cements were evaluated. Determination of the setting temperature and time for the PMMA composite cements revealed that the maximum temperature during setting decreased with increasing Fe3O4 and TiO2 content while the setting time increased. The PMMA composite cements had dense microstructures regardless of the ceramic content. The nominal compressive strength for the samples ranged between 83 MPa and 94 MPa, which is sufficient for bone-filling applications. Furthermore, the PMMA composite cement containing 25 mass% Fe3O4 generated heat under AC magnetic field, and its temperature reached 42.3°C after 10 min. Therefore, our findings contribute to the development of novel PMMA bone cements using functional ceramic components.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"96690940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Laser-pyrolysed paper electrodes for the square-wave anodic stripping voltammetric detection of lead 激光热解纸电极方波阳极溶出伏安法检测铅

Medical devices & sensors Pub Date : 2020-08-07 DOI: 10.1002/mds3.10115

Nikola Tasić, Lucas de Sousa de Oliveira, Thiago R. L. C. Paixão, Luís Moreira Gonçalves

引用次数: 7

Perspectives on smart stents with sensors: From conventional permanent to novel bioabsorbable smart stent technologies 传感器智能支架的前景:从传统的永久性到新型生物可吸收智能支架技术

Medical devices & sensors Pub Date : 2020-08-07 DOI: 10.1002/mds3.10116

Jithin Vishnu, Geetha Manivasagam

{"title":"Perspectives on smart stents with sensors: From conventional permanent to novel bioabsorbable smart stent technologies","authors":"Jithin Vishnu, Geetha Manivasagam","doi":"10.1002/mds3.10116","DOIUrl":"10.1002/mds3.10116","url":null,"abstract":"Cardiovascular stent angioplasty represents the pre-eminent choice for the treatment of coronary artery disease. Despite the widespread developments in this arena such as new-generation drug-eluting stents and transient bioabsorbable stents, the stent technologies are still associated with several clinical complications associated with stent thrombosis and in-stent restenosis. Pertinent ‘smart stent’ systems incorporated with sensors are garnering immense research interest in view of their potential to mitigate/reduce several adverse outcomes associated with stents. In this minireview, we attempt to provide a timely overview on the most recent developments in the field of smart stent systems with embedded sensors. The first two sections of this review discuss about the smart stent technology to detect stent endothelialization and in-stent restenosis. Next, we briefly summarize the propitious bioabsorbable smart stent systems, and the review concludes by highlighting the future perspectives that can foster this research arena. The latest advancements in this research field by integrating sensors in stents have demonstrated immense potentiality in mitigating the risks associated with cardiovascular clinical complications to ameliorate the problems associated with millions of people worldwide.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44630804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Biomedical applications of polyphosphazenes 聚磷腈的生物医学应用

Medical devices & sensors Pub Date : 2020-08-02 DOI: 10.1002/mds3.10113

Kenneth S. Ogueri, Kennedy S. Ogueri, Chinedu C. Ude, Harry R. Allcock, Cato T. Laurencin

引用次数: 8

Whole virus detection using aptamers and paper-based sensor potentiometry 利用适体和基于纸张的传感器电位测定法进行全病毒检测

Medical devices & sensors Pub Date : 2020-08-01 DOI: 10.1002/mds3.10112

Subhashish Dolai, Massood Tabib-Azar

{"title":"Whole virus detection using aptamers and paper-based sensor potentiometry","authors":"Subhashish Dolai, Massood Tabib-Azar","doi":"10.1002/mds3.10112","DOIUrl":"10.1002/mds3.10112","url":null,"abstract":"Paper-based sensors, microfluidic platforms and electronics have attracted attention in the past couple of decades because they are flexible, can be recycled easily, environmentally friendly and inexpensive. Here, we report a paper-based potentiometric sensor to detect the whole Zika virus with a minimum sensitivity of 0.26 nV/Zika and a minimum detectable signal (MDS) of 2.4x107 Zika. Our paper sensor works very similar to a P-N junction where a junction is formed between two different regions with different electrochemical potentials on the paper. These two regions with slightly different ionic contents, ionic species and concentrations, produce a potential difference given by the Nernst equation. Our paper sensor consists of 2-3 × 10 mm segments of paper with conducting silver paint contact patches on two ends. The paper is dipped in a buffer solution containing aptamers designed to bind to the capsid proteins on Zika. We then added the Zika (in its own buffer) to the region close to one of the silver paint contacts. The Zika virus (40 nm diameter with 43 kDa or 7.1 × 10−20 gm weight) became immobilized in the paper's pores and bonded with the resident aptamers creating a concentration gradient. Atomic force microscopy and Raman spectroscopy were carried out to verify that both the aptamer and Zika become immobilized in the paper. The potential measured between the two silver paint contacts reproducibly became more negative upon adding the Zika. We also showed that a liquid crystalline display (LCD) powered by the sensor can be used to read the sensor output.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38303160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Non-conventional starch nanoparticles for drug delivery applications 用于药物输送的非常规淀粉纳米颗粒

Medical devices & sensors Pub Date : 2020-07-16 DOI: 10.1002/mds3.10111

Omar P. Troncoso, Fernando G. Torres

{"title":"Non-conventional starch nanoparticles for drug delivery applications","authors":"Omar P. Troncoso, Fernando G. Torres","doi":"10.1002/mds3.10111","DOIUrl":"10.1002/mds3.10111","url":null,"abstract":"Starch has been used for a variety of biomedical and pharmacological applications, including drug delivery systems. Most of the starch-based drug delivery systems have been developed using starches extracted from commercial crops, including potato, maize, corn, cassava and wheat. However, there are several agricultural underutilized crops that could be useful sources of starch. The availability and low cost of these underutilized crops have triggered the interest in the use of non-conventional starches for diverse applications, especially in the food industry where they are used as emulsifiers, and gelling and thickening agents. The properties of starch are strongly dependent on the botanical source. It has been found that using starches from different sources can result in the preparation of nanoparticles with different properties. In this paper, we report the use of conventional and non-conventional starches in the development of novel nanoparticle drug delivery systems. The processing routes used for the preparation of both starch and starch nanoparticles are reviewed together with the most recent applications including oral, parental and transdermal delivery for cancer, diabetes, hyperuricemia and hypertension treatments, among others.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45061736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Solid-state ion sensor for on-chip determination of potassium ion in body fluid 片上测定体液中钾离子的固态离子传感器

Medical devices & sensors Pub Date : 2020-07-13 DOI: 10.1002/mds3.10110

Prem C. Pandey, Govind Pandey, Roger J. Narayan

{"title":"Solid-state ion sensor for on-chip determination of potassium ion in body fluid","authors":"Prem C. Pandey, Govind Pandey, Roger J. Narayan","doi":"10.1002/mds3.10110","DOIUrl":"10.1002/mds3.10110","url":null,"abstract":"This article describes a synthetic route for the fabrication of all-solid-state potentiometric ion-sensing device for on-chip determination of potassium ion in body fluid. The sensing electrodes comprised of (a) a solid-state reference electrode made from a Ag/AgCl-printed electrode covered with a solid-electrolyte-embedded membrane made from siloxane polymer and (b) solid-state ion-selective electrode as working electrode made by assembling ionophore-impregnated PVC membrane casting solution over a ion exchanger-impregnated membrane. The ion exchanger-impregnated membrane is cast by assembling siloxane–polyindole nanodispersion over working electrode of screen-printed electrode to yield constant dipolar potential. The screen-printed electrodes comprising of all-solid-state reference and working electrode can be operated under zero current flow to monitor potassium ion in given sample. The configuration of the printed electrodes is designed to fix a microneedle assembly over the working portion of both reference and working electrodes for transdermal ion sensing. The functional alkoxysilanes derived from nanodispersion allow to make solid-state reference electrode avoiding the use of internal filling solution providing innovation in designing potentiometric sensor. In one aspect, a potentiometric device for detecting analyte in biological fluid that can include a array of hollowed microneedle in which each needle acts as protruded needle structure including an exterior wall forming a hollow interior covering both solid-state working and reference electrode with an opening at terminal end in such that one microneedle is converted into a potassium ion-selective electrode.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41505544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Porous microneedles on a paper for screening test of prediabetes 纸上的多孔微针用于糖尿病前期的筛选试验

Medical devices & sensors Pub Date : 2020-07-08 DOI: 10.1002/mds3.10109

Hakjae Lee, Gwenaël Bonfante, Yui Sasaki, Nobuyuki Takama, Tsuyoshi Minami, Beomjoon Kim

{"title":"Porous microneedles on a paper for screening test of prediabetes","authors":"Hakjae Lee, Gwenaël Bonfante, Yui Sasaki, Nobuyuki Takama, Tsuyoshi Minami, Beomjoon Kim","doi":"10.1002/mds3.10109","DOIUrl":"10.1002/mds3.10109","url":null,"abstract":"Porous microneedles are expected to have a variety of potential for applications in diagnostics owing to their ability to penetrate human skin painlessly and extract bio-fluid by capillary action. In this paper, a ‘Porous Microneedle on a Paper substrate’ (PMP) is proposed as a novel platform for direct integration of sensors. A microneedle array with height of approximately 840 μm was prepared on a paper. The fabrication process consists of salt leaching and heat press moulding. In this method, the salt particles are utilized as porogen materials. Mixture of the biodegradable polymer and the salt was shaped into microneedles by moulding. Furthermore, the polymer penetrated the paper matrix owing to heating during the pressing process. Subsequently, the salt particles are removed to develop the porous structure. Various ratios of salt to polymer were investigated to adjust the porosity of microneedles as well as their sample absorption property. A paper-based glucose sensor was integrated into the platform to demonstrate the absorption property of the microneedles, and showed successful sample extraction and glucose concentration analysis from agarose gel-based skin mimic. The developed platform has the potential to integrate various paper-based bio-sensors to painless, disposal and fast screening and diagnostic test for patient, as well as those with prediabetes.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48103826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Biodegradable 3D porous zinc alloy scaffold for bone fracture fixation devices 用于骨折固定装置的可生物降解三维多孔锌合金支架

Medical devices & sensors Pub Date : 2020-07-01 DOI: 10.1002/mds3.10108

M Bobby Kannan, Jonathon Chappell, Hadis Khakbaz, Mehdi Taherishargh, Thomas Fiedler

{"title":"Biodegradable 3D porous zinc alloy scaffold for bone fracture fixation devices","authors":"M Bobby Kannan, Jonathon Chappell, Hadis Khakbaz, Mehdi Taherishargh, Thomas Fiedler","doi":"10.1002/mds3.10108","DOIUrl":"10.1002/mds3.10108","url":null,"abstract":"In this study, a three-dimensional (3D) porous zinc alloy (Zn-Al4) scaffold was produced using counter-gravity infiltration casting method and its in vitro degradation behaviour was evaluated using an electrochemical technique in simulated body fluid (SBF) for potential applications in bone fracture fixation devices. The porous zinc alloy exhibited porosity of ~60% with interconnected pores, and the pore size was 1–2 mm. The in vitro potentiodynamic polarization results showed that the degradation rate of the porous zinc alloy was 0.16 mm/year, which is ~15% higher than that of the non-porous pure zinc metal (0.14 mm/year). Highly biocompatible calcium phosphate (CaP) was electrochemically deposited on the porous zinc alloy and its in vitro degradation behaviour was also studied. The micrographs of the CaP deposited porous zinc alloy revealed uniformly coverage of CaP particles on the outer surface of the alloy and partial deposition on the inside of the pores. The morphology of the deposited CaP particles was predominantly spherical-shaped, but flake-like particles were also evident on the inside of the pores. Interestingly, the degradation rate of the CaP deposited porous zinc alloy (0.5 mm/year) was three times higher than that of the porous zinc alloy. It can be hypothesized that the restricted SBF flow through the partially blocked pores by the CaP particles have locally raised the pH inside the pores and thus increased the degradation.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"99375418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Viral filtration using carbon-based materials 利用碳基材料进行病毒过滤

Medical devices & sensors Pub Date : 2020-06-19 DOI: 10.1002/mds3.10107

Rupy Kaur Matharu, Harshit Porwal, Biqiong Chen, Lena Ciric, Mohan Edirisinghe

{"title":"Viral filtration using carbon-based materials","authors":"Rupy Kaur Matharu, Harshit Porwal, Biqiong Chen, Lena Ciric, Mohan Edirisinghe","doi":"10.1002/mds3.10107","DOIUrl":"10.1002/mds3.10107","url":null,"abstract":"Viral infections alone are a significant cause of morbidity and mortality worldwide and have a detrimental impact on global healthcare and socio-economic development. The discovery of novel antiviral treatments has gained tremendous attention and support with the rising number of viral outbreaks. In this work, carbonaceous materials, including graphene nanoplatelets and graphene oxide nanosheets, were investigated for antiviral properties. The materials were characterized using scanning electron microscopy and transmission electron microscopy. Analysis showed the materials to be two-dimensional with lateral dimensions ranging between 1 and 4 µm for graphene oxide and 110 ± 0.11 nm for graphene nanoplatelets. Antiviral properties were assessed against a DNA virus model microorganism at concentrations of 0.5, 1.0 and 2.0 wt/v%. Both carbonaceous nanomaterials exhibited potent antiviral properties and gave rise to a viral reduction of 100% across all concentrations tested. Graphene oxide nanosheets were then incorporated into polymeric fibres, and their antiviral behaviour was examined after 3 and 24 hr. A viral reduction of 39% was observed after 24 hr of exposure. The research presented here showcases, for the first time, the antiviral potential of several carbonaceous nanomaterials, also included in a carrier polymer. These outcomes can be translated and implemented in many fields and devices to prevent viral spread and infection.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38303159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23